Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway

International Journal of Immunopathology and Pharmacology

Volumn 28, Issue 3, 2015, Pages 362-373

  Wang, Feng ^a   Mao, Yong ^b   You, Qingjun ^b   Hua, Dong ^b   Cai, Dongyan ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b JIANGNAN UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Lung cancer; PI3K Akt mTOR pathway; Piperlongumine

Indexed keywords

3 METHYLADENINE; ALKALOID DERIVATIVE; AUTOPHAGY PROTEIN 5; BECLIN 1; DOCETAXEL; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PIPERLONGUMINE; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; 3-METHYLADENINE; ADENINE; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; PIPERLONGUMININE; TARGET OF RAPAMYCIN KINASE;

A549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CANCER RESISTANCE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; A-549 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; FEMALE; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

A549 CELLS; ADENINE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DIOXOLANES; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84944897211     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/0394632015598849     Document Type: Article

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