Identification and small molecule inhibition of an activating transcription factor 4 (ATF4)-dependent pathway to age-related skeletal muscle weakness and atrophy

Journal of Biological Chemistry

Volumn 290, Issue 42, 2015, Pages 25497-25511

  Ebert, Scott M ^a,c,d   Dyle, Michael C ^a,c   Bullard, Steven A ^a,c   Dierdorff, Jason M ^a,c   Murry, Daryl J ^b   Fox, Daniel K ^a   Bongers, Kale S ^a,c   Lira, Vitor A ^a,b   Meyerholz, David K ^a   Talley, John J ^d   Adams, Christopher M ^a,b,d  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Emmyon Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CHEMICAL ACTIVATION; MOLECULES; MUSCULOSKELETAL SYSTEM; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ACTIVATING TRANSCRIPTION FACTOR; DISEASE PROCESS; MOLECULAR MECHANISM; MRNA EXPRESSION; MUSCLE WEAKNESS; SKELETAL MUSCLE; SMALL MOLECULE INHIBITOR; SMALL MOLECULES;

MUSCLE;

ACTIVATING TRANSCRIPTION FACTOR 4; ALKALOID; MESSENGER RNA; TOMATIDINE; UNCLASSIFIED DRUG; URSOLIC ACID; ATF4 PROTEIN, MOUSE; TOMATINE; TRITERPENE;

ADULT; AGE DISTRIBUTION; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG TARGETING; DRUG TOLERABILITY; EX VIVO STUDY; IN VIVO STUDY; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; MUSCLE WEAKNESS; MYOBLAST; MYOTUBE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; YOUNG ADULT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SARCOPENIA; SKELETAL MUSCLE;

ACTIVATING TRANSCRIPTION FACTOR 4; AGING; ANIMALS; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; RNA, MESSENGER; SARCOPENIA; TOMATINE; TRITERPENES;

EID: 84945199535     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.681445     Document Type: Article

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