Ccq1-Tpz1TPP1 interaction facilitates telomerase and SHREC association with telomeres in fission yeast

Molecular Biology of the Cell

Volumn 26, Issue 21, 2015, Pages 3857-3866

  Moser, Bettina A ^a   Raguimova, Olga N ^a,b   Nakamura, Toru M ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CCQ1 PROTEIN; FUNGAL PROTEIN; HISTONE DEACETYLASE; SNF2 HISTONE DEACETYLASE CONTAINING REPRESSOR COMPLEX; TELOMERASE; TPZ1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CCQ1 PROTEIN, S POMBE; CELL CYCLE PROTEIN; CHECKPOINT KINASE 2; DEOXYNUCLEOTIDE 3'-PHOSPHATASE; HETEROCHROMATIN; NUCLEOTIDASE; PROTEIN KINASE; SCHIZOSACCHAROMYCES POMBE PROTEIN; TELOMERE BINDING PROTEIN; TPZ1 PROTEIN, S POMBE;

ARTICLE; CELL DEATH; CELL DIVISION; CELL ELONGATION; CELL MUTANT; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE CHECKPOINT; EPISTASIS; GENE MUTATION; GENETIC CROSS; HAPLOIDY; HETEROCHROMATIN; IMMUNOPRECIPITATION; NONHUMAN; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SCHIZOSACCHAROMYCES; SOUTHERN BLOTTING; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; WESTERN BLOTTING; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

CARRIER PROTEINS; CELL CYCLE PROTEINS; CHECKPOINT KINASE 2; HETEROCHROMATIN; NUCLEOTIDASES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERASE; TELOMERE; TELOMERE SHORTENING; TELOMERE-BINDING PROTEINS;

EID: 84945923975     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E15-07-0481     Document Type: Article

References (29)

1. Alfa C, Fantes P, Hyams J, McLoed M, Warbrick E (1993). Experiments with Fission Yeast, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
2. Amberg DC, Burke DJ, Strathern JN (2005). Methods in Yeast Genetics, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
3. Baumann P, Cech TR (2001). Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292, 1171-1175.
4. Blackburn EH, Greider CW, Szostak JW (2006). Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med 12, 1133-1138.
5. Chang YT, Moser BA, Nakamura TM (2013). Fission yeast shelterin regulates DNA polymerases and Rad3ATR kinase to limit telomere extension. PLoS Genet 9, e1003936.
6. Cooper JP, Nimmo ER, Allshire RC, Cech TR (1997). Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385, 744-747.
7. Flory MR, Carson AR, Muller EG, Aebersold R (2004). An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome. Mol Cell 16, 619-630.
8. Harland JL, Chang YT, Moser BA, Nakamura TM (2014). Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr-93 phosphorylation and telomerase recruitment. PLoS Genet 10, e1004708.
9. Jun HI, Liu J, Jeong H, Kim JK, Qiao F (2013). Tpz1 controls a telomerasenonextendible telomeric state and coordinates switching to an extendible state via Ccq1. Genes Dev 27, 1917-1931.
10. Kanoh J, Ishikawa F (2001). spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr Biol 11, 1624-1630.
11. Khair L, Subramanian L, Moser BA, Nakamura TM (2010). Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment. J Biol Chem 285, 5327-5337.
12. Lopez-Girona A, Tanaka K, Chen XB, Baber BA, McGowan CH, Russell P (2001). Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proc Natl Acad Sci USA 98, 11289-11294.
13. Marchler-Bauer A, Panchenko AR, Shoemaker BA, Thiessen PA, Geer LY, Bryant SH (2002). CDD: a database of conserved domain alignments with links to domain three-dimensional structure. Nucleic Acids Res 30, 281-283.
14. Miyoshi T, Kanoh J, Saito M, Ishikawa F (2008). Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science 320, 1341-1344.
15. Moser BA, Chang YT, Kosti J, Nakamura TM (2011). Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast. Nat Struct Mol Biol 18, 1408-1413.
16. Moser BA, Chang YT, Nakamura TM (2014). Telomere regulation during the cell cycle in fission yeast. Methods Mol Biol 1170, 411-424.
17. Moser BA, Nakamura TM (2009). Protection and replication of telomeres in fission yeast. Biochem Cell Biol 87, 747-758.
18. Moser BA, Subramanian L, Chang YT, Noguchi C, Noguchi E, Nakamura TM (2009a). Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J 28, 810-820.
19. Moser BA, Subramanian L, Khair L, Chang YT, Nakamura TM (2009b). Fission yeast Tel1ATM and Rad3ATR promote telomere protection and telomerase recruitment. PLoS Genet 5, e1000622.
20. Motwani T, Doris R, Holmes SG, Flory MR (2010). Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe. Eukaryot Cell 9, 1612-1621.
21. Nakamura TM, Moser BA, Russell P (2002). Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161, 1437-1452.
22. Nimmo ER, Pidoux AL, Perry PE, Allshire RC (1998). Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature 392, 825-828.
23. Palm W, de Lange T (2008). How shelterin protects mammalian telomeres. Annu Rev Genet 42, 301-334.
24. Reyes C, Serrurier C, Gauthier T, Gachet Y, Tournier S (2015). Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction. J Cell Biol 208, 713-727.
25. Sonnhammer EL, Eddy SR, Durbin R (1997). Pfam: a comprehensive database of protein domain families based on seed alignments. Proteins 28, 405-420.
26. Sugiyama T, Cam HP, Sugiyama R, Noma K, Zofall M, Kobayashi R, Grewal SI (2007). SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128, 491-504.
27. Tomita K, Cooper JP (2008). Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller. Genes Dev 22, 3461-3474.
28. Webb CJ, Zakian VA (2008). Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. Nat Struct Mol Biol 15, 34-42.
29. Yamazaki H, Tarumoto Y, Ishikawa F (2012). Tel1ATM and Rad3ATR phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev 26, 241-246.