Engineering ketocarotenoid biosynthesis in potato tubers

Metabolic Engineering

Volumn 8, Issue 3, 2006, Pages 253-263

  Morris, Wayne L ^a   Ducreux, Laurence J M ^a   Fraser, Paul D ^b   Millam, Steve ^a   Taylor, Mark A ^a  

^a SCOTTISH CROP RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Astaxanthin; bkt1; Co transformation; Ketocarotenoid; Ketocarotenoid Solanum phureja; Solanum tuberosum

Indexed keywords

BACTERIA; BIOSYNTHESIS; ENZYMES; GENES; HEALTH; PLANTS (BOTANY);

ASTAXANTHIN; CO-TRANSFORMATION; KETOCAROTENOID; SOLANUM TUBEROSUM;

PIGMENTS;

ASTAXANTHIN; BETA KETOLASE; CAROTENOID; ENZYME; KETOCAROTENOID; KETOLUTEIN; PHYTOENE SYNTHASE; UNCLASSIFIED DRUG;

ALGAL GENETICS; ARTICLE; GENE EXPRESSION; POTATO; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN SYNTHESIS; SERANUM PHUREJA; TRANSGENE;

CAROTENOIDS; GENETIC ENGINEERING; PLANT PROTEINS; PLANT STEMS; PLANTS, GENETICALLY MODIFIED; SOLANUM TUBEROSUM;

ALGAE; SOLANUM PHUREJA; SOLANUM TUBEROSUM;

EID: 33646519223     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2006.01.001     Document Type: Article

References (44)

1. Beatty S., Nolan J., Kavanagh H., and O'Donovan O. Arch. Biochem. Biophys. 430 (1986) 70-76
2. Bennedsen M., Wang X., Willen R., Wadstrom T., and Andersen L.P. Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes. Immunol. Lett. 70 (1999) 185-189
3. Bevan M., Barker R., Goldsbrough A., Jarvis M., Kavanagh T., and Iturriaga G. The structure and transcription start site of a major potato tuber protein gene. Nucleic Acids Res 14 (1986) 4625-4638
4. Chang M.M., Culley D., Choi J.J., and Hadwiger L.A. Agrobacterium-mediated co-transformation of a pea beta-1,3-glucanase and chitinase genes in potato (Solanum tuberosum L. c.v. Russet Burbank) using a single selectable marker. Plant Sci 163 (2002) 83-89
5. Chew B.P., Park J.S., Wong M.W., and Wong T.S. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res 19 (1999) 1849-1853
6. Cunningham F.X., and Gantt E. A study in scarlet: enzymes of ketocarotenoid biosynthesis in the flowers of Adonis aestivalis. Plant J 41 (2005) 478-492
7. Czeczuga B. Ketocarotenoids-autumn carotenoids in Metasequoia glyptostroboides. Biochem. Syst. Ecol. 15 (1987) 303-306
8. Demmig-Adams B., Gilmore A.M., and Adams III W.W. Carotenoids 3: in vivo function of carotenoids in higher plants. FASEB J 10 (1996) 403-412
9. Draper J., and Scott R.J. The isolation of plant nucleic acids. In: Draper J., et al. (Ed). Plant Genetic Transformation and Gene Expression: A Laboratory Manual (1988), Blackwell Scientific Publications, Oxford, UK 199-236
10. Ducreux L.J., Morris W.L., Hedley P.E., Shepherd T., Davies H.V., Millam S., and Taylor M.A. Metabolic engineering of high carotenoid potato tubers containing enhanced levels of beta-carotene and lutein. J. Exp. Bot. 56 (2005) 81-89
11. Ducreux L.J., Morris W.L., Taylor M.A., and Millam S. Agrobacterium-mediated transformation of Solanum phureja. Plant Cell Rep 24 (2005) 10-14
12. Fraser P.D., and Bramley P.M. The biosynthesis and nutritional uses of carotenoids. Prog. Lipid Res. 43 (2004) 228-265
13. Fraser P.D., Romer S., Shipton C.A., Mills P.B., Kiano J.W., Misawa N., Drake R., Schuch W., and Bramley P.M. Evalution of transgenic tomato plants expressing an additional phytoene synthase in a fruit specific manner. PNAS 99 (2002) 1092-1097
14. Fraser P.D., Römer S., Shipton C.A., Mills P.B., Kiano J.W., Misawa N., Drake R.G., Schuch W., and Bramley P.M. Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner. Proc. Natl. Acad. Sci. USA 99 (2002) 1092-1097
15. Gann P.H., and Khachik F. Tomatoes or lycopene versus prostate cancer: is evolution anti-reductionist?. J. Natl. Cancer Inst. 95 (2003) 1563-1565
16. Goodwin T. The Biochemistry of Carotenoids (1980), Chapman & Hall, London
17. Grunewald K., Hirschberg J., and Hagen C. Ketocarotenoid biosynthesis outside of plastids in the unicellular green alga Haematococcus pluvialis. J. Biol. Chem. 276 (2001) 6023-6029
18. Guerin M., Huntley M.E., and Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol 21 (2003) 210-216
19. Harker, M., Hirschberg, J., 1999. Paracoccus marcussii crtW, crtZ, crtY, crtI, crtB and crtE genes. Genbank accession number Y15112 .
20. Huang, J., Chen, F., Sandmann, G., 2005. Stress-related differential expression of multiple β-carotene ketolase genes in the unicellular green alga Haematococcus pluvialis. J. Biotech. DOI:10.1016/j.jbiotec.2005.09.002
21. Johnson E.A., and An G.H. Astaxanthin from microbial sources. Crit. Rev. Biotechnol. 11 (1991) 297-326
22. Jyonouchi H., Sun S., and Gross M. Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent stimulant and antigen. Nutr. Cancer 23 (1995) 171-183
23. Krinsky N.I., Landrum J.T., and Bone R.A. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu. Rev. Nutr. 23 (2003) 171-201
24. Li L., Paolillo D.J., Parthasarathy M.V., Dimuzio E.M., and Garvin D.F. A novel gene mutation that confers abnormal patterns of beta-carotene accumulation in cauliflower (Brassica oleracea var. botrytis). Plant J. 26 (2001) 59-67
25. Lindgren L.O., Stalberg K.G., and Hoglund A.S. Seed-specific overexpression of an endogenous Arabidopsis phytoene synthase gene results in delayed germination and increased levels of carotenoids, chlorophyll, and abscisic acid. Plant Physiol. 132 (2003) 779-785
26. Livak, K.J., 1997. Relative quantitation of gene expression. User Bulletin No. 2: ABI PRISM 7700 Sequence Detection System. PE Applied Biosystems, Foster City, CA, USA.
27. Lotan T., and Hirschberg J. Cloning and expression in Escherichia coli of the gene encoding beta-C-4-oxygenase, that converts beta-carotene to the ketocarotenoid canthaxanthin in Haematococcus pluvialis. FEBS Lett 364 (1995) 125-128
28. Mann V., Harker M., Pecker I., and Hirschberg J. Metabolic engineering of astaxanthin production in tobacco flowers. Nat. Biotechnol. 18 (2000) 888-892
29. Mayne S.T. Beta-carotene, carotenoids, and disease prevention in humans. FASEB J 10 (1996) 690-701
30. Misawa N., Satomi Y., Kondo K., Yokoyama A., Kajiwara S., Saito T., Ohtani T., and Miki W. Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J. Bacteriol. 177 (1995) 6575-6584
31. Misawa N., Kajiwara S., Kondo K., Yokoyama A., Satomi Y., Saito T., Miki W., and Ohtani T. Canthaxanthin biosynthesis by the conversion of methylene to keto groups in a hydrocarbon beta-carotene by a single gene. Biochem. Biophys. Res. Commun. 209 (1995) 867-876
32. Morris W.L., Ducreux L., Griffiths D.W., Stewart D., Davies H.V., and Taylor M.A. Carotenogenesis during tuber development and storage in potato. J. Exp. Bot. 55 (2004) 975-982
33. Pettersson A., and Lignell A. Astaxanthin deficiency in eggs and fry of Baltic salmon (Salmo salar) with M74 syndrome. Ambio 28 (1999) 43-47
34. Ralley L., Enfissi E.M., Misawa N., Schuch W., Bramley P.M., and Fraser P.D. Metabolic engineering of ketocarotenoid formation in higher plants. Plant J 39 (2004) 477-486
35. Renstrom B., Berger H., and Liaaen-Jensen S. Esterified, optically pure (3S, 3′S)-astaxanthin from flowers of Adonis annua. Biochem. Syst. Ecol. 9 (1981) 249-250
36. Römer S., Lubeck J., Kauder F., Steiger S., Adomat C., and Sandmann G. Genetic engineering of a zeaxanthin-rich potato by antisense inactivation and co-suppression of carotenoid epoxidation. Metab. Eng. 4 (2002) 263-272
37. Sambrook J., Fritsch E.F., and Maniatis T. Molecular Cloning; A Laboratory Manual (1989), Cold Spring Harbor Laboratory Press, New York
38. Stalberg K.G., Lindgren L.O., Ek B., and Hoglund A.S. Synthesis of ketocarotenoids in the seed of Arabidopsis thaliana. Plant J 36 (2003) 771-779
39. Tanaka T., Makita H., Ohnishi M., Mori H., Satoh K., and Hara A. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin. Cancer Res. 55 (1995) 4059-4064
40. Taylor M.A., and Ramsay G. Carotenoid biosynthesis in plant storage organs: recent advances and prospects for improving plant food quality. Physiol. Plant. 124 (2005) 143-151
41. van den Berg H., Faulks R., Fernando Granado H., Hirschberg J., Olmedilla B., Sandmann G., Southon S., and Stahl W. The potential for the improvement of carotenoid levels in foods and the likely systemic effects. J. Sci. Food Agric. 80 (2000) 880-912
42. Verhees J., van der Krol A.R., Vreugdenhil D., and van der Plas L.H. Characterization of gene expression during potato tuber development in individuals and populations using the luciferase reporter system. Plant Mol. Biol. 50 (2002) 653-665
43. Wang X., Willen R., and Wadstrom T. Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrob. Agents Chemother. 44 (2000) 2452-2457
44. Yuan J.P., and Chen F. Purification of trans-astaxanthin from a high-yielding astaxanthin ester-producing strain of the microalga Haematococcus pluvialis. Food Chem. 68 (2000) 443-448