Ketocarotenoid production in soybean seeds through metabolic engineering

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Pierce, Emily C ^a   LaFayette, Peter R ^a   Ortega, María A ^a   Joyce, Blake L ^b   Kopsell, Dean A ^c   Parrott, Wayne A ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CAROTENE; ASTAXANTHIN; BETA CAROTENE; BETA CAROTENE HYDROXYLASE; BETA CAROTENE KETOLASE; BETA CRYPTOXANTHIN; CANTHAXANTHIN; CAROTENOID; KETOCAROTENOID; LYCOPENE; OXYGENASE; PHYTOENE; PHYTOENE SYNTHASE; TRANSFERASE; UNCLASSIFIED DRUG; VITAMIN; XANTHOPHYLL; BACTERIAL DNA;

ARTICLE; BACTERIAL GENE; BIOACCUMULATION; BREVUNDIMONAS; CONTROLLED STUDY; CRTB GENE; CRTW GENE; DRY WEIGHT; GENE IDENTIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLIC ENGINEERING; MOLECULAR DYNAMICS; NONHUMAN; PANTOEA; PANTOEA ANANATIS; PLANT SEED; SOYBEAN; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR CLONING; PHYSIOLOGY; PLANT GENE; TRANSGENE; TRANSGENIC PLANT;

CANTHAXANTHIN; CAROTENOIDS; CLONING, MOLECULAR; DNA, BACTERIAL; GENE EXPRESSION REGULATION, PLANT; GENES, PLANT; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; PLANTS, GENETICALLY MODIFIED; SEEDS; SOYBEANS; TRANSGENES;

EID: 84945893667     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0138196     Document Type: Article

References (51)

1. Farré G, Sanahuja G, Naqvi S, Bai C, Capell T, Zhu C, et al. Travel advice on the road to carotenoids in plants. Plant Sci. 2010; 179: 28-48.
2. Nishino H, Murakoshi M, Ii T, Takemura M, Kuchide M, Kanazawa M. Carotenoids in cancer chemoprevention. Cancer and Metastasis Rev. 2002; 21: 257-264.
3. Cho E, Hankinson SE, Rosner B, Willett WC, Colditz GA. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. Am J Clin Nutr. 2008; 87: 1837. PMID: 18541575
4. Sommer A. Vitamin A deficiency, child health, and survival. Nutrition. 1997; 13: 484-485. PMID: 9225350
5. Fuller B, Smith D, Howerton A, Kern D. Anti-inflammatory effects of CoQ10 and colorless carotenoids. Journal Cosmet Dermatol. 2006; 5: 30-38.
6. Uchiyama S, Sumida T, Yamaguchi M. Oral administration of β-cryptoxanthin induces anabolic effects on bone components in the femoral tissues of rats in vivo. Biol Pharm Bull. 2004; 27: 232-235. PMID: 14758041
7. Moran NA, Jarvik T. Lateral transfer of genes from fungi underlies carotenoid production in aphids. Science. 2010; 328: 624. doi: 10.1126/science.1187113 PMID: 20431015
8. Fukatsu T. A fungal past to insect color. Science. 2010; 328: 574-575. doi: 10.1126/science.1190417 PMID: 20431000
9. Nys Y. Dietary carotenoids and egg yolk coloration-a review. Archiv für Geflügelkunde. 2000; 64: 45-54.
10. Sunde ML. Introduction to the Symposium. Poult Sci. 1992; 71: 709-710. PMID: 1594521
11. Brufau J. Yolk-The golden opportunity. International table egg production supplement. Int Poult Prod. 1997; 5: 17-25.
12. Beardsworth P, Hernandez J. Yolk colouration-an important egg quality attribute. Int Poult Prod. 2004; 12: 17-18.
13. Rosa AP, Scher A, Sorbara JO, Boemo LS, Forgiarini J, Londero A. Effects of canthaxanthin on the productive and reproductive performance of broiler breeders. Poult Sci. 2012; 91: 660-666. doi: 10.3382/ps.2011-01582 PMID: 22334741
14. Li J, Zhu D, Niu J, Shen S, Wang G. An economic assessment of astaxanthin production by large scale cultivation of Haematococcus pluvialis. Biotechnol Adv. 2011; 29(6): 568-574. doi: 10.1016/j. biotechadv.2011.04.001 PMID: 21497650
15. Scaife MA, Burja AM, Wright PC. Characterization of cyanobacterial β-carotene ketolase and hydroxylase genes in Escherichia coli, and their application for astaxanthin biosynthesis. Biotechnol Bioeng. 2009; 103: 944-955. doi: 10.1002/bit.22330 PMID: 19365869
16. Ukibe K, Hashida K, Yoshida N, Takagi H. Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance. Appl Environ Microbiol. 2009; 75: 7205-7211. doi: 10.1128/AEM.01249-09 PMID: 19801484
17. Ducreux LJM, Morris WL, Hedley PE, Shepherd T, Davies HV, Millam S, et al. Metabolic engineering of high carotenoid potato tubers containing enhanced levels of β-carotene and lutein. J Exp Bot. 2005; 56: 81-89. PMID: 15533882
18. Aluru M, Yang X, Rong G, Zhenguo W, Shanshan L, White WS. Generation of transgenic maize with enhanced provitamin A content. J Exp Bot. 2008; 59: 3551-3562. doi: 10.1093/jxb/ern212 PMID: 18723758
19. Diretto G, Al-Babili S, Tavazza R, Papacchioli V, Beyer P, Giuliano G. Metabolic engineering of potato carotenoid content through tuber-specific overexpression of a bacterial mini-pathway. PLoS One. 2007; 2: e350-e350. PMID: 17406674
20. Fraser PD, Romer S, Shipton CA, Mills PB, Kiano JW, Misawa N, et al. Evaluation of transgenic tomato plants expressing an additional phytoene synthase. Proc Natl Acad Sci USA. 2002; 99: 1092. PMID: 11805345
21. Fujisawa M, Watanabe M, Choi S-K, Teramoto M, Ohyama K, Misawa N. Enrichment of carotenoids in flaxseed (Linum usitatissimum) by metabolic engineering with introduction of bacterial phytoene synthase gene crtB. J Biosci Bioeng. 2008; 105: 636-641. doi: 10.1263/jbb.105.636 PMID: 18640603
22. Shewmaker CK, Sheehy JA, Daley M, Colburn S, Ke DY. Seed-specific overexpression of phytoene synthase: increase in carotenoids and other metabolic effects. Plant J. 1999; 20: 401-412. PMID: 10607293
23. Fujisawa M, Takita E, Harada H, Sakurai N, Suzuki H, Ohyama K, et al. Pathway engineering of Brassica napus seeds using multiple key enzyme genes involved in ketocarotenoid formation. J Exp Bot. 2009; 60: 1319-1332. doi: 10.1093/jxb/erp006 PMID: 19204032
24. Hasunuma T, Miyazawa S-I, Yoshimura S, Shinzaki Y, Tomizawa K-I, Shindo K, et al. Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering. Plant J. 2008; 55: 857-868. doi: 10.1111/j.1365-313X.2008.03559.x PMID: 18494855
25. Jayaraj J, Devlin R, Punja Z. Metabolic engineering of novel ketocarotenoid production in carrot plants. Transgenic Res. 2008; 17: 489-501. PMID: 17682834
26. Mann V, Harker M, Pecker I, Hirschberg J. Metabolic engineering of astaxanthin production in tobacco flowers. Nat Biotechnol. 2000; 18: 888-892. PMID: 10932161
27. Morris WL, Ducreux LJM, Fraser PD, Millam S, Taylor MA. Engineering ketocarotenoid biosynthesis in potato tubers. Metab Eng. 2006; 8: 253-263. PMID: 16542864
28. Burt AJ, Caston L, Leeson S, Shelp BJ, Lee EA. Development and utilization of high carotenoid maize germplasm: Proof of concept. Crop Sci. 2013; 53: 554-563.
29. Lopez AB, Van Eck J, Conlin BJ, Paolillo DJ, O'Neill J, Li L. Effect of the cauliflower Or transgene on carotenoid accumulation and chromoplast formation in transgenic potato tubers. J Exp Bot. 2008; 59: 213-223. doi: 10.1093/jxb/erm299 PMID: 18256051
30. Cunningham FX, Gantt E. Genes and enzymes of carotenoid biosynthesis in plants. Annu Rev Plant Physiol Plant Mol Biol. 1998; 49: 557. PMID: 15012246
31. Paine JA, Shipton CA, Chaggar S, Howells RM, Kennedy MJ, Vernon G, et al. Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat Biotechnol. 2005; 23: 482-487. PMID: 15793573
32. Ye X, Al-Babili S, Klöti A, Zhang J, Lucca P, Beyer P, et al. Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science. 2000; 287: 303-305. PMID: 10634784
33. Monma M, Terao J, Ito M, Saito M, Chikuni K. Carotenoid components in soybean seeds varying with seed color and maturation stage. Biosci Biotechnol Biochem. 1994; 58: 926-930.
34. Ravanello MP, Ke D, Alvarez J, Huang B, Shewmaker CK. Coordinate expression of multiple bacterial carotenoid genes in canola leading to altered carotenoid production. Metab Eng. 2003; 5: 255-263. PMID: 14642353
35. Schmidt MA, Parrott WA, Hildebrand DF, Berg RH, Cooksey A, Pendarvis K, He Y, McCarthy F, Herman EM. Transgenic soya bean seeds accumulating β-carotene exhibit the collateral enhancements of high oleate and high protein content traits. Plant Biotechnol J. 2014; 13(4): 590-600. doi: 10.1111/pbi. 12286 PMID: 25400247
36. Cunningham FX Jr, Gantt E. A study in scarlet: enzymes of ketocarotenoid biosynthesis in the flowers of Adonis aestivalis. Plant J. 2005; 41: 478-492. PMID: 15659105
37. Misawa N, Yamano S, Linden H, de Felipe MR, Lucas M, Ikenaga H, et al. (1993) Functional expression of the Erwinia uredovora carotenoid biosynthesis gene crtI in transgenic plants showing an increase of β-carotene biosynthesis activity and resistance to the bleaching herbicide norflurazon. Plant J. 1993; 4: 833-840. PMID: 8275101
38. Yoshino M, Nagamatsu A, Tsutsumi K, Kanazawa A. The regulatory function of the upstream sequence of the β-conglycinin α-subunit gene in seed-specific transcription is associated with the presence of the RY sequence. Genes Genet Syst. 2006; 81: 135-141. PMID: 16755137
39. Garbarino JE, Belknap WR. Isolation of a ubiquitin-ribosomal protein gene (ubi3) from potato and expression of its promoter in transgenic plants. Plant Mol Biol. 1994; 24: 119-127. PMID: 8111011
40. Trick HN, Dinkins RD, Santarém ER, Samoyolov V, Meurer C, et al. Recent advances in soybean transformation. Plant Tissue Cult Biotechnol. 1997; 3: 9-26.
41. Samoylov V, Tucker D, Thibaud-Nissen F, Parrott W. A liquid-medium-based protocol for rapid regeneration from embryogenic soybean cultures. Plant Cell Rep. 1998; 18: 49-54.
42. Lassner MW, Peterson P, Yoder JI. Simultaneous amplification of multiple DNA fragments by polymerase chain reaction in the analysis of transgenic plants and their progeny. Plant Mol Biol Rep. 1989; 7: 116-128.
43. Schmidt MA, Tucker DM, Cahoon EB, Parrott WA. Towards normalization of soybean somatic embryo maturation. Plant Cell Rep. 2005; 24: 383-391. PMID: 15856235
44. Kurilich AC, Juvik JA. Quantification of Carotenoid and Tocopherol Antioxidants in Zea mays. J Agric Food Chem. 1999; 47: 1948-1955. PMID: 10552476
45. Kopsell DA, Barickman TC, Sams CE, McElroy JS. Influence of nitrogen and sulfur on biomass production and carotenoid and glucosinolate concentrations in watercress (Nasturtium officinale R. Br.). J Agric Food Chem. 2007; 55: 10628-10634. PMID: 18052091
46. Emenhiser C, Simunovic N, Sander LC, Schwartz SJ. Separation of geometrical carotenoid isomers in biological extracts using a polymeric C30 column in reversed-phase liquid chromatography. J Agric Food Chem. 1996; 44: 3887-3893.
47. Davies BH, Köst HP. Chromatographic methods for the separation of carotenoids. CRC handbook of chromatography, plant pigments. 1988; 1: 1-185.
48. Kim MJ, Kim JK, Kim HJ, Pak JH, Lee JH, Kim DH, et al. Genetic modification of the soybean to enhance the β-Carotene content through seed-specific expression. PLoS One. 2012; 7: e48287. doi: 10.1371/journal.pone.0048287 PMID: 23118971
49. Grashorn M, Steinberg W. Deposition rates of canthaxanthin in egg yolks. Archiv für Geflügelkunde. 2002; 66: 258-262.
50. th WPSA European Symposium on Poultry Nutrition, Strasbourg, France; 2007. pp. 731-734.
51. Bjerkeng B, Refstie S, Fjalestad KT, Storebakken T, Rødbotten M, Roem AJ. Quality parameters of the flesh of Atlantic salmon (Salmo salar) as affected by dietary fat content and full-fat soybean meal as a partial substitute for fish meal in the diet. Aquaculture. 1997; 157: 297-309.