Effect of alcohol on diethylnitrosamine-induced hepatic toxicity: Critical role of ROS, lipid accumulation, and mitochondrial dysfunction

Experimental and Toxicologic Pathology

Volumn 67, Issue 10, 2015, Pages 491-498

  Sun, Quangui ^a   Long, Zi ^a   Wu, Hao ^a   Liu, Ying ^a   Wang, Lele ^a   Zhang, Xiaodi ^a   Wang, Xin ^a   Hai, Chunxu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Alcohol; Diethylnitrosamine; Hepatic injury; Mitochondrial dysfunction; ROS

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; CARCINOGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CYTOCHROME P450 2E1; DIETHYLNITROSAMINE; LIPID; REACTIVE OXYGEN METABOLITE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; INFLAMMATORY CELL; LIPID STORAGE; LIVER FIBROSIS; LIVER INJURY; LIVER TOXICITY; LONG TERM EXPOSURE; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SURVIVAL RATE; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CONFOCAL MICROSCOPY; DISEASE MODEL; DRINKING BEHAVIOR; DRUG EFFECTS; LIPID METABOLISM; LIVER; METABOLISM; MITOCHONDRION; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TOXIC HEPATITIS; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ALCOHOL DRINKING; ANIMALS; BLOTTING, WESTERN; CARCINOGENS; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84945451310     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2015.07.003     Document Type: Article

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