Mitochondrial genetics regulate breast cancer Tumorigenicity and Metastatic potential

Cancer Research

Volumn 75, Issue 20, 2015, Pages 4429-4436

  Feeley, Kyle P ^a   Bray, Alexander W ^a   Westbrook, David G ^a   Johnson, Larry W ^b   Kesterson, Robert A ^b   Ballinger, Scott W ^a   Welch, Danny R ^c  

^a Department of Pathology   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST TUMOR; COHORT ANALYSIS; CONTROLLED STUDY; EMBRYO; FEMALE; MALE; METASTASIS POTENTIAL; MITOCHONDRIAL GENETICS; MITOCHONDRIAL GENOME; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; CELL TRANSFORMATION; DISEASE MODEL; EPITHELIUM CELL; EXPERIMENTAL MAMMARY NEOPLASM; GENETICS; HUMAN; METABOLISM; METASTASIS; MITOCHONDRION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PATHOLOGY; TUMOR VOLUME;

ANIMALS; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NEOPLASM METASTASIS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; TUMOR BURDEN;

EID: 84945580744     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0074     Document Type: Article

References (30)

1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.
2. King MC. "The race" to clone BRCA1. Science 2014;343:1462-5.
3. Winter SF, Hunter KW. Mouse modifier genes in mammary tumorigenesis and metastasis. J Mamm Gland Biol Neopl 2008;13:337-42.
4. Perou CM, Sorlie T, Eisen MB, Van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature 2000;406: 747-52.
5. Krupke DM, Begley DA, Sundberg JP, Bult CJ, Eppig JT. The mouse tumor biology database. Nature Rev Cancer 2008;8:459-65.
6. Crawford NPS, Walker RC, Lukes L, Officewala JS, Williams RW, Hunter KW. The Diasporin Pathway: A tumor progression-related transcriptional network that predicts breast cancer survival. Clin Exptl Metastasis 2008;25:357-69.
7. Hunter KW, Broman KW, LeVoyer T, Lukes L, Cozma D, Debies MT, et al. Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res 2001;61:8866-72.
8. Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH, et al. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer 1998;77:640-4.
9. Sevignani C, Calin GA, Nnadi SC, Shimizut M, Davulurit RV, Hyslop T, et al. MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci 2007;104:8017-22.
10. Hunter KW. Allelic diversity in the host genetic background may be an important determinant in tumor metastatic dissemination. Cancer Lett 2003;200:97-105.
11. Park YG, Lukes L, Yang H, Debies MT, Samant RS, Welch DR, et al. Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1. Mamm Genome 2002;13:289-92.
12. Lin EY, Jones JG, Li P, Zhu UY, Whitney KD, Muller WJ, et al. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003;163:2113-26.
13. Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirusmiddle T oncogene: A transgenic mousemodel for metastatic disease. Molec Cell Biol 1992;12:954-61.
14. Park YG, Zhao XH, Lesueur F, Lowy DR, Lancaster M, Pharoah P, et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locusMtes1. Nat Genet 2005;37:1055-62.
15. Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, et al. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. PLoS Genet 2007;3:e214.
16. Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, et al. ROS-generatingmitochondrialDNAmutations can regulate tumor cell metastasis. Science 2008;320:661-4.
17. Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, et al. Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. Biochem J 2013;455:157-67.
18. Cook LM, Cao X, Dowell AE, Debies MT, Edmonds MD, Beck BH, et al. Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis. Clin Exptl Metastasis 2012;29:315-25.
19. Welch DR. Technical considerations for studying cancer metastasis in vivo. Clin Exptl Metastasis 1997;15:272-306.
20. Feeley KP, Westbrook DG, Bray AW, Ballinger SW. An ex-vivo model for evaluating bioenergetics in aortic rings. Redox Biol 2014;2C:1003-7.
21. Liu W, Beck BH, Vaidya KS, Nash KT, Feeley KP, Ballinger SW, et al. Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. Cancer Res 2014;74:954-63.
22. Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007;11:37-51.
23. Bell EL, Emerling BM, Ricoult SJ, Guarente L. SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Oncogene 2011;30:2986-96.
24. van Ginkel PR, Sareen D, Subramanian L, Walker Q, Darjatmoko SR, Lindstrom MJ, et al. Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Clin Cancer Res 2007;13:5162-9.
25. Dranka BP, Hill BG, Darley-Usmar VM. Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free Radic Biol Med 2010;48:905-14.
26. Bayona-Bafaluy MP, cin-Perez R, Mullikin JC, Park JS, Moreno-Loshuertos R, Hu P, et al. Revisiting the mousemitochondrial DNA sequence. Nucleic Acids Res 2003;31:5349-55.
27. Santidrian AF, Matsuno-Yagi A, Ritland M, Seo BB, LeBoeuf SE, Gay LJ, et al. Mitochondrial complex I activity and NAD+ /NADH balance regulate breast cancer progression. JCI 2013;123: 1068-81.
28. Sen S, Kawahara B, Chaudhuri G. Mitochondrial-Associated nitric oxide synthase activity inhibits cytochrome c oxidase: implications for breast cancer. Free Radic Biol Med 2013;57:210-20.
29. Petros JA, Baumann AK, Ruiz-Pesini E, Amin MB, Sun CQ, Hall J, et al. mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci 2005;102:719-24.
30. Yizhak K, Le Devedec SE, Rogkoti VM, Baenke F, de Boer VC, Frezza C, et al. A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration. Mol Syst Biol 2014;10:744.