Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed

Human and Experimental Toxicology

Volumn 31, Issue 5, 2012, Pages 506-517

  Adedara, I A ^a   Farombi, E O ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

ethylene glycol monoethyl ether; kolaviron; oxidative stress; rats; reproductive toxicity; vitamin E

Indexed keywords

2 ETHOXYETHANOL; ALPHA TOCOPHEROL; ANTIOXIDANT; CATALASE; FLAVONOID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; KOLAVIRON; LACTATE DEHYDROGENASE; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATION; ENZYME ACTIVITY; EPIDIDYMIS; GARCINIA KOLA; MALE; NONHUMAN; PLANT SEED; PRIORITY JOURNAL; PROSTATE; RAT; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS; TREATMENT OUTCOME;

ANIMALS; ANTIOXIDANTS; CATALASE; EPIDIDYMIS; ETHYLENE GLYCOLS; FLAVONOIDS; GARCINIA KOLA; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MALE; MALONDIALDEHYDE; PROSTATE; RATS; RATS, WISTAR; SEEDS; SOLVENTS; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SUPEROXIDE DISMUTASE; TESTIS; VITAMIN E;

GARCINIA KOLA; RATTUS;

EID: 84864262172     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327111424301     Document Type: Article

References (61)

1. de Ketttenis P. The historic and current use of glycol ethers: a picture of change. Toxicol Lett. 2005 ; 156: 5-11 (Pubitemid 40221758)
2. Barbee SJ, Terrill JB, DeSousa DJ, Conaway CC. Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and the rabbit. Environ Health Perspect. 1984 ; 57: 157-163 (Pubitemid 14008601)
3. Lamb JC, Gulati DK, Russell VS, Hommel L, Sabharwal PS. Reproductive toxicity of ethylene glycol monoethyl ether tested by continuous breeding of CD-1 mice. Environ Health Perspect. 1984 ; 57: 85-90 (Pubitemid 14008591)
4. Wang RS, Ohtani K, Suda M, Nikajima T. Inhibitory effect of ethylene glycol monoethyl ether on rat sperm motion. Ind Health. 2006 ; 44: 665-668 (Pubitemid 44763714)
5. Ratcliffe JM, Schrader SM, Clapp DE, Halperin WE, Turner TW, Hornung RW. Semen quality in workers exposed to 2-ethoxyethanol. Br J Ind Med. 1989 ; 46: 399-406 (Pubitemid 19149783)
6. Johanson G. Toxicity review of ethylene glycol monomethyl ether and its acetate ester. Crit Rev Toxicol. 2000 ; 30: 307-345 (Pubitemid 30368445)
7. Adedara IA, Farombi EO. Induction of oxidative damage in the testes and spermatozoa and hematotoxicity in rats exposed to multiple doses of ethylene glycol monoethyl ether. Hum Exp Toxicol. 2010 ; 29: 801-812
8. Ho YS, Magnenat JL, Gargano M, Cao J. The nature of antioxidant defence mechanisms: a lesson from transgenic studies. Environ Health Perspect. 1998 ; 106: 1219-1228 (Pubitemid 28554531)
9. Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J. Studies on protective role of vitamin C and E against polychlorinated biphenyls (Aroclor 1254)-induced oxidative damage in Leydig cells. Free Radical Res. 2005 ; 39: 1259-1272 (Pubitemid 41601429)
10. Agarwal A, Varghese AC, Sharma RK. Markers of oxidative stress and sperm chromatin integrity. Methods Mol Biol. 2009 ; 590: 377-402
11. Lucesoli F, Caligiuri M, Roberti MF, Perazzo JC, Fraga CG. Dose-dependent increase of oxidative damage in the testis of rats subjected to acute iron overload. Arch Biochem Biophys. 1999 ; 372: 37-43
12. Iwasaki A, Gagnon C. Formation of reactive oxygen species in spermatozoa in infertile men. Fertil Steril. 1992 ; 57: 409-418
13. Hutchinson J, Dalziel JM Flora of West Tropical Africa. 1956 ; Vol. 1. 2nd ed. London: HMSO. London: HMSO ; 1956 :
14. Iwu MM. Flavonoids of Garcinia kola seeds. J Nat Products (Lloydia). 1982 ; 45: 650-651
15. Terashima K, Takawa Y, Niwa M. Powerful antioxidative agents based on Garcinoic acid from Garcinia kola. Bioorg Med Chem. 2002 ; 10: 1619-1625 (Pubitemid 34214724)
16. Adegbehingbe OO, Adesanya SA, Idowu TO, Okimi OC, Oyelami OA, Iwalewa EO. Clinical effects of Garcinia kola in knee osteoarthritis. J Ortho Surg Res. 2008 ; 3: 34-43
17. Farombi EO, Tahnteng JG, Agboola AO, Nwankwo JO, Emerole GO. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron-a Garcinia kola seed extract. Food Chem Toxicol. 2000 ; 38: 535-541 (Pubitemid 30319353)
18. Farombi EO. Mechanisms for the hepatoprotective action of kolaviron: studies on hepatic enzymes, microsomal lipids and lipid peroxidation in carbon tetrachloride-treated rats. Pharmacol Res. 2000 ; 4: 75-80
19. Farombi EO. Molecular, therapeutic aspects of redox biochemistry. Bahorun T Gurib-Fakim A, ed. London: OICA International (UK) ; 2003: 207-226.
20. Farombi EO, Akuru TO, Alabi MC. Kolaviron modulates cellular redox status and impairment of membrane protein activities by potassium bromate (KBrO3) in rats. Pharmacol Res. 2002 ; 45: 63-68 (Pubitemid 35425514)
21. Farombi EO, Shrotriya S, Surh YJ. Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-κB and AP-1. Life Sci. 2009 ; 84: 149-155
22. Nwankwo JO, Tahnteng JG, Emerole GO. Inhibition of aflatoxin B1 genotoxicity in human liver-derived HepG2 cells by kolaviron biflavonoids and molecular mechanisms of action. Eur J Cancer Prev. 2000 ; 9: 351-361
23. Farombi EO, Moller P, Dragsted LO. Ex-vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells. Cell Biol Toxicol. 2004 ; 20: 71-82 (Pubitemid 38988054)
24. Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO. Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol. 2007 ; 100: 43-48 (Pubitemid 46051442)
25. Iwu MM. Antihepatoxic constituents of Garcinia kola seeds. Experientia. 1985 ; 41: 699-700 (Pubitemid 15001049)
26. Washington, DC: US Department of Health and Human Services ; 1996 :
27. Clairborne A Handbook of methods for oxygen radical research. Greewald AR, ed. Boca Raton, FL: CRC Press ; 1995: 237-242.
28. Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972 ; 247: 3170-3175
29. Wolff SP. Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol. 1994 ; 233: 182-189
30. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973 ; 179: 588-590
31. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974 ; 249: 7130-7139
32. Vassault A Methods of enzymatic analysis. 3 rd ed.New York: Plenum, 1983, pp.118-125. Bergmeyer HU, ed. New York: Plenum ; 1983: 118-125.
33. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem. 1951 ; 193: 265-275
34. Jollow DJ, Mitchell J.R., Zampaglione N, Gillette J.R.. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 1974 ; 11: 151-169
35. Zemjanis R Diagnostic and therapeutic technique in animal reproduction. 2 nd ed. Baltimore, MD, USA: William and Wilkins Company, 1970, pp.139-153. Zemjanis R, ed. Baltimore, MD, USA: William and Wilkins Company ; 1970: 139-153.
36. Pant N, Srivastava SP. Testicular and spermatotoxic effects of quinalphos in rats. J Appl Toxicol. 2003 ; 23: 271-274 (Pubitemid 36950297)
37. Joyce KL, Porcelli J, Cooke PS. Neonatal goitrogen treatment increases adult testes size and sperm production in the mouse. J Androl. 1993 ; 14: 448-455 (Pubitemid 24001032)
38. Wells ME, Awa OA. New technique for assessing acrosomal characteristics of spermatozoa. J Dairy Sci. 1970 ; 53: 227
39. McLachlan R, de Krester D. Male infertility: the case for continued research. MJA. 2001 ; 174: 116-117 (Pubitemid 32149354)
40. Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol. 2008 ; 59: 2-11 (Pubitemid 350285578)
41. Aitken RJ, Roman SD Molecular mechanisms in spermatogenesis. Cheng CY, ed. Lands Bioscience and Springer Science, USA ; 2008: 154-171..
42. Johnson F, Giulivi C. Superoxide dismutases and their impact upon human health. Mol Aspects Med. 2005 ; 26: 340-352 (Pubitemid 41225357)
43. Peltola V, Huhtaniemi I, Ahotupa M. Antioxidant enzyme activity in the maturing rat testis. J Androl. 1992 ; 13: 450-455
44. Zini A, Schlegel PN. Catalase mRNA expression in the male rat reproductive tract. J Androl. 1996 ; 17: 473-480 (Pubitemid 26403607)
45. Farombi EO, Akanni OO, Emerole GO. Antioxidative and scavenging activities of kolaviron in vitro. Pharm Biol. 2002 ; 40: 107-116
46. Iwu MM Plant flavonoids in biology and medicine: biochemical, pharmacological and structure-activity relationships. Cody V Middleton E Harborne JB, ed. New York: Alan R. Liss ; 1986: 485-488.
47. Celik I, Suzek H. Effect of subacute treatment of ethylene glycol on serum marker enzymes and erythrocyte and tissue antioxidant defence systems and lipid peroxidation in rats. Chem Biol Interact. 2007 ; 167: 145-152 (Pubitemid 46498020)
48. Smith GJ, Litwack GC. Role of ligandin and the glutathione S-transferases in binding steroid metabolites, carcinogens and other compounds. Rev Biochem Toxicol. 1980 ; 2: 1-47
49. Grootegoed JA, Jansen R, Van der Molen HJ. The role of glucose, pyruvate and lactate in ATP production by rat spermatocytes and spermatids. Biochim Biophys Acta. 1984 ; 767: 248-256 (Pubitemid 15218676)
50. Bajpai M, Gupta G, Setty BS. Changes in carbohydrate metabolism of testicular germ cells during meiosis in the rat. Eur J Endocrinol. 1998 ; 138: 322-327 (Pubitemid 28154783)
51. Riera MF, Meroni SB, Gomez GE, Schteingart HF, Pellizzari EH, Cigorraga SB. Regulation of lactate production by FSH, IL1 beta and TNF alpha in rat sertoli cells. Gen Comp Endocrinol. 2001 ; 122: 88-97 (Pubitemid 32368258)
52. Erkkila K, Aito H, Aalto K, Pentikainen V, Dunkel L. Lactate inhibits germ cell apoptosis in human testes. Mol Hum Reprod. 2002 ; 8: 109-117 (Pubitemid 34144970)
53. Yamamato T, Horii I, Yoshida T. Integrated NMR-based metabonomic investigation of early metabolic effects of ethylene glycol monomethyl ether (EGME) on male reproductive organs in rats. J Toxicol Sci. 2007 ; 32: 515-528
54. Sudharsan PT, Mythili Y, Selvakumar E, Varalakshmi P. Cardioprotective effect of pentacyclic triterpene, lupeol and its ester on cyclophosphamide- induced oxidative stress. Hum Exp Toxicol. 2005 ; 24: 313-318 (Pubitemid 40942615)
55. Iwu MM, Igboko OA, Okunji CO, Tempesta S. Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola. J Pharm Pharmacol. 1990 ; 42: 290-292 (Pubitemid 20195781)
56. Ghosh D, Das UB, Ghosh S, Mallick M, Depnath J. Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: a correlative study with testicular oxidative stress. Drug Chem Toxicol. 2002 ; 25: 281-292 (Pubitemid 34831279)
57. Hudson BFJ, Lewis JI. Polyhydroxy flavonoid antioxidants for edible oils. Structural criteria for activity. Food Chem. 1983 ; 10: 147-155
58. Cook NS, Samman S. Flavonoids: Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem. 1996 ; 7: 66-76 (Pubitemid 26086316)
59. Mora A, Paya M, Rios JL, Alcaraz MJ. Structure activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymes lipid peroxidation. Biochem Pharmacol. 1997 ; 40: 793-797
60. Farombi EO, Nwaokeafor IA. Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats. Clin Exp Pharmacol Physiol. 2005 ; 32: 667-674 (Pubitemid 41025830)
61. Combs G The vitamins. New York: Academic Press ; 1992: 179-203.