NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer

Hepatology

Volumn 62, Issue 5, 2015, Pages 1466-1479

  Siddique, Hifzur R ^a   Feldman, Douglas E ^a   Chen, Chia Lin ^a   Punj, Vasu ^b   Tokumitsu, Hiroshi ^c   Machida, Keigo ^a,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c OKAYAMA UNIVERSITY   (Japan)

^d Southern California Research Center for Alcoholic Liver and Pancreatic Disease and Cirrhosis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; NUMB PROTEIN; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C ZETA; PROTEIN P53; TRANSCRIPTION FACTOR NANOG; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; AURKA PROTEIN, HUMAN; CD133 ANTIGEN; GLYCOPROTEIN; HOMEODOMAIN PROTEIN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; NANOG PROTEIN, HUMAN; NERVE PROTEIN; NUMB PROTEIN, HUMAN; PEPTIDE; PROTEIN KINASE C; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL LINE; CELL DIFFERENTIATION; CELL RENEWAL; ENZYME ACTIVITY; HEPATOMA CELL; HOMEOSTASIS; HUMAN; HUMAN TISSUE; LIVER CANCER; MOUSE; NONHUMAN; PHOSPHORYLATION; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; STEM CELL; ANIMAL; CANCER STEM CELL; CHEMISTRY; GENETICS; HEP-G2 CELL LINE; LIVER TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING;

AC133 ANTIGEN; ANIMALS; ANTIGENS, CD; AURORA KINASE A; GLYCOPROTEINS; HEP G2 CELLS; HOMEODOMAIN PROTEINS; HUMANS; LIVER NEOPLASMS; MEMBRANE PROTEINS; MICE; NANOG HOMEOBOX PROTEIN; NEOPLASTIC STEM CELLS; NERVE TISSUE PROTEINS; PEPTIDES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84945451033     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27987     Document Type: Article

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