Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 22, 2015, Pages 5237-5242

  Seo, Woo Duck ^a   Lee, Ji Hae ^b   Jia, Yaoyao ^b   Wu, Chunyan ^b   Lee, Sung Joon ^b  

^a National Institute of Crop Science   (South Korea)

^b Korea University   (South Korea)

Author keywords

AMPK; Gluconeogenesis; Glucose uptake; Saponarin

Indexed keywords

CALCIUM; CAMP RESPONSIVE ELEMENT BINDING PROTEIN REGULATED TRANSCRIPTION COACTIVATOR 2; FLAVONE DERIVATIVE; GLUCOSE TRANSPORTER 4; HISTONE DEACETYLASE 5; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MYOCYTE ENHANCER FACTOR 2; PROTEIN; SAPONARIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; APIGENIN; BENZIMIDAZOLE DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CREB1 PROTEIN, HUMAN; CRTC2 PROTEIN, HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENZYME ACTIVATOR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; GLUCOSE; GLUCOSIDE; HDAC5 PROTEIN, HUMAN; HISTONE DEACETYLASE; METFORMIN; NAPHTHALIMIDE DERIVATIVE; PYRONE DERIVATIVE; SLC2A4 PROTEIN, HUMAN; STO 609; THIOPHENE DERIVATIVE; TRANSCRIPTION FACTOR;

ANTIDIABETIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEPG2 CELL LINE; IN VITRO STUDY; INSULIN SENSITIVITY; NONHUMAN; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; UPREGULATION; HUMAN; INSULIN RESISTANCE; METABOLISM; PHOSPHORYLATION;

AMP-ACTIVATED PROTEIN KINASES; APIGENIN; BENZIMIDAZOLES; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENZYME ACTIVATORS; FORKHEAD TRANSCRIPTION FACTORS; GLUCONEOGENESIS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GLUCOSIDES; HEP G2 CELLS; HISTONE DEACETYLASES; HUMANS; INSULIN RESISTANCE; METFORMIN; NAPHTHALIMIDES; PHOSPHORYLATION; PYRONES; THIOPHENES; TRANSCRIPTION FACTORS;

EID: 84945913792     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.09.057     Document Type: Article

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