Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 19, 2015, Pages 4320-4324

  Muthyala, Ramaiah ^a   Shin, Woo Shik ^a,b   Xie, Jiashu ^a   Sham, Yuk Yin ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Biomedical Informatics and Computational Biology Program   (United States)

Author keywords

Drug resistance; HDAC; Leukemia; Pyrithione; Thiohydroxamic acid

Indexed keywords

1 HYDROXYPYRIDINE 2 THIONE DERIVATIVE; ANTILEUKEMIC AGENT; DASATINIB; DIMER; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; IMATINIB; MONOMER; PYRIDINE DERIVATIVE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT; HISTONE DEACETYLASE; PYRITHIONE; THIOKETONE;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CELL PROLIFERATION; CELL VIABILITY ASSAY; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOTOXICITY; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STABILITY; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL; MOLECULAR DOCKING; MOUSE; NONHUMAN; X RAY CRYSTALLOGRAPHY; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG SCREENING; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIONES;

EID: 84945462693     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.07.065     Document Type: Article

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