Glutamine May Repress the Weak LPS and Enhance the Strong Heat Shock Induction of Monocyte and Lymphocyte HSP72 Proteins but May Not Modulate the HSP72 mRNA in Patients with Sepsis or Trauma

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Briassouli, Efrossini ^a   Tzanoudaki, Marianna ^b   Goukos, Dimitris ^a   Routsi, Christina ^a   Nanas, Serafim ^a   Vardas, Kostas ^a   Apostolou, Kleovoulos ^a   Kanariou, Maria ^b   Daikos, George ^a   Briassoulis, George ^c  

^a UNIVERSITY OF ATHENS   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^c UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; HEAT SHOCK PROTEIN 72; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; HEAT SHOCK; HUMAN; INJURY; LYMPHOCYTE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HEAT SHOCK RESPONSE; IMMUNOLOGY; METABOLISM; PATHOLOGY;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMINE; HEAT-SHOCK RESPONSE; HSP72 HEAT-SHOCK PROTEINS; HUMANS; LIPOPOLYSACCHARIDES; LYMPHOCYTES; MONOCYTES; RNA, MESSENGER; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WOUNDS AND INJURIES;

EID: 84945940110     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/806042     Document Type: Article

References (61)

1. N. P. O'Grady, P. S. Barie, J. G. Bartlett et al., "Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America," Critical Care Medicine, vol. 36, no. 4, pp. 1330-1349, 2008.
2. B. H. Lee, D. Inui, G. Y. Suh et al., "Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study," Critical Care, vol. 16, article R33, 2012.
3. P. J. Young,M. Saxena,R. Beasley et al., "Early peak temperature andmortality in critically ill patients with or without infection," Intensive Care Medicine, vol. 38, no. 3, pp. 437-444, 2012.
4. J. Li and J.-Y. Jiang, "Chinese Head Trauma Data Bank: effect of hyperthermia on the outcome of acute head trauma patients," Journal of Neurotrauma, vol. 29, no. 1, pp. 96-100, 2012.
5. S. Eyers, M. Weatherall, P. Shirtcliffe, K. Perrin, and R. Beasley, "The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analysis," Journal of the Royal Society ofMedicine, vol. 103, no. 10, pp. 403-411, 2010.
6. D. J. Niven, H. T. Stelfox, and K. B. Laupland, "Antipyretic therapy in febrile critically ill adults: a systematic review and meta-analysis," Journal of Critical Care, vol. 28, no. 3, pp. 303-310, 2013.
7. J. Villar, S. P. Ribeiro, J. B. M. Mullen, M. Kuliszewski, M. Post, and A. S. Slutsky, "Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model," Critical CareMedicine, vol. 22, no. 6, pp. 914-921, 1994.
8. B. Henderson and F. Kaiser, "Do reciprocal interactions between cell stress proteins and cytokines create a new intra-/extracellular signalling nexus?" Cell Stress and Chaperones, vol. 18, no. 6, pp. 685-701, 2013.
9. Y.-T. King, C.-S. Lin, J.-H. Lin, and W.-C. Lee, "Wholebody hyperthermia-induced thermotolerance is associated with the induction of heat shock protein 70 in mice," Journal of Experimental Biology, vol. 205, part 2, pp. 273-278, 2002.
10. M. T. Pritchard, Z. Li, and E. A. Repasky, "Nitric oxide production is regulated by fever-range thermal stimulation of murine macrophages," Journal of Leukocyte Biology, vol. 78, no. 3, pp. 630-638, 2005.
11. Y. Shi, Z. Tu, D. Tang et al., "The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways," Shock, vol. 26, no. 3, pp. 277-284, 2006.
12. K. C. Kregel, "Invited review: heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance," Journal of Applied Physiology, vol. 92, no. 5, pp. 2177-2186, 2002.
13. M. Song, M. R. Pinsky, and J. A. Kellum, "Heat shock factor 1 inhibits nuclear factor-B nuclear binding activity during endotoxin tolerance and heat shock," Journal of Critical Care, vol. 23, no. 3, pp. 406-415, 2008.
14. C.-G. Yoo, S. Lee, C.-T. Lee, Y. W. Kim, S. K. Han, and Y.-S. Shim, "Anti-inflammatory effect of heat shock protein induction is related to stabilization of IB through preventing IB kinase activation in respiratory epithelial cells," The Journal of Immunology, vol. 164, no. 10, pp. 5416-5423, 2000.
15. P. E. Wischmeyer, M. Kahana, R. Wolfson, H. Ren, M. M. Musch, and E. B. Chang, "Glutamine inducesheat shockprotein and protects against endotoxin shock in the rat," Journal of Applied Physiology, vol. 90, no. 6, pp. 2403-2410, 2001.
16. P. E. Wischmeyer, J. Riehm, K. D. Singleton et al., "Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells," Nutrition, vol. 19, no. 1, pp. 1-6, 2003.
17. T. R. Ziegler, L. G. Ogden, K. D. Singleton et al., "Parenteral glutamine increases serum heat shock protein 70 in critically ill patients," Intensive Care Medicine, vol. 31, no. 8, pp. 1079-1086, 2005.
18. J. A. Carcillo, J. M. Dean, R. Holubkov et al., "The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial," Pediatric Critical Care Medicine, vol. 13, no. 2, pp. 165-173, 2012.
19. D. Heyland, J. Muscedere, P. E. Wischmeyer et al., "A randomized trial of glutamine and antioxidants in critically ill patients," The New England Journal ofMedicine, vol. 368, no. 16, pp. 1489-1497, 2013.
20. G. Briassoulis, O. Filippou, M. Kanariou, and T. Hatzis, "Comparative effects of early randomized immune or non-immuneenhancing enteral nutrition on cytokine production in children with septic shock," Intensive Care Medicine, vol. 31, no. 6, pp. 851-858, 2005.
21. A. R. H. van Zanten, F. Sztark,U. X. Kaisers et al., "High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-protein enteral nutrition and nosocomial infections in the ICU: a randomized clinical trial," The Journal of the AmericanMedical Association, vol. 312, no. 5, pp. 514-524, 2014.
22. R. V. Vince, K. Oliver, A. W. Midgley, L. R. McNaughton, and L. A. Madden, "In vitro heat shock of human monocytes results in a proportional increase of inducibleHsp70 expression according to the basal content," Amino Acids, vol. 38, no. 5, pp. 1423-1428, 2010.
23. E. Briassouli, D. Goukos, G. Daikos et al., "Glutamine suppressesHsp72 notHsp90 and is not inducing Th1,Th2, orTh17 cytokine responses in human septic PBMCs," Nutrition, vol. 30, no. 10, pp. 1185-1194, 2014.
24. K. Vardas, K. Apostolou, E. Briassouli et al., "Early response roles for prolactin cortisol and circulating and cellular levels of heat shock proteins 72 and 90 in severe sepsis and SIRS," BioMed Research International, vol. 2014, Article ID 803561, 8 pages, 2014.
25. S. E. L. Temple, K. Y. Cheong, K. G. Ardlie, D. Sayer, and G. W. Waterer, "The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A andHSPA1B," Intensive Care Medicine, vol. 30, no. 9, pp. 1761-1767, 2004.
26. R. P. Dellinger, M. M. Levy, A. Rhodes et al., "Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012," Critical Care Medicine, vol. 41, no. 2, pp. 580-637, 2013.
27. D. L. Basi, K. F. Ross, J. S. Hodges, and M. C. Herzberg, "The modulation of tissue factor by endothelial cells during heat shock," The Journal of Biological Chemistry, vol. 278, no. 13, pp. 11065-11071, 2003.
28. M. Cöeffier, R. Marion, P. Ducrotté, and P. Déchelotte, "Modulating effect of glutamine on IL-1-induced cytokine production by human gut," Clinical Nutrition, vol. 22, no. 4, pp. 407-413, 2003.
29. K. D. Singleton, V. E. Beckey, and P. E. Wischmeyer, "Glutamine prevents activation of NF-B and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis," Shock, vol. 24, no. 6, pp. 583-589, 2005.
30. J. D. Vargas-Alarcón, G. Londoño, R. Hernández-Pacheco et al., "Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies," Annals of the Rheumatic Diseases, vol. 61, no. 1, pp. 48-51, 2002.
31. N. Hashiguchi, H. Ogura, H. Tanaka et al., "Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsis," Journal of Trauma-Injury, Infection and Critical Care, vol. 51, no. 6, pp. 1104-1109, 2001.
32. P. M. Yamada, F. T. Amorim, P. Moseley, R. Robergs, and S. M. Schneider, "Effect of heat acclimation on heat shock protein 72 and interleukin-10 in humans," Journal of Applied Physiology, vol. 103, no. 4, pp. 1196-1204, 2007.
33. J. P. McClung, J. D. Hasday, J.-R. He et al., "Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells," The American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 294, no. 1,pp. R185-R191, 2008.
34. S. Schroeder, J. Bischoff, L. E. Lehmann et al., "Endotoxin inhibits heat shock protein 70 (HSP70) expression in peripheral blood mononuclear cells of patients with severe sepsis," Intensive Care Medicine, vol. 25, no. 1, pp. 52-57, 1999.
35. G. Matíc, D. V. Milutinovíc, J. Nestorov et al., "Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD," Psychiatry Research, vol. 215, no. 2, pp. 379-385, 2014.
36. J. Y. Kim, N. Kim, Z. Zheng, J. E. Lee, and M. A. Yenari, "The 70 kDa heat shock protein protects against experimental traumatic brain injury," Neurobiology of Disease, vol. 58,pp. 289-295, 2013.
37. K. Dokladny, M. N. Zuhl, M. Mandell et al., "Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy," The Journal of Biological Chemistry, vol. 288, no. 21, pp. 14959-14972, 2013.
38. M. R. Jacquier-Sarlin, K. Fuller, A. T. Dinh-Xuan,M.-J. Richard, and B. S. Polla, "Protective effects of hsp70 in inflammation," Experientia, vol. 50, no. 11, pp. 1031-1038, 1994.
39. A. Bettaieb and D. A. Averill-Bates, "Thermotolerance induced at a mild temperature of 40?C alleviates heat shock-induced ER stress and apoptosis in HeLa cells," Biochimica et Biophysica Acta, vol. 1853, no. 1, pp. 52-62, 2015.
40. L.-C. Lin, H.-W. Chen, and R.-C. Yang, "Expression of Hsp72 in lymphocytes in patients with febrile convulsion," Kaohsiung Journal of Medical Sciences, vol. 21, no. 3, pp. 101-107, 2005.
41. A. Bouchama, M. M. Hammami, E. Al Shail, and E. DeVol, "Differential effects of in vitro and in vivo hyperthermia on the production of interleukin-10," Intensive Care Medicine, vol. 26, no. 11, pp. 1646-1651, 2000.
42. T. R. Ziegler, K. Benfell, R. J. Smith et al., "Safety and metabolic effects of L-glutamine administration in humans.," Journal of Parenteral and Enteral Nutrition, vol. 14, no. 4, supplement, pp. 137S-146S, 1990.
43. H. Brunengraber andC. R. Roe, "Anapleroticmolecules: current and future," Journal of Inherited Metabolic Disease, vol. 29, no. 2-3, pp. 327-331, 2006.
44. O. E. Owen, S. C. Kalhan, and R. W. Hanson, "The key role of anaplerosis and cataplerosis for citric acid cycle function," Journal of Biological Chemistry, vol. 277, no. 34, pp. 30409-30412, 2002.
45. E. Roth, "Nonnutritive effects of glutamine," Journal of Nutrition, vol. 138, no. 10, pp. 2025S-2031S, 2008.
46. L. V. Marino, N. Pathan, R. Meyer, V. J. Wright, and P. Habibi, "The effect of 2 mMol glutamine supplementation on HSP70 and TNF-release by LPS stimulated blood from healthy children," Clinical Nutrition, 2014.
47. V. F. Cruzat, A. Bittencourt, S. P. Scomazzon, J. S. M. Leite, P. I. H. De Bittencourt, and J. Tirapegui, "Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia," Nutrition, vol. 30, no. 5, pp. 602-611, 2014.
48. G. P. Oliveira, J. D. Silva, C. C. de Aráujo et al., "Intravenous glutamine administration reduces lung and distal organ injury in malnourished rats with sepsis," Shock, vol. 41, no. 3, pp. 222-232, 2014.
49. H. Xue, D. Slavov, and P. E. Wischmeyer, "Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression,"The Journal of Biological Chemistry, vol. 287, no. 48, pp. 40400-40413, 2012.
50. J. Pérez-Bárcena, C. Cresp, V. Regueiro et al., "Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit," Critical Care, vol. 14, no. 6, article R233, 2010.
51. D. K. Heyland and R. Dhaliwal, "Role of glutamine supplementation in critical illness given the results of the REDOXS Study," Journal of Parenteral and Enteral Nutrition, vol. 37, no. 4, pp. 442-443, 2013.
52. P. C. Rodas, O. Rooyackers, C. Hebert, ? A. Norberg, and J. Wernerman, "Glutamine and glutathione at ICU admission in relation to outcome," Clinical Science, vol. 122, no. 12, pp. 591-597, 2012.
53. H. M. O.-V. Straaten, R. J. Bosman, M. Treskes, H. J. I. van der Spoel, and D. F. Zandstra, "Plasma glutamine depletion and patient outcome in acute ICU admissions," Intensive Care Medicine, vol. 27, no. 1, pp. 84-90, 2001.
54. B. R. Bistrian, "Glutamine and antioxidants in critically ill patients,"The New England Journal of Medicine, vol. 369, no. 5, pp. 482-485, 2013.
55. E. Briassouli and G. Briassoulis, "Glutamine randomized studies in early life: the unsolved riddle of experimental and clinical studies," Clinical and Developmental Immunology, vol. 2012, Article ID 749189, 17 pages, 2012.
56. M. Liang, X. Wang, Y. Yuan, Q. Zhou, C. Tong, and W. Jiang, "Different effect of glutamine on macrophage tumor necrosis factor-alpha release and heat shock protein 72 expression in vitro and in vivo," Acta Biochimica et Biophysica Sinica, vol. 41, no. 2, pp. 171-177, 2009.
57. J. D. Johnson and M. Fleshner, "Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72," Journal of Leukocyte Biology, vol. 79, no. 3, pp. 425-434, 2006.
58. A. R. H. van Zanten, R. Dhaliwal, D. Garrel, and D. K. Heyland, "Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis," Critical Care, vol. 19, no. 1, article 294, 2015.
59. K. Zhang, Z. P. Xu, J. Lu et al., "Potential for layered double hydroxides-based, innovative drug delivery systems," International Journal ofMolecular Sciences, vol. 15,no. 5, pp. 7409-7428, 2014.
60. M. Grodzik, F. Sawosz, E. Sawosz et al., "Nano-nutrition of chicken embryos. The effect of in ovo administration of diamond nanoparticles and L-glutamine on molecular responses in chicken embryo pectoral muscles," International Journal of Molecular Sciences, vol. 14, no. 11, pp. 23033-23044, 2013.
61. A. M. A. Rahman, M. Ryczko, M. Nakano et al., "Golgi Nglycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake andmetabolism," Glycobiology, vol. 25, no. 2, pp. 225-240, 2015.