Topical omega-3 and omega-6 fatty acids for treatment of dry eye

Archives of Ophthalmology

Volumn 126, Issue 2, 2008, Pages 219-225

  Rashid, Saadia ^a,b   Jin, Yiping ^a,b   Ecoiffier, Tatiana ^a,b   Barabino, Stefano ^a,b,c   Schaumberg, Debra A ^a,b,d   Dana, M Reza ^a,b,e  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF GENOA   (Italy)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CYTOKINE; FLUORESCEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 6; LINOLEIC ACID; LINOLENIC ACID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; DRUG EFFICACY; DRY EYE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADMINISTRATION, TOPICAL; ALPHA-LINOLENIC ACID; ANIMALS; ANTIGENS, CD11B; CELL COUNT; CONJUNCTIVA; CORNEA; CYTOKINES; DISEASE MODELS, ANIMAL; DRY EYE SYNDROMES; FLUORESCEIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; LINOLEIC ACID; MICE; MICE, INBRED C57BL; MONOCYTES; OPHTHALMIC SOLUTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

EID: 39049160663     PISSN: 00039950     EISSN: 00039950     Source Type: Journal    
DOI: 10.1001/archophthalmol.2007.61     Document Type: Article

References (45)

1. Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol. 2000;118(9):1264-1268.
2. Schein OD, Hochberg MC, Munoz B, et al. Dry eye and dry mouth in the elderly: a population-based assessment. Arch Intern Med. 1999;159(12):1359-1363.
3. Miljanovic BM, Dana R, Sullivan DA, Schaumberg DA. Impact of dry eye syndrome on vision-related quality of life among women. Am J Ophthalmol. 2007; 143(3):409-415.
4. Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf. 2004;2(2):124-130.
5. Pflugfelder SC. Antiinflammatory therapy for dry eye. Am J Ophthalmol. 2004;137 (2):337-342.
6. Flower RJ, Perretti M. Controlling inflammation, a fat chance. J Exp Med. 2005; 201(5):671-674.
7. Aragona P, Bucolo C, Spinella R, Giuffrida S, Ferreri G. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren's syndrome patients. Invest Ophthalmol Vis Sci. 2005;46(12):4474-4479.
8. Barabino S, Rolando M, Camicione P, et al. Systemic linoleic and gammalinolenic acid therapy in dry eye syndrome with an inflammatory component. Cornea. 2003;22(2):97-101.
9. Miljanovic B, Trivedi KA, Dana MR, Gilbard JP, Buring JE, Schaumberg DA. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr. 2005;82(4):887-893.
10. Simopoulos AP. The importance of ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmocother. 2002;56(8):365-379.
11. Barabino S, Shen L, Chen L, Rashid S, Rolandao M, Dana MR. The controlled-environment chamber: a new mouse model of dry eye. Invest Ophthalmol Vis Sci. 2005;46(8):2766-2771.
12. Barabino S, Chen W, Dana MR. Tear film and ocular surface tests in animal models of dry eye: uses and limitations. Exp Eye Res. 2004;79(5):613-621.
13. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995;21(4):221-232.
14. Hamrah P, Zhang Q, Liu Y, Dana MR. Novel characterization of MHC class IInegative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci. 2002;43(3):639-646.
15. Hamrah P, Liu Y, Zhang Q, Dana MR. Alterations in corneal stromal dendritic cell phenotype and distribution in inflammation. Arch Ophthalmol. 2003;121 (8):1132-1140.
16. Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004; 45(12):4293-4301.
17. Gulati A, Sacchetti M, Bonini S, Dana R. Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome. Arch Ophthalmol. 2006;124(5):710-716.
18. Emken EA, Adlof RO, Gulley RM. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochim Biophys Acta. 1994;1213(3):277-288.
19. Gerster H. Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? Int J Vitam Nutr Res. 1998;68(3):159-173.
20. Brash AR, Boeglin WE, Chang MS. Discovery of a second 15S-lipoxygenase in humans. Proc Natl Acad Sci U S A. 1997;94(12):6148-6152.
21. Liminga M, Oliw E. cDNA cloning of 15-lipoxygenase type 2 and 12-lipoxygenases of bovine corneal epithelium. Biochim Biophys Acta. 1999;1437 (2):124-135.
22. Gronert K, Maheswari N, Khan N, Hassan IR, Dunn M, Laniado Schwartzman M. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J Biol Chem. 2005;280(15):15267-15278.
23. Dana MR, Yamada J, Streilein JW. Topical interleukin 1 receptor antagonist promotes corneal transplant survival. Transplantation. 1997;63(10):1501-1507.
24. Brito BE, O'Rourke LM, Pan Y, Anglin J, Planck SR, Rosenbaum JT. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci. 1999;40(11):2583-2589.
25. Rosenbaum JT, Planck ST, Huang XN, Rick L, Ansel JC. Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. Invest Ophthalmol Vis Sci. 1995;36(10):2151-2155.
26. Fabre EJ, Bureau J, Pouliquen Y, Lorans G. Binding sites for human interleukin 1 alpha, gamma interferon and tumor necrosis factor on cultured fibroblasts of normal cornea and keratoconus. Curr Eye Res. 1991;10(7):585-592.
27. Wilson SE, Mohan RR, Mohan RR, Ambrosio R Jr, Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res. 2001;20(5):625-637.
28. Wilson SE, He YG, Weng J, et al. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp Eye Res. 1996;62(4):325-327.
29. West-Mays JA, Strissel KJ, Sadow PM, Fini ME. Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop. Proc Natl Acad Sci U S A. 1995;92(15):6768-6772.
30. Trousdale MD, Zhu Z, Stevenson D, Schechter JE, Ritter T, Mircheff AK. Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. J Autoimmune Dis. 2005;2:6.
31. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res. 1999;19(3):201-211.
32. Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC. Pro- and antiinflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001;42(10):2283-2292.
33. Morris DD, Henry MM, Moore JN, Fischer JK. Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. Am J Vet Res. 1991;52(4):528-532.
34. James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr. 2000;71(1)(suppl):343S- 348S.
35. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med. 1989;320(5):265-271.
36. Abbas AK, Lichtman AH, Pober JS. Cytokines: Cellular and Molecular Immunology. Philadelphia, PA: WB Saunders Co; 1997:250-276.
37. Hamrah P, Liu Y, Zhang Q, Dana MR. The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci. 2003; 44(2):581-589.
38. Hamrah P, Huq S, Liu Y, Zhang Q, Dana MR. Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leukoc Biol. 2003; 74(2):172-178.
39. Stern ME, Gao J, Schwalb TA, et al. Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest Ophthalmol Vis Sci. 2002; 43(8):2609-2614.
40. Dekaris I, Zhu S, Dana MR. TNF-alpha regulates corneal Langerhans cell migration. J Immunol. 1999;162(7):4235-4239.
41. Callanan D, Peeler J, Niederkorn JY. Characteristics of rejection of orthotopic corneal allografts in the rat. Transplantation. 1988;45(2):437-443.
42. McLeish W, Rubsamen P, Atherton SS, Streilein JW. Immunobiology of Langerhans cells on the ocular surface: II, role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. Reg Immunol. 1989;2(4):236-243.
43. Jager MJ, Bradley D, Atherton S, Streilein JW. Presence of Langerhans cells in the central cornea linked to the development of ocular herpes in mice. Exp Eye Res. 1992;54(6):835-841.
44. Theander E, Horrobin DF, Jacobsson LT, Manthrope R. Gammalinolenic acid treatment of fatigue associated with primary Sjogren's syndrome. Scand J Rheumatol. 2002;31(2):72-79.
45. Schaeffer L, Gohlke H, Muller M, et al. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet. 2006;15(11):1745-1756.