Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia

British Journal of Pharmacology

Volumn 172, Issue 20, 2015, Pages 5009-5023

  Zhao, Jingru ^a,d   Zhang, Xiangjian ^a,b,c   Dong, Lipeng ^a   Wen, Ya ^a   Zheng, Xiufen ^a   Zhang, Cong ^a   Chen, Rong ^a,b,c   Zhang, Ye ^a   Li, Yaoru ^a   He, Tingting ^a   Zhu, Xingyuan ^a   Li, Litao ^d  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Hebei Collaborative Innovation Center for Cardio cerebrovascular Disease   (China)

^c Hebei Collaborative Innovation Center for Cardiocerebrovascular Disease   (China)

^d HEBEI GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CINNAMALDEHYDE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; ACROLEIN; ANTIINFLAMMATORY AGENT; CCL2 PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; TLR4 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ATTENUATION; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CHEMOKINE CCL2 GENE; CONTROLLED STUDY; DRUG EFFECT; ELAM 1 GENE; ENCEPHALITIS; GENE EXPRESSION; IL 1BETA GENE; MALE; MOUSE; NEUROPROTECTION; NEWBORN; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TNF ALPHA GENE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECTS; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY;

ACROLEIN; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; E-SELECTIN; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERLEUKIN-1BETA; MALE; MICE; NEUROPROTECTIVE AGENTS; NF-KAPPA B; RNA, MESSENGER; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; WATER;

EID: 84945281479     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13270     Document Type: Article

References (59)

1. Akira S, Takeda K, (2004). Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
2. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al., (2013a). The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors. Br J Pharmacol 170: 1676-1705.
3. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al., (2013b). The Concise Guide to PHARMACOLOGY 2013/14: Enzymes. Br J Pharmacol 170: 1797-1867.
4. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, et al., (1997). Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 28: 1233-1244.
5. Barone FC, Feuerstein GZ, (1999). Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab 19: 819-834.
6. Barone FC, Schmidt DB, Hillegass LM, Price WJ, White RF, Feuerstein GZ, et al., (1992). Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia. Stroke 23: 1337-1347.
7. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H, (1986a). Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17: 472-476.
8. Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM, (1986b). Evaluation of 2,3,5-triphenyltetrazolium chloride as stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17: 1304-1308.
9. Breckwoldt MO, Chen JW, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, et al., (2008). Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc Natl Acad Sci U S A 105: 18584-18589.
10. Caso JR, Pradillo JM, Hurtado O, Lorenzo P, Moro MA, Lizasoain I, (2007). Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115: 1599-1608.
11. Chan SJ, Wong WS, Wong PT, Bian JS, (2010). Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia. Br J Pharmacol 161: 668-679.
12. Danton GH, Dietrich WD, (2003). Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 62: 127-136.
13. Dong L, Qiao H, Zhang X, Zhang X, Wang C, Wang L, et al., (2013). Parthenolide is neuroprotective in rat experimental stroke model: downregulating NF-κB, phospho-p38MAPK, and caspase-1 and ameliorating BBB permeability. Mediators Inflamm 2013: 370804.
14. Donnan GA, Fisher M, Macleod M, Davis SM, (2008). Stroke. Lancet 371: 1612-1623.
15. Downes CE, Crack PJ, (2010). Neural injury following stroke: are toll-like receptors the link between the immune system and the CNS? Br J Pharmacol 160: 1872-1888.
16. Fan H, Li L, Zhang X, Liu Y, Yang C, Yang Y, et al., (2009). Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediators Inflamm 2009: 704706.
17. Hatashita S, Hoff JT, Salamat SM, (1988). Ischemic brain edema and the osomotic gradient between blood and brain. J Cereb Blood Flow Metab 8: 552-559.
18. He ZD, Qiao CF, Han QB, Cheng CL, Xu HX, Jiang RW, et al., (2005). Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem 53: 2424-2428.
19. Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhauser C, (2001). Nuclear factor-κappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276: 32008-32015.
20. Ho SC, Chang KS, Chang PW, (2013). Inhibition of neuroinflammation by cinnamon and its main components. Food Chem 138: 2275-2282.
21. Hughes PM, Allegrini PR, Rudin M, Perry VH, Mir AK, Wiessner C, (2002). Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model. J Cereb Blood Flow Metab 22: 308-317.
22. Hwa JS, Jin YC, Lee YS, Ko YS, Kim YM, Shi LY, et al., (2012). 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. J Ethnopharmacol 139: 605-615.
23. Jiang T, Gao L, Guo J, Lu J, Wang Y, Zhang Y, (2012). Suppressing inflammation by inhibiting the NF-kappaB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia. Br J Pharmacol 167: 1520-1532.
24. Jiang T, Yu JT, Zhu XC, Wang HF, Tan MS, Cao L, et al., (2014). Acute metformin preconditioning confers neuroprotection against focal cerebral ischemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol 171: 3146-3157.
25. Jiang N, Moyle M, Soule HR, Rote WE, Chopp M, (1995). Neutrophil inhibitory factor is neuroprotective after focal ischemia in rats. Ann Neurol 38: 935-942.
26. Kilic U, Kilic E, Matter CM, Bassetti CL, Hermann DM, (2008). TLR4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis 31: 33-40.
27. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
28. Kim JW, Jin YC, Kim YM, Rhie S, Kim HJ, Seo HG, et al., (2009). Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-κappaB activation. Life Sci 84: 227-234.
29. Kleinig TJ, Vink R, (2009). Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options. Curr Opin Neurol 22: 294-301.
30. Kobayashi T, Walsh MC, Choi Y, (2004). The role of TRAF6 in signal transduction and the immune response. Microbes Infect 6: 1333-1338.
31. Lee JY, Kang HS, Park BE, Moon HJ, Sim SS, Kim CJ, (2009). Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis. J Ethnopharmacol 126: 244-251.
32. Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, et al., (2002). The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 22: 2478-2486.
33. Liu Z, He D, Zhang X, Li Y, Zhu C, Dong L, et al., (2012). Neuroprotective effect of early and short-time applying sophoridine in pMCAO rat brain: down-regulated TRAF6 and up-regulated p-ERK1/2 expression, ameliorated brain infarction and edema. Brain Res Bull 88: 379-384.
34. Longa EZ, Weinstein PR, Carlson S, Cummins R, (1989). Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91.
35. Matzinger P, (2002). The danger model: a renewed sense of self. Science 296: 301-305.
36. McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
37. Medzhitov R, (2001). Toll-like receptors and innate immunity. Nat Rev 1: 135-145.
38. Miyahara T, Koyama H, Miyata T, Shigematsu H, Inoue J, Takato T, et al., (2004). Inflammatory signaling pathway containing TRAF6 contributes to neointimal formation via diverse mechanisms. Cardiovasc Res 64: 154-164.
39. Moskowitz MA, Lo EH, Iadecola C, (2010). The science of stroke: mechanisms in search of treatments. Neuron 67: 181-198.
40. Mulcahy NJ, Ross J, Rothwell NJ, Loddick SA, (2003). Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br J Pharmacol 140: 471-476.
41. O'Neill LA, (2003). The role of MyD88-like adapters in toll-like receptor signal transduction. Biochem Soc Trans 31: 643-647.
42. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al., (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucl Acids Res 42 (Database Issue): D1098-1106.
43. Pyo JH, Jeong YK, Yeo S, Lee JH, Jeong MY, Kim SH, et al., (2013). Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biol Pharm Bull 36: 1928-1935.
44. Qiao H, Zhang X, Zhu C, Dong L, Wang L, Zhang X, et al., (2012). Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia. Brain Res 1448: 71-81.
45. Rausch PG, Pryzwansky KB, Spitznagel JK, (1978). Immunocytochemical identification of azurophilic and specific granule markers in the giant granules of Chediak-Higashi neutrophils. N Engl J Med 298: 693-698.
46. Reddy AM, Seo JH, Ryu SY, Kim YS, Kim YS, Min KR, et al., (2004). Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-κappaB inhibitors from Cinnamomum cassia. Planta Med 70: 823-827.
47. Ridder DA, Schwaninger M, (2009). NF-kappaB signaling in cerebral ischemia. Neurosci 158: 995-1006.
48. Tatlisumak T, Carano RA, Takano K, Opgenorth TJ, Sotak CH, Fisher M, (1998). A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study. Stroke 29: 850-857.
49. Vallabhapurapu S, Karin M, (2009). Regulation and function of NF-κappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733.
50. Wang X, Yue TL, Barone FC, Feuerstein GZ, (1995). Demonstration of increased endothelial leukocyte adhesion molecule I mRNA expression in rat ischemic cortex. Stroke 26: 1665-1669.
51. Wang YC, Lin S, Yang QW, (2011). Toll-like receptors in cerebral ischemic inflammatory injury. J Neuroinflammation 8: 134.
52. Weston RM, Jarrott B, Ishizuka Y, Callaway JK, (2006). AM-36 modulates the neutrophil inflammatory response and reduces breakdown of the blood brain barrier after endothelin-1 induced focal brain ischaemia. Br J Pharmacol 149: 712-723.
53. Weston RM, Jones NM, Jarrott B, Callaway JK, (2007). Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury. J Cereb Blood Flow Metab 27: 100-114.
54. Williams AJ, Berti R, Dave JR, Elliot PJ, Adams J, Tortella FC, (2004). Delayed treatment of ischemia/reperfusion brain injury: extended therapeutic window with the proteasome inhibitor MLN519. Stroke 35: 1186-1191.
55. Xu Z, Croslan DR, Harris AE, Ford GD, Ford BD, (2006). Extended therapeutic window and functional recovery after intraarterial administration of neuregulin-1 after focal ischemic stroke. J Cereb Blood Flow Metab 26: 527-535.
56. Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, et al., (2008). Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem Pharmacol 75: 494-502.
57. Zhang J, Fu B, Zhang X, Chen L, Zhang L, Zhao X, et al., (2013). Neuroprotective effect of bicyclol in rat ischemic stroke: down-regulates TLR4, TLR9, TRAF6, NF- κ B, MMP-9 and up-regulates claudin-5 expression. Brain Res 1528: 80-88.
58. Zhao BS, Huo HR, Ma YY, Liu HB, Li LF, Sui F, et al., (2008). Effects of 3-phenyl-propenal on the expression of toll-like receptors and downstream signaling components on raw264.7 murine macrophages. Am J Chin Med 36: 159-169.
59. Zheng Z, Yenari MA, (2004). Post-ischemic inflammation: molecular mechanisms and therapeutic implications. Neurol Res 26: 884-892.