메뉴 건너뛰기




Volumn 4, Issue , 2013, Pages

The p53-PUMA axis suppresses iPSC generation

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN P21; PROTEIN P53; PUMA PROTEIN;

EID: 84880837087     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3174     Document Type: Article
Times cited : (55)

References (48)
  • 1
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 2
    • 70450224866 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and reprogramming: Seeing the science through the hype
    • Izpisua Belmonte, J. C., Ellis, J., Hochedlinger, K. & Yamanaka, S. Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nat. Rev. Genet. 10, 878-883 (2009).
    • (2009) Nat. Rev. Genet , vol.10 , pp. 878-883
    • Izpisua Belmonte, J.C.1    Ellis, J.2    Hochedlinger, K.3    Yamanaka, S.4
  • 3
    • 63049090064 scopus 로고    scopus 로고
    • A fresh look at iPS cells
    • Yamanaka, S. A fresh look at iPS cells. Cell 137, 13-17 (2009).
    • (2009) Cell , vol.137 , pp. 13-17
    • Yamanaka, S.1
  • 4
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells
    • Park, I. H. et al. Disease-specific induced pluripotent stem cells. Cell 134, 877-886 (2008).
    • (2008) Cell , vol.134 , pp. 877-886
    • Park, I.H.1
  • 5
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch, R. & Young, R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132, 567-582 (2008).
    • (2008) Cell , vol.132 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 6
    • 77953466536 scopus 로고    scopus 로고
    • Nuclear reprogramming to a pluripotent state by three approaches
    • Yamanaka, S. & Blau, H. M. Nuclear reprogramming to a pluripotent state by three approaches. Nature 465, 704-712 (2010).
    • (2010) Nature , vol.465 , pp. 704-712
    • Yamanaka, S.1    Blau, H.M.2
  • 7
    • 71449109765 scopus 로고    scopus 로고
    • Direct cell reprogramming is a stochastic process amenable to acceleration
    • Hanna, J. et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 462, 595-601 (2009).
    • (2009) Nature , vol.462 , pp. 595-601
    • Hanna, J.1
  • 8
    • 77952172633 scopus 로고    scopus 로고
    • Dynamic single-cell imaging of direct reprogramming reveals an early specifying event
    • Smith, Z. D., Nachman, I., Regev, A. & Meissner, A. Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nat. Biotechnol. 28, 521-526 (2010).
    • (2010) Nat. Biotechnol , vol.28 , pp. 521-526
    • Smith, Z.D.1    Nachman, I.2    Regev, A.3    Meissner, A.4
  • 9
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    • Laurent, L. C. et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 8, 106-118 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 106-118
    • Laurent, L.C.1
  • 10
    • 79952755179 scopus 로고    scopus 로고
    • Genomic instability in iPS: Time for a break
    • Blasco, M. A., Serrano, M. & Fernandez-Capetillo, O. Genomic instability in iPS: time for a break. EMBO J. 30, 991-993 (2011).
    • (2011) EMBO J. , vol.30 , pp. 991-993
    • Blasco, M.A.1    Serrano, M.2    Fernandez-Capetillo, O.3
  • 11
    • 79952126043 scopus 로고    scopus 로고
    • Copy number variation and selection during reprogramming to pluripotency
    • Hussein, S. M. et al. Copy number variation and selection during reprogramming to pluripotency. Nature 471, 58-62 (2011).
    • (2011) Nature , vol.471 , pp. 58-62
    • Hussein, S.M.1
  • 12
    • 79952258224 scopus 로고    scopus 로고
    • Somatic coding mutations in human induced pluripotent stem cells
    • Gore, A. et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 471, 63-67 (2011).
    • (2011) Nature , vol.471 , pp. 63-67
    • Gore, A.1
  • 13
    • 84860644898 scopus 로고    scopus 로고
    • Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells
    • Young, M. A. et al. Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. Cell Stem Cell 10, 570-582 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 570-582
    • Young, M.A.1
  • 14
    • 80053913326 scopus 로고    scopus 로고
    • Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming
    • Quinlan, A. R. et al. Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming. Cell Stem Cell 9, 366-373 (2011).
    • (2011) Cell Stem Cell , vol.9 , pp. 366-373
    • Quinlan, A.R.1
  • 15
    • 84860640679 scopus 로고    scopus 로고
    • Erosion of dosage compensation impacts human iPSC disease modeling
    • Mekhoubad, S. et al. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell 10, 595-609 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 595-609
    • Mekhoubad, S.1
  • 16
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • Vousden, K. H. & Prives, C. Blinded by the light: the growing complexity of p53. Cell 137, 413-431 (2009).
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 17
  • 18
    • 0034628848 scopus 로고    scopus 로고
    • Cell cycle. Piecing together the p53 puzzle
    • Carr, A. M. Cell cycle. Piecing together the p53 puzzle. Science 287, 1765-1766 (2000).
    • (2000) Science , vol.287 , pp. 1765-1766
    • Carr, A.M.1
  • 19
    • 0035265686 scopus 로고    scopus 로고
    • Puma a novel proapoptotic gene is induced by p53
    • Nakano, K. & Vousden, K. H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 20
    • 0035265823 scopus 로고    scopus 로고
    • PUMA induces the rapid apoptosis of colorectal cancer cells
    • Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W. & Vogelstein, B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7, 673-682 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 673-682
    • Yu, J.1    Zhang, L.2    Hwang, P.M.3    Kinzler, K.W.4    Vogelstein, B.5
  • 21
    • 69349100455 scopus 로고    scopus 로고
    • Linking the p53 tumour suppressor pathway to somatic cell reprogramming
    • Kawamura, T. et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460, 1140-1144 (2009).
    • (2009) Nature , vol.460 , pp. 1140-1144
    • Kawamura, T.1
  • 22
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-21 pathway
    • Hong, H. et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-1135 (2009).
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1
  • 23
    • 54949136146 scopus 로고    scopus 로고
    • Two supporting factors greatly improve the efficiency of human iPSC generation
    • Zhao, Y. et al. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3, 475-479 (2008).
    • (2008) Cell Stem Cell , vol.3 , pp. 475-479
    • Zhao, Y.1
  • 24
    • 69349098834 scopus 로고    scopus 로고
    • Stem cells: The promises and perils of p53
    • Krizhanovsky, V. & Lowe, S. W. Stem cells: the promises and perils of p53. Nature 460, 1085-1086 (2009).
    • (2009) Nature , vol.460 , pp. 1085-1086
    • Krizhanovsky, V.1    Lowe, S.W.2
  • 25
    • 69349094006 scopus 로고    scopus 로고
    • A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    • Marion, R. M. et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149-1153 (2009).
    • (2009) Nature , vol.460 , pp. 1149-1153
    • Marion, R.M.1
  • 26
    • 69349098273 scopus 로고    scopus 로고
    • Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
    • Utikal, J. et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460, 1145-1148 (2009).
    • (2009) Nature , vol.460 , pp. 1145-1148
    • Utikal, J.1
  • 27
    • 69349103956 scopus 로고    scopus 로고
    • The Ink4/Arf locus is a barrier for iPS cell reprogramming
    • Li, H. et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460, 1136-1139 (2009).
    • (2009) Nature , vol.460 , pp. 1136-1139
    • Li, H.1
  • 28
    • 68149108384 scopus 로고    scopus 로고
    • PUMA a potent killer with or without p53
    • Yu, J. & Zhang, L. PUMA, a potent killer with or without p53. Oncogene 27(Suppl 1), S71-S83 (2008).
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Yu, J.1    Zhang, L.2
  • 29
    • 77955869467 scopus 로고    scopus 로고
    • Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation
    • Labi, V. et al. Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Gene Dev. 24, 1602-1607 (2010).
    • (2010) Gene Dev , vol.24 , pp. 1602-1607
    • Labi, V.1
  • 30
    • 77955912797 scopus 로고    scopus 로고
    • Apoptosis-promoted tumorigenesis: Gamma-irradiationinduced thymic lymphomagenesis requires Puma-driven leukocyte death
    • Michalak, E. M. et al. Apoptosis-promoted tumorigenesis: gamma-irradiationinduced thymic lymphomagenesis requires Puma-driven leukocyte death. Gene Dev. 24, 1608-1613 (2010).
    • (2010) Gene Dev , vol.24 , pp. 1608-1613
    • Michalak, E.M.1
  • 31
    • 77951753647 scopus 로고    scopus 로고
    • Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation
    • Yu, H. et al. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood 115, 3472-3480 (2010).
    • (2010) Blood , vol.115 , pp. 3472-3480
    • Yu, H.1
  • 32
    • 77954709903 scopus 로고    scopus 로고
    • Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
    • Shao, L. et al. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 115, 4707-4714 (2010).
    • (2010) Blood , vol.115 , pp. 4707-4714
    • Shao, L.1
  • 33
    • 44349122954 scopus 로고    scopus 로고
    • PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome
    • Qiu, W. et al. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell 2, 576-583 (2008).
    • (2008) Cell Stem Cell , vol.2 , pp. 576-583
    • Qiu, W.1
  • 34
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and - Independent apoptotic pathways
    • Jeffers, J. R. et al. Puma is an essential mediator of p53-dependent and - independent apoptotic pathways. Cancer Cell 4, 321-328 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1
  • 35
    • 0242410719 scopus 로고    scopus 로고
    • P53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    • Villunger, A. et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302, 1036-1038 (2003).
    • (2003) Science , vol.302 , pp. 1036-1038
    • Villunger, A.1
  • 36
    • 39149086020 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from fibroblast cultures
    • Takahashi, K., Okita, K., Nakagawa, M. & Yamanaka, S. Induction of pluripotent stem cells from fibroblast cultures. Nat. Protoc. 2, 3081-3089 (2007).
    • (2007) Nat. Protoc , vol.2 , pp. 3081-3089
    • Takahashi, K.1    Okita, K.2    Nakagawa, M.3    Yamanaka, S.4
  • 37
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1
  • 38
    • 79956006207 scopus 로고    scopus 로고
    • Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21
    • Leibowitz, B. J. et al. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Mol. Cancer Res. 9, 616-625 (2011).
    • (2011) Mol. Cancer Res , vol.9 , pp. 616-625
    • Leibowitz, B.J.1
  • 39
    • 0028913739 scopus 로고
    • A p53-dependent mouse spindle checkpoint
    • Cross, S. M. et al. A p53-dependent mouse spindle checkpoint. Science 267, 1353-1356 (1995).
    • (1995) Science , vol.267 , pp. 1353-1356
    • Cross, S.M.1
  • 40
    • 0028802618 scopus 로고
    • Proliferation enhancement by spontaneous multiplication of chromosome 7 in rheumatic synovial cells in vitro
    • Ermis, A. et al. Proliferation enhancement by spontaneous multiplication of chromosome 7 in rheumatic synovial cells in vitro. Hum. Genet. 96, 651-654 (1995).
    • (1995) Hum. Genet , vol.96 , pp. 651-654
    • Ermis, A.1
  • 41
    • 3543013739 scopus 로고    scopus 로고
    • Resolution of anaphase bridges in cancer cells
    • Hoffelder, D. R. et al. Resolution of anaphase bridges in cancer cells. Chromosoma 112, 389-397 (2004).
    • (2004) Chromosoma , vol.112 , pp. 389-397
    • Hoffelder, D.R.1
  • 42
    • 68549135405 scopus 로고    scopus 로고
    • Common themes of dedifferentiation in somatic cell reprogramming and cancer
    • Daley, G. Q. Common themes of dedifferentiation in somatic cell reprogramming and cancer. Cold Spring Harb. Symp. Quant. Biol. 73, 171-174 (2008).
    • (2008) Cold Spring Harb. Symp. Quant. Biol , vol.73 , pp. 171-174
    • Daley, G.Q.1
  • 43
    • 80053331459 scopus 로고    scopus 로고
    • PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice
    • Qiu, W. et al. PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice. Hepatology 54, 1249-1258 (2011).
    • (2011) Hepatology , vol.54 , pp. 1249-1258
    • Qiu, W.1
  • 44
    • 79961243711 scopus 로고    scopus 로고
    • Bid is a positive regulator for donor-derived lymphoid cell regeneration in gamma-irradiated recipients
    • e941
    • Shen, H. et al. Bid is a positive regulator for donor-derived lymphoid cell regeneration in gamma-irradiated recipients. Exp. Hematol. 39, 947-957 e941 (2011).
    • (2011) Exp. Hematol , vol.39 , pp. 947-957
    • Shen, H.1
  • 45
    • 0346455759 scopus 로고    scopus 로고
    • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
    • Liu, G. et al. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat. Genet. 36, 63-68 (2004).
    • (2004) Nat. Genet , vol.36 , pp. 63-68
    • Liu, G.1
  • 46
    • 44049095767 scopus 로고    scopus 로고
    • In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
    • Michalak, E. M., Villunger, A., Adams, J. M. & Strasser, A. In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ. 15, 1019-1029 (2008).
    • (2008) Cell Death Differ , vol.15 , pp. 1019-1029
    • Michalak, E.M.1    Villunger, A.2    Adams, J.M.3    Strasser, A.4
  • 47
  • 48
    • 80053320274 scopus 로고    scopus 로고
    • Apoptosis: A barrier against cancer no more?
    • Baumgartner, F. & Villunger, A. Apoptosis: a barrier against cancer no more? Hepatology 54, 1121-1124 (2011).
    • (2011) Hepatology , vol.54 , pp. 1121-1124
    • Baumgartner, F.1    Villunger, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.