Seed-specific overexpression of phytoene synthase: Increase in carotenoids and other metabolic effects

Plant Journal

Volumn 20, Issue 4, 1999, Pages 401-412

  Shewmaker, Christine K ^a   Sheehy, Julie A ^a   Daley, Maureen ^a   Colburn, Susan ^b   Ke, Dang Yang ^a  

^a Calgene LLC   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; BIOCHEMICAL PATHWAY; CHLOROPHYLL; ENZYME SYNTHESIS; GENE OVEREXPRESSION; GENE PRODUCT; LINOLEIC ACID; LINOLENIC ACID; METABOLITE; OLEIC ACID; PHYTOENE SYNTHASE; PHYTOENE; PLASTID; PROTEIN TARGETING; TOCOPHEROL; TRANSGENIC PLANT; XANTHOPHYLL;

BRASSICA NAPUS;

EID: 0033388648     PISSN: 09607412     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-313X.1999.00611.x     Document Type: Article

References (55)

1. Arigoni, D., Sagner, S., Latzel, C., Eisenreich, W., Bacher, A. and Zenk, M.H. (1997) Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular rearrangement. Proc. Natl Acad. Sci. USA, 94, 10600-10605.
2. Armstrong, G.A. (1997) Genetics of eubacterial carotenoid biosynthesis: a colorful tale. Annu. Rev. Microbiol. 51, 629-659.
3. Bartley, G.E. and Scolnik, P.A. (1995) Plant carotenoids: Pigments for photoprotection, visual attraction, and human health. Plant Cell, 7, 1027-1038.
4. Bartley, G.E., Viitanen, P.V., Bacot, K.O. and Scolnik, P.S. (1992) A tomato gene expressed during fruit ripening encodes an enzyme of the carotenoid biosynthesis pathway. J. Biol. Chem, 267, 5036-5039.
5. Bauernfeind, J.C., Adams, C.R. and Marusich, W.L. (1981) Carotenoids and other vitamin A precursors in aninal feed. In Carotenoids as Colorants and Vitamin A Precursors (Bauernfeind, J.C., ed.) New York: Academic Press, pp. 563-743.
6. Ben-Amotz, A., Shaish, A. and Avron, M. (1989) Mode of action of the massively accumulated β-carotene of Dunaliela bardawil in protecting the alga against damage by excess irradiation. Plant. Physiol. 91, 1040-1043.
7. Boussiba, S. and Vonshak, A. (1991) Astaxanthin accumulation in the green alga Haematococcus pluvialis. Plant Cell Physiol. 32, 1077-1082.
8. Browse, J., McCourt, P.J. and Sommerville, C.R. (1986) Fatty acid composition of leaf lipids determined after combined digestion and fatty acid methyl ester formation from fresh tissue. Anal. Biochem. 152, 141-152.
9. Bruneau, J.M., Worrell, A.C., Cambou, B., Lando, D. and Voelker, T. (1991) Sucrose phosphate synthase, a key enzyme for sucrose biosynthesis in plants. Plant Physiol. 96, 473-478.
10. Buckner, B., San Miguel, P., Janick-Buckner, D. and Bennetzen, J.L. (1996) The y1 gene of maize codes for phytoene synthase. Genetics, 143, 479-488.
11. Burkhardt, P.K., Beyer, P., Wunn, J., Klöti, A., Armstrong, G.A., Schledz, M., von Lintig, J. and Potrykus, I. (1997) Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis. Plant J. 11, 1071-1078.
12. Camara, B., Hugeney, P., Bouvier, F., Kuntz, M. and Monéger, R. (1995) Biochemistry and molecular biology of chromoplast development. Int Rev. Cytology, 163, 175-247.
13. Chamovitz, D., Misawa, N., Sandmann, G. and Hirschberg, J. (1992) Molecular cloning and expression in Esherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme. FEBS Lett. 296, 305-310.
14. Clegg, A.J. (1973) Composition and related nutritional and organoleptic aspects of palm oil. J. Am. Oil Chem. Soc. 50, 321-324.
15. Craft, N.E. (1992) Carotenoid reverse-phase high-performance liquid chromatography methods: reference compendium. Meth Enzymol, 213, 185-205.
16. Crouch, M.L. and Sussex, I.M. (1981) Development and storage-protein synthesis in Brassica napus L. embryos in vivo and in vitro. Planta, 153, 64-74.
17. Cunningham, F.X. and Gantt, E. (1998) Genes and enzymes of carotenoid biosynthesis in plants. Annu. Rev. Plant. Physio. Plant Mol. Biol. 49, 557-583.
18. Cunningham, F.X., Pogson, B., Sun, Z., McDonald, K.A., DellaPenna, D. and Gantt, E. (1996) Functional analysis of the β and ε lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell, 8, 1613-1626.
19. Deruere, J., Romer, S., d'Harlinque, A., Backhaus, R.A., Kuntz, M. and Camara, B. (1994) Fibril assembly and carotenoid overaccumulation in chromoplasts: a model for subramolecular lipoprotein structure. Plant Cell, 6, 119-133.
20. Disch, A., Hemmerlin, A., Bach, T.J. and Rohmer, M. (1998) Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. Biochem. J. 331, 615-621.
21. Edwards, R.S. and Reuter, F.H. (1967) Pigment changes during the maturation of tomato fruit. Food Techn. Australia, 19, 352-357.
22. Fray, R.G., Wallace, A., Fraser, P.D., Valero, D., Hedden, P., Bramley, P.M. and Grierson, D. (1995) Constitutive expression of a fruit phytoene synthase gene in transgenic tomatoes causes dwarfism by redirecting metabolites from the gibberelin pathway. Plant J. 8, 693-701.
23. Giovannucci, E., Atscherio, A. and Rimm, E.B. (1995) Intake of carotenoids and retinol in relation to risk of prostate cancer. J. Natl Cancer Inst. 87, 1767-1776.
24. Goddijn, O.J.M. and Pen, J. (1995) Plants as bioreactors. TIB Biotech, 13, 379-387.
25. Gross, J. (1991). Pigments in Vegetables: Chlorophylls and Carotenoids. New York: Van Nostrand Reinhold.
26. Grotewold, E., Chamberlin, M., Snook, M., Siame, B., Butler, L., Swenson, J., Maddock, S., St. Clair, G. and Bowen, B. (1998) Engineering secondary metabolism in maize cells by ectopic expression of transcription factors. Plant Cell, 10, 721-740.
27. Hauptmann, R., Eschenfeldt, W.H., English, J. and Brinkhaus, F.L. (1997) Enhanced carotenoid accumulation in storage organs of genetically engineered plants. US Patent, 5,618,988.
28. Johjima, T. and Matsuzoe, N. (1995) Relationship between color value (a/b) and colored carotene content in fruit of various tomato cultivars and breeding line. Acta Hortic. 412, 152-159.
29. Klein, A.M., Hugueney, P., Sandmann, G. and Kuntz, M. (1995) Molecular cloning and functional expression in E. coli of a novel plant enzyme mediating zeta-carotene desaturation. FEBS Lett. 372, 199-202.
30. Kohlmeier, L., Kark, J.D., Gomez-Garcia, E. et al. (1997) Lycopene and myocardial infarction risk in EURAMIC study. Am. J. Epidemiology, 146, 618-626.
31. Kridl, J.C., McCarter, D.W., Rose, R.E., Scherer, D.E., Knutzon, D.S., Radke, S.E. and Knauf, V.C. (1991) Isolation and characterization of an expressed napin gene from Brassica rapa. Seed Sci. Res. 1, 209-219.
32. Lichtenthaler, H., Rohmer, M. and Schwender, J. (1997) Two independent pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants. Physiol. Plant. 101, 643-652.
33. May, C.Y. (1994) Palm oil carotenoids. Food Nut. Bullet. 15, 130-137.
34. McBride, K.E. and Summerfelt, K.R. (1990) Improved binary vectors for Agrobacterium-mediated plant transformation. Plant. Mol. Biol. 23, 269-276.
35. Misawa, N., Nakagawa, M., Kobayashi, K., Yamano, S., Izawa, Y., Nakamura, K. and Harashima, K. (1990) Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J. Bacteriol. 172, 6704-6712.
36. Misawa, N., Masamoto, K., Hori, T., Ohtani, T., Boger, P. and Sandmann, G. (1994) Expression of an Erwinia phytoene desaturase gene not only confers resistance to herbicides interfering with carotenoid biosynthesis but also alters xanthophyll metabolism in transgenic plants. Plant J. 6, 481-489.
37. Misawa, N., Satomi, Y., Kondo, K., Yokoyama, A., Kajiwara, S., Saito, T., Ohtani, T. and Miki, W. (1995) Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J. Bacteriol. 177, 6575-6584.
38. Misawa, N., Yamano, S., Linden, H., de Felipe, M.R., Lucas, M., Ikenaga, H. and Sandmann, G. (1993) Functional expression of the Erwinia uredovora carotenoid biosynthesis gene crtl in transgenic plants showing an increase of β-carotene biosynthesis activity and resistance to the bleaching herbicide norflurazon. Plant J. 4, 833-840.
39. Nelis, H.J. and De Leenheer, A.P. (1991) Microbial sources of carotenoid pigments used in foods and feeds. J. Appl. Bacteriol. 70, 181-191.
40. Perry, K.L., Simonitch, T.A., Harrison-Lavoie, K.J. and Liu, S.-T. (1986) Cloning and regulation of Erwinia herbicola pigment genes. J. Bacteriol. 168, 607-612.
41. Quackenbush, F.W. and Miller, S.L. (1972) Composition and analysis of the carotenoids of marigold petals. J. Am. Oil Anal Chem, 55, 617-621.
42. Radke, S.E., Turner, J.C. and Facciotti, D. (1992) Transformation and regeneration of Brassica rapa using Agrobacterium tumefaciens. Plant Cell Reports, 11, 499-505.
43. Ray, J., Moureau, P., Bird, C., Bird, A., Grierson, D., Maunders, M., Truesdale, M., Bramley, P. and Schuch, W. (1992) Cloning and characterization of a gene involved in phytoene synthesis from tomato. Plant Mol. Biol. 19, 401-404.
44. Salunkhe, D.K., Chavan, J.K., Adsule, R.N. and Kadam, S.S. (1992). World Oilseeds: Chemistry, Technology and Utilization. New York: Van Nostrand Reinhold.
45. Sandmann, G. and Misawa, N. (1992) New functional assignment of the carotenogenic genes crtB and crtE with constructs of these genes from Erwinia species. FEMS Microbiol. Letts. 90, 253-258.
46. Sandmann, G. (1994) Phytoene desaturase: genes, enzymes and phylogentic aspects. J. Plant Physiol. 143, 444-447.
47. Santos, M.F. and Mesquita, J.F. (1984) Ultrastructural study of Haematococcus lacustris (Girod.) Rostafinski (Volvocales) I. Some aspects of carotenogenisis. Cytologia, 49, 215-228.
48. Sommerburg, O., Keunen, J.E.E., Bird, A.C. and van Kuijk, F.J.G.M. (1998) Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br. J. Opthamology, 82, 907-910.
49. Schaller, H., Grausem, B., Benveniste, P., Chye, M.-L., Tan, C.-T., Song, Y.-H. and Chua, N.-H. (1995) Expression of the Hevea brasiliensis (H.B.K.) Mull Arg 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 in tobacco results in sterol overproduction. Plant Physiol. 109, 761-770.
50. Sjödahl, S., Gustavsson, H., Rödin, J., Lenman, M., Höglund, A. and Rask, L. (1991) Cruciferin gene families are expressed coordinately but with tissue-specific differences during Brassica napus seed development. Plant Mol. Biol. 23, 1165-1176.
51. Sun, Z., Gantt, E. and Cunningham, F.X. (1996) Cloning and functional analysis of the β-carotene hydroxylase of Arabidopsis thaliana. J. Bio. Chem. 271, 24349-24352.
52. Taylor, C. (1998) Factories of the future? Metabolic engineering in plant cells. Plant Cell, 10, 641-644.
53. Voelker, T.A., Worrell, A.C., Anderson, L., Bleibaum, J., Fan, C., Hakwins, D.J., Radke, S.E. and Davies, H.M. (1992) Fatty acid biosynthesis redirected to medium chains in transgenic oilseed plants. Science, 257, 72-74.
54. Webb, D.M. and Knapp, S. (1990) DNA extraction from a previously recalcitrant plant genus. Plant Mol. Biol. Report, 8, 180-185.
55. Yun, D.-J., Hashimoto, T. and Yamada, Y. (1992) Metabolic engineering of medicinal plants: Transgenic Atropa belladonna with an improved alkaloid composition. Proc. Natl Acad. Sci. USA, 89, 11799-11803.