Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

Journal of Medicinal Chemistry

Volumn 58, Issue 20, 2015, Pages 7931-7937

  Nagahara, Takashi ^b   Saitoh, Tsuyoshi ^a   Kutsumura, Noriki ^a   Irukayama Tomobe, Yoko ^a   Ogawa, Yasuhiro ^a   Kuroda, Daisuke ^c   Gouda, Hiroaki ^c   Kumagai, Hidetoshi ^a,d   Fujii, Hideaki ^b   Yanagisawa, Masashi ^a,d   Nagase, Hiroshi ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' METHOXY N,N DIMETHYL 3' [N [3 [[2 (3 METHYLBENZAMIDO)ETHYL]AMINO]PHENYL]SULFAMOYL](1,1' BIPHENYL) 3 CARBOXAMIDE; AMIDE; G PROTEIN COUPLED RECEPTOR; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN RECEPTOR 2 AGONIST; UNCLASSIFIED DRUG; 4'-METHOXY-N,N-DIMETHYL-3'-(N-(3-((2-(3-METHYLBENZAMIDO)ETHYL)AMINO)PHENYL)SULFAMOYL)-(1,1'-BIPHENYL)-3-CARBOXAMIDE; BENZAMIDE DERIVATIVE; CALCIUM; MOLECULAR LIBRARY; OREXIN RECEPTOR; SULFONAMIDE;

AGONIST; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; EC50; STRUCTURE ACTIVITY RELATION; AGONISTS; ANIMAL; CATAPLEXY; CHEMICAL STRUCTURE; CHO CELL LINE; CRICETULUS; HAMSTER; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR LIBRARY; NARCOLEPSY; SYNTHESIS; TUMOR CELL LINE; X RAY DIFFRACTION;

ANIMALS; BENZAMIDES; CALCIUM; CATAPLEXY; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; NARCOLEPSY; OREXIN RECEPTORS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; X-RAY DIFFRACTION;

EID: 84945332430     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00988     Document Type: Article

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