메뉴 건너뛰기




Volumn 112, Issue 43, 2015, Pages E5825-E5833

IκBζ is a key driver in the development of psoriasis

Author keywords

Cytokines; Inflammation; I B ; Psoriasis

Indexed keywords

DEFB4 PROTEIN; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; I KAPPA B; I KAPPA B ZETA; IMIQUIMOD; INTERLEUKIN 17; INTERLEUKIN 17C; INTERLEUKIN 19; INTERLEUKIN 23; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NUCLEAR RECEPTOR COACTIVATOR; PROTEIN; PSORIASIN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE;

EID: 84945583576     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1509971112     Document Type: Article
Times cited : (100)

References (51)
  • 4
    • 0344926414 scopus 로고    scopus 로고
    • Etanercept as monotherapy in patients with psoriasis
    • Leonardi CL, et al.; Etanercept Psoriasis Study Group (2003) Etanercept as monotherapy in patients with psoriasis. N Engl J Med 349(21):2014-2022.
    • (2003) N Engl J Med , vol.349 , Issue.21 , pp. 2014-2022
    • Leonardi, C.L.1
  • 5
    • 84876292569 scopus 로고    scopus 로고
    • Effect of IL-17A blockade with secukinumab in autoimmune diseases
    • Patel DD, Lee DM, Kolbinger F, Antoni C (2013) Effect of IL-17A blockade with secukinumab in autoimmune diseases. Ann Rheum Dis 72(Suppl 2):ii116-ii123.
    • (2013) Ann Rheum Dis , vol.72 , pp. ii116-ii123
    • Patel, D.D.1    Lee, D.M.2    Kolbinger, F.3    Antoni, C.4
  • 6
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN (2001) Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned? Annu Rev Immunol 19:163-196.
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 7
    • 84904545875 scopus 로고    scopus 로고
    • Secukinumab in plaque psoriasis: Results of two phase 3 trials
    • Langley RG, et al.; ERASURE Study Group; FIXTURE Study Group (2014) Secukinumab in plaque psoriasis: Results of two phase 3 trials. N Engl J Med 371(4):326-338.
    • (2014) N Engl J Med , vol.371 , Issue.4 , pp. 326-338
    • Langley, R.G.1
  • 8
    • 84923105894 scopus 로고    scopus 로고
    • Secukinumab: First global approval
    • Sanford M, McKeage K (2015) Secukinumab: First global approval. Drugs 75(3):329-338.
    • (2015) Drugs , vol.75 , Issue.3 , pp. 329-338
    • Sanford, M.1    McKeage, K.2
  • 9
    • 84922410788 scopus 로고    scopus 로고
    • Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis
    • Mease PJ (2015) Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. Curr Opin Rheumatol 27(2):127-133.
    • (2015) Curr Opin Rheumatol , vol.27 , Issue.2 , pp. 127-133
    • Mease, P.J.1
  • 10
    • 79951512605 scopus 로고    scopus 로고
    • Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
    • Chiricozzi A, et al. (2011) Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. J Invest Dermatol 131(3):677-687.
    • (2011) J Invest Dermatol , vol.131 , Issue.3 , pp. 677-687
    • Chiricozzi, A.1
  • 11
    • 20544461306 scopus 로고    scopus 로고
    • Inverse regulation of the nuclear factor-kappaB binding to the p53 and interleukin-8 kappaB response elements in lesional psoriatic skin
    • Johansen C, et al. (2005) Inverse regulation of the nuclear factor-kappaB binding to the p53 and interleukin-8 kappaB response elements in lesional psoriatic skin. J Invest Dermatol 124(6):1284-1292.
    • (2005) J Invest Dermatol , vol.124 , Issue.6 , pp. 1284-1292
    • Johansen, C.1
  • 12
    • 84880869807 scopus 로고    scopus 로고
    • The complexity of NF-κB signaling in inflammation and cancer
    • Hoesel B, Schmid JA (2013) The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer 12:86.
    • (2013) Mol Cancer , vol.12 , pp. 86
    • Hoesel, B.1    Schmid, J.A.2
  • 13
    • 80051988785 scopus 로고    scopus 로고
    • Hierarchies of NF-κB target-gene regulation
    • Smale ST (2011) Hierarchies of NF-κB target-gene regulation. Nat Immunol 12(8): 689-694.
    • (2011) Nat Immunol , vol.12 , Issue.8 , pp. 689-694
    • Smale, S.T.1
  • 14
    • 3142581432 scopus 로고    scopus 로고
    • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    • Yamamoto M, et al. (2004) Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 430(6996):218-222.
    • (2004) Nature , vol.430 , Issue.6996 , pp. 218-222
    • Yamamoto, M.1
  • 15
    • 33646006080 scopus 로고    scopus 로고
    • IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta
    • Cowland JB, Muta T, Borregaard N (2006) IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. J Immunol 176(9):5559-5566.
    • (2006) J Immunol , vol.176 , Issue.9 , pp. 5559-5566
    • Cowland, J.B.1    Muta, T.2    Borregaard, N.3
  • 16
    • 77951979898 scopus 로고    scopus 로고
    • Induction of neutrophil gelatinaseassociated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta
    • Karlsen JR, Borregaard N, Cowland JB (2010) Induction of neutrophil gelatinaseassociated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta. J Biol Chem 285(19):14088-14100.
    • (2010) J Biol Chem , vol.285 , Issue.19 , pp. 14088-14100
    • Karlsen, J.R.1    Borregaard, N.2    Cowland, J.B.3
  • 17
    • 42749093043 scopus 로고    scopus 로고
    • The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA
    • Trinh DV, Zhu N, Farhang G, Kim BJ, Huxford T (2008) The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA. J Mol Biol 379(1):122-135.
    • (2008) J Mol Biol , vol.379 , Issue.1 , pp. 122-135
    • Trinh, D.V.1    Zhu, N.2    Farhang, G.3    Kim, B.J.4    Huxford, T.5
  • 18
    • 77951877914 scopus 로고    scopus 로고
    • IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors
    • Okamoto K, et al. (2010) IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature 464(7293):1381-1385.
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1381-1385
    • Okamoto, K.1
  • 19
    • 84929157252 scopus 로고    scopus 로고
    • Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
    • Tsoi LC, et al. (2015) Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nat Commun 6:7001.
    • (2015) Nat Commun , vol.6 , pp. 7001
    • Tsoi, L.C.1
  • 20
    • 47249161701 scopus 로고    scopus 로고
    • Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium
    • Kao CY, Kim C, Huang F, Wu R (2008) Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium. J Biol Chem 283(22):15309-15318.
    • (2008) J Biol Chem , vol.283 , Issue.22 , pp. 15309-15318
    • Kao, C.Y.1    Kim, C.2    Huang, F.3    Wu, R.4
  • 21
    • 84866022852 scopus 로고    scopus 로고
    • Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease
    • Tian S, et al. (2012) Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease. PLoS One 7(9):e44274.
    • (2012) PLoS One , vol.7 , Issue.9 , pp. e44274
    • Tian, S.1
  • 22
    • 84902544820 scopus 로고    scopus 로고
    • Transcriptome analysis of psoriasis in a large case-control sample: RNAseq provides insights into disease mechanisms
    • Li B, et al. (2014) Transcriptome analysis of psoriasis in a large case-control sample: RNAseq provides insights into disease mechanisms. J Invest Dermatol 134(7):1828-1838.
    • (2014) J Invest Dermatol , vol.134 , Issue.7 , pp. 1828-1838
    • Li, B.1
  • 23
    • 66949162673 scopus 로고    scopus 로고
    • Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis
    • van der Fits L, et al. (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 182(9):5836-5845.
    • (2009) J Immunol , vol.182 , Issue.9 , pp. 5836-5845
    • Van Der-Fits, L.1
  • 24
    • 79251569587 scopus 로고    scopus 로고
    • IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A
    • Rizzo HL, et al. (2011) IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A. J Immunol 186(3):1495-1502.
    • (2011) J Immunol , vol.186 , Issue.3 , pp. 1495-1502
    • Rizzo, H.L.1
  • 25
    • 12544255812 scopus 로고    scopus 로고
    • Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization
    • Yamazaki S, Muta T, Matsuo S, Takeshige K (2005) Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization. J Biol Chem 280(2):1678-1687.
    • (2005) J Biol Chem , vol.280 , Issue.2 , pp. 1678-1687
    • Yamazaki, S.1    Muta, T.2    Matsuo, S.3    Takeshige, K.4
  • 26
    • 31144468296 scopus 로고    scopus 로고
    • Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2
    • Johansen C, et al. (2006) Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2. J Immunol 176(3):1431-1438.
    • (2006) J Immunol , vol.176 , Issue.3 , pp. 1431-1438
    • Johansen, C.1
  • 27
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson NJ, et al. (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8(9):950-957.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 950-957
    • Wilson, N.J.1
  • 28
    • 13244284850 scopus 로고    scopus 로고
    • The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin
    • Johansen C, et al. (2005) The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin. Br J Dermatol 152(1):37-42.
    • (2005) Br J Dermatol , vol.152 , Issue.1 , pp. 37-42
    • Johansen, C.1
  • 29
    • 84876829022 scopus 로고    scopus 로고
    • Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity
    • Andrés RM, Hald A, Johansen C, Kragballe K, Iversen L (2013) Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity. Exp Dermatol 22(5):323-328.
    • (2013) Exp Dermatol , vol.22 , Issue.5 , pp. 323-328
    • Andrés, R.M.1    Hald, A.2    Johansen, C.3    Kragballe, K.4    Iversen, L.5
  • 30
    • 13444269249 scopus 로고    scopus 로고
    • Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
    • Sano S, et al. (2005) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11(1):43-49.
    • (2005) Nat Med , vol.11 , Issue.1 , pp. 43-49
    • Sano, S.1
  • 31
    • 34547467781 scopus 로고    scopus 로고
    • Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation
    • Matsuo S, Yamazaki S, Takeshige K, Muta T (2007) Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation. Biochem J 405(3):605-615.
    • (2007) Biochem J , vol.405 , Issue.3 , pp. 605-615
    • Matsuo, S.1    Yamazaki, S.2    Takeshige, K.3    Muta, T.4
  • 32
    • 11244320356 scopus 로고    scopus 로고
    • Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease
    • Shiina T, et al. (2004) Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease. J Biol Chem 279(53):55493-55498.
    • (2004) J Biol Chem , vol.279 , Issue.53 , pp. 55493-55498
    • Shiina, T.1
  • 33
    • 49049084082 scopus 로고    scopus 로고
    • Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice
    • Ueta M, et al. (2008) Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice. Invest Ophthalmol Vis Sci 49(8):3387-3394.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.8 , pp. 3387-3394
    • Ueta, M.1
  • 34
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng Y, et al. (2007) Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445(7128):648-651.
    • (2007) Nature , vol.445 , Issue.7128 , pp. 648-651
    • Zheng, Y.1
  • 35
    • 37549011317 scopus 로고    scopus 로고
    • Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    • Zaba LC, et al. (2007) Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 204(13):3183-3194.
    • (2007) J Exp Med , vol.204 , Issue.13 , pp. 3183-3194
    • Zaba, L.C.1
  • 36
    • 67349195975 scopus 로고    scopus 로고
    • IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not
    • Wolk K, et al. (2009) IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J Mol Med (Berl) 87(5):523-536.
    • (2009) J Mol Med (Berl) , vol.87 , Issue.5 , pp. 523-536
    • Wolk, K.1
  • 37
    • 84855367696 scopus 로고    scopus 로고
    • IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice
    • Van Belle AB, et al. (2012) IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice. J Immunol 188(1):462-469.
    • (2012) J Immunol , vol.188 , Issue.1 , pp. 462-469
    • Van Belle, A.B.1
  • 38
    • 14844342604 scopus 로고    scopus 로고
    • IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
    • Boniface K, et al. (2005) IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol 174(6):3695-3702.
    • (2005) J Immunol , vol.174 , Issue.6 , pp. 3695-3702
    • Boniface, K.1
  • 39
    • 84919783193 scopus 로고    scopus 로고
    • A 52-week, open-label study of the efficacy and safety of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with chronic plaque psoriasis
    • Gordon KB, et al. (2014) A 52-week, open-label study of the efficacy and safety of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with chronic plaque psoriasis. J Am Acad Dermatol 71(6):1176-1182.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.6 , pp. 1176-1182
    • Gordon, K.B.1
  • 40
    • 84909948434 scopus 로고    scopus 로고
    • IL-17 induces inflammation-associated gene products in blood monocytes, and treatment with ixekizumab reduces their expression in psoriasis patient blood
    • Wang CQ, et al. (2014) IL-17 induces inflammation-associated gene products in blood monocytes, and treatment with ixekizumab reduces their expression in psoriasis patient blood. J Invest Dermatol 134(12):2990-2993.
    • (2014) J Invest Dermatol , vol.134 , Issue.12 , pp. 2990-2993
    • Wang, C.Q.1
  • 41
    • 84925226246 scopus 로고    scopus 로고
    • Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment
    • e3
    • Papp K, et al. (2014) Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment. J Am Acad Dermatol 71(6):1183-1190.e3.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.6 , pp. 1183-1190
    • Papp, K.1
  • 42
    • 58349105187 scopus 로고    scopus 로고
    • Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin
    • Johansen C, et al. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol 160(2):319-324.
    • (2009) Br J Dermatol , vol.160 , Issue.2 , pp. 319-324
    • Johansen, C.1
  • 43
    • 81255158784 scopus 로고    scopus 로고
    • IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
    • Ramirez-Carrozzi V, et al. (2011) IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol 12(12):1159-1166.
    • (2011) Nat Immunol , vol.12 , Issue.12 , pp. 1159-1166
    • Ramirez-Carrozzi, V.1
  • 44
    • 84906535154 scopus 로고    scopus 로고
    • The IL-23-IL-17 immune axis: From mechanisms to therapeutic testing
    • Gaffen SL, Jain R, Garg AV, Cua DJ (2014) The IL-23-IL-17 immune axis: From mechanisms to therapeutic testing. Nat Rev Immunol 14(9):585-600.
    • (2014) Nat Rev Immunol , vol.14 , Issue.9 , pp. 585-600
    • Gaffen, S.L.1    Jain, R.2    Garg, A.V.3    Cua, D.J.4
  • 45
    • 84906311286 scopus 로고    scopus 로고
    • IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms
    • Ha HL, et al. (2014) IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms. Proc Natl Acad Sci USA 111(33):E3422-E3431.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.33 , pp. E3422-E3431
    • Ha, H.L.1
  • 46
    • 84862631939 scopus 로고    scopus 로고
    • CIKS/Act1-mediated signaling by IL-17 cytokines in context: Implications for how a CIKS gene variant may predispose to psoriasis
    • Sønder SU, Paun A, Ha HL, Johnson PF, Siebenlist U (2012) CIKS/Act1-mediated signaling by IL-17 cytokines in context: Implications for how a CIKS gene variant may predispose to psoriasis. J Immunol 188(12):5906-5914.
    • (2012) J Immunol , vol.188 , Issue.12 , pp. 5906-5914
    • Sønder, S.U.1    Paun, A.2    Ha, H.L.3    Johnson, P.F.4    Siebenlist, U.5
  • 47
    • 33846022750 scopus 로고    scopus 로고
    • Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
    • Chang SH, Park H, Dong C (2006) Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem 281(47):35603-35607.
    • (2006) J Biol Chem , vol.281 , Issue.47 , pp. 35603-35607
    • Chang, S.H.1    Park, H.2    Dong, C.3
  • 48
    • 0029989339 scopus 로고    scopus 로고
    • Immune and inflammatory responses in TNF alpha-deficient mice: A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    • Pasparakis M, Alexopoulou L, Episkopou V, Kollias G (1996) Immune and inflammatory responses in TNF alpha-deficient mice: A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184(4): 1397-1411.
    • (1996) J Exp Med , vol.184 , Issue.4 , pp. 1397-1411
    • Pasparakis, M.1    Alexopoulou, L.2    Episkopou, V.3    Kollias, G.4
  • 49
    • 0021982891 scopus 로고
    • Increased DNA synthesis of uninvolved psoriatic epidermis is maintained in vitro
    • Kragballe K, Desjarlais L, Marcelo CL (1985) Increased DNA synthesis of uninvolved psoriatic epidermis is maintained in vitro. Br J Dermatol 112(3):263-270.
    • (1985) Br J Dermatol , vol.112 , Issue.3 , pp. 263-270
    • Kragballe, K.1    Desjarlais, L.2    Marcelo, C.L.3
  • 50
    • 84876786104 scopus 로고    scopus 로고
    • IκBζ is a transcriptional key regulator of CCL2/MCP-1
    • Hildebrand DG, et al. (2013) IκBζ is a transcriptional key regulator of CCL2/MCP-1. J Immunol 190(9):4812-4820.
    • (2013) J Immunol , vol.190 , Issue.9 , pp. 4812-4820
    • Hildebrand, D.G.1
  • 51
    • 80055106751 scopus 로고    scopus 로고
    • Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
    • Ghoreschi K, et al. (2011) Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208(11):2291-2303.
    • (2011) J Exp Med , vol.208 , Issue.11 , pp. 2291-2303
    • Ghoreschi, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.