Structural characteristics of oil-poor dilutable fish oil omega-3 microemulsions for ophthalmic applications

Journal of Colloid and Interface Science

Volumn 463, Issue , 2016, Pages 83-92

  Lidich, Nina ^a   Aserin, Abraham ^a   Garti, Nissim ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Cryo TEM; Drug delivery system; Dry eye syndrome; Omega fatty acids; Self diffusion NMR; Solubilization

Indexed keywords

DROPS; FATTY ACIDS; NON NEWTONIAN FLOW; SURFACE ACTIVE AGENTS; VISCOSITY;

CRYO-TEM; DRUG DELIVERY SYSTEM; DRY EYE; SELF-DIFFUSION; SOLUBILIZATION;

MICROEMULSIONS;

DOCOSAHEXAENOIC ACID; FISH OIL; LONG CHAIN TRIACYLGLYCEROL; OMEGA 3 FATTY ACID; WATER OIL CREAM;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DILUTION; DRUG DELIVERY SYSTEM; ELECTRIC CONDUCTIVITY; LIGHT SCATTERING; MICROEMULSION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SOLUBILIZATION; TRANSMISSION ELECTRON MICROSCOPY; VISCOSITY; WATER CONTENT; X RAY CRYSTALLOGRAPHY;

EID: 84945962886     PISSN: 00219797     EISSN: 10957103     Source Type: Journal    
DOI: 10.1016/j.jcis.2015.10.024     Document Type: Article

References (56)

1. Schulman J.H., Stoeckenius W., Prince L.M. Mechanism of formation and structure of microemulsions by electron microscopy. J. Phys. Chem. 1959, 63:1677-1680.
2. Strey R. Microemulsion microstructure and interfacial curvature. Colloid Polym. Sci. 1994, 272:1005-1019.
3. Danielsson I., Lindman B. The definition of microemulsion. Colloids Surf. 1981, 3:391-392.
4. Hatzopoulos M.H., Eastoe J., Dowding P.J., Grillo I. Cylinder to sphere transition in reverse microemulsions: the effect of hydrotropes. J. Colloid Interface Sci. 2013, 392:304-310.
5. Spernath A., Aserin A. Microemulsions as carriers for drugs and nutraceuticals. Adv. Colloid Interface Sci. 2006, 128:47-64.
6. Kogan A., Garti N. Microemulsions as transdermal drug delivery vehicles. Adv. Colloid Interface Sci. 2006, 123:369-385.
7. Lawrence M.J., Rees G.D. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 2012, 64:175-193.
8. Sintov A.C. Transdermal delivery of curcumin via microemulsion. Int. J. Pharm. 2015, 481:97-103.
9. Spernath A., Aserin A., Sintov A.C., Garti N. Phosphatidylcholine embedded micellar systems: enhanced permeability through rat skin. J. Colloid Interface Sci. 2008, 318:421-429.
10. Lee M.-H., Kao L., Lin C.-C. Comparison of the antioxidant and transmembrane permeative activities of the different polygonum cuspidatum extracts in phospholipid-based microemulsions. J. Agric. Food Chem. 2011, 59:9135-9141.
11. Liu C.-H., Chang F.-Y., Hung D.-K. Terpene microemulsions for transdermal curcumin delivery: effects of terpenes and cosurfactants. Colloids Surf. B 2011, 82:63-70.
12. Hathout R.M., Nasr M. Transdermal delivery of betahistine hydrochloride using microemulsions: physical characterization, biophysical assessment, confocal imaging and permeation studies. Colloids Surf. B 2013, 110:254-260.
13. Li Y., Song J., Tian N., Cai J., Huang M., Xing Q., Wang Y., Wu C., Hu H. Improving oral bioavailability of metformin hydrochloride using water-in-oil microemulsions and analysis of phase behavior after dilution. Int. J. Pharm. 2014, 473:316-325.
14. Vandamme T.F. Microemulsions as ocular drug delivery systems: recent developments and future challenges. Prog. Retin. Eye Res. 2002, 21:15-34.
15. Peng C.C., Bengani L.C., Jung H.J., Leclerc J., Gupta C., Chauhan A. Emulsions and microemulsions for ocular drug delivery. J. Drug Deliv. Sci. Technol. 2011, 21:111-121.
16. R.R. Hegde, A. Verma, A. Ghosh, Microemulsion: new insights into the ocular drug delivery, ISRN Pharm. 2013 (2013), Article ID 826798.
17. Swanson D., Block R., Mousa S.A. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv. Nutr. 2012, 3:1-7.
18. McMurray D.N., Bonilla D.L., Chapkin R.S. N-3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization. Chem. Phys. Lipids 2011, 164:626-635.
19. Pinazo-Duran M.D., Galbis-Estrada C., Pons-Vazquez S., Cantu-Dibildox J., Marco-Ramirez C., Benitez-del-Castillo J. Effects of a nutraceutical formulation based on the combination of antioxidants and omega-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders. Clin. Interv. Aging 2013, 8:139-147.
20. J.-Y. Wang, Y. Wang, M. Saito, Effect of dietary supplementation of DHA on peroxidizability of rat retina. In: M.C. Teale (Eds.), Omega 3 Fatty Acid Research, 2006, pp. 241-263.
21. SanGiovanni J.P., Chew E.Y., Clemons T.E., Davis M.D., Ferris F.L., Gensler G.R., Kurinij N., Lindblad A.S., Milton R.C., Seddon J.M., Sperduto R.D. The relationship of dietary lipid intake and age-related macular degeneration in a case-control study - AREDS report no. 20. Arch. Ophthalmol. 2007, 125:671-679.
22. Dawczynski J., Jentsch S., Schweitzer D., Hammer M., Lang G.E., Strobel J. Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study. Graefes Arch. Clin. Exp. Ophthalmol. 2013, 251:2711-2723.
23. Kangari H., Eftekhari M.H., Sardari S., Hashemi H., Salamzadeh J., Ghassemi-Broumand M., Khabazkhoob M. Short-term consumption of oral omega-3 and dry eye syndrome. Ophthalmology 2013, 120:2191-2196.
24. Bhargava R., Kumar P., Kumar M., Mehra N., Mishra A. A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. Int. J. Ophthalmol. 2013, 6:811-816.
25. Li Z., Choi J.-H., Oh H.-J., Park S.-H., Lee J.-B., Yoon K.C. Effects of eye drops containing a mixture of omega-3 essential fatty acids and hyaluronic acid on the ocular surface in desiccating stress-induced murine dry eye. Curr. Eye Res. 2014, 39:871-878.
26. Rashid S., Jin Y., Ecoiffier T., Barabino S., Schaumberg D.A., Dana R. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. Arch. Ophthalmol. 2008, 126:219-225.
27. Sugasini D., Lokesh B.R. Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. Mol. Cell Biochem. 2013, 382:203-216.
28. Kumar N.S. D-optimal experimental approach for designing topical microemulsion of itraconazole: characterization and evaluation of antifungal efficacy against a standardized Tinea pedis infection model in Wistar rats. Eur. J. Pharm. Sci. 2015, 67:97-112.
29. Deutch-Kolevzon R., Aserin A., Garti N. Synergistic cosolubilization of omega-3 fatty acid esters and CoQ(10) in dilutable microemulsions. Chem. Phys. Lipids 2011, 164:654-663.
30. Zheng M.Y., Liu F., Wang Z.W., Baoyindugurong J.H. Formation and characterization of self-assembling fish oil microemulsions. Colloid J. 2011, 73:319-326.
31. Vanderhoeven P.H.C., Lyklema J. Electrostatic stabilization in nonaqueous media. Adv. Colloid Interface Sci. 1992, 42:205-277.
32. Garti N., Hoshen G., Aserin A. Lipolysis and structure controlled drug release from reversed hexagonal mesophase. Colloids Surf. B 2012, 94:36-43.
33. Ezrahi S., Wachtel E., Aserin A., Garti N. Structural polymorphism in a four-component nonionic microemulsion. J. Colloid Interface Sci. 1997, 191:277-290.
34. Stilbs P. Fourier transform pulsed-gradient spin-echo studies of molecular diffusion. Prog. Nucl. Magn. Reson. Spectrosc. 1987, 19:1-45.
35. Fisher S., Wachtel E.J., Aserin A., Garti N. Solubilization of simvastatin and phytosterols in a dilutable microemulsion system. Colloids Surf. B 2013, 107:35-42.
36. Senatra D., Guarini G.G.T., Gabrielli G., Zoppi M. Low-temperature study of w/o microemulsions by differential scanning calorimetry and dielectric measurements. J. Phys. 1984, 45:1159-1174.
37. Yaghmur A., Aserin A., Tiunova I., Garti N. Sub-zero temperature behaviour of non-ionic microemulsions in the presence of propylene glycol by DSC. J. Therm. Anal. Calorim. 2002, 69:163-177.
38. Nir I., Aserin A., Libster D., Garti N. Solubilization of a dendrimer into a microemulsion. J. Phys. Chem. B 2010, 114:16723-16730.
39. Bellare J.R., Davis H.T., Scriven L.E., Talmon Y. Controlled environment vitrification system - an improved sample preparation. J. Electron Microsc. Tech. 1988, 10:87-111.
40. Sharma S.C., Warr G.G. Phase behavior, self-assembly, and emulsification of Tween 80/water mixtures with limonene and perfluoromethyldecalin. Langmuir 2012, 28:11707-11713.
41. Kogan A., Shalev D.E., Raviv U., Aserin A., Garti N. Formation and characterization of ordered bicontinuous microemulsions. J. Phys. Chem. B 2009, 113:10669-10678.
42. de Campo L., Yaghmur A., Garti N., Leser M.E., Folmer B., Glatter O. Five-component food-grade microemulsions: structural characterization by SANS. J. Colloid Interface Sci. 2004, 274:251-267.
43. Teubner M., Strey R. Origin of the scattering peak in microemulsions. J. Chem. Phys. 1987, 87:3195-3200.
44. Lapteva M., Kalia Y.N. Microstructured bicontinuous phase formulations: their characterization and application in dermal and transdermal drug delivery. Expert Opin. Drug Deliv. 2013, 10:1043-1059.
45. Chevalier Y., Zemb T. The structure of micelles and microemulsions. Rep. Prog. Phys. 1990, 53:279-371.
46. Gazeau D., Bellocq A.M., Roux D., Zemb T. Experimental evidence for bicontinuous structures in L3 phases. Prog. Colloid Polym. Sci. 1989, 79:226-232.
47. Zemb T. Flexibility, persistence length and bicontinuous microstructures in microemulsions. C. R. Chimie 2009, 12:218-224.
48. Duvail M., Dufreche J.-F., Arleth L., Zemb T. Stiff and flexible water-poor microemulsions: disconnected and bicontinuous microstructures, their phase diagrams, and scattering properties. Prog. Colloid Interface Sci. 2014, 4:503-528.
49. Garti N., Aserin A., Tiunova I., Ezrahi S. Sub-zero temperature behaviour of water in non-ionic microemulsions. J. Therm. Anal. Calorim. 1998, 51:63-78.
50. Kogan A., Aserin A., Garti N. Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution. J. Colloid Interface Sci. 2007, 315:637-647.
51. Tamhane V.A., Dhaware D.G., Khandelwal N., Giri A.P., Panchagnula V. Enhanced permeation, leaf retention, and plant protease inhibitor activity with bicontinuous microemulsions. J. Colloid Interface Sci. 2012, 383:177-183.
52. Wang W., Wei H., Du Z., Tai X., Wang G. Formation and characterization of fully dilutable microemulsion with fatty acid methyl esters as oil phase. ACS Sustain. Chem. Eng. 2015, 3:443-450.
53. Spernath A., Aserin A., Garti N. Phase transition induced by water dilution in phospholipid U-type food-grade microemulsions studied by DSC. J. Therm. Anal. Calorim. 2006, 83:297-308.
54. Rozner S., Aserin A., Garti N. Competitive solubilization of cholesterol and phytosterols in nonionic microemulsions studied by pulse gradient spin-echo NMR. J. Colloid Interface Sci. 2008, 321:418-425.
55. Radomska-Soukharev A., Wojciechowska J. Microemulsions as potential ocular drug delivery systems: phase diagrams and physical properties depending on ingredients. Acta Pol. Pharm. 2005, 62:465-471.
56. Garti N., Avrahami M., Aserin A. Improved solubilization of celecoxib in U-type nonionic microemulsions and their structural transitions with progressive aqueous dilution. J. Colloid Interface Sci. 2006, 299:352-365.