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Volumn 5, Issue , 2015, Pages

Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: Its implications in gastric carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE SHP 2;

EID: 84945958804     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15749     Document Type: Article
Times cited : (37)

References (40)
  • 1
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser, M. J. et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55, 2111-2115 (1995).
    • (1995) Cancer Res , vol.55 , pp. 2111-2115
    • Blaser, M.J.1
  • 2
    • 0030975595 scopus 로고    scopus 로고
    • Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection
    • Parsonnet, J., Friedman, G. D., Orentreich, N. and Vogelman, H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 40, 297-301 (1997).
    • (1997) Gut , vol.40 , pp. 297-301
    • Parsonnet, J.1    Friedman, G.D.2    Orentreich, N.3    Vogelman, H.4
  • 3
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
    • Ferlay, J. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136, E359-E386 (2015).
    • (2015) Int J Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1
  • 4
    • 0034695879 scopus 로고    scopus 로고
    • Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell
    • Covacci, A. and Rappuoli, R. Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell. J Exp Med 191, 587-592 (2000).
    • (2000) J Exp Med , vol.191 , pp. 587-592
    • Covacci, A.1    Rappuoli, R.2
  • 5
    • 84872005854 scopus 로고    scopus 로고
    • Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA
    • Hayashi, T. et al. Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA. Cell host microbe 12, 20-33 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 20-33
    • Hayashi, T.1
  • 6
    • 84859727213 scopus 로고    scopus 로고
    • Multistep activation of the Helicobacter pylori effector CagA
    • Muller, A. Multistep activation of the Helicobacter pylori effector CagA. The Journal of clinical investigation 122, 1192-1195, (2012).
    • (2012) The Journal of Clinical Investigation , vol.122 , pp. 1192-1195
    • Muller, A.1
  • 7
    • 0033456273 scopus 로고    scopus 로고
    • Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori
    • Segal, E. D., Cha, J., Lo, J., Falkow, S. and Tompkins, L. S. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci USA 96, 14559-14564 (1999).
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14559-14564
    • Segal, E.D.1    Cha, J.2    Lo, J.3    Falkow, S.4    Tompkins, L.S.5
  • 8
    • 4544334936 scopus 로고    scopus 로고
    • Oncogenic mechanisms of the Helicobacter pylori CagA protein
    • Hatakeyama, M. Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer 4, 688-694 (2004).
    • (2004) Nat Rev Cancer , vol.4 , pp. 688-694
    • Hatakeyama, M.1
  • 9
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi, H. et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci USA 99, 14428-14433 (2002).
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14428-14433
    • Higashi, H.1
  • 10
    • 84863098366 scopus 로고    scopus 로고
    • Association between cagA and vacA genotypes and pathogenesis in a Helicobacter pylori infected population from South-eastern Sweden
    • Karlsson, A., Ryberg, A., Dehnoei, M. N., Borch, K. and Monstein, H. J. Association between cagA and vacA genotypes and pathogenesis in a Helicobacter pylori infected population from South-eastern Sweden. BMC Microbiol 12, 129 (2012).
    • (2012) BMC Microbiol , vol.12 , pp. 129
    • Karlsson, A.1    Ryberg, A.2    Dehnoei, M.N.3    Borch, K.4    Monstein, H.J.5
  • 11
    • 70450170758 scopus 로고    scopus 로고
    • A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori
    • Xia, Y., Yamaoka, Y., Zhu, Q., Matha, I. and Gao, X. A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori. PLoS One 4, e7736 (2009).
    • (2009) PLoS One , vol.4 , pp. e7736
    • Xia, Y.1    Yamaoka, Y.2    Zhu, Q.3    Matha, I.4    Gao, X.5
  • 12
    • 0037169076 scopus 로고    scopus 로고
    • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    • Higashi, H. et al. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295, 683-686, (2002).
    • (2002) Science , vol.295 , pp. 683-686
    • Higashi, H.1
  • 13
    • 43049093663 scopus 로고    scopus 로고
    • The tyrosine phosphatase Shp2 (PTPN11) in cancer
    • Chan, G., Kalaitzidis, D. and Neel, B. G. The tyrosine phosphatase Shp2 (PTPN11) in cancer. Cancer Metastasis Rev 27, 179-192 (2008).
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 179-192
    • Chan, G.1    Kalaitzidis, D.2    Neel, B.G.3
  • 14
    • 38949199463 scopus 로고    scopus 로고
    • Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
    • Ohnishi, N. et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci USA 105, 1003-1008 (2008).
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1003-1008
    • Ohnishi, N.1
  • 15
    • 46049098358 scopus 로고    scopus 로고
    • Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    • Basso, D. et al. Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology 135, 91-99 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 91-99
    • Basso, D.1
  • 16
    • 79953125222 scopus 로고    scopus 로고
    • Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer
    • Batista, S. A. et al. Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer. BMC Microbiol 11, 61 (2011).
    • (2011) BMC Microbiol , vol.11 , pp. 61
    • Batista, S.A.1
  • 17
    • 84965088105 scopus 로고    scopus 로고
    • The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population
    • Beltran-Anaya, F. et al. The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population. BMC Gastroenterol 14, 2 (2014).
    • (2014) BMC Gastroenterol , vol.14 , pp. 2
    • Beltran-Anaya, F.1
  • 18
    • 84860282568 scopus 로고    scopus 로고
    • The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma
    • Ferreira, R. M., Machado, J. C., Leite, M., Carneiro, F. and Figueiredo, C. The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma. Histopathology 60, 992-998 (2012).
    • (2012) Histopathology , vol.60 , pp. 992-998
    • Ferreira, R.M.1    Machado, J.C.2    Leite, M.3    Carneiro, F.4    Figueiredo, C.5
  • 19
    • 79960443215 scopus 로고    scopus 로고
    • High prevalence of virulence-associated genotypes in Helicobacter pylori clinical isolates in the Region del Maule Chile
    • Gonzalez, I. et al. High prevalence of virulence-associated genotypes in Helicobacter pylori clinical isolates in the Region del Maule, Chile. Scand J Infect Dis 43, 652-655 (2011).
    • (2011) Scand J Infect Dis , vol.43 , pp. 652-655
    • Gonzalez, I.1
  • 20
    • 77950958214 scopus 로고    scopus 로고
    • CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions
    • Sicinschi, L. A. et al. CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin Microbiol Infect 16, 369-378 (2010).
    • (2010) Clin Microbiol Infect , vol.16 , pp. 369-378
    • Sicinschi, L.A.1
  • 21
    • 84859571797 scopus 로고    scopus 로고
    • Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
    • Aceto, N. et al. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med 18, 529-537 (2012).
    • (2012) Nat Med , vol.18 , pp. 529-537
    • Aceto, N.1
  • 22
    • 84933530310 scopus 로고    scopus 로고
    • Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases
    • Sausgruber, N. et al. Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases. Oncogene 34, 2272-2278 (2015).
    • (2015) Oncogene , vol.34 , pp. 2272-2278
    • Sausgruber, N.1
  • 23
    • 84902980458 scopus 로고    scopus 로고
    • Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis
    • Wang, H. C., Chiang, W. F., Huang, H. H., Shen, Y. Y. and Chiang, H. C. Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis. BMC Cancer 14, 442 (2014).
    • (2014) BMC Cancer , vol.14 , pp. 442
    • Wang, H.C.1    Chiang, W.F.2    Huang, H.H.3    Shen, Y.Y.4    Chiang, H.C.5
  • 24
    • 78649615616 scopus 로고    scopus 로고
    • SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion
    • Yang, X., Dutta, U. and Shaw, L. M. SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion. Mol Cell Biol 30, 5306-5317 (2010).
    • (2010) Mol Cell Biol , vol.30 , pp. 5306-5317
    • Yang, X.1    Dutta, U.2    Shaw, L.M.3
  • 26
    • 0032548830 scopus 로고    scopus 로고
    • Crystal structure of the tyrosine phosphatase SHP-2
    • Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M. J. and Shoelson, S. E. Crystal structure of the tyrosine phosphatase SHP-2. Cell 92, 441-450 (1998).
    • (1998) Cell , vol.92 , pp. 441-450
    • Hof, P.1    Pluskey, S.2    Dhe-Paganon, S.3    Eck, M.J.4    Shoelson, S.E.5
  • 27
    • 80053009203 scopus 로고    scopus 로고
    • Potentiation of Helicobacter pylori CagA protein virulence through homodimerization
    • Nagase, L., Murata-Kamiya, N. and Hatakeyama, M. Potentiation of Helicobacter pylori CagA protein virulence through homodimerization. J Biol Chem 286, 33622-33631 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 33622-33631
    • Nagase, L.1    Murata-Kamiya, N.2    Hatakeyama, M.3
  • 28
    • 34249090814 scopus 로고    scopus 로고
    • Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
    • Saadat, I. et al. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447, 330-333 (2007).
    • (2007) Nature , vol.447 , pp. 330-333
    • Saadat, I.1
  • 29
    • 2342429370 scopus 로고    scopus 로고
    • Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation
    • Higashi, H. et al. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem 279, 17205-17216 (2004).
    • (2004) J Biol Chem , vol.279 , pp. 17205-17216
    • Higashi, H.1
  • 30
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. and Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 31
    • 77955959294 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis
    • Acosta, N., Quiroga, A., Delgado, P., Bravo, M. M. and Jaramillo, C. Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis. World J Gastroenterol 16, 3936-3943 (2010).
    • (2010) World J Gastroenterol , vol.16 , pp. 3936-3943
    • Acosta, N.1    Quiroga, A.2    Delgado, P.3    Bravo, M.M.4    Jaramillo, C.5
  • 32
    • 73449093843 scopus 로고    scopus 로고
    • Analysis of 3-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population
    • Shokrzadeh, L. et al. Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population. J Gastroenterol Hepatol 25, 172-177 (2010).
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 172-177
    • Shokrzadeh, L.1
  • 33
    • 84873673705 scopus 로고    scopus 로고
    • Bacterial EPIYA effectors-where do they come from? What are they? Where are they going?
    • Hayashi, T., Morohashi, H. and Hatakeyama, M. Bacterial EPIYA effectors-where do they come from? What are they? Where are they going? Cell Microbiol 15, 377-385 (2013).
    • (2013) Cell Microbiol , vol.15 , pp. 377-385
    • Hayashi, T.1    Morohashi, H.2    Hatakeyama, M.3
  • 34
    • 79960459880 scopus 로고    scopus 로고
    • CagA phosphorylation-dependent MMP-9 expression in gastric epithelial cells
    • Nam, Y. H. et al. CagA phosphorylation-dependent MMP-9 expression in gastric epithelial cells. Helicobacter 16, 276-283 (2011).
    • (2011) Helicobacter , vol.16 , pp. 276-283
    • Nam, Y.H.1
  • 35
    • 84555179609 scopus 로고    scopus 로고
    • Extracellular matrix degradation and remodeling in development and disease
    • Lu, P., Takai, K., Weaver, V. M. and Werb, Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol 3, a005058 (2011).
    • (2011) Cold Spring Harb Perspect Biol , vol.3 , pp. a005058
    • Lu, P.1    Takai, K.2    Weaver, V.M.3    Werb, Z.4
  • 36
    • 84915763166 scopus 로고    scopus 로고
    • The extracellular matrix modulates the hallmarks of cancer
    • Pickup, M. W., Mouw, J. K. and Weaver, V. M. The extracellular matrix modulates the hallmarks of cancer. EMBO Rep 15, 1243-1253 (2014).
    • (2014) EMBO Rep , vol.15 , pp. 1243-1253
    • Pickup, M.W.1    Mouw, J.K.2    Weaver, V.M.3
  • 37
    • 84883541737 scopus 로고    scopus 로고
    • PolyQ disease: Misfiring of a developmental cell death program?
    • Blum, E. S., Schwendeman, A. R. and Shaham, S. PolyQ disease: misfiring of a developmental cell death program? Trends Cell Biol 23, 168-174 (2013).
    • (2013) Trends Cell Biol , vol.23 , pp. 168-174
    • Blum, E.S.1    Schwendeman, A.R.2    Shaham, S.3
  • 38
    • 80054784559 scopus 로고    scopus 로고
    • Instability of the octarepeat region of the human prion protein gene
    • Li, B., Qing, L., Yan, J. and Kong, Q. Instability of the octarepeat region of the human prion protein gene. PLoS One 6, e26635 (2011).
    • (2011) PLoS One , vol.6 , pp. e26635
    • Li, B.1    Qing, L.2    Yan, J.3    Kong, Q.4
  • 39
    • 33646016600 scopus 로고    scopus 로고
    • Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA
    • Naito, M. et al. Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. Gastroenterology 130, 1181-1190 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 1181-1190
    • Naito, M.1
  • 40
    • 77955292149 scopus 로고    scopus 로고
    • Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein
    • Murata-Kamiya, N., Kikuchi, K., Hayashi, T., Higashi, H. and Hatakeyama, M. Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein. Cell Host Microbe 7, 399-411 (2010).
    • (2010) Cell Host Microbe , vol.7 , pp. 399-411
    • Murata-Kamiya, N.1    Kikuchi, K.2    Hayashi, T.3    Higashi, H.4    Hatakeyama, M.5


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