Dynamic Methylation of Numb by Set8 Regulates Its Binding to p53 and Apoptosis

Molecular Cell

Volumn 50, Issue 4, 2013, Pages 565-576

  Dhami, GurpreetKaur ^a   Liu, Huadong ^a   Galka, Marek ^a   Voss, Courtney ^a   Wei, Ran ^a   Muranko, Kimberly ^a   Kaneko, Tomonori ^a   Cregan, SeanP ^b   Li, Lin ^c   Li, ShawnShun Cheng ^a  

^a WESTERN UNIVERSITY   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; LYSINE METHYLTRANSFERASE SET 8; METHYLTRANSFERASE; PROTEIN NUMB; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL NUCLEUS; HUMAN; METHYLATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BINDING SITES; CELL LINE; CELL LINE, TUMOR; DOXORUBICIN; HELA CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; IMMUNOBLOTTING; LYSINE; MCF-7 CELLS; MEMBRANE PROTEINS; METHYLATION; MICROSCOPY, CONFOCAL; MUTATION; NERVE TISSUE PROTEINS; PROTEIN BINDING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84878188387     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2013.04.028     Document Type: Article

References (43)

1. Aebersold R., Mann M. Mass spectrometry-based proteomics. Nature 2003, 422:198-207.
2. Anderson L., Hunter C.L. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol. Cell. Proteomics 2006, 5:573-588.
3. Black J.C., Whetstine J.R. Chromatin landscape: methylation beyond transcription. Epigenetics 2011, 6:9-15.
4. Black J.C., Van Rechem C., Whetstine J.R. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol. Cell 2012, 48:491-507.
5. Brooks C.L., Gu W. p53 regulation by ubiquitin. FEBS Lett. 2011, 585:2803-2809.
6. Carter S., Vousden K.H. A role for Numb in p53 stabilization. Genome Biol. 2008, 9:221.
7. Chen J., Xu J., Zhao W., Hu G., Cheng H., Kang Y., Xie Y., Lu Y. Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Int. J. Biochem. Cell Biol. 2005, 37:2273-2283.
8. Cheng Q., Cross B., Li B., Chen L., Li Z., Chen J. Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage. Mol. Cell. Biol. 2011, 31:4951-4963.
9. Colaluca I.N., Tosoni D., Nuciforo P., Senic-Matuglia F., Galimberti V., Viale G., Pece S., Di Fiore P.P. NUMB controls p53 tumour suppressor activity. Nature 2008, 451:76-80.
10. Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 2007, 8:286-298.
11. Ferreira C.G., Tolis C., Giaccone G. p53 and chemosensitivity. Ann. Oncol. 1999, 10:1011-1021.
12. Greer E.L., Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat. Rev. Genet. 2012, 13:343-357.
13. Guendel I., Carpio L., Pedati C., Schwartz A., Teal C., Kashanchi F., Kehn-Hall K. Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function. PLoS ONE 2010, 5:e11379. 10.1371/journal.pone.0011379.
14. Guntur V.P., Waldrep J.C., Guo J.J., Selting K., Dhand R. Increasing p53 protein sensitizes non-small cell lung cancer to paclitaxel and cisplatin invitro. Anticancer Res. 2010, 30:3557-3564.
15. Huang J., Berger S.L. The emerging field of dynamic lysine methylation of non-histone proteins. Curr. Opin. Genet. Dev. 2008, 18:152-158.
16. Jørgensen S., Eskildsen M., Fugger K., Hansen L., Larsen M.S., Kousholt A.N., Syljuåsen R.G., Trelle M.B., Jensen O.N., Helin K., Sørensen C.S. SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J.Cell Biol. 2011, 192:43-54.
17. Juven-Gershon T., Shifman O., Unger T., Elkeles A., Haupt Y., Oren M. The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol. Cell. Biol. 1998, 18:3974-3982.
18. Karaczyn A., Bani-Yaghoub M., Tremblay R., Kubu C., Cowling R., Adams T.L., Prudovsky I., Spicer D., Friesel R., Vary C., Verdi J.M. Two novel human NUMB isoforms provide a potential link between development and cancer. Neural Dev. 2010, 5:31.
19. Kontaki H., Talianidis I. Lysine methylation regulates E2F1-induced cell death. Mol. Cell 2010, 39:152-160.
20. Li S.C., Zwahlen C., Vincent S.J., McGlade C.J., Kay L.E., Pawson T., Forman-Kay J.D. Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat. Struct. Biol. 1998, 5:1075-1083.
21. Li Z., Nie F., Wang S., Li L. Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc. Natl. Acad. Sci. USA 2011, 108:3116-3123.
22. MacLean B., Tomazela D.M., Shulman N., Chambers M., Finney G.L., Frewen B., Kern R., Tabb D.L., Liebler D.C., MacCoss M.J. Skyline: an open source document editorfor creating and analyzing targeted proteomics experiments. Bioinformatics 2010, 26:966-968.
23. Mellert H.S., Stanek T.J., Sykes S.M., Rauscher F.J., Schultz D.C., McMahon S.B. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. J.Biol. Chem. 2011, 286:4264-4270.
24. Misquitta-Ali C.M., Cheng E., O'Hanlon D., Liu N., McGlade C.J., Tsao M.S., Blencowe B.J. Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol. Cell. Biol. 2011, 31:138-150.
25. Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Global, invivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2006, 127:635-648.
26. Pece S., Confalonieri S., Romano P., Di Fiore P.P. NUMB-ing down cancer by more than just a NOTCH. Biochim. Biophys. Acta 2011, 1815:26-43.
27. Pece S., Serresi M., Santolini E., Capra M., Hulleman E., Galimberti V., Zurrida S., Maisonneuve P., Viale G., Di Fiore P.P. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J.Cell Biol. 2004, 167:215-221.
28. Picotti P., Bodenmiller B., Mueller L.N., Domon B., Aebersold R. Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics. Cell 2009, 138:795-806.
29. Picotti P., Rinner O., Stallmach R., Dautel F., Farrah T., Domon B., Wenschuh H., Aebersold R. High-throughput generation of selected reaction-monitoring assays for proteins and proteomes. Nat. Methods 2010, 7:43-46.
30. Prados J., Melguizo C., Ortiz R., Vélez C., Alvarez P.J., Arias J.L., Ruíz M.A., Gallardo V., Aranega A. Doxorubicin-loaded nanoparticles: new advances in breast cancer therapy. Anticancer. Agents Med. Chem. 2012, 12:1058-1070.
31. Rathert P., Dhayalan A., Murakami M., Zhang X., Tamas R., Jurkowska R., Komatsu Y., Shinkai Y., Cheng X., Jeltsch A. Protein lysine methyltransferase G9a acts on non-histone targets. Nat. Chem. Biol. 2008, 4:344-346.
32. Rice J.C., Allis C.D. Histone methylation versus histone acetylation: new insights into epigenetic regulation. Curr. Opin. Cell Biol. 2001, 13:263-273.
33. Shi X., Kachirskaia I., Yamaguchi H., West L.E., Wen H., Wang E.W., Dutta S., Appella E., Gozani O. Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol. Cell 2007, 27:636-646.
34. Souza P.P., Völkel P., Trinel D., Vandamme J., Rosnoblet C., Héliot L., Angrand P.O. The histone methyltransferase SUV420H2 and heterochromatin proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol. 2009, 10:41.
35. Sykes S.M., Mellert H.S., Holbert M.A., Li K., Marmorstein R., Lane W.S., McMahon S.B. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell 2006, 24:841-851.
36. Taverna S.D., Li H., Ruthenburg A.J., Allis C.D., Patel D.J. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat. Struct. Mol. Biol. 2007, 14:1025-1040.
37. Uemura T., Shepherd S., Ackerman L., Jan L.Y., Jan Y.N. numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 1989, 58:349-360.
38. Verdi J.M., Bashirullah A., Goldhawk D.E., Kubu C.J., Jamali M., Meakin S.O., Lipshitz H.D. Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. Proc. Natl. Acad. Sci. USA 1999, 96:10472-10476.
39. Vogelstein B., Lane D., Levine A.J. Surfing the p53 network. Nature 2000, 408:307-310.
40. Wang P., Yu J., Zhang L. The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc. Natl. Acad. Sci. USA 2007, 104:4054-4059.
41. West L.E., Gozani O. Regulation of p53 function by lysine methylation. Epigenomics 2011, 3:361-369.
42. Yan B., Omar F.M., Das K., Ng W.H., Lim C., Shiuan K., Yap C.T., Salto-Tellez M. Characterization of Numb expression in astrocytomas. Neuropathology 2008, 28:479-484.
43. Zhang X., Wen H., Shi X. Lysine methylation: beyond histones. Acta Biochim. Biophys. Sin. (Shanghai) 2012, 44:14-27.