Evaluation of adrenocortical function in 3-7 aged asthmatic children treated with moderate doses of fluticasone propionate: Reliability of dehydroepiandrosterone sulphate (dhea-s) as a screening test

Allergologia et Immunopathologia

Volumn 39, Issue 3, 2011, Pages 154-158

  Sahiner, U M ^a   Cetinkaya, S ^a   Ozmen, S ^a   Arslan, Z ^a  

^a DR SAMI ULUS CHILDREN S HOSPITAL   (Turkey)

Author keywords

Adrenal axis supression; Asthma; Children; Dehydroepiandrosterone sulphate; Fluticasone propionate

Indexed keywords

CORTICOTROPIN; FLUTICASONE PROPIONATE; GLUCOSE; HYDROCORTISONE; PRASTERONE SULFATE;

ADRENAL CORTEX FUNCTION; ADRENAL GLAND; ARTICLE; ASTHMATIC STATE; CHILD; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICOTROPIN TEST; DIAGNOSTIC VALUE; DIET RESTRICTION; DRUG RESPONSE; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; LONG TERM CARE; LOW DRUG DOSE; MALE; RELIABILITY; SCREENING TEST;

ANDROSTADIENES; ASTHMA; BIOLOGICAL MARKERS; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOASSAY; MALE; PITUITARY-ADRENAL SYSTEM;

EID: 79956144716     PISSN: 03010546     EISSN: 15781267     Source Type: Journal    
DOI: 10.1016/j.aller.2010.06.005     Document Type: Article

References (34)

1. National Asthma Education and Practice Program. Guidelines for the diagnosis and management of asthma: update on selected topics-2002. J Allegy Clin Immunol. 2002; 110 Suppl 5: S141-S219.
2. Todd G., Dunlop K., McNaboe J., Ryan M.F., Carson D. Growth and adrenal supression in asthmatic children treated with high dose fluticasone propionate. Lancet 1996, 348:27-29.
3. Patel L., Wales J.K., Kibirige M.S., Massarano A.A., Couriel JM, Clayton P.E. Symptomatic adrenal insufficiency during inhaled corticosteroid treatment. Arch Dis Child 2001, 85:330-334.
4. Drake A.J., Howells R.J., Shield J.P., Prendiville A., Ward P.S., Crowne E.C. Symptomatic adrenal insufficiency presenting with hypoglycaemia in children with asthma receiving high dose inhaled fluticasone propionate. BMJ 2002, 324:1081-1082.
5. Derendorf H. Pharmacokinetic and pharmacodynamic properties of inhaled corticosteroids in relation to efficacy and safety. Respir Med. 1997, 91(Suppl A):22-28.
6. Lipworth B.J. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arc Intern Med. 1999, 159:941-955.
7. Szefler S.J., Martin R.J., King T.S., Boushey H.A., Cherniack R.M., Chinchilli V.M., et al. For the Asthma Clinical Research Network of the National Heart. Lung and Blood Institute. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002, 109:410-418.
8. Brus R. Effects of high dose inhaled corticosteroids on plasma cortisol concentrations in healthy adults. Arch Intern Med. 1999, 159:1903-1908.
9. Jarvis B., Faulds D. Inhaled fluticasone propionate: A review of its therapeutc efficacy at dosages < or =500 mikrog/day in adults and adolescents with mild to moderate asthma. Drugs. 1999, 57:769-803.
10. Chervinsky P., Van As A., Bronsky E.A., Dockhorn R., Noonan M., LaForce C., et al. Fluticasone propionate aerosol for the treatment of adults with mild to moderate asthma. J Allergy Clin Immunol. 1994, 94:676-683. For the Fluticasone Propionate Asthma Study Group.
11. Weiner P., Berar-Yanay N., Davidovich A., Magadle R. Nocturnal cortisol secretion in asthmatic patients after inhalation of fluticasone propionate. Chest 1999, 116:931-934.
12. Nelson H.S., Stricker W., Casale T.B., Raff H., Fourre J.A., Aron D.C., et al. A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroids. J Clin Pharmacol. 2002, 42:319-326.
13. Peden D., Berger W., Noonan M., Thomas M.R., Hendrics V.L., Hamedani A.G., et al. Inhaled fluticasone propionate delivered by means of two different multidose powder inhalers is effective and safe in a large paediatric population with persistent asthma. J Allergy Clin Immunol. 1998, 102:32-38.
14. Hoekstra M.O., Grol M.H., Bouman K., Stijnen T., Köeter G.H., Kauffman H.F., et al. Fluticasone propionate in children with moderate asthma. Am J Respir Crit Care Med 1996, 154:1039-1044.
15. Verona E., Petrov D., Cserhati E., Hofman J., Geppe N., Medley H., et al. Fluticasone propionate in asthma: a long term dose comparison study. Arch Dis Child 2003, 88:503-509.
16. Price J., Russell G., Hindmarsh P., Weller P., Heaf D.P., Wiliams J. Growth during one year of treatment with fluticasone propionate or sodium cromoglycate in children with asthma. Pediatr Pulmonol 1997, 24:178-186.
17. Zöllner E.W. Hypothalamic-pituitary-adrenal axis supression in asthmatic children on inhaled corticosteroids: Part 1. Which test should be used?. Pediatr Allergy Immunol 2007, 18:401-409.
18. Fitzgerald D., Van Asperen P., Melis C., Honner M., Smith L., Ambler G. Fluticasone propionate 750 micrograms/day versus beclomethasone dipropionate 1500 micrograms/day: comparison of efficacy and adrenal function in paediatric asthma. Thorax 1998, 53:656-661.
19. Kannisto S., Korppi M., Remes K., Voutilainen R. Adrenal supression, evaluated by a low dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids. J Clin Endocrinol Metab. 2000, 85:652-657.
20. Broide J., Soferman R., Kivity S., Golander A., Dickstein G., Spirer Z., et al. Low dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J Clin Endocrinol Metab 1995, 80:1243-1246.
21. Parker L.N. Control of adrenal androgen secretion. Endocrinol Metab Clin North Am 1991, 20:401-421.
22. Kannisto S., Laatikainen A., Taivainen A., Savolainen K., Tukiainen H., Voutilainen R. Serum dehydroepiandrosterone sulfate concentration as an indicator of adrenocortical suppression during inhaled steroid therapy in adult asthmatic patients. Eur J Endocrinol 2004, 150:687-690.
23. Kannisto S., Korppi M., Remes K., Voutilainen R. Serum dehydroepiandrosterone sulfate concentration as an indicator of adrenocortical supression in asthmatic children treated with inhaled steroids. J Clin Endocrinol Metab 2001, 86:4908-4912.
24. Dorsey M.J., Cohen L.E., Phipatanakul W., Denufrio D., Schneider L.C. Assessment of adrenal supression in children with asthma treated with inhaled corticosteroids: use of dehydroepiandrosterone sulfate as a screening test. Ann Allergy Asthma Immunol 2006, 97:182-186.
25. Gonc E.N., Kandemir N., Kinik S.T. Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. Horm Res. 2003, 60:191-197.
26. Holt S., Suder A., Weatherall M., Cheng S., Shirtcliffe P., Beasley R. Dose-response relation of inhaled fluticasone proionate in adolescents and adults with asthma: meta analysis. BMJ 2001, 323:253-256.
27. Taylor A.V., Laoprasert N., Zimmerman D., Sachs M.I. Adrenal supression secondary to inhaled fluticasone propionate. Ann Allergy Asthma Immunol 1999, 83:68-70.
28. Wong J., Zacharin M., Hocking N., Robinson P.J. Growth and adrenal supression in asthmatic children on moderate to high doses of fluticasone propionate. J Paediatr Child Health 2002, 38:59-62.
29. Todd G.R.G., Acerini C.L., Ross-Russell R., Zahra S., Warner J.T., McCance D. Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom. Arch Dis Child 2002, 87:457-461.
30. Eid N., Morton R., Olds B., Clark P., Sheikh S., Looney S. Decreased morning serum cortisol levels in children with asthma treated with inhaled fluticasone propionate. Pediatrics 2002, 109:217-221.
31. Cutler G.B., Davis S.E., Johnsonbaugh R.E., Loriaux D.L. Dissociation of cortisol and adrenal androgen secretion in patients with secondary adrenal insufficiency. J Clin Endocrinol Metab 1979, 49:604-609.
32. Rittmaster R.S., Loriaux D.L., Cutler G.B. Sensitivity of cortisol and adrenal androgens to dexamethasone suppression in hirsute women. J Clin Endocrinol Metab 1985, 61:462-466.
33. Kreitzer P.M., Blethen S.L., Festa R.S., Chasalow F.I. Deyhdroepiandrosterone sulfate levels are not supressible by glucocorticoids before adrenarche. J Clin Endocrinol Metab 1989, 69:1309-1311.
34. Ferguson A.C., Spier S., Manjra A., Versteegh F.G.A., Mark S., Zhang P. Efficacy and safety of high dose inhaled steroids in children with asthma: a comparison of fluticasone propionate with budesonide. J Pediatr 1999, 134:422-427.