In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device

Biofabrication

Volumn 7, Issue 3, 2015, Pages

  Skardal, Aleksander ^a,b   Devarasetty, Mahesh ^a,b   Soker, Shay ^a,b   Hall, Adam R ^a,b  

^a WAKE FOREST BAPTIST HEALTH   (United States)

^b Virginia Tech Wake Forest School of Biomedical Engineering and Sciences   (United States)

Author keywords

fluidic devices; hydrogel; photopolymerization; tissue engineering; toxicology

Indexed keywords

FLUIDIC DEVICES; HYDROGELS; MICROFLUIDICS; PHOTOPOLYMERIZATION; TISSUE ENGINEERING; UREA;

EXTRACELLULAR MATRICES; MICRO-FLUIDIC DEVICES; MICROFLUIDIC PLATFORMS; PROOF OF PRINCIPLES; TISSUE CONSTRUCTS; TISSUE ENGINEERED CONSTRUCTS; TOXICOLOGY; UV-CROSSLINKABLE;

TISSUE;

ALCOHOL; HYDROGEL;

BIOLOGICAL MODEL; CELL SURVIVAL; CYTOLOGY; DEVICES; EQUIPMENT DESIGN; HEPG2 CELL LINE; HUMAN; HYDROGEL; LIVER; MICROFLUIDIC ANALYSIS; PROCEDURES; TISSUE ENGINEERING; TISSUE MICROARRAY; TOXICITY TESTING;

CELL SURVIVAL; EQUIPMENT DESIGN; ETHANOL; HEP G2 CELLS; HUMANS; HYDROGEL; LIVER; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, BIOLOGICAL; TISSUE ARRAY ANALYSIS; TISSUE ENGINEERING; TOXICITY TESTS;

EID: 84945207367     PISSN: 17585082     EISSN: 17585090     Source Type: Journal    
DOI: 10.1088/1758-5090/7/3/031001     Document Type: Article

References (33)

1. Hughes J P, Rees S, Kalindjian S B and Philpott K L 2011 Principles of early drug discovery Br. J. Pharmacol. 162 1239-49
2. Barrila J et al 2010 Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions Nat. Rev. Microbiol. 8 791-801
3. Achilli T M, Meyer J and Morgan J R 2012 Advances in the formation, use and understanding of multi-cellular spheroids Expert Opin. Biol. Ther. 12 1347-60
4. Drewitz M et al 2011 Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues Biotechnol. J. 6 1488-96
5. Ho W J et al 2010 Incorporation of multicellular spheroids into 3D polymeric scaffolds provides an improved tumor model for screening anticancer drugs Cancer science. 101 2637-43
6. Baker B M and Chen C S 2012 Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues J. Cell Sci. 125 3015-24
7. McDonald J C et al 2000 Fabrication of microfluidic systems in poly(dimethylsiloxane) Electrophoresis. 21 27-40
8. Qin D, Xia Y and Whitesides G M 2010 Soft lithography for micro- and nanoscale patterning Nat Protoc. 5 491-502
9. Zhang J, Skardal A and Prestwich G D 2008 Engineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recovery Biomaterials 29 4521-31
10. Jakab K et al 2008 Tissue engineering by self-assembly of cells printed into topologically defined structures Tissue Eng. A 14 413-21
11. Murphy S V and Atala A 2013 Organ engineering - combining stem cells, biomaterials, and bioreactors to produce bioengineered organs for transplantation BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology 35 163-72
12. Bischel L L, Lee S H and Beebe D J 2012 A practical method for patterning lumens through ECM hydrogels via viscous finger patterning J. Lab. Autom. 17 96-103
13. Cheung Y K, Gillette B M, Zhong M, Ramcharan S and Sia S K 2007 Direct patterning of composite biocompatible microstructures using microfluidics Lab Chip. 7 574-9
14. Gao D, Liu J, Wei H B, Li H F, Guo G S and Lin J M 2010 A microfluidic approach for anticancer drug analysis based on hydrogel encapsulated tumor cells Anal. Chim. Acta. 665 7-14
15. Koh W G, Revzin A and Pishko M V 2002 Poly(ethylene glycol) hydrogel microstructures encapsulating living cells Langmuir 18 2459-62
16. Prestwich G D 2008 Engineering a clinically-useful matrix for cell therapy Organogenesis 4 42-7
17. Skardal A, Smith L, Bharadwaj S, Atala A, Soker S and Zhang Y 2012 Tissue specific synthetic ECM hydrogels for 3D in vitro maintenance of hepatocyte function Biomaterials 33 4565-75
18. Xia Y and Whitesides G M 1998 Soft lithography Annu. Rev. Mater Sci. 28 153-84
19. Kirker K R, Luo Y, Morris S E, Shelby J and Prestwich G D 2004 Glycosaminoglycan hydrogels as supplemental wound dressings for donor sites J. Burn. Care Rehabil. 25 276-86
20. Kirker K R, Luo Y, Nielson J H, Shelby J and Prestwich G D 2002 Glycosaminoglycan hydrogel films as bio-interactive dressings for wound healing Biomaterials 23 3661-71
21. Liu Y, Skardal A, Shu X Z and Prestwich G D 2008 Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injury J. Orthop. Res. 26 562-9
22. Skardal A, Zhang J, McCoard L, Oottamasathien S and Prestwich G D 2010 Dynamically crosslinked gold nanoparticle - hyaluronan hydrogels Adv. Mater. 22 4736-40
23. Skardal A, Zhang J, McCoard L, Xu X, Oottamasathien S and Prestwich G D 2010 Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting Tissue Eng. A 16 2675-85
24. Skardal A, Zhang J and Prestwich G D 2010 Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol tetracrylates Biomaterials 31 6173-81
25. Skardal A, Sarker S F, Crabbe A, Nickerson C A and Prestwich G D 2010 The generation of 3D tissue models based on hyaluronan hydrogel-coated microcarriers within a rotating wall vessel bioreactor Biomaterials 31 8426-35
26. Murphy S V, Skardal A and Atala A 2013 Evaluation of hydrogels for bio-printing applications J. Biomed. Mater. Res. A 101 272-84
27. Wilkening S, Stahl F and Bader A 2003 Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties Drug. Metab. Dispos. 31 1035-42
28. Matsuzawa A, Matsusaki M and Akashi M 2015 Construction of three-dimensional liver tissue models by cell accumulation technique and maintaining their metabolic functions for long-term culture without medium change J. Biomed. Mater. Res. A 103 1554-64
29. Honer Z U et al 2006 Three-dimensional organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis Microbes Infect. 8 1813-25
30. Carterson A J et al 2005 A549 lung epithelial cells grown as three-dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis Infect Immun. 73 1129-40
31. Hjelm B E, Berta A N, Nickerson C A, Arntzen C J and Herbst-Kralovetz M M 2010 Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model Biol. Reprod. 82 617-27
32. LaMarca H L et al 2005 Three-dimensional growth of extravillous cytotrophoblasts promotes differentiation and invasion Placenta. 26 709-20
33. Nickerson C A et al 2001 Three-dimensional tissue assemblies: novel models for the study of Salmonella enterica serovar Typhimurium pathogenesis Infect Immun. 69 7106-20