Evaluation of the administration time effect on the cumulative cortisol suppression and cumulative lymphocytes suppression for once-daily inhaled corticosteroids: A population modeling/simulation approach

Journal of Clinical Pharmacology

Volumn 48, Issue 9, 2008, Pages 1069-1080

  Wu, Kai ^a   Goyal, Navin ^b   Stark, Jeffrey G ^c   Hochhaus, Günther ^b,d  

^a NOVARTIS   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c CEDRA Corporation   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

Asthma; Corticosteroid; Glucocorticoids; Modeling; Simulation

Indexed keywords

BUDESONIDE; CORTICOSTEROID; FLUTICASONE PROPIONATE; GLUCOCORTICOID; HYDROCORTISONE;

ADULT; ARTICLE; ASTHMA; CORRELATION ANALYSIS; CORTISOL SUPPRESSION; DISTRIBUTION VOLUME; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG HALF LIFE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; LYMPHOCYTE; LYMPHOCYTE SUPPRESSION; MALE; NORMAL HUMAN; PATIENT COMPLIANCE; PHARMACODYNAMICS; POPULATION MODEL; SIMULATION; SINGLE DRUG DOSE; STOCHASTIC MODEL;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADULT; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; BIOLOGICAL MARKERS; BUDESONIDE; CIRCADIAN RHYTHM; COMPUTER SIMULATION; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; HUMANS; HYDROCORTISONE; LYMPHOCYTES; MALE; MODELS, BIOLOGICAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STOCHASTIC PROCESSES; YOUNG ADULT;

EID: 49649102884     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270008320607     Document Type: Article

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