Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy

Journal of Biological Chemistry

Volumn 289, Issue 21, 2014, Pages 14913-14924

  Dyle, Michael C ^a   Ebert, Scott M ^a   Cook, Daniel P ^a   Kunkel, Steven D ^a   Fox, Daniel K ^a   Bongers, Kale S ^a   Bullard, Steven A ^a,b   Dierdorff, Jason M ^a   Adams, Christopher M ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED RECOVERY; MAMMALS; MOLECULES;

EFFECTIVE THERAPY; MRNA EXPRESSION; MUSCLE ATROPHY; SKELETAL MUSCLE; SMALL MOLECULE INHIBITOR; SMALL MOLECULES; THERAPEUTIC AGENTS; TOMATO PLANTS;

MUSCLE;

NATURAL PRODUCT; TOMATIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CELL GROWTH; CONTROLLED STUDY; CONVALESCENCE; DRUG DESIGN; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; MALE; MITOCHONDRION; MOUSE; MUSCLE ATROPHY; MUSCLE EXERCISE; MUSCLE HYPERTROPHY; MUSCLE STRENGTH; MYOTUBE; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TOMATO;

MTOR COMPLEX (MTORC); MUSCLE ATROPHY; SKELETAL MUSCLE; SKELETAL MUSCLE METABOLISM; SYSTEMS BIOLOGY; TOMATIDINE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; DRUG DISCOVERY; GENE EXPRESSION; HL-60 CELLS; HUMANS; IMMUNOBLOTTING; MALE; MCF-7 CELLS; MICE; MICE, INBRED C57BL; MITOCHONDRIA, MUSCLE; MULTIPROTEIN COMPLEXES; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MYOBLASTS, SKELETAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOMATINE; TOR SERINE-THREONINE KINASES;

EID: 84901466630     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.556241     Document Type: Article

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