A convenient and rapid approach for the synthesis of 1-benzyl-3-heterocyclic pyrazoles

Tetrahedron Letters

Volumn 50, Issue 39, 2009, Pages 5479-5481

  Curtis, Michael P ^a   Sammons, Matthew F ^a   Piotrowski, David W ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC COMPOUND; PYRAZOLE DERIVATIVE;

ARTICLE; BENZYLATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; ONE POT SYNTHESIS; REACTION ANALYSIS; SUZUKI REACTION; SYNTHESIS;

EID: 68349157410     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.07.062     Document Type: Article

References (10)

1. McLaughlin M., Marcantonio K., Chen C., and Davies I.W. J. Org. Chem. 73 (2008) 4309
2. Primas N., Mahatsekake C., Bouillon A., Lancelot J.-C., Sopkovà-de Oliveira Santos J., Lohier J.-F., and Rault S. Tetrahedron 64 (2008) 4596
3. Wang L., Woods K.W., Li Q., Barr K.J., McCroskey R.W., Hannick S.M., Gherke L., Credo R.B., Hui Y., Marsh K., Warner R., Lee J.Y., Zielinski-Mozng N., Frost D., Rosenberg S., and Sham H.L. J. Med. Chem. 45 (2002) 1697
4. Price S., Bordogna W., Bull R.J., Clark D.E., Crackett P.H., Dyke H.J., Gill M., Harris N.V., Gorski J., Lloyd J., Lockey P.M., Mullett J., Roach A.G., Roussel F., and White A.B. Bioorg. Med. Chem. Lett. 17 (2007) 370
5. The benzylic protons for 1a = δ 5.37 ppm and 6a = δ 6.01 ppm; 1b = 5.40 ppm and 6b = δ 6.05 ppm; 1e = δ 5.46 ppm; 1g = δ 5.45 ppm; 1l = δ 5.47 ppm.
6. Patel M., Bacheler L.T., Rayner M.M., Cordova B.C., Klabe R.M., Erickson-Viitanen S., and Seitz S.P. Bioorg. Med. Chem. Lett. 8 (1998) 823
7. Pavlik W., and Kurzweil E.M. J. Heterocycl. Chem. 29 (1992) 1357
8. Balle T., Perregaard J., Ramirez M.T., Larsen A.K., SØby K.K., Liljefors T., and Andersen K. J. Med. Chem. 46 (2003) 265
9. Campeau L., and Fagnou K. Chem. Soc. Rev. 36 (2007) 1058
10. Tyrrell E., and Brookes P. Synthesis (2003) 469