Evidence of hypothalamic-pituitary-adrenal axis suppression during moderate-to-high-dose inhaled corticosteroid use

European Journal of Pediatrics

Volumn 174, Issue 11, 2015, Pages 1421-1431

  Cavkaytar, Ozlem ^a   Vuralli, Dogus ^a   Arik Yilmaz, Ebru ^a   Buyuktiryaki, Betul ^a   Soyer, Ozge ^a   Sahiner, Umit M ^a   Kandemir, Nurgun ^a   Sekerel, Bulent E ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Adverse effect; Asthma; Hypothalamic pituitary adrenal axis; Low dose ACTH stimulation test; Treatment

Indexed keywords

BUDESONIDE; CICLESONIDE; CORTICOSTEROID; FLUTICASONE; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE HYDROFLUOROALKANE; HYDROCORTISONE; UNCLASSIFIED DRUG; ANTIASTHMATIC AGENT; GLUCOCORTICOID;

ADOLESCENT; ARTICLE; ASTHMA; BODY MASS; CHILD; CLINICAL FEATURE; CORTICOSTEROID THERAPY; CORTICOTROPIN TEST; DRUG MEGADOSE; DRUG USE; DRY POWDER INHALER; FACE MASK; FEMALE; FOLLOW UP; HOSPITALIZATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INHALER; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; NEBULIZATION; PRACTICE GUIDELINE; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; TREATMENT DURATION; DRUG EFFECTS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INFANT; INHALATIONAL DRUG ADMINISTRATION;

ADMINISTRATION, INHALATION; ADOLESCENT; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; FEMALE; GLUCOCORTICOIDS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFANT; MALE; PITUITARY-ADRENAL SYSTEM;

EID: 84945492449     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-015-2610-9     Document Type: Article

References (40)

1. Agwu JC, Spoudeas H, Hindmarsh PC, Pringle PJ, Brook CG (1999) Tests of adrenal insufficiency. Arch Dis Child 80:330–333
2. Barnes PJ, Pedersen S, Busse WW (1998) Efficacy and safety of inhaled corticosteroids. New developments. Am J Resp Crit Care Med 157:S1–53
3. Broide J, Soferman R, Kivity S, Golander A, Dickstein G, Spirer Z, Weisman Y (1995) Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J Clin Endocrinol Metab 80:1243–1246
4. Bruni FM, De Luca G, Venturoli V, Boner AL (2009) Intranasal corticosteroids and adrenal suppression. Neuroimmunomodulation 16:353–362
5. Cetinkaya F, Kayiran P, Memioglu N, Tarim OF, Eren N, Erdem E (2008) Effects of nebulized corticosteroids therapy on hypothalamic-pituitary-adrenal axis in young children with recurrent or persistent wheeze. Pediatr Allergy Immunol 19:773–776
6. Chopra D, Bhandari B, Wardhan N (2012) Ciclesonide—a novel corticosteroid for the management of asthma. Curr Clin Pharmacol 7:73–77
7. Covar RA, Fuhlbrigge AL, Williams P, Kelly HW the Childhood Asthma Management Program Research Group (2012) The Childhood Asthma Management Program (CAMP): contributions to the understanding of therapy and the natural history of childhood asthma. Curr Resp Care Rep 1:243–250
8. Drake AJ, Howells RJ, Shield JP, Prendiville A, Ward PS, Crowne EC (2002) Symptomatic adrenal insufficiency presenting with hypoglycaemia in children with asthma receiving high dose inhaled fluticasone propionate. BMJ 324:1081–1082
9. Fan Y, Ma L, Pippins J, Limb S, Xu Y, Sahajwalla CG (2013) Impact of study design on the evaluation of inhaled and intranasal corticosteroids’ effect on hypothalamic-pituitary-adrenal axis function, part I: general overview of HPA axis study design. J Pharm Sci 102:3513–3527
10. Gelfand EW, Georgitis JW, Noonan M, Ruff ME (2006) Once-daily ciclesonide in children: efficacy and safety in asthma. J Pediatr 148:377–383
11. Georgitis JW (1999) The 1997 asthma management guidelines and therapeutic issues relating to the treatment of asthma. National Heart, Lung, and Blood Institute. Chest 115:210–217
12. Global Strategy for Asthma Management and Prevention. (GINA updated 2014). Available via http://www.ginasthma.org/. Accessed 10 June 2014.
13. Goldberg S, Einot T, Algur N, Schwartz S, Greenberg AC, Picard E, Virgilis D, Kerem E (2002) Adrenal suppression in asthmatic children receiving low-dose inhaled budesonide: comparison between dry powder inhaler and pressurized metered-dose inhaler attached to a spacer. Ann Allergy Asthma Immunol 89:566–571
14. Goldsobel AB, Chipps BE (2010) Cough in the pediatric population. J Pediatr 156:352–358
15. Gonc EN, Kandemir N, Kinik ST (2003) Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. Horm Res 60:191–197
16. Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ, Bacharier LB, Lemanske RF Jr, Strunk RC, Allen DB, Bloomberg GR, Heldt G, Krawiec M, Larsen G, Liu AH, Chinchilli VM, Sorkness CA, Taussig LM, Martinez FD (2006) Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 354:1985–1997
17. Hagg E, Asplund K, Lithner F (1987) Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency. Clin Endocrinol (Oxf) 26:221–226
18. Hawcutt DB, Jorgensen AL, Wallin N, Thompson B, Peak M, Lacy D, Newland P, Didi M, Couriel J, Blair J, Pirmohamed M, Smyth RL (2014) Adrenal responses to a low dose short synacthen test in children with asthma. Clin Endocrinol (Oxf) 82:648–656
19. Heller MK, Laks J, Kovesi TA, Ahmet A (2010) Reversal of adrenal suppression with ciclesonide. J Asthma 47:337–339
20. Jones SL, Trainer PJ, Perry L, Wass JA, Besser GM, Grossman A (1994) An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year. Clin Endocrinol (Oxf) 41:123–128
21. Lipworth BJ, Clark DJ, McFarlane LC (1997) Adrenocortical activity with repeated twice daily dosing of fluticasone propionate and budesonide given via a large volume spacer to asthmatic school children. Thorax 52:686–689
22. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group (2000) N Engl J Med 343:1054–1063.
23. Lougheed MD, Lemiere C, Dell SD, Ducharme FM, Fitzgerald JM, Leigh R, Licskai C, Rowe BH, Bowie D, Becker A, Boulet LP, Canadian Thoracic Society Asthma Management Continuum--2010 Consensus (2010) Summary for children six years of age and over, and adults. Can Respir J 17:15–24
24. Miller WL, Achermann JC, Flock CE (2008) The adrenal cortex and its disorders. In: Sperling MA (ed) Pediatric endocrinology, 3rd edn. Saunders, Philadelphia, pp 444–511
25. National Asthma Education and Prevention Program (2007) Expert Panel Report 3: Guidelines for the diagnosis and management of asthma. (NIH publication No. 08–4051). Bethesda, MD: National Institute of Health. Available via http://www.nhlbi.nih.gov/files/docs/guidelines/asthsumm.pdf. Accessed 10 June 2014.
26. Ozbek OY, Turktas I, Bakirtas A, Bideci A (2006) Evaluation of hypothalamic-pituitary-adrenal axis suppression by low-dose (0.5 microg) and standard-dose (250 microg) adrenocorticotropic hormone (ACTH) tests in asthmatic children treated with inhaled corticosteroid. J Pediatr Endocrinol Metab 19:1015–1023
27. Sahiner UM, Cetinkaya S, Ozmen S, Arslan Z (2011) Evaluation of adrenocortical function in 3-7 aged asthmatic children treated with moderate doses of fluticasone propionate: reliability of dehydroepiandrosterone sulphate (dhea-s) as a screening test. Allergol Immunopathol 39:154–158
28. Shah A, Stanhope R, Matthew D (1992) Hazards of pharmacological tests of growth hormone secretion in childhood. BMJ 304:173–174
29. Skoner JD, Schaffner TJ, Schad CA, Kwon AY, Skoner DP (2008) Addressing steroid phobia: improving the risk-benefit ratio with new agents. Allergy Asthma Proc 29:358–364
30. Smith RW, Downey K, Gordon M, Hudak A, Meeder R, Barker S, Smith WG (2012) Prevalence of hypothalamic-pituitary-adrenal axis suppression in children treated for asthma with inhaled corticosteroid. Paediatr Child Health 17:e34–e39
31. Schwarz RH, Neacsu O, Ascher DP, Alpan O (2012) Induced symptomatic adrenal suppression: case report and review of the literature. Clin Pediatr 51:1184–1190
32. Todd GR, Acerini CL, Ross-Russell R, Zahra S, Warner JT, McCance D (2002) Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom. Arch Dis Child 87:457–461
33. Von Berg A, Engelstatter R, Minic P, Sreckovic M, Garcia Garcia ML, Latos T, Vermeulen JH, Leichtl S, Hellbardt S, Bethke TD (2007) Comparison of the efficacy and safety of ciclesonide 160 microg once daily vs. budesonide 400 microg once daily in children with asthma. Pediatr Allergy Immunol 18:391–400
34. Wu K, Goyal N, Stark JG, Hochhaus G (2008) Evaluation of the administration time effect on the cumulative cortisol suppression and cumulative lymphocytes suppression for once-daily inhaled corticosteroids: a population modeling/simulation approach. J Clin Pharmacol 48:1069–1080
35. Zeiger RS, Szefler SJ, Phillips BR, Schatz M, Martinez FD, Chinchilli VM, Lemanske RF, Strunk RC, Larsen G, Spahn JD, Bacharier LB, Bloomberg GR, Guilbert TW, Heldt G, Morgan WJ, Moss MH, Sorkness CA, Taussig LM, Childhood Asthma Research and Education Network of National Heart Lung, and Blood Institute (2006) Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. J Allergy Clin Immunol 117:45–52
36. Zollner EW (2007) Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled corticosteroids: part 1. Which test should be used? Pediatr Allergy Immunol 18:401–409
37. Zollner EW, Lombard CJ, Galal U, Hough FS, Irusen EM, Weinberg E (2012) Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children. Pediatrics 130:e1512–e1519
38. Zollner EW, Lombard C, Galal U, Hough S, Irusen E, Weinberg E (2011) Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled and nasal corticosteroids—more common than expected? J Pediatr Endocrinol Metab 24:529–534
39. Zollner EW, Lombard C, Galal U, Hough S, Irusen E, Weinberg E (2011) Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled and nasal corticosteroids: is the early-morning serum adrenocorticotropic hormone (ACTH) a useful screening test? Pediatr Allergy Immunol 22:614–620
40. Zora JA, Zimmerman D, Carey TL, O’Connell EJ, Yunginger JW (1986) Hypothalamic-pituitary-adrenal axis suppression after short-term, high-dose glucocorticoid therapy in children with asthma. J Allergy Clin Immunol 77:9–13