Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats

Toxicology Reports

Volumn 2, Issue , 2015, Pages 1357-1366

  Akinyemi, Ayodele Jacob ^a,b,c   Adedara, Isaac A ^c,d   Thome, Gustavo Roberto ^c   Morsch, Vera Maria ^c   Rovani, Monique Tomazele ^c   Mujica, Lady Katerine Serrano ^c   Duarte, Thiago ^e   Duarte, Marta ^e   Oboh, Ganiyu ^a   Schetinger, Maria Rosa Chitolina ^c  

^a FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

^b AFE BABALOLA UNIVERSITY   (Nigeria)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^d UNIVERSITY OF IBADAN   (Nigeria)

^e Centro de Ciências da Saude Universidade Luterana do Brazil ULBRA   (Brazil)

Author keywords

Ginger; Hypertension; L NAME; Male fertility; Turmeric

Indexed keywords

ARGINASE; ATENOLOL; DICHLOROFLUORESCEIN; GLUTATHIONE TRANSFERASE; N (G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PLANT MEDICINAL PRODUCT; REACTIVE OXYGEN METABOLITE; TESTOSTERONE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL; TURMERIC; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL VIABILITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS; GINGER; HYPERTENSION; LIPID PEROXIDATION; MALE; MICROPLATE READER; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; RAT; REPRODUCTION; SPERMATOZOON MOTILITY; SYSTOLIC BLOOD PRESSURE;

EID: 84944882124     PISSN: 22147500     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxrep.2015.10.001     Document Type: Article

References (66)

1. Abarikwu S.O., Pant A.B., Farombi E.O. The dietary antioxidant, quercetin protects Sertoli-germcell co-culture from atrazine-induced oxidative damage. J. Biochem. Mol. Toxicol. 2012, 26:477-485.
2. Adams M.L., Nock B., Truong R., Cicero T.J. Nitric oxide control of steroidogenesis: endocrine effects of NG-nitro-l-arginine and comparisons to alcohol. Life Sci. 1992, 50:PL35-PL40.
3. Adebayo A., Olamide A., Helen A., Oluwaseun H.I., Olusegun S., Selimot H.A. Toxicity effects of amlodipine on the testis histology in adult Wistar rats. Am. J. Med. Med. Sci. 2012, 2:36-40.
4. Adedara I.A., Farombi E.O. Chemoprotection of ethyleneglycol monoethyl ether induced reproductive toxicity in malerats by kolaviron, isolated biflavonoid from Garcinia kola seed. Hum. Exp. Toxicol. 2012, 31:506-517.
5. Aggarwal B.B., Harikumar K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplasic diseases. Int. J. Biochem. Cell 2009, 41:40-59.
6. Aitken R.J. The Amoroso lecture. The humanspermatozoon-a cell in crisis?. J. Reprod. Fertil. 1999, 115:1-7.
7. Akinyemi A.J., Ademiluyi A.O., Oboh G. Inhibition of angiotensin-1-converting enzyme activity in high cholesterol fed diet in rats by two varieties of ginger (Zingiber officinale). J. Med. Food 2014, 17(3):317-323.
8. Akinyemi A.J., Thome G.R., Morsch V.M., Stefanello N., Goularte J.F., Bello-Klein A., Oboh G., Schetinger M.R.C. Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats. J. Funct. Foods 2015, 17:792-801.
9. Akinyemi A.J., Oboh G., Ademiluyi A.O., Boligon A.A., Athayde M.L. Effect of two ginger varieties on arginase activity in hypercholesterolemic rats. J. Acupunct. Meridian Stud. 2015, 10.1016/j.jams.2015.03.003.
10. Alvarez J.G., Touchstone J.C., Blasco L., Storey B.T. Spontaneous lipid peroxidation and production of hydrogen peroxide in human spermatozoa. J. Androl. 1987, 8:338-348.
11. Ammon H.P.T., Anazoda M.I., Safayhi H., Dhawan B.N., Srimal R.C. Curcumin: a potent inhibitor of Leukotriene B4 formation in rat peritoneal polymorphonuclear neutrophils (PMNL). Planta Med. 1992, 58:26-28.
12. Arun N., Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum. Nutr. 2002, 57:41-52.
13. Aybek H., Aybek Z., Rota S., Sxen N., Akbulut M. The effects of diabetes mellitus, age, and vitamin E on testicular oxidative stress. Fertil. Steril. 2008, 90:755-760.
14. Azu O.O. Testicular morphology in spontaneously hypertensive rat model: oxidant status and stereological implications. Andrologia 2015, 47:123-137.
15. Balbinott A.W., Irigoyen M.C., Brasileiro-Santos M.S. Dose-dependent autonomic dysfunction in chronic L-NAME hypertensive diabetic rats. J. Cardiovasc. Pharmacol. 2005, 46:563-569.
16. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
17. Briones A.M., Touyz R.M. Oxidative stress and hypertension: current concepts. Curr. Hypertens. Rep. 2010, 12:135-142.
18. Burnett A.L., Ricker D.D., Chamness S.L. Localization of nitric oxide synthase in the reproductive organs of male rat. Biol. Reprod. 1995, 52:1-7.
19. Cardoso A.M., Abdalla F.H., Bagatini M.D., Martins C.C., Fiorin F.S., Baldissarelli J., da Costa P., Mello F.F., Fiorenza A.M., Serres J.D., Gonçalves J.F., Chaves H., Royes L.F., Belló-Klein A., Morsch V.M., Schetinger M.R. Swimming training prevents alterations in acetylcholinesterase and butyrylcholinesterase activities in hypertensive rats. Am. J. Hypertens. 2014, 27:522-529.
20. Cardoso A.M., Bagatini M.D., Martins C.C., Abdalla F.H., Zanini D., Schmatz R., Gutierres J., Pimentel V.C., Thomé G., Leal C.A., Vieira J.M., Stefanello N., da Silva F.F., Baldissareli J., Royes L.F., Klein A.B., Morsch V.M., Schetinger M.R. Exercise training prevents ecto-nucleotidases alterations in platelets of hypertensive rats. Mol. Cell. Biochem. 2012, 371:147-156.
21. Chan E.W.C., Lim Y., Wong S. Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species. Food Chem. 2009, 113:166-172.
22. Clancy R.M., Lesczynska-Pikiak L., Abramson S.B. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide production via a direct action on the NADPH oxidase. J. Clin. Invest. 1992, 90:1116-1121.
23. Clark J.T. Sexual function in altered physiological states: comparison of effects of hypertension, diabetes, hyperprolactinemia, and others to "normal" aging in male rats. Neurosci. Biobehav. Rev. 1995, 19:279-302.
24. Dusing R. Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men. Blood Press. Suppl. 2003, 12:29-34.
25. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
26. Fickling S.A., Williams D., Vallance P., Nussey S.S., Whitley G.S. Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and preeclampsia. Lancet 1993, 41:1447-1451.
27. Furstenau C.R., Ramos D.B., Vuaden F.C., Casali E.A., Monteiro P.S., Trentin D.S., Gossenheimer A.N., Bogo M.R., Bonan C.D., Barreto-Chaves M.L., Sarkis J.J., Wofchuk S.T. L-NAME treatment alters ectonucleotidase activities in kidney membranes of rats. Life Sci. 2010, 87:325-332.
28. Furstenau C.R., Trentin D.S., Gossenheimer A.N., Ramos D.B., Casali E.A., Barreto-Chaves M.L., Sarkis J.J. Ectonucleotidase activities are altered in serum and platelets of L-NAME-treated rats. Blood Cells Mol. Dis. 2008, 41:223-229.
29. Ghayur M.N., Gilani A.H. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J. Cardiovasc. Pharmacol. 2005, 45:74-80.
30. Ghayur M.N., Gilani A.H., Afridi M.B. Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascul. Pharmacol. 2005, 43:234-241.
31. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferase: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
32. Hafez D.A. Effect of extracts of ginger roots and cinnamon bark on fertility of male diabetic rats. J. Am. Sci. 2010, 6:940-947.
33. Hancock K.D., Coleman E.S., Tao Y.X., Morrison E.E., Braden T.D., Kemppainen B.W., Akingbemi B.T. Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling. Toxicol. Lett. 2009, 184:169-175.
34. Huang J., Roby K.F., Pace J.L. Cellular localization and hormonal regulation of inducible nitric oxide synthase in mouse uterus. J. Leukoc. Biol. 1995, 57:27-35.
35. Jeyendran R., van der Ven H., Perez-Pelaez M. Development of an assay to assess the functional integrity of human sperm membranes and its relationship to other semen characteristics. J. Reprod. Fertil. 1984, 70:219-228.
36. Kim S.W., Cuong T.D., Hung T.M., Ryoo S., Lee J.H., Min B.S. Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica. Arch. Pharm. Res. 2013, 36:922-926.
37. Kowluru R.A., Kanwar M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr. Metab. 2007, 4(1):8.
38. Lerman L.O., Chade A.R., Sica V., Napoli C. Animal models of hypertension: an overview. J. Lab. Clin. Med. 2005, 146:160-173.
39. Lim C.J., Cuong T.D., Hung T.M., Ryoo S., Lee J.H., Kim E.H. Arginase ii inhibitory activity of phenolic compounds from Saururus chinensis. Bull. Korean Chem. Soc. 2012, 33:3079-3082.
40. Lovato F.L., Adedara I.A., Barbisan F., Moreira K.L.S., da Rocha M.I.U.M., da Cruz I.B. Quercetin ameliorates polychlorinated biphenyls-induced testicular DNA damage in rats. Andrologia 2015, 10.1111/and.12417.
41. Mallick C., Mandal S., Barik B., Bhattacharya A., Ghosh D. Protection of testicular dysfunctions by MTEC, a formulated herbal drug, in streptozotocin induced diabetic rat. Biol. Pharm. Bull. 2007, 30:84-90.
42. McCall T.B., Broughton-Smith N.K., Palmer R.M.J. Synthesis of nitric oxide from l-arginine by neutrophils. Biochem. J. 1989, 261:293-296.
43. Mendez J.D., Sosa A., Palomar-Morales M. Effect of l-arginine on arginase activity in male accessory sex glands of alloxan-treated rats. Reprod. Toxicol. 2002, 16:809-813.
44. Miranda K.M., Espay M.G., Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001, 5:62-71.
45. Morakino A.O., Adeniyi O.S., Arikawe A.P. Effects of Zingiber officinale on reproductive functions of the male rat. Afr. J. Biomed. Res. 2008, 2:329-339.
46. Moselhy W.A., Helmy N.A., Abdel-Halim B.R., Nabil T.M., Abdel-Hamid M.I. Role of ginger against the reproductive toxicity of aluminium chloride in albino male rats. Reprod. Domet. Anim. 2012, 47:335-343.
47. Oboh G., Ademiluyi A.O., Akinyemi A.J. Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale). Exp. Toxicol. Pathol. 2012, 64:315-319.
48. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
49. Oktem F., Kirbas A., Armagan A., Kuybulu A.E., Yilmaz H.R., Ozguner F., Uz E. Lisinopril attenuates renal oxidative injury in L-NAME-induced hypertensive rats. Mol. Cell. Biochem. 2011, 352:247-253.
50. Pulla Reddy A.C.H., Lokesh B.R. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol. Cell. Biochem. 1992, 111:117-124.
51. Reisser D., Onier-Cherix N., Jeannin J.F. Arginase activity is inhibited by L-NAME, both in vitro and in vivo. J. Enzyme Inhib. Med. Chem. 2002, 17:267-270.
52. Santillo M., Colantuoni A., Mondola P., Guida B., Damiano S. NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis. Front. Physiol. 2015, 6:194-201.
53. Sekiwa Y., Kubota K., Kobayashi A. Isolation of novel glycosides from ginger and their antioxidative activity. J. Agric. Food Chem. 2000, 8:373-379.
54. Seligman S.P., Abramson S.B., Young B.K., Buyon J.P. The role of nitric oxide in the pathogenesis of pre-eclampsia. Am. J. Obstet. Gynaecol. 1994, 172:944-948.
55. Sherrill J.D., Sparks M., Dennis J., Mansour M., Kemppainen B.W., Bartol F.F., Morrison E.E., Akingbemi B.T. Developmental exposures of male rats to soy isoflavones impact Leydig cell differentiation. Biol. Reprod. 2010, 83:488-501.
56. Sowers J.R., Epstein M. Diabetes mellitus and associated hypertension, vascular disease, and nephropathy: an update. Hypertension 1995, 26:869-879.
57. The Wealth of India, A dictionary of Indian raw materials and industrial products, first supplement series vol. II, New Delhi: National Institute of Science Communication, CSIR, 2001, pp. 264-293.
58. Vanhoutte P.M. Arginine and arginase: endothelial NO synthase double crossed?. Circ. Res. 2008, 102:866-868.
59. Virag R., Bouilly P., Frydman D. Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 1985, 1:181-184.
60. Wells M.E., Awa O.A. New technique for assessing acrosomal characteristics of spermatozoa. J. Dairy Sci. 1970, 53(2):227-232.
61. Yoshida S., Hiyoshi K., Ichinose T., Takano H., Oshio S., Sugawara I., Takeda K., Shibamoto T. Effect of nanoparticles on the male reproductive system of mice. Int. J. Androl. 2009, 32:337-342.
62. 2 and co-solvents: a study of the antioxidant action of the extracts. J. Supercrit. Fluids 2002, 24:57-67.
63. Zapolska-Downar D., Zapolski-Downar A., Naruszewicz M., Siennicka A., Krasnodebska B., Kołdziej B. Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes. Life Sci. 2002, 71:2897-2908.
64. Zhao H., Xu S., Wang Z., Li Y., Guo W., Lin C., Gong S., Li C., Wang G., Cai L. Repetitive exposures to low-dose X-rays attenuate testicular apoptotic cell death in streptozotocin-induced diabetes rats. Toxicol. Lett. 2010, 192:356-364.
65. Yang H.S., Han D.K., Kim J.R., Sim J.C. Effect of alpha-tocopherol on cadmium induced-toxicity in rat testis and carcinogenesis. Korean Med. J. 2006, 21:445-451.
66. Khaki A., Fatemek F., Mohammad N., Amir A.K., Chelar C.O., Marefat N., Mohammad H. The effects of ginger on spermatogenesis and sperm parameters. Iran J. Reprod. Med. 2009, 7:7-12.