Targeting acute inflammation to complement spinal cord repair

Neural Regeneration Research

Volumn 10, Issue 10, 2015, Pages 1596-1598

  Brennan, Faith H ^a   Ruitenberg, Marc J ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Trauma Critical Care and Recovery Brisbane Diamantina Health Partners   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; CXCL1 CHEMOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; STAT PROTEIN;

ASTROCYTE; HUMAN; INFLAMMATION; MICROGLIA; NERVOUS SYSTEM INJURY; NOTE; SPINAL CORD INJURY; SPINAL CORD REGENERATION;

EID: 84945534644     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.165268     Document Type: Note

References (12)

1. Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM, Anderson AJ (2010) Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain 133:433-447.
2. Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, Woodruff TM, Ruitenberg MJ (2015) The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury. J Neurosci 35:6517-6531.
3. Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC (2007) C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 446:203-207.
4. Gensel JC, Nakamura S, Guan Z, van Rooijen N, Ankeny DP, Popovich PG (2009) Macrophages promote axon regeneration with concurrent neurotoxicity. J Neurosci 29:3956-3968.
5. Haynes T, Luz-Madrigal A, Reis ES, Echeverri Ruiz NP, Grajales-Esquivel E, Tzekou A, Tsonis PA, Lambris JD, Del Rio-Tsonis K (2013) Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun 4:2312.
6. Jacob A, Hack B, Chen P, Quigg RJ, Alexander JJ (2011) C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-kappaB. J Neurochem 119:1041-1051.
7. Kroner A, Greenhalgh AD, Zarruk JG, Passos Dos Santos R, Gaestel M, David S (2014) TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 83:1098-1116.
8. Lee JY, Choi HY, Ahn HJ, Ju BG, Yune TY (2014) Matrix metalloproteinase- 3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury. Am J Pathol 184:2985-3000.
9. Li L, Xiong ZY, Qian ZM, Zhao TZ, Feng H, Hu S, Hu R, Ke Y, Lin J (2014) Complement C5a is detrimental to histological and functional locomotor recovery after spinal cord injury in mice. Neurobiol Dis 66:74-82.
10. Okada S, Nakamura M, Mikami Y, Shimazaki T, Mihara M, Ohsugi Y, Iwamoto Y, Yoshizaki K, Kishimoto T, Toyama Y, Okano H (2004) Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury. J Neurosci Res 76:265-276.
11. Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H (2006) Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 12:829-834.
12. Pineau I, Lacroix S (2007) Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved. J Comp Neurol 500:267-285.