Cadmium treatment suppresses DNA polymerase δ catalytic subunit gene expression by acting on the p53 and Sp1 regulatory axis

DNA Repair

Volumn 35, Issue , 2015, Pages 90-105

  Antoniali, Giulia ^a   Marcuzzi, Federica ^a   Casarano, Elena ^a   Tell, Gianluca ^a  

^a UNIVERSITY OF UDINE   (Italy)

Author keywords

Base excision repair; Cadmium; Neurotoxicity; P53; Sp1

Indexed keywords

AP ENDONUCLEASE 1; CADMIUM; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA DIRECTED DNA POLYMERASE BETA; PROTEIN P53; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; XRCC1 PROTEIN; CARCINOGEN; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE GAMMA; DNA LIGASE; NEUROTOXIN; POLD1 PROTEIN, HUMAN; POLLUTANT; SP1 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1;

ARTICLE; CARCINOGENICITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA POLYMERASE DELTA GENE; DNA REPAIR; DOWN REGULATION; ENZYME ACTIVITY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOGENICITY; NERVE CELL; NEUROTOXICITY; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; ANTAGONISTS AND INHIBITORS; CARCINOGENESIS; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; POLLUTANT; TOXICITY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

CADMIUM; CARCINOGENESIS; CARCINOGENS; CATALYTIC DOMAIN; CELL LINE, TUMOR; DNA POLYMERASE BETA; DNA POLYMERASE III; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; DOWN-REGULATION; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION; HUMANS; NEURONS; NEUROTOXINS; PROMOTER REGIONS, GENETIC; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84945127538     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2015.08.007     Document Type: Article

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