Adrenal responses to a low-dose short synacthen test in children with asthma

Clinical Endocrinology

Volumn 82, Issue 5, 2015, Pages 648-656

  Hawcutt, Daniel B ^a   Jorgensen, Andrea L ^a   Wallin, Naomi ^b   Thompson, Ben ^a   Peak, Matthew ^b   Lacy, David ^c   Newland, Paul ^b   Didi, Mo ^b   Couriel, Jon ^b   Blair, Jo ^b   Pirmohamed, Munir ^a   Smyth, Rosalind L ^d  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ALDER HEY CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

^c ARROWE PARK HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CORTICOSTEROID; FLUTICASONE; HYDROCORTISONE; MOMETASONE FUROATE; PREDNISOLONE; TETRACOSACTIDE; STEROID;

ADOLESCENT; ADRENAL FUNCTION; ADRENAL SUPPRESSION; ADULT; AGE; ARTICLE; ASTHMA; CHILD; CHILDHOOD DISEASE; CLINICAL ASSESSMENT; CORRELATION ANALYSIS; DEMOGRAPHY; DOSE CALCULATION; DOSE RESPONSE; DRUG RESPONSE; FEMALE; GENDER; HUMAN; HYDROCORTISONE BLOOD LEVEL; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; UNITED KINGDOM; UNSPECIFIED SIDE EFFECT; ADRENAL GLAND; BLOOD; CHEMISTRY; COHORT ANALYSIS; DRUG EFFECTS; ORAL DRUG ADMINISTRATION; PRESCHOOL CHILD; PREVALENCE;

ADMINISTRATION, ORAL; ADOLESCENT; ADRENAL CORTEX HORMONES; ADRENAL GLANDS; ASTHMA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COSYNTROPIN; FEMALE; HUMANS; HYDROCORTISONE; MALE; PREVALENCE; STEROIDS; UNITED KINGDOM;

EID: 84926613950     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12655     Document Type: Article

References (33)

1. Office for National Statistics. (1998) Key Health Statistics from General Practice. Office for National Statistics, Newport, South Wales.
2. British Thoracic Society/Scottish Intercollegiate Guidelines Network. (2012) British Guideline on the Management of Asthma: A national clinical guideline.
3. National Guideline C. Medications: expert panel report 3: guidelines for the diagnosis and management of asthma. Agency for Healthcare Research and Quality (AHRQ), Rockville MD. Available from: http://www.guideline.gov (accessed 19 July 2011).
4. Todd, G.R., Acerini, C.L., Ross-Russell, R., et al,. (2002) Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom. Archives of Disease in Childhood, 87, 457-461.
5. Priftis, K.N., Papadimitriou, A., Gatsopoulou, E., et al,. (2006) The effect of inhaled budesonide on adrenal and growth suppression in asthmatic children. European Respiratory Journal, 27, 316-320.
6. Paton, J., Jardine, E., McNeill, E., et al,. (2006) Adrenal responses to low dose synthetic ACTH (Synacthen) in children receiving high dose inhaled fluticasone. Archives of Disease in Childhood, 91, 808-813.
7. Sim, D., Griffiths, A., Armstrong, D., et al,. (2003) Adrenal suppression from high-dose inhaled fluticasone propionate in children with asthma. European Respiratory Journal, 21, 633-636.
8. Broide, J., Soferman, R., Kivity, S., et al,. (1995a) Low-dose adrenocorticotropin test reveals impaired adrenal-function in patients taking inhaled corticosteroids. Journal of Clinical Endocrinology and Metabolism, 80, 1243-1246.
9. Kannisto, S., Korppi, M., Remes, K., et al,. (2000) Adrenal suppression, evaluated by a low dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids. Journal of Clinical Endocrinology & Metabolism, 85, 652-657.
10. Patel, L., Wales, J.K., Kibirige, M.S., et al,. (2001) Symptomatic adrenal insufficiency during inhaled corticosteroid treatment. Archives of Disease in Childhood, 85, 330-334.
11. Shenoy, S.D., Swift, P.G., &, Cody, D., (2006) Growth impairment and adrenal suppression on low-dose inhaled beclomethasone. Journal of Paediatrics and Child Health, 42, 143-144.
12. Zhang, L.J., Axelsson, I., Chung, M., et al,. (2011) Dose response of inhaled corticosteroids in children with persistent asthma: a systematic review. Pediatrics, 127, 129-138.
13. Crowley, S., Hindmarsh, P.C., Honour, J.W., et al,. (1993) Reproducibility of the cortisol response to stimulation with a low-dose of Acth(1-24)-the effect of basal cortisol-levels and comparison of low-dose with high-dose secretory dynamics. Journal of Endocrinology, 136, 167-172.
14. Brown, P.H., Blundell, G., Greening, A.P., et al,. (1991) Screening for hypothalamo-pituitary-adrenal axis suppression in asthmatics taking high-dose inhaled corticosteroids. Respiratory Medicine, 85, 511-516.
15. Rasmuson, S., Olsson, T., &, Hagg, E., (1996) A low dose ACTH test to assess the function of the hypothalamic-pituitary-adrenal axis. Clinical Endocrinology, 44, 151-156.
16. Agwu, J.C., Spoudeas, H., Hindmarsh, P.C., et al,. (1999) Tests of adrenal insufficiency. Archives of Disease in Childhood, 80, 330-333.
17. Demay, M.C.R., Magny, J.P., Idres, N., et al,. (2006) Use of the low-dose corticotropin stimulation test for the monitoring of children with asthma treated with inhaled corticosteroids. Hormone Research, 66, 51-60.
18. Blair, J.C., Lancaster, G., Titman, A., et al,. (2014) Early morning salivary cortisol and cortisone, and adrenal responses to a simplified low dose short Synacthen test in children with asthma. Clinical Endocrinology, 80, 376-383.
19. Wade, M., Baid, S., Calis, K., et al,. (2010) Technical details influence the diagnostic accuracy of the 1 {micro}g ACTH stimulation test. European Journal of Endocrinology, 162, 109-113.
20. Jennings, B.H., Andersson, K.E., &, Johansson, S.A., (1991) Assessment of systemic effects of inhaled glucocorticosteroids-comparison of the effects of inhaled budesonide and oral prednisolone on adrenal-function and markers of bone turnover. European Journal of Clinical Pharmacology, 40, 77-82.
21. Gamble, J., Stevenson, M., McClean, E., et al,. (2009) The prevalence of nonadherence in difficult asthma. American Journal of Respiratory and Critical Care Medicine, 180, 817-822.
22. Kazlauskaite, R., Evans, A.T., Villabona, C.V., et al,. (2008) Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis. Journal of Clinical Endocrinology & Metabolism, 93, 4245-4253.
23. (GINA) GIfA. (2011) Pocket guide for Asthma Management and Prevention (in adults and children older than 5 years). [cited 23 October 2012]; Available from: http://www.ginasthma.org/uploads/users/files/GINA-Pocket-April20.pdf.
24. Jonetz-Mentzel, L., &, Wiedemann, G., (1993) Establishment of reference ranges for cortisol in neonates, infants, children and adolescents. European Journal of Clinical Chemistry and Clinical Biochemistry: Journal of the Forum of European Clinical Chemistry Societies, 31, 525-529 Epub 1993/08/01.
25. Thaler, L.M., &, Blevins, L.S., (1998) The low dose (1-mu g) adrenocorticotropin stimulation test in the evaluation of patients with suspected central adrenal insufficiency. Journal of Clinical Endocrinology & Metabolism, 83, 2726-2729.
26. Zöllner, E.W., Lombard, C.J., Galal, U., et al,. (2012) Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children. Pediatrics, 130, e1512-e1519.
27. Gupta, A., Cheetham, T., Jaffray, C., et al,. (2009) Repeatability of the low-dose ACTH test in asthmatic children on inhaled corticosteroids. Acta Pædiatrica, 98, 1945-1949.
28. Stroud, L.R., Papandonatos, G.D., Williamson, D.E., et al,. (2004) Sex differences in the effects of pubertal development on responses to a corticotropin-releasing hormone challenge-The Pittsburgh Psychobiologic Studies. In:, R.E. Dahl, L.P. Spear, eds. Adolescent Brain Development: Vulnerabilities and Opportunities. New York Acad Sciences, New York, NY, 348-351.
29. Oppenheimer, D.A., Carroll, B.A., &, Yousem, S., (1983) Sonography of the normal neonatal adrenal-gland. Radiology, 146, 157-160.
30. Walker, C.D., Garcia, R., &, Gagne, H., (1997) Developmental shift in catecholaminergic control of ACTH secretion in the rat. Dev Brain Dysfunct, 10, 405-417.
31. Desai, M., &, Oppenheimer, J.J., (2011) Medication adherence in the asthmatic child and adolescent. Current Allergy and Asthma Reports, 11, 454-464.
32. Conn, K.M., Halterman, J.S., Lynch, K., et al,. (2007) The impact of parents' medication beliefs on asthma management. Pediatrics, 120, E521-E526.
33. Zhang, L., Prietsch Sílvio, O.M., &, Ducharme Francine, M., (2014) Inhaled corticosteroids in children with persistent asthma: effects on growth. Cochrane Database of Systematic Reviews [Internet]. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009471.pub2/abstract.