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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 19, 2015, Pages 4203-4209

7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent

(16) Bavetsias, Vassilios a Pérez Fuertes, Yolanda a McIntyre, Patrick J b Atrash, Butrus a Kosmopoulou, Magda a O'Fee, Lisa a Burke, Rosemary a Sun, Chongbo a Faisal, Amir a,c Bush, Katherine a Avery, Sian a Henley, Alan a Raynaud, Florence I a Linardopoulos, Spiros a Bayliss, Richard a,b Blagg, Julian a

a INSTITUTE OF CANCER RESEARCH (United Kingdom)

b UNIVERSITY OF LEICESTER (United Kingdom)

c LAHORE UNIVERSITY OF MANAGEMENT SCIENCES (Pakistan)

Author keywords

Aurora kinase; Aurora A; Imidazo 4,5 b pyridine

Indexed keywords

7 (PYRAZOL 4 YL) 3H IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; AURORA A KINASE; AURORA B KINASE; AURORA KINASE INHIBITOR; HISTONE H3; IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; AURORA KINASE; IMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ALKYLATION; AMINATION; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CHLORINATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DFG MOTIF; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG HYDROLYSIS; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HINGE REGION; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; METABOLIC STABILITY; MICROWAVE IRRADIATION; MOUSE; NONHUMAN; PHARMACOKINETIC PARAMETERS; PROTEIN BINDING; PROTEIN MOTIF; SUZUKI REACTION; VOLUME OF DISTRIBUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; LIVER MICROSOME; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; AURORA KINASES; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIDAZOLES; MICE; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84945461652 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.08.003 Document Type: Article

Times cited : (14)

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