Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line

International Journal of Pharmaceutics

Volumn 495, Issue 2, 2015, Pages 1028-1037

  Zeng, Ni ^a,b   Mignet, Nathalie ^a   Dumortier, Gilles ^a   Olivier, Elodie ^c   Seguin, Johanne ^a   Maury, Marc ^b   Scherman, Daniel ^a   Rat, Patrice ^c   Boudy, Vincent ^a,d  

^a CNRS   (France)

^b Unither Développement Bordeaux   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Apoptosis; Buccal tolerance; Digital holographic microscopy; Necrosis; Pluronic; Xanthan gum

Indexed keywords

HOE 33342; NEUTRAL RED; POLOXAMER; SALBUTAMOL SULFATE; XANTHAN; HYDROGEL; SALBUTAMOL; TISSUE ADHESIVE;

APOPTOSIS ASSAY; ARTICLE; BUCCAL DRUG ADMINISTRATION; CELL LINE; CELL VIABILITY ASSAY; CHEEK MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIGITAL HOLOGRAPHIC MICROSCOPY; DIGITAL MICROSCOPE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG SYNTHESIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYDROGEL; MEMBRANE INTEGRITY; MEMBRANE PERMEABILITY; MEMBRANE STRUCTURE; MICROSCOPY; MTT ASSAY; PRIORITY JOURNAL; RESAZURIN ASSAY; TR146 CELL LINE; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; APOPTOSIS; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; PERMEABILITY; PROCEDURES;

ADMINISTRATION, BUCCAL; ALBUTEROL; APOPTOSIS; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; EPITHELIAL CELLS; HUMANS; HYDROGEL; PERMEABILITY; POLOXAMER; TISSUE ADHESIVES;

EID: 84945217682     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.09.045     Document Type: Article

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