메뉴 건너뛰기




Volumn 59, Issue 4, 2015, Pages 420-438

New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer

Author keywords

Anticarcinogenic agents; Prostate specific antigen; Prostatic neoplasms; Radiopharmaceuticals; Radium Ra 223 dichloride

Indexed keywords

BOMBESIN; RADIOPHARMACEUTICAL AGENT; RADIUM CHLORIDE RA 223; SAMARIUM 153; STRONTIUM 89;

EID: 84945119633     PISSN: 18244785     EISSN: 18271936     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (27)

References (106)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide. Sources, methods and major patterns in GLOBOCAN 2012
    • Ferlay J, Soerjomataram I, Dikshit R et al. Cancer incidence and mortality worldwide. Sources, methods and major patterns in GLOBOCAN 2012. IntJ Cancer 2015;136:E359-86.
    • (2015) IntJ Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3
  • 2
    • 84885350053 scopus 로고    scopus 로고
    • Prostate cancer: ESMO clinical practice guidelines for diagnosis, treatment and followup
    • Horwich A, Parker C, De Reijke T. et al. Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and followup. Ann Oncol 2013;24(Suppl. 6):106-14.
    • (2013) Ann Oncol , vol.24 , pp. 106-114
    • Horwich, A.1    Parker, C.2    De Reijke, T.3
  • 4
    • 4944246790 scopus 로고    scopus 로고
    • Targeting the androgen receptor: Improving outcomes for castration-resistant prostate cancer
    • Scher HI, Buchanan G, Gerald W et al. Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer. Endocr Relat Cancer 2004;11:459-76.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 459-476
    • Scher, H.I.1    Buchanan, G.2    Gerald, W.3
  • 5
    • 84899755833 scopus 로고    scopus 로고
    • Synthesis, radiolabelling and in vitro characterization of the gallium-68-, yttrium-90- and lutetium-177-labelled PSMA ligand, CHX-a"-DTPA-DUPA-pep
    • Baur B, Solbach C, Andreolli E et al. Synthesis, Radiolabelling and In Vitro Characterization of the Gallium-68-, Yttrium-90- and Lutetium-177-Labelled PSMA Ligand, CHX-A"-DTPA-DUPA-Pep. Pharmaceuticals (Basel) 2014;7:517-29.
    • (2014) Pharmaceuticals (Basel) , vol.7 , pp. 517-529
    • Baur, B.1    Solbach, C.2    Andreolli, E.3
  • 6
    • 33747105269 scopus 로고    scopus 로고
    • 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer
    • 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer. T Nucl Med 2006;47:1144-52.
    • (2006) T Nucl Med , vol.47 , pp. 1144-1152
    • Lantry, L.E.1    Cappelletti, E.2    Maddalena, M.E.3
  • 7
    • 84919432477 scopus 로고    scopus 로고
    • Radionuclide therapy for osseous metastases in prostate cancer
    • Abi-Ghanem AS, Me Grath MA, Jacene HA. Radionuclide therapy for osseous metastases in prostate cancer. Semin Nucl Med 2015;45:66-80.
    • (2015) Semin Nucl Med , vol.45 , pp. 66-80
    • Abi-Ghanem, A.S.1    Me Grath, M.A.2    Jacene, H.A.3
  • 8
    • 84925013961 scopus 로고    scopus 로고
    • Integrating bone targeting radiopharmaceuticals into the management of patients with castrate-resistant prostate cancer with symptomatic bone metastases
    • Blacksburg SRI, Witten MR, Haas JA. Integrating bone targeting radiopharmaceuticals into the management of patients with castrate-resistant prostate cancer with symptomatic bone metastases. Curr Treat Options Oncol 2015; l6:325.
    • (2015) Curr Treat Options Oncol , vol.16 , pp. 325
    • Blacksburg, S.R.I.1    Witten, M.R.2    Haas, J.A.3
  • 9
    • 84964696188 scopus 로고    scopus 로고
    • Targeting bone metastases in prostate cancer: Improving clinical outcome
    • Body JJ, Casimiro S, Costa L. Targeting bone metastases in prostate cancer: improving clinical outcome. Nat Rev Urol 2015;12:340-56.
    • (2015) Nat Rev Urol , vol.12 , pp. 340-356
    • Body, J.J.1    Casimiro, S.2    Costa, L.3
  • 10
    • 84880428467 scopus 로고    scopus 로고
    • Alpha emitter Radium-223 and survival in metastatic prostate cancer
    • Parker C, Nilsson S, Heinrich D et al. Alpha emitter Radium-223 and survival in metastatic prostate cancer. N Engl J Med 2013;369:213-23.
    • (2013) N Engl J Med , vol.369 , pp. 213-223
    • Parker, C.1    Nilsson, S.2    Heinrich, D.3
  • 11
    • 84908302358 scopus 로고    scopus 로고
    • Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods
    • Guerra Liberal FD, Tavares AA, Tavares JM. Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods. Med Phys 20l4; 4l: ll4l01.
    • (2014) Med Phys , vol.41 , pp. 114101
    • Guerra Liberal, F.D.1    Tavares, A.A.2    Tavares, J.M.3
  • 12
    • 84890531221 scopus 로고    scopus 로고
    • Radiometabolic treatment of bone-metastasizing cancer: From 186rhenium to 223radium
    • Rubini G, Nicoletti A, Rubini D et al. Radiometabolic treatment of bone-metastasizing cancer: from 186rhenium to 223radium. Cancer Biother Radiopharm 2014;29:1-11.
    • (2014) Cancer Biother Radiopharm , vol.29 , pp. 1-11
    • Rubini, G.1    Nicoletti, A.2    Rubini, D.3
  • 13
    • 0036733694 scopus 로고    scopus 로고
    • The PLACORHEN study: A double-blind, placebo-controlled, randomized radionuclide study with (186) Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium Study
    • Han SH, De Klerk JM, Tan S et al. The PLACORHEN study: a double-blind, placebo-controlled, randomized radionuclide study with (186) Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium Study. J Nucl Med 2002;43:1150-6.
    • (2002) J Nucl Med , vol.43 , pp. 1150-1156
    • Han, S.H.1    De Klerk, J.M.2    Tan, S.3
  • 14
    • 0025950294 scopus 로고
    • Rhenium-186 (Sn) HEDP for treatment of painful osseous metastases: Results of a double-blind crossover comparison with placebo
    • Maxon HR 3rd, Schroder LE, Hertzberg VS et al. Rhenium-186 (Sn) HEDP for treatment of painful osseous metastases: results of a double-blind crossover comparison with placebo. J Nucl Med 1991;32:1877-81.
    • (1991) J Nucl Med , vol.32 , pp. 1877-1881
    • Maxon, H.R.1    Schroder, L.E.2    Hertzberg, V.S.3
  • 15
    • 11244281049 scopus 로고    scopus 로고
    • The benefit of bone-seeking radiopharmaceuticals in the treatment of metastatic bone pain
    • Liepe K, Runge R, Kotzerke J. The benefit of bone-seeking radiopharmaceuticals in the treatment of metastatic bone pain. J Cancer Res Clin Oncol 2005;131:60-6.
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 60-66
    • Liepe, K.1    Runge, R.2    Kotzerke, J.3
  • 16
    • 34447545672 scopus 로고    scopus 로고
    • 89Sr in the treatment of painful skeletal metastasis
    • 89Sr in the treatment of painful skeletal metastasis. Nucl Med Commun 2007;28:623-30.
    • (2007) Nucl Med Commun , vol.28 , pp. 623-630
    • Liepe, K.1    Kotzerke, J.2
  • 17
    • 34247636849 scopus 로고    scopus 로고
    • 89Sr vs !53Sm EDTMP: Comparison of treatment efficacy of painful bone metastases in prostate and breast carcinoma
    • 89Sr vs !53Sm EDTMP: comparison of treatment efficacy of painful bone metastases in prostate and breast carcinoma. Nucl Med Commun 2007;28:245-50.
    • (2007) Nucl Med Commun , vol.28 , pp. 245-250
    • Baczyk, M.1    Czepczynski, R.2    Milecki, P.3
  • 18
    • 84927565244 scopus 로고    scopus 로고
    • Practical guide to the use of radium 223 dichloride
    • Den RB, Doyle LA, Knudsen E. Practical guide to the use of radium 223 dichloride. Can J Urol 2014;21(suppl. 1):70-6.
    • (2014) Can J Urol , vol.21 , pp. 70-76
    • Den, R.B.1    Doyle, L.A.2    Knudsen, E.3
  • 19
    • 0023901242 scopus 로고
    • Strontium-89 therapy: Measurement of absorbed dose to skeletal metastases
    • Blake GM, Zivanovic MA, Blaquiere RM et al. Strontium-89 therapy: measurement of absorbed dose to skeletal metastases. J Nucl Med 1988;29:549-57.
    • (1988) J Nucl Med , vol.29 , pp. 549-557
    • Blake, G.M.1    Zivanovic, M.A.2    Blaquiere, R.M.3
  • 20
    • 19944386284 scopus 로고    scopus 로고
    • Radioisotopes for the palliation of metastatic bone cancer: A systematic review
    • Finlay IG, Mason MD, Shelley M. Radioisotopes for the palliation of metastatic bone cancer: a systematic review. Lancet Oncol 2005;6:392-400.
    • (2005) Lancet Oncol , vol.6 , pp. 392-400
    • Finlay, I.G.1    Mason, M.D.2    Shelley, M.3
  • 21
    • 0027308916 scopus 로고
    • Strontium 89 therapy and relief of pain in patients with prostatic carcinoma metastatic to bone: A dose response relationship?
    • Mertens WC, Stitt L, Porter AT. Strontium 89 therapy and relief of pain in patients with prostatic carcinoma metastatic to bone: a dose response relationship? Am J Clin Oncol 1993;16:238-42.
    • (1993) Am J Clin Oncol , vol.16 , pp. 238-242
    • Mertens, W.C.1    Stitt, L.2    Porter, A.T.3
  • 22
    • 0027252452 scopus 로고
    • Results of a randomized phase III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer
    • Porter AT, McEwan AJ, Powe JE et al. Results of a randomized phase III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer. Int J Radiat Oncol Biol Phys 1993;25:805-13.
    • (1993) Int J Radiat Oncol Biol Phys , vol.25 , pp. 805-813
    • Porter, A.T.1    McEwan, A.J.2    Powe, J.E.3
  • 23
    • 0029785223 scopus 로고    scopus 로고
    • Radiosensitization with low dose carboplatin enhances pain palliation in radioisotope therapy with strontium-89
    • Sciuto R, Maini CL, Tofani A et al. Radiosensitization with low dose carboplatin enhances pain palliation in radioisotope therapy with strontium-89. Nucl Med Commun 1996;17:799-804.
    • (1996) Nucl Med Commun , vol.17 , pp. 799-804
    • Sciuto, R.1    Maini, C.L.2    Tofani, A.3
  • 24
    • 0036152138 scopus 로고    scopus 로고
    • 89Sr therapy for painful bone metastases from prostate cancer: A randomized clinical trial
    • 89Sr therapy for painful bone metastases from prostate cancer: a randomized clinical trial. J Nucl Med 2002;43:79-86.
    • (2002) J Nucl Med , vol.43 , pp. 79-86
    • Sciuto, R.1    Festa, A.2    Rea, S.3
  • 25
    • 0035798930 scopus 로고    scopus 로고
    • Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: A randomized phase II trial
    • Tu SM, Millikan RE, Mengistu B et al. Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: a randomized phase II trial. Lancet 2001;357:336-41.
    • (2001) Lancet , vol.357 , pp. 336-341
    • Tu, S.M.1    Millikan, R.E.2    Mengistu, B.3
  • 26
    • 0028233520 scopus 로고
    • A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer
    • Quilty PM, Kirk D, Bolger JJ et al. A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. Radiother Oncol 1994;31:33-40.
    • (1994) Radiother Oncol , vol.31 , pp. 33-40
    • Quilty, P.M.1    Kirk, D.2    Bolger, J.J.3
  • 27
    • 0142259750 scopus 로고    scopus 로고
    • Strontium (89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: A phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group
    • Oosterhof GO, Roberts JT, De Reijke TM et al. Strontium (89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: a phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group. Eur Urol 2003;44:519-26.
    • (2003) Eur Urol , vol.44 , pp. 519-526
    • Oosterhof, G.O.1    Roberts, J.T.2    De Reijke, T.M.3
  • 28
    • 0027958545 scopus 로고
    • Dosimetry and toxicity of samarium-153-EDTMP administered for bone pain due to skeletal metastases
    • Bayouth JE, Macey DJ, Kasi LP et al. Dosimetry and Toxicity of Samarium-153-EDTMP Administered for Bone Pain Due to Skeletal Metastases. J Nucl Med 1994;35:63-9.
    • (1994) J Nucl Med , vol.35 , pp. 63-69
    • Bayouth, J.E.1    Macey, D.J.2    Kasi, L.P.3
  • 29
    • 33746856752 scopus 로고    scopus 로고
    • Samarium for osteoblastic bone metastases and osteosarcoma
    • Anderson P. Samarium for Osteoblastic Bone Metastases and Osteosarcoma. Expert Opin Pharmacother 2006;11:1475-86.
    • (2006) Expert Opin Pharmacother , vol.11 , pp. 1475-1486
    • Anderson, P.1
  • 32
    • 0031954325 scopus 로고    scopus 로고
    • Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: A double-blind placebo-controlled clinical trial
    • Serafini AN, Houston SJ, Resche I et al. Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: a double-blind placebo-controlled clinical trial. J Clin Oncol 1998;16:1574-81.
    • (1998) J Clin Oncol , vol.16 , pp. 1574-1581
    • Serafini, A.N.1    Houston, S.J.2    Resche, I.3
  • 33
    • 2342509633 scopus 로고    scopus 로고
    • Samarium-153-Lexidronam complex for treatment of painful bone metastases in hormonerefractory prostate cancer
    • Sartor O, Reid RH, Hoskin PJ et al. Samarium-153-Lexidronam complex for treatment of painful bone metastases in hormonerefractory prostate cancer. Urology 2004;63:940-5.
    • (2004) Urology , vol.63 , pp. 940-945
    • Sartor, O.1    Reid, R.H.2    Hoskin, P.J.3
  • 34
    • 34250368094 scopus 로고    scopus 로고
    • 153Sm-EDTMP combined with chemotherapy in patients with metastatic hormone-refractory prostate cancer
    • 153Sm-EDTMP combined with chemotherapy in patients with metastatic hormone-refractory prostate cancer. Eur J Nucl Med Mol Imaging 2007;34:1023-30.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 1023-1030
    • Ricci, S.1    Boni, G.2    Pastina, I.3
  • 35
    • 84889252465 scopus 로고    scopus 로고
    • 153Sm-EDTMP and docetaxel administerd sequentially to patients with metastatic castration-resistant prostate cancer
    • 153Sm-EDTMP and docetaxel administerd sequentially to patients with metastatic castration-resistant prostate cancer. Nucl Med Comm 2014;35:88-94.
    • (2014) Nucl Med Comm , vol.35 , pp. 88-94
    • Borsò, E.1    Boni, G.2    Pastina, I.3
  • 36
    • 84945130244 scopus 로고    scopus 로고
    • The SAMDOCET study: !53Sm-EDTMP and Docetaxel versus Docetaxel in Taxane-naïve patients with metastatic castration-refractory prostate cancer
    • Borsò E Mazzarri S, Boni G et al. The SAMDOCET study: !53Sm-EDTMP and Docetaxel versus Docetaxel in Taxane-naïve patients with metastatic castration-refractory prostate cancer. Eur J Nucl Med 2013;40(Suppl 2):S4W.
    • (2013) Eur J Nucl Med , vol.40 , pp. S4W
    • Borsò, E.1    Mazzarri, S.2    Boni, G.3
  • 37
    • 80455127104 scopus 로고    scopus 로고
    • 188Re-HEDP therapy of hormone-refractory bone metastases of prostate cancer: A retrospective analysis
    • 188Re-HEDP therapy of hormone-refractory bone metastases of prostate cancer: A retrospective analysis. J Nucl Med 2011;52:1721-6.
    • (2011) J Nucl Med , vol.52 , pp. 1721-1726
    • Biersack, H.J.1    Palmedo, H.2    Andrs, A.3
  • 38
    • 84960199997 scopus 로고    scopus 로고
    • 177Lu-labeled methylene diphosphonate
    • Bethesda, MD: National Center for Biotechnology Information, © 2004-2013 Internet, cited on 2015, Sep. 15
    • 177Lu-labeled methylene diphosphonate, in Molecular Imaging and Contrast Agent Database (MICAD).. Bethesda, MD: National Center for Biotechnology Information, © 2004-2013 [Internet] Available from: http://www.ncbi.nlm.nih.gov/books/NBK56203 [cited on 2015, Sep. 15].
    • Molecular Imaging and Contrast Agent Database (MICAD)
    • Chopra, A.1
  • 39
    • 0002483967 scopus 로고
    • Evaluation of phosphorus-32 for intractable pain secondary to prostatic carcinoma metastases
    • Joshi DP, Seery WH, Goldberg LG et al. Evaluation of phosphorus-32 for intractable pain secondary to prostatic carcinoma metastases. JAMA 1965;193:621-623.
    • (1965) JAMA , vol.193 , pp. 621-623
    • Joshi, D.P.1    Seery, W.H.2    Goldberg, L.G.3
  • 40
    • 74949105909 scopus 로고    scopus 로고
    • Systemic metabolic radiopharmaceutical therapy in the treatment of metastatic bone pain
    • Paes FM, Serafini AN. Systemic metabolic radiopharmaceutical therapy in the treatment of metastatic bone pain. Semin Nucl Med 2010;40:89-104.
    • (2010) Semin Nucl Med , vol.40 , pp. 89-104
    • Paes, F.M.1    Serafini, A.N.2
  • 41
    • 0031929619 scopus 로고    scopus 로고
    • Treatment of metastatic bone pain with tin-117m Stannic diethylene triamine penta-acetic cid: A phase I/II clinical study
    • Srivastava SC, Atkins HL, Krishnamurthy GT et al. Treatment of metastatic bone pain with tin-117m Stannic diethylene triamine penta-acetic cid: A phase I/II clinical study. Clin Cancer Res 1998;4:61-8.
    • (1998) Clin Cancer Res , vol.4 , pp. 61-68
    • Srivastava, S.C.1    Atkins, H.L.2    Krishnamurthy, G.T.3
  • 42
    • 84872974331 scopus 로고    scopus 로고
    • Efficacy and safety of 177Lu-EDTMP in bone metastatic pain palliation in breast cancer and hormone refractory prostate cancer: A phase II study
    • Yuan J, Liu C, Liu X et al. Efficacy and safety of 177Lu-EDTMP in bone metastatic pain palliation in breast cancer and hormone refractory prostate cancer: A phase II study. Clin Nucl Med 2013;38:88-92.
    • (2013) Clin Nucl Med , vol.38 , pp. 88-92
    • Yuan, J.1    Liu, C.2    Liu, X.3
  • 43
    • 84945120478 scopus 로고    scopus 로고
    • Development of l66holmiumrl, 2 propylene di-amino tetra (methylene phosphonic acid) as a possible bone palliation agent
    • Zolghadri S, Jalilian AR, Yousefnia H et al. Development of l66Holmiumrl, 2 Propylene Di-amino Tetra (Methylene phosphonic acid) as a Possible Bone Palliation Agent. World J Nucl Med 2014;13:28-33.
    • (2014) World J Nucl Med , vol.13 , pp. 28-33
    • Zolghadri, S.1    Jalilian, A.R.2    Yousefnia, H.3
  • 44
    • 67349116345 scopus 로고    scopus 로고
    • 170Tm-EDTMP: A potential cost-effective alternative to (89) SrCl (2) for bone pain palliation
    • Das T, Chakraborty S, Sarma HD et al. 170Tm-EDTMP: a potential cost-effective alternative to (89) SrCl (2) for bone pain palliation. Nucl Med Biol 2009;36:561-8.
    • (2009) Nucl Med Biol , vol.36 , pp. 561-568
    • Das, T.1    Chakraborty, S.2    Sarma, H.D.3
  • 45
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007;26:225-39.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 46
    • 34548016053 scopus 로고    scopus 로고
    • Oxygen tension is an important mediator of the transformation of osteoblasts to osteocytes
    • Hirao M, Hashimoto J, Yamasaki N et al. Oxygen tension is an important mediator of the transformation of osteoblasts to osteocytes. J Bone Mineral Metab 2007;25:266-76.
    • (2007) J Bone Mineral Metab , vol.25 , pp. 266-276
    • Hirao, M.1    Hashimoto, J.2    Yamasaki, N.3
  • 47
    • 0001060653 scopus 로고
    • Responses of cultured cells, tumors and normal tissues to radiations of different linear energy transfer
    • Ebert M, Howard A, editors, Amsterdam, Netherlands: North-Holland
    • Barensden GW Responses of cultured cells, tumors and normal tissues to radiations of different linear energy transfer. In: Ebert M, Howard A, editors. Current Topics in Radiation Research. Volume IV Amsterdam, Netherlands: North-Holland; 1968. pp. 293-356.
    • (1968) Current Topics in Radiation Research. , vol.4 , pp. 293-356
    • Barensden, G.W.1
  • 48
    • 84878216530 scopus 로고    scopus 로고
    • Influence of acute hypoxia and radiation quality on cell survival
    • Tinganelli W, Ma NY, Von Neubeck C et al. Influence of acute hypoxia and radiation quality on cell survival. J Radiat Res 2013;54(Suppl. 1):i23-30.
    • (2013) J Radiat Res , vol.54 , pp. i23-i30
    • Tinganelli, W.1    Ma, N.Y.2    Von Neubeck, C.3
  • 50
    • 0022400309 scopus 로고
    • Calculations of physical and chemical reactions produced in irradiated water containing DNA
    • Wright HA, Magee JL, Hamm RN et al. Calculations of physical and chemical reactions produced in irradiated water containing DNA. Radiat Prot Dosimetry 1985;13:133-6.
    • (1985) Radiat Prot Dosimetry , vol.13 , pp. 133-136
    • Wright, H.A.1    Magee, J.L.2    Hamm, R.N.3
  • 51
    • 0024262929 scopus 로고
    • Induction of DNA double-strand breaks by ionizing radiation of different quality and their relevance for cell inactivation
    • Kampf G. Induction of DNA double-strand breaks by ionizing radiation of different quality and their relevance for cell inactivation. Radiobiol Radiother (Berl) 1988;29:631-58.
    • (1988) Radiobiol Radiother (Berl) , vol.29 , pp. 631-658
    • Kampf, G.1
  • 52
    • 0026044529 scopus 로고
    • Radiobiology of alpha particles. III. Cell inactivation by alpha-particle traversals of the cell nucleus
    • Raju MR, Eisen Y, Carpenter S et al. Radiobiology of alpha particles. III. Cell inactivation by alpha-particle traversals of the cell nucleus. Radiat Res 1991;128:204-9.
    • (1991) Radiat Res , vol.128 , pp. 204-209
    • Raju, M.R.1    Eisen, Y.2    Carpenter, S.3
  • 53
    • 75749110617 scopus 로고    scopus 로고
    • MIRD pamphlet no. 22 (abridged): Radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy
    • Sgouros G, Roeske JC, McDevitt MR et al. MIRD pamphlet no. 22 (abridged): Radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy. J Nucl Med 2010;51:311-28.
    • (2010) J Nucl Med , vol.51 , pp. 311-328
    • Sgouros, G.1    Roeske, J.C.2    McDevitt, M.R.3
  • 54
    • 1442351111 scopus 로고    scopus 로고
    • Thorium and actinium polyphosphonate compounds as bone seeking alpha particleemitting agents
    • Henriksen G, Bruland ØS, Larsen RH. Thorium and actinium polyphosphonate compounds as bone seeking alpha particleemitting agents. Anticancer Res 2004;24:101.
    • (2004) Anticancer Res , vol.24 , pp. 101
    • Henriksen, G.1    Bruland, Ø.S.2    Larsen, R.H.3
  • 55
    • 0036189154 scopus 로고    scopus 로고
    • Renaissance of 224Ra for the treatment of ankylosing spondylitis: Clinical experiences
    • Tiepolt C, Grüning T, Franke WG. Renaissance of 224Ra for the treatment of ankylosing spondylitis: clinical experiences. Nucl Med Commun. 2002;23:61-6.
    • (2002) Nucl Med Commun. , vol.23 , pp. 61-66
    • Tiepolt, C.1    Grüning, T.2    Franke, W.G.3
  • 56
    • 20644447798 scopus 로고    scopus 로고
    • First clinical experience with a-emitting Radium-223 in the treatment of skeletal metastases
    • Nilsson S, Larsen RH, Foss SD et al. First Clinical Experience with A-Emitting Radium-223 in the Treatment of Skeletal Metastases. Clin Cancer Res 2005;11:4451-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 4451-4459
    • Nilsson, S.1    Larsen, R.H.2    Foss, S.D.3
  • 59
    • 84976585919 scopus 로고    scopus 로고
    • cited on 2015, Sept 15
    • Xofigo: summary of product characteristics. European Medicines Agency; [Internet], Available from: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Product-Information/human/002653/WC500156l72.pdf [cited on 2015, Sept 15].
    • Xofigo: Summary of Product Characteristics
  • 61
    • 34347244905 scopus 로고    scopus 로고
    • Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: A randomised, multicentre, placebo-controlled phase II study
    • Nilsson S, Franzen L, Parker C et al. Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study. Lancet Oncol 2007;8:587-594.
    • (2007) Lancet Oncol , vol.8 , pp. 587-594
    • Nilsson, S.1    Franzen, L.2    Parker, C.3
  • 62
    • 84945160914 scopus 로고    scopus 로고
    • Highlights of prescribing information, Xofigo (radium Ra 223dichloride) Injection, for intravenous use
    • Internet, cited on 2015, Sep. 15
    • Highlights of prescribing information, Xofigo (radium Ra 223dichloride) Injection, for intravenous use. US Food and Drug Administration; [Internet], Available from: www.accessdata.fda.gov/drugsatfda-docs/label/2013/2039711bl.pdf [cited on 2015, Sep. 15]
    • US Food and Drug Administration
  • 65
    • 84897939554 scopus 로고    scopus 로고
    • Bone-seeking radiopharmaceuticals for treatment of osseous metastases, part 1: A therapy with 223ra-dichloride
    • Pandit-Taskar N, Larson SM, Carrasquillo JA. Bone-Seeking Radiopharmaceuticals for Treatment of Osseous Metastases, Part 1: a Therapy with 223Ra-Dichloride. J Nucl Med 2014;55:268-74.
    • (2014) J Nucl Med , vol.55 , pp. 268-274
    • Pandit-Taskar, N.1    Larson, S.M.2    Carrasquillo, J.A.3
  • 66
    • 84866745304 scopus 로고    scopus 로고
    • Serum alkaline phosphatase changes predict survival independent of PSA changes in men with castration-resistant prostate cancer and bone metastasis receiving chemotherapy
    • Sonpavde G, Pond GR, Berry WR et al. Serum alkaline phosphatase changes predict survival independent of PSA changes in men with castration-resistant prostate cancer and bone metastasis receiving chemotherapy. Urol Oncol 2012;30:607-13.
    • (2012) Urol Oncol , vol.30 , pp. 607-613
    • Sonpavde, G.1    Pond, G.R.2    Berry, W.R.3
  • 67
    • 84858706749 scopus 로고    scopus 로고
    • A randomized, doseresponse, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer
    • Nilsson S, Strang P, Aksnesr AK et al. A randomized, doseresponse, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer. Eur J Cancer 2012:48:678-86.
    • (2012) Eur J Cancer , vol.48 , pp. 678-686
    • Nilsson, S.1    Strang, P.2    Aksnesr, A.K.3
  • 68
    • 84871926771 scopus 로고    scopus 로고
    • A randomized, doubleblind, dose-finding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castrationresistant prostate cancer
    • Parker CC, Pascoe S, Chodacki A et al. A randomized, doubleblind, dose-finding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castrationresistant prostate cancer. Eur Urol 2013;63:189-97.
    • (2013) Eur Urol , vol.63 , pp. 189-197
    • Parker, C.C.1    Pascoe, S.2    Chodacki, A.3
  • 69
    • 84908594586 scopus 로고    scopus 로고
    • Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: A prespecified subgroup analysis from the randomised, double-blind, phase 3
    • Hoskin P, Sartor O, O'Sullivan JM et al. Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: a prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial. 2014;15:1397-406.
    • (2014) ALSYMPCA trial. , vol.15 , pp. 1397-1406
    • Hoskin, P.1    Sartor, O.2    O'Sullivan, J.M.3
  • 70
    • 84901638475 scopus 로고    scopus 로고
    • Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: Results from a phase 3, double-blind, randomised trial
    • Sartor O, Coleman R, Nilsson S et al. Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial. Lancet Oncol 2014;15:738-46.
    • (2014) Lancet Oncol , vol.15 , pp. 738-746
    • Sartor, O.1    Coleman, R.2    Nilsson, S.3
  • 71
    • 84886604050 scopus 로고    scopus 로고
    • Pain analysis from the phase III randomized ALSYMPCA study with radium-223dichloride (Ra-223) in patients with castration-resistant prostate cancer (CRPC) with bone metastases [abstract]
    • Nilsson S, Sartor O, Bruland OS et al. Pain analysis from the phase III randomized ALSYMPCA study with radium-223dichloride (Ra-223) in patients with castration-resistant prostate cancer (CRPC) with bone metastases [abstract], J Clin Oncol 2013;31(Suppl.6):5038.
    • (2013) J Clin Oncol , vol.31 , pp. 5038
    • Nilsson, S.1    Sartor, O.2    Bruland, O.S.3
  • 73
    • 84864568658 scopus 로고    scopus 로고
    • Internet, cited on 2015, Sep. 15
    • U. S. National Institutes of Health. Clinical Trial.gov; [Internet], Available from https://clinicaltrials.gov/ct2/results?term=r adium&show-down=Y [cited on 2015, Sep. 15].
    • Clinical Trial.gov
    • U. S. National Institutes of Health1
  • 74
    • 0023547004 scopus 로고
    • Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
    • Horoszewicz JS, Kawinski E, Murphy GP. Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients. Anticancer Res 1987;7:927-35.
    • (1987) Anticancer Res , vol.7 , pp. 927-935
    • Horoszewicz, J.S.1    Kawinski, E.2    Murphy, G.P.3
  • 75
    • 0028281780 scopus 로고
    • Expression of the prostatespecific membrane antigen
    • Israeli RS, Powell CT, Corr JG et al. Expression of the prostatespecific membrane antigen. Cancer Res 1994;54:1807-11.
    • (1994) Cancer Res , vol.54 , pp. 1807-1811
    • Israeli, R.S.1    Powell, C.T.2    Corr, J.G.3
  • 76
    • 0029169509 scopus 로고
    • Expression of prostatespecific membrane antigen (PSMA) in normal, benign and malignant prostate tissues
    • Wright GL Jr, Haley C, Beckett ML et al. Expression of prostatespecific membrane antigen (PSMA) in normal, benign and malignant prostate tissues. Urol Oncol 1995;1:18-28.
    • (1995) Urol Oncol , vol.1 , pp. 18-28
    • Wright, G.L.1    Haley, C.2    Beckett, M.L.3
  • 77
    • 0035105994 scopus 로고    scopus 로고
    • Utility of capromab pendetide (ProstaScint) imaging in the management of prostate cancer
    • Rosenthal SA, Haseman MK, Polascik TJ. Utility of capromab pendetide (ProstaScint) imaging in the management of prostate cancer. Techniques in Urology 2001;7:27-37.
    • (2001) Techniques in Urology , vol.7 , pp. 27-37
    • Rosenthal, S.A.1    Haseman, M.K.2    Polascik, T.J.3
  • 78
    • 0030940108 scopus 로고    scopus 로고
    • Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line
    • Troyer JK, Beckett ML, Wright GL Jr. Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line. Prostate 1997;30:232-42.
    • (1997) Prostate , vol.30 , pp. 232-242
    • Troyer, J.K.1    Beckett, M.L.2    Wright, G.L.3
  • 79
    • 0030866116 scopus 로고    scopus 로고
    • Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium
    • Liu H, Moy P, Kim S et al. Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. Cancer Res 1997;57:3629-34.
    • (1997) Cancer Res , vol.57 , pp. 3629-3634
    • Liu, H.1    Moy, P.2    Kim, S.3
  • 80
    • 0034665171 scopus 로고    scopus 로고
    • In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen
    • Smith-Jones PM, Vallabahajosula S, Goldsmith SJ et al. In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen. Cancer Res 2000;60:5237-43.
    • (2000) Cancer Res , vol.60 , pp. 5237-5243
    • Smith-Jones, P.M.1    Vallabahajosula, S.2    Goldsmith, S.J.3
  • 81
    • 0006003159 scopus 로고    scopus 로고
    • A novel humanized antibody against prostate specific membrane antigen (PSMA) for in vivo targeting and therapy
    • Hamilton A, King S, Liu H et al. A novel humanized antibody against prostate specific membrane antigen (PSMA) for in vivo targeting and therapy. Proc Am Assoc Cancer Res 1998;39:440.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 440
    • Hamilton, A.1    King, S.2    Liu, H.3
  • 82
    • 22044451179 scopus 로고    scopus 로고
    • Phase I trial of 177lu-tetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer
    • Bander NH, Milowsky MI, Nanus DM et al. Phase I trial of 177lu-tetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer. J Clin Oncol 2005;23:4591-601.
    • (2005) J Clin Oncol , vol.23 , pp. 4591-4601
    • Bander, N.H.1    Milowsky, M.I.2    Nanus, D.M.3
  • 83
    • 84884536175 scopus 로고    scopus 로고
    • Phase II study of lutetium-177 labeled anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 for metastatic castrationresistant prostate cancer
    • Tagawa ST, Milowsky MI, Morris M et al Phase II study of lutetium-177 labeled anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 for metastatic castrationresistant prostate cancer. Clin Cancer Res 2013;18:5182-91.
    • (2013) Clin Cancer Res , vol.18 , pp. 5182-5191
    • Tagawa, S.T.1    Milowsky, M.I.2    Morris, M.3
  • 84
    • 84891116667 scopus 로고    scopus 로고
    • Bone marrow recovery and subsequent chemotherapy following radiolabeled anti-prostate-specific membrane antigen monoclonal antibody J591 in men with metastatic castration-resistant prostate cancer
    • Tagawa ST, Akhtar NH, Nikolopoulou A et al. Bone marrow recovery and subsequent chemotherapy following radiolabeled anti-prostate-specific membrane antigen monoclonal antibody J591 in men with metastatic castration-resistant prostate cancer. Front Oncol 2013;3:214.
    • (2013) Front Oncol , vol.3 , pp. 214
    • Tagawa, S.T.1    Akhtar, N.H.2    Nikolopoulou, A.3
  • 85
    • 84925300464 scopus 로고    scopus 로고
    • Targeting prostate-specific membrane antigen for personalized therapies in prostate cancer: Morphologic and molecular backgrounds and future promises
    • Santoni M, Scarpelli M, Mazzucchelli R et al. Targeting Prostate-specific membrane antigen for personalized therapies in prostate cancer: morphologic and molecular backgrounds and future promises. Journal of Biological Regulators and Homeostatic Agents 2014;28:555-63.
    • (2014) Journal of Biological Regulators and Homeostatic Agents , vol.28 , pp. 555-563
    • Santoni, M.1    Scarpelli, M.2    Mazzucchelli, R.3
  • 86
    • 84878158200 scopus 로고    scopus 로고
    • 68Ga generators
    • 68Ga generators. Appl Radiat Isot 2013;76:24-30.
    • (2013) Appl Radiat Isot , vol.76 , pp. 24-30
    • Rosch, F.1
  • 87
    • 84903582764 scopus 로고    scopus 로고
    • 68Ga]Ga-PSMA-HBED-CC: A new PET tracer for imaging of prostate cancer
    • 68Ga]Ga-PSMA-HBED-CC: a new PET tracer for imaging of prostate cancer. Pharmaceuticals 2014;7:779-96.
    • (2014) Pharmaceuticals , vol.7 , pp. 779-796
    • Eder, M.1    Neels, O.2    Muller, M.3
  • 89
    • 84890590469 scopus 로고    scopus 로고
    • 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer
    • 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging 2014;41:11-20.
    • (2014) Eur J Nucl Med Mol Imaging , vol.41 , pp. 11-20
    • Afshar-Oromieh, A.1    Zechmann, C.M.2    Malcher, A.3
  • 90
    • 84945118108 scopus 로고    scopus 로고
    • Diagnosis and follow-up of recurring and metastatic prostate cancer by Ga-68 prostate-specific membrane antigen positron emission tomography/computed tomography
    • Kulkarni H, Wester HJ, Baum RP. Diagnosis and follow-up of recurring and metastatic prostate cancer by Ga-68 prostate-specific membrane antigen positron emission tomography/computed tomography. World J Nucl Med 2015; l4(Suppl 1):S36.
    • (2015) World J Nucl Med , vol.14 , pp. S36
    • Kulkarni, H.1    Wester, H.J.2    Baum, R.P.3
  • 91
    • 84925491704 scopus 로고    scopus 로고
    • Linker modifications of DOTA-conjugated inhibitors of the prostate-specific membrane antigen (PSMA)
    • Benesova M, Schafer M, Bauder-Wiist U et al. Linker modifications of DOTA-conjugated inhibitors of the prostate-specific membrane antigen (PSMA). Eur J Nucl Med Mol Imaging 2013;40(Suppl 2):S281.
    • (2013) Eur J Nucl Med Mol Imaging , vol.40 , pp. S281
    • Benesova, M.1    Schafer, M.2    Bauder-Wiist, U.3
  • 93
    • 84943699054 scopus 로고    scopus 로고
    • 177Lu]Lutetium-labelled PSMA ligand-induced remission in a patient with metastatic prostate cancer
    • 177Lu]Lutetium-labelled PSMA ligand-induced remission in a patient with metastatic prostate cancer. Eur J Nucl Med Mol Imaging 2015;42:987-8.
    • (2015) Eur J Nucl Med Mol Imaging , vol.42 , pp. 987-988
    • Kratochwil, C.1    Giesel, F.L.2    Eder, M.3
  • 94
    • 84945121211 scopus 로고    scopus 로고
    • Theranostics of prostate cancer (PRLT) using Ga-68 and Lu-177 labeled prostatespecific membrane antigen small molecule. A new horizon for nuclear medicine
    • Baum RP, Kulkarni H, Schuchardt C et al. Theranostics of prostate cancer (PRLT) using Ga-68 and Lu-177 labeled prostatespecific membrane antigen small molecule. A new horizon for nuclear medicine. World J Nucl Med 2015;14(Suppl 1):S33.
    • (2015) World J Nucl Med , vol.14 , pp. S33
    • Baum, R.P.1    Kulkarni, H.2    Schuchardt, C.3
  • 95
    • 0020626777 scopus 로고
    • Identification and characterization of variant forms of the gastrin-releasing peptide (GRP)
    • McDonald TJ, Jornvall H, Tatemoto K. Identification and characterization of variant forms of the gastrin-releasing peptide (GRP). FEBS Lett 1983;156:349-56.
    • (1983) FEBS Lett , vol.156 , pp. 349-356
    • McDonald, T.J.1    Jornvall, H.2    Tatemoto, K.3
  • 96
    • 67651102575 scopus 로고    scopus 로고
    • Peptide-targeted diagnostics and radiotherapeutics
    • Tweedle MF. Peptide-targeted diagnostics and radiotherapeutics. Accounts Chem Res 2009;42:958-68.
    • (2009) Accounts Chem Res , vol.42 , pp. 958-968
    • Tweedle, M.F.1
  • 97
    • 33747105269 scopus 로고    scopus 로고
    • 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer
    • 177Lu-AMBA: synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer. T Nucl Med 2006;47:1144-52.
    • (2006) T Nucl Med , vol.47 , pp. 1144-1152
    • Lantry, L.E.1    Cappelletti, E.2    Maddalena, M.E.3
  • 98
    • 69349085452 scopus 로고    scopus 로고
    • 177Lu-AMBA bombesin analogue in hormone refractory prostate cancer patients: A phase I escalation study with single-cycle administrations
    • Bodei L, Ferrari M, Nunn A et al. 177Lu-AMBA bombesin analogue in hormone refractory prostate cancer patients: a phase I escalation study with single-cycle administrations. Eur J Nucl Med Mol Imaging 2007;34(Suppl 2):S221.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. S221
    • Bodei, L.1    Ferrari, M.2    Nunn, A.3
  • 99
    • 4644360336 scopus 로고    scopus 로고
    • Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors
    • Zhang H, Chen J, Waldherr C et al. Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors. Cancer Res 2004;64:6707-15.
    • (2004) Cancer Res , vol.64 , pp. 6707-6715
    • Zhang, H.1    Chen, J.2    Waldherr, C.3
  • 101
    • 84894728566 scopus 로고    scopus 로고
    • "To serve and protect": Enzyme inhibitors as radiopeptide escorts promote tumor targeting
    • Nock BA, Maina T, Krenning EP et al. "To serve and protect": enzyme inhibitors as radiopeptide escorts promote tumor targeting. J Nucl Med 2014;55:121-7.
    • (2014) J Nucl Med , vol.55 , pp. 121-127
    • Nock, B.A.1    Maina, T.2    Krenning, E.P.3
  • 102
    • 0033039587 scopus 로고    scopus 로고
    • Pretargeting with the affinity enhancement system for radioimmunotherapy
    • Barbet J, Kraeber-Bodere F, Vuillez JP et al. Pretargeting with the affinity enhancement system for radioimmunotherapy. Cancer Biother Radiopharm 1999;14:153-66.
    • (1999) Cancer Biother Radiopharm , vol.14 , pp. 153-166
    • Barbet, J.1    Kraeber-Bodere, F.2    Vuillez, J.P.3
  • 103
    • 0033104343 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptors in the human prostate: Relation to neoplastic transformation
    • Markwalder R, Reubi JC. Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Cancer Res 1999;59:1152-9.
    • (1999) Cancer Res , vol.59 , pp. 1152-1159
    • Markwalder, R.1    Reubi, J.C.2
  • 104
    • 84878863911 scopus 로고    scopus 로고
    • An update of radiolabeled bombesinn analogs for gastrin-releasing peptide receptor targeting
    • Yu Z, Ananias HJ, Carlucci G et al. An update of radiolabeled bombesinn analogs for gastrin-releasing peptide receptor targeting. Curr Pharm Des 2013;19:3329-41.
    • (2013) Curr Pharm Des , vol.19 , pp. 3329-3341
    • Yu, Z.1    Ananias, H.J.2    Carlucci, G.3
  • 105
    • 84897021830 scopus 로고    scopus 로고
    • Preclinical evaluation of a bispecific low-molecular heterodimer targeting both PSMA and GRPR for improved PET imaging and therapy of prostate cancer
    • Eder M, Schäfer M, Bauder-Wiist U et al. Preclinical evaluation of a bispecific low-molecular heterodimer targeting both PSMA and GRPR for improved PET imaging and therapy of prostate cancer. The Prostate 2014;74:659-68.
    • (2014) The Prostate , vol.74 , pp. 659-668
    • Eder, M.1    Schäfer, M.2    Bauder-Wiist, U.3
  • 106
    • 84921293040 scopus 로고    scopus 로고
    • Characterization and evaluation of DOTA-conjugated bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy
    • Stott Reynolds TJ, Schehr R, Liu D et al Characterization and evaluation of DOTA-conjugated bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy. Nucl Med Biol 2015;42:99-108.
    • (2015) Nucl Med Biol , vol.42 , pp. 99-108
    • Stott Reynolds, T.J.1    Schehr, R.2    Liu, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.