Orexin and orexin receptors

Hypocretins: Integrators of Physiological Functions

Volumn , Issue , 2005, Pages 13-23

  Sakurai, Takeshi ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84857411000     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/0-387-25446-3_2     Document Type: Chapter

References (25)

1. A. Wise, S. C. Jupe and S. Rees, The identification of ligands at orphan G-protein coupled receptors., Annu Rev Pharmacol Toxicol. 44, 43-66 (2004).
2. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R. M. Chemelli, H. Tanaka, S. C. Williams, J. A. Richardson, G. P. Kozlowski, S. Wilson, J. R. Arch, R. E. Buckingham, A. C. Haynes, S. A. Carr, R. S. Annan, D. E. McNulty, W. S. Liu, J. A. Terrett, N. A. Elshourbagy, D. J. Bergsma and M. Yanagisawa, Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior., Cell. 92, 573-85 (1998).
3. L. De Lecea, T. S. Kilduff, C. Peyron, X. Gao, P. E. Foye, P. E. Danielson, C. Fukuhara, E. L. Battenberg, V. T. Gautvik, F. S. N. Bartlett, W. N. Frankel, A. N. Van Den Pol, F. E. Bloom, K. M. Gautvik and J. G. Sutcliffe, The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity., Proc Natl Acad Sci U S A. 95, 322-7. (1998).
4. T. Sakurai, T. Moriguchi, K. Furuya, N. Kajiwara, T. Nakamura, M. Yanagisawa and K. Goto, Structure and function of human prepro-orexin gene., J Biol Chem. 274, 17771-6 (1999).
5. A. Yamanaka, C. T. Beuckmann, J. T. Willie, J. Hara, N. Tsujino, M. Mieda, M. Tominaga, K. Yagami, F. Sugiyama, K. Goto, M. Yanagisawa and T. Sakurai, Hypothalamic orexin neurons regulate arousal according to energy balance in mice., Neuron. 38, 701-13 (2003).
6. J. Hara, C. T. Beuckmann, T. Nambu, J. T. Willie, R. M. Chemelli, C. M. Sinton, F. Sugiyama, K. Yagami, K. Goto, M. Yanagisawa and T. Sakurai, Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity., Neuron. 30, 345-54 (2001).
7. M. Hakansson, L. De Lecea, J. G. Sutcliffe, M. Yanagisawa and B. Meister, Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus., J Neuroendocrinol. 11, 653-63 (1999).
8. B. Griffond, P. Y. Risold, C. Jacquemard, C. Colard and D. Fellmann, Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area., Neurosci Lett. 262, 77-80 (1999).
9. J. T. Willie, R. M. Chemelli, C. M. Sinton, S. Tokita, S. C. Williams, Y. Y. Kisanuki, J. N. Marcus, C. Lee, J. K. Elmquist, K. A. Kohlmeier, C. S. Leonard, J. A. Richardson, R. E. Hammer and M. Yanagisawa, Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes., Neuron. 38, 715-30 (2003).
10. J. T. Willie, R. M. Chemelli, C. M. Sinton and Y. M., To eat or to sleep? Orexin in the regulation of feeding and wakefulness., Annu Rev Neurosci. 24, 429-58 (2001).
11. J. Chen and H. S. Randeva, Genomic Organization of Mouse Orexin Receptors: Characterization of Two Novel Tissue-Specific SpliceVariants., Mol Endocrinol. (2004).
12. Y. Zhu, Y. Miwa, A. Yamanaka, T. Yada, M. Shibahara, Y. Abe, T. Sakurai and K. Goto, Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins., J Pharmacol Sci. 92, 259-66. (2003).
13. J. J. Hagan, R. A. Leslie, S. Patel, M. L. Evans, T. A. Wattam, S. Holmes, C. D. Benham, S. G. Taylor, C. Routledge, P. Hemmati, R. P. Munton, T. E. Ashmeade, A. S. Shah, J. P. Hatcher, P. D. Hatcher, D. N. Jones, M. I. Smith, D. C. Piper, A. J. Hunter, R. A. Porter and N. Upton, Orexin A activates locus coeruleus cell firing and increases arousal in the rat., Proc Natl Acad Sci U S A. 96, 10911-6 (1999).
14. T. Nakamura, K. Uramura, T. Nambu, T. Yada, K. Goto, M. Yanagisawa and T. Sakurai, Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system., Brain Res. 873, 181-7 (2000).
15. A. Yamanaka, N. Tsujino, H. Funahashi, K. Honda, J. L. Guan, Q. P. Wang, M. Tominaga, K. Goto, S. Shioda and T. Sakurai, Orexins activate histaminergic neurons via the orexin 2 receptor., Biochem Biophys Res Commun. 290, 1237-45 (2002).
16. Y. Li, X. B. Gao, T. Sakurai and A. N. Van Den Pol, Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system., Neuron. 36, 1169-81 (2002).
17. S. Muroya, H. Funahashi, A. Yamanaka, D. Kohno, K. Uramura, T. Nambu, M. Shibahara, M. Kuramochi, M. Takigawa, M. Yanagisawa, T. Sakurai, S. Shioda and T. Yada, Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus., Eur J Neurosci. 19, 1524-34 (2004).
18. L. K. Malendowicz, C. Tortorella and G. G. Nussdorfer, Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade., J Steroid Biochem Mol Biol. 70, 185-8. (1999).
19. G. Mazzocchi, L. K. Malendowicz, L. Gottardo, F. Aragona and G. G. Nussdorfer, Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade., J Clin Endocrinol Metab. 86, 778-82 (2001).
20. H. S. Randeva, E. Karteris, D. Grammatopoulos and E. W. Hillhouse, Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis., J Clin Endocrinol Metab. 86, 4808-13 (2001).
21. T. Nanmoku, K. Isobe, T. Sakurai, A. Yamanaka, K. Takekoshi, Y. Kawakami, K. Ishii, K. Goto and T. Nakai, Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells., Biochem Biophys Res Commun. 274, 310-5 (2000).
22. S. Hilairet, M. Bouaboula, D. Carriere, G. Le Fur and P. Casellas, Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716., J Biol Chem. 278, 23731-7 (2003).
23. M. B. Dalrymple, K. M. Kroeger, R. M. Seeber and K. A. Edine, Use of BRET analysis to determine arrestin interactions, homo- and hetero-dimerisation between G ptotein-coupled receptors orexin type I and II., 85th Annual Endocreine Meeting. P1-66 (2003).
24. J. N. Marcus, C. J. Aschkenasi, C. E. Lee, R. M. Chemelli, C. B. Saper, M. Yanagisawa and J. K. Elmquist, Differential expression of orexin receptors 1 and 2 in the rat brain., J Comp Neurol. 435, 6-25. (2001).
25. S. Asahi, S. Egashira, M. Matsuda, H. Iwaasa, A. Kanatani, M. Ohkubo, M. Ihara, T. Sakurai and H. Morishima, Structure-activity regulation studies on the novel nuropeptide orexin., Peptide Sci., 37-40 (1999).