A role for Numb in p53 stabilization

Genome Biology

Volumn 9, Issue 5, 2008, Pages

  Carter, Stephanie ^a   Vousden, Karen H ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; NOTCH RECEPTOR; ONCOPROTEIN; PROTEIN MDM2; PROTEIN NUMB; PROTEIN P53; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; JUVENILE HORMONE; MEMBRANE PROTEIN; NERVE PROTEIN; NUMB PROTEIN, DROSOPHILA; NUMB PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CELL; CARCINOGENESIS; CELL FATE; DNA DAMAGE; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; GENE LOSS; GENE OVEREXPRESSION; HUMAN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA INTERFERENCE; SHORT SURVEY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; BREAST TUMOR; METABOLISM; REVIEW;

ANIMALS; BREAST NEOPLASMS; DROSOPHILA PROTEINS; HUMANS; JUVENILE HORMONES; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 48949118769     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2008-9-5-221     Document Type: Short Survey

References (29)

1. Vogelstein B Lane D Levine AJ Surfing the p53 network. Nature 2000, 408:307-310. 10.1038/35042675 11099028
2. Fang S Jensen JP Ludwig RL Vousden KH Weissman AM Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000, 275:8945-8951. 10.1074/jbc.275.12.8945 10722742
3. Haupt Y Maya R Kazaz A Oren M Mdm2 promotes the rapid degradation of p53. Nature 1997, 387:296-299. 10.1038/387296a0 9153395
4. Kubbutat MH Jones SN Vousden KH Regulation of p53 stability by Mdm2. Nature 1997, 387:299-303. 10.1038/387299a0 9153396
5. Hainaut P Hollstein M p53 and human cancer: The first ten thousand mutations. Adv Cancer Res 2000, 77:81-137. 10549356
6. Momand J Jung D Wilczynski S Niland J The MDM2 gene amplification database. Nucleic Acids Res 1998, 26:3453-3459. 147746 9671804 10.1093/ nar/26.15.3453
7. Sherr CJ Divorcing ARF and p53: An unsettled case. Nat Rev Cancer 2006, 6:663-673. 10.1038/nrc1954 16915296
8. Moll UM Riou G Levine AJ Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion. Proc Natl Acad Sci USA 1992, 89:7262-7266. 49686 1353891 10.1073/pnas.89.15.7262
9. Samuels-Lev Y O'Connor DJ Bergamaschi D Trigiante G Hsieh JK Zhong S Campargue I Naumovski L Crook T Lu X ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001, 8:781-794. 10.1016/S1097-2765(01)00367-7 11684014
10. Colaluca IN Tosoni D Nuciforo P Senic-Matuglia F Galimberti V Viale G Pece S Di Fiore PP NUMB controls p53 tumour suppressor activity. Nature 2008, 451:76-80. 10.1038/nature06412 18172499
11. Frise E Knoblich JA Younger-Shepherd S Jan LY Jan YN The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci USA 1996, 93:11925-11932. 38160 8876239 10.1073/pnas.93.21.11925
12. Koch U Radtke F Notch and cancer: A double-edged sword. Cell Mol Life Sci 2007, 64:2746-2762. 10.1007/s00018-007-7164-1 17687513
13. Kuo CT Mirzadeh Z Soriano-Navarro M Rasin M Wang D Shen J Sestan N Garcia-Verdugo J Alvarez-Buylla A Jan LY Jan YN Post-natal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 2006, 127:1253-1264. 1876765 17174898 10.1016/j.cell.2006.10.041
14. Di Marcotullio L Ferretti E Greco A De Smaele E Po A Sico MA Alimandi M Giannini G Maroder M Screpanti I Gulino A Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol 2006, 8:1415-1423. 10.1038/ncb1510 17115028
15. Pece S Serresi M Santolini E Capra M Hulleman E Galimberti V Zurrida S Maisonneuve P Viale G Di Fiore PP Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 2004, 167:215-221. 2172557 15492044 10.1083/jcb.200406140
16. Juven-Gershon T Shifman O Unger T Elkeles A Haupt Y Oren M The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol Cell Biol 1998, 18:3974-3982. 108982 9632782
17. Yogosawa S Miyauchi Y Honda R Tanaka H Yasuda H Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem Biophys Res Commun 2003, 302:869-872. 10.1016/S0006-291X(03)00282-1 12646252
18. Ma J Martin JD Zhang H Auger KR Ho TF Kirkpatrick RB Grooms MH Johanson KO Tummino PJ Copeland RA Lai Z A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination. Biochemistry 2006, 45:9238-9245. 10.1021/bi060661u 16866370
19. Wallace M Worrall E Pettersson S Hupp TR Ball KL Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol Cell 2006, 23:251-263. 10.1016/ j.molcel.2006.05.029 16857591
20. Honda R Yasuda H Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J 1999, 18:22-27. 1171098 9878046 10.1093/emboj/18.1.22
21. Xirodimas D Saville MK Edling C Lane DP Lain S Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene 2001, 20:4972-4983. 10.1038/sj.onc.1204656 11526482
22. Lindstrom MS Deisenroth C Zhang Y Putting a finger on growth surveillance: Insight into MDM2 zinc finger-ribosomal protein interactions. Cell Cycle 2007, 6:434-437. 17329973
23. Itahana K Mao H Jin A Itahana Y Clegg HV Lindstrom MS Bhat KP Godfrey VL Evan GI Zhang Y Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 2007, 12:355-366. 10.1016/j.ccr.2007.09.007 17936560
24. Berdnik D Torok T Gonzalez-Gaitan M Knoblich JA The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell 2002, 3:221-231. 10.1016/S1534-5807(02)00215-0 12194853
25. Nishimura T Kaibuchi K Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell 2007, 13:15-28. 10.1016/j.devcel.2007.05.003 17609107
26. Santolini E Puri C Salcini AE Gagliani MC Pelicci PG Tacchetti C Di Fiore PP Numb is an endocytic protein. J Cell Biol 2000, 151:1345-1352. 2190585 11121447 10.1083/jcb.151.6.1345
27. McGill MA McGlade CJ Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intra-cellular domain. J Biol Chem 2003, 278:23196-23203. 10.1074/jbc.M302827200 12682059
28. Rossi M De Laurenzi V Munarriz E Green DR Liu YC Vousden KH Cesareni G Melino G The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 2005, 24:836-848. 549609 15678106 10.1038/sj.emboj.7600444
29. Rhyu MS Jan LY Jan YN Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 1994, 76:477-491. 10.1016/0092-8674(94)90112-0 8313469