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Volumn 5, Issue , 2015, Pages

Erratum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease (Scientific Reports (2016) 5:14781 DOI: 10.1038/srep14781);Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease

Author keywords

[No Author keywords available]

Indexed keywords

MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE;

EID: 84944809968     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep20750     Document Type: Erratum
Times cited : (46)

References (51)
  • 1
    • 84893714667 scopus 로고    scopus 로고
    • 2013 Thomas Willis Award Lecture: Causation and collaboration for stroke research
    • Lo, E. H. 2013 Thomas Willis Award Lecture: Causation and collaboration for stroke research. Stroke 45, 305-308 (2014
    • (2014) Stroke , vol.45 , pp. 305-308
    • Lo, E.H.1
  • 2
    • 0021743001 scopus 로고
    • Blockade of N-methyl-D-Aspartate receptors may protect against ischemic damage in the brain
    • Simon, R. P., Swan, J. H., Griffiths, T. & Meldrum, B. S. Blockade of N-methyl-D-Aspartate receptors may protect against ischemic damage in the brain. Science 226, 850-852 (1984
    • (1984) Science , vol.226 , pp. 850-852
    • Simon, R.P.1    Swan, J.H.2    Griffiths, T.3    Meldrum, B.S.4
  • 3
    • 79952850719 scopus 로고    scopus 로고
    • Oxidative stress in ischemic brain damage: Mechanisms of cell death and potential molecular targets for neuroprotection
    • Chen, H. et al. Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid. Redox. Signal. 14, 1505-1517 (2011
    • (2011) Antioxid. Redox. Signal. , vol.14 , pp. 1505-1517
    • Chen, H.1
  • 4
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl, U., Iadecola, C. & Moskowitz, M. A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22, 391-397 (1999
    • (1999) Trends Neurosci. , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 5
    • 0036830627 scopus 로고    scopus 로고
    • NMDA receptor pathways as drug targets
    • Suppl
    • Kemp, J. A. & McKernan, R. M. NMDA receptor pathways as drug targets. Nat. Neurosci. 5 Suppl, 1039-1042 (2002
    • (2002) Nat. Neurosci. , vol.5 , pp. 1039-1042
    • Kemp, J.A.1    McKernan, R.M.2
  • 6
    • 80055006684 scopus 로고    scopus 로고
    • Emerging mechanisms of disrupted cellular signaling in brain ischemia
    • Tymianski, M. Emerging mechanisms of disrupted cellular signaling in brain ischemia. Nat. Neurosci. 14, 1369-1373 (2011
    • (2011) Nat. Neurosci. , vol.14 , pp. 1369-1373
    • Tymianski, M.1
  • 7
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders
    • Hardingham, G. E. & Bading, H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat. Rev. Neurosci. 11, 682-696 (2010
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 8
    • 84898678139 scopus 로고    scopus 로고
    • Extrasynaptic NMDA receptor involvement in central nervous system disorders
    • Parsons, M. P. & Raymond, L. A. Extrasynaptic NMDA receptor involvement in central nervous system disorders. Neuron 82, 279-293 (2014
    • (2014) Neuron , vol.82 , pp. 279-293
    • Parsons, M.P.1    Raymond, L.A.2
  • 9
    • 0141954291 scopus 로고    scopus 로고
    • The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease
    • Rogawski, M. A. & Wenk, G. L. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev. 9, 275-308 (2003
    • (2003) CNS Drug Rev. , vol.9 , pp. 275-308
    • Rogawski, M.A.1    Wenk, G.L.2
  • 10
    • 0031034905 scopus 로고    scopus 로고
    • Mechanism of memantine block of NMDA-Activated channels in rat retinal ganglion cells: Uncompetitive antagonism
    • Chen, H. S. & Lipton, S. A. Mechanism of memantine block of NMDA-Activated channels in rat retinal ganglion cells: uncompetitive antagonism. J. Physiol. 499 (Pt 1), 27-46 (1997
    • (1997) J. Physiol. , vol.499 , pp. 27-46
    • Chen, H.S.1    Lipton, S.A.2
  • 11
    • 33645095476 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
    • Lipton, S. A. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. 5, 160-170 (2006
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 160-170
    • Lipton, S.A.1
  • 12
    • 34648843243 scopus 로고    scopus 로고
    • Pathologically activated therapeutics for neuroprotection
    • Lipton, S. A. Pathologically activated therapeutics for neuroprotection. Nat. Rev. Neurosci. 8, 803-808 (2007
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 803-808
    • Lipton, S.A.1
  • 13
    • 77955855654 scopus 로고    scopus 로고
    • Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses
    • Xia, P., Chen, H. S., Zhang, D. & Lipton, S. A. Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J. Neurosci. 30, 11246-11250 (2010
    • (2010) J. Neurosci. , vol.30 , pp. 11246-11250
    • Xia, P.1    Chen, H.S.2    Zhang, D.3    Lipton, S.A.4
  • 14
    • 0026564448 scopus 로고
    • Open-channel block of N-methyl-D-Aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity
    • Chen, H. S. et al. Open-channel block of N-methyl-D-Aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci. 12, 4427-4436 (1992
    • (1992) J. Neurosci. , vol.12 , pp. 4427-4436
    • Chen, H.S.1
  • 15
    • 1842418653 scopus 로고    scopus 로고
    • Emerging therapies for vascular dementia and vascular cognitive impairment
    • Erkinjuntti, T., Roman, G., Gauthier, S., Feldman, H. & Rockwood, K. Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke 35, 1010-1017 (2004
    • (2004) Stroke , vol.35 , pp. 1010-1017
    • Erkinjuntti, T.1    Roman, G.2    Gauthier, S.3    Feldman, H.4    Rockwood, K.5
  • 16
    • 0036314492 scopus 로고    scopus 로고
    • Efficacy and safety of memantine in patients with mild to moderate vascular dementia: A randomized, placebo-controlled trial (MMM 300
    • Orgogozo, J. M., Rigaud, A. S., Stoffler, A., Mobius, H. J. & Forette, F. Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300). Stroke 33, 1834-1839 (2002
    • (2002) Stroke , vol.33 , pp. 1834-1839
    • Orgogozo, J.M.1    Rigaud, A.S.2    Stoffler, A.3    Mobius, H.J.4    Forette, F.5
  • 17
    • 84871712919 scopus 로고    scopus 로고
    • The smallest stroke: Occlusion of one penetrating vessel leads to infarction and a cognitive deficit
    • Shih, A. Y. et al. The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat. Neurosci 16, 55-63 (2013
    • (2013) Nat. Neurosci , pp. 55-63
    • Shih, A.Y.1
  • 18
    • 84879732252 scopus 로고    scopus 로고
    • Abeta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
    • Talantova, M. et al. Abeta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc. Natl. Acad. Sci. USA 110, E2518-2527 (2013
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E2518-2527
    • Talantova, M.1
  • 19
    • 33745614291 scopus 로고    scopus 로고
    • The pharmacology of aminoadamantane nitrates
    • Wang, Y. et al. The pharmacology of aminoadamantane nitrates. Curr. Alzheimer Res. 3, 201-204 (2006
    • (2006) Curr. Alzheimer Res. , vol.3 , pp. 201-204
    • Wang, Y.1
  • 20
    • 0033995950 scopus 로고    scopus 로고
    • Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation
    • Choi, Y. B. et al. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat. Neurosci. 3, 15-21 (2000
    • (2000) Nat. Neurosci. , vol.3 , pp. 15-21
    • Choi, Y.B.1
  • 21
    • 0027959803 scopus 로고
    • Actions of redox-related congeners of nitric oxide at the NMDA receptor
    • Lipton, S. A. & Stamler, J. S. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology 33, 1229-1233 (1994
    • (1994) Neuropharmacology , vol.33 , pp. 1229-1233
    • Lipton, S.A.1    Stamler, J.S.2
  • 22
    • 33845702060 scopus 로고    scopus 로고
    • Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif
    • Takahashi, H. et al. Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif. Neuron 53, 53-64 (2007
    • (2007) Neuron , vol.53 , pp. 53-64
    • Takahashi, H.1
  • 23
    • 23944511459 scopus 로고    scopus 로고
    • Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-Aspartate-gated channels
    • Chen, H. S. & Lipton, S. A. Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-Aspartate-gated channels. J. Pharmacol. Exp. Ther. 314, 961-971 (2005
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 961-971
    • Chen, H.S.1    Lipton, S.A.2
  • 24
    • 16344367248 scopus 로고    scopus 로고
    • Amantadine inhibits NMDA receptors by accelerating channel closure during channel block
    • Blanpied, T. A., Clarke, R. J. & Johnson, J. W. Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J. Neurosci. 25, 3312-3322 (2005
    • (2005) J. Neurosci. , vol.25 , pp. 3312-3322
    • Blanpied, T.A.1    Clarke, R.J.2    Johnson, J.W.3
  • 25
    • 0025295264 scopus 로고
    • And extracellular changes of [Ca2+ ] in hypoxia and ischemia in rat brain in vivo
    • Silver, I. A. & Erecinska, M. Intracellular and extracellular changes of [Ca2+ ] in hypoxia and ischemia in rat brain in vivo. J. Gen. Physiol. 95, 837-866 (1990
    • (1990) J. Gen. Physiol. , vol.95 , pp. 837-866
    • Silver, I.A.1    Intracellular, E.M.2
  • 26
    • 0029887686 scopus 로고    scopus 로고
    • Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels
    • Wollmuth, L. P., Kuner, T., Seeburg, P. H. & Sakmann, B. Differential contribution of the NR1- And NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels. J. Physiol. 491 (Pt 3), 779-797 (1996
    • (1996) J. Physiol. , vol.491 , pp. 779-797
    • Wollmuth, L.P.1    Kuner, T.2    Seeburg, P.H.3    Sakmann, B.4
  • 27
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • Lipton, S. A. et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364, 626-632 (1993
    • (1993) Nature , vol.364 , pp. 626-632
    • Lipton, S.A.1
  • 28
    • 0036752945 scopus 로고    scopus 로고
    • Cysteine regulation of protein function-As exemplified by NMDA-receptor modulation
    • Lipton, S. A. et al. Cysteine regulation of protein function-As exemplified by NMDA-receptor modulation. Trends Neurosci. 25, 474-480 (2002
    • (2002) Trends Neurosci. , vol.25 , pp. 474-480
    • Lipton, S.A.1
  • 29
    • 0031020529 scopus 로고    scopus 로고
    • Trapping channel block of NMDA-Activated responses by amantadine and memantine
    • Blanpied, T. A., Boeckman, F. A., Aizenman, E. & Johnson, J. W. Trapping channel block of NMDA-Activated responses by amantadine and memantine. J. Neurophysiol. 77, 309-323 (1997
    • (1997) J. Neurophysiol. , vol.77 , pp. 309-323
    • Blanpied, T.A.1    Boeckman, F.A.2    Aizenman, E.3    Johnson, J.W.4
  • 30
    • 0035862957 scopus 로고    scopus 로고
    • Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor
    • Choi, Y., Chen, H. V. & Lipton, S. A. Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor. J. Neurosci. 21, 392-400 (2001
    • (2001) J. Neurosci. , vol.21 , pp. 392-400
    • Choi, Y.1    Chen, H.V.2    Lipton, S.A.3
  • 31
    • 70350412253 scopus 로고    scopus 로고
    • Memantine binding to a superficial site on NMDA receptors contributes to partial trapping
    • Kotermanski, S. E., Wood, J. T. & Johnson, J. W. Memantine binding to a superficial site on NMDA receptors contributes to partial trapping. J. Physiol. 587, 4589-4604 (2009
    • (2009) J. Physiol. , vol.587 , pp. 4589-4604
    • Kotermanski, S.E.1    Wood, J.T.2    Johnson, J.W.3
  • 32
    • 33745034018 scopus 로고    scopus 로고
    • The chemical biology of clinically tolerated NMDA receptor antagonists
    • Chen, H. S. & Lipton, S. A. The chemical biology of clinically tolerated NMDA receptor antagonists. J. Neurochem. 97, 1611-1626 (2006
    • (2006) J. Neurochem. , vol.97 , pp. 1611-1626
    • Chen, H.S.1    Lipton, S.A.2
  • 33
    • 34948842904 scopus 로고    scopus 로고
    • A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse
    • Parsons, C. G., Stoffler, A. & Danysz, W. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse. Neuropharmacology 53, 699-723 (2007
    • (2007) Neuropharmacology , vol.53 , pp. 699-723
    • Parsons, C.G.1    Stoffler, A.2    Memantine, D.W.3
  • 34
    • 0032543788 scopus 로고    scopus 로고
    • Neuroprotective concentrations of the N-methyl-D-Aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation
    • Chen, H. S. et al. Neuroprotective concentrations of the N-methyl-D-Aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86, 1121-1132 (1998
    • (1998) Neuroscience , vol.86 , pp. 1121-1132
    • Chen, H.S.1
  • 35
    • 71549143207 scopus 로고    scopus 로고
    • Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
    • Okamoto, S. et al. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat. Med. 15, 1407-1413 (2009
    • (2009) Nat. Med. , vol.15 , pp. 1407-1413
    • Okamoto, S.1
  • 36
    • 0032947526 scopus 로고    scopus 로고
    • Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
    • Ikonomidou, C. et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283, 70-74 (1999
    • (1999) Science , vol.283 , pp. 70-74
    • Ikonomidou, C.1
  • 37
    • 0036795176 scopus 로고    scopus 로고
    • Drug-induced apoptotic neurodegeneration in the developing brain
    • Olney, J. W. et al. Drug-induced apoptotic neurodegeneration in the developing brain. Brain Pathol. 12, 488-498 (2002
    • (2002) Brain Pathol. , vol.12 , pp. 488-498
    • Olney, J.W.1
  • 38
    • 21844450866 scopus 로고    scopus 로고
    • A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia
    • Gu, Z. et al. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J. Neurosci. 25, 6401-6408 (2005
    • (2005) J. Neurosci. , vol.25 , pp. 6401-6408
    • Gu, Z.1
  • 39
    • 0037119624 scopus 로고    scopus 로고
    • S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death
    • Gu, Z. et al. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297, 1186-1190 (2002
    • (2002) Science , vol.297 , pp. 1186-1190
    • Gu, Z.1
  • 40
    • 0031951510 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
    • Wang, Y. F. et al. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat. Med. 4, 228-231 (1998
    • (1998) Nat. Med. , vol.4 , pp. 228-231
    • Wang, Y.F.1
  • 41
    • 1842684070 scopus 로고    scopus 로고
    • Turning down, but not off
    • Lipton, S. A. Turning down, but not off. Nature 428, 473 (2004
    • (2004) Nature , vol.428 , pp. 473
    • Lipton, S.A.1
  • 42
    • 0026485192 scopus 로고
    • Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
    • Ischiropoulos, H. et al. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch. Biochem. Biophys. 298, 431-437 (1992
    • (1992) Arch. Biochem. Biophys. , vol.298 , pp. 431-437
    • Ischiropoulos, H.1
  • 43
    • 0025343312 scopus 로고
    • Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current
    • Leonard, J. P. & Kelso, S. R. Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current. Neuron 4, 53-60 (1990
    • (1990) Neuron , vol.4 , pp. 53-60
    • Leonard, J.P.1    Kelso, S.R.2
  • 44
    • 0025006846 scopus 로고
    • Modulation of N-methyl-D-Aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones
    • Vyklicky, L., Jr., Benveniste, M. & Mayer, M. L. Modulation of N-methyl-D-Aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones. J. Physiol. 428, 313-331 (1990
    • (1990) J. Physiol. , vol.428 , pp. 313-331
    • Vyklicky, L.1    Benveniste, M.2    Mayer, M.L.3
  • 45
    • 0025788797 scopus 로고
    • Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture
    • Bekkers, J. M. & Stevens, C. F. Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture. Proc. Natl. Acad. Sci. USA 88, 7834-7838 (1991
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7834-7838
    • Bekkers, J.M.1    Stevens, C.F.2
  • 46
    • 0025891886 scopus 로고
    • Epileptiform activity in microcultures containing one excitatory hippocampal neuron
    • Segal, M. M. Epileptiform activity in microcultures containing one excitatory hippocampal neuron. J. Neurophysiol. 65, 761-770 (1991
    • (1991) J. Neurophysiol. , vol.65 , pp. 761-770
    • Segal, M.M.1
  • 47
    • 0025223462 scopus 로고
    • Epileptiform activity in microcultures containing small numbers of hippocampal neurons
    • Segal, M. M. & Furshpan, E. J. Epileptiform activity in microcultures containing small numbers of hippocampal neurons. J. Neurophysiol. 64, 1390-1399 (1990
    • (1990) J. Neurophysiol. , vol.64 , pp. 1390-1399
    • Segal, M.M.1    Furshpan, E.J.2
  • 48
    • 0035849715 scopus 로고    scopus 로고
    • The biotin switch method for the detection of S-nitrosylated proteins
    • pl1
    • Jaffrey, S. R. & Snyder, S. H. The biotin switch method for the detection of S-nitrosylated proteins. Sci. STKE 2001, pl1 (2001
    • (2001) Sci. STKE , pp. 2001
    • Jaffrey, S.R.1    Snyder, S.H.2
  • 49
    • 33745315287 scopus 로고    scopus 로고
    • S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    • Uehara, T. et al. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 441, 513-517 (2006
    • (2006) Nature , vol.441 , pp. 513-517
    • Uehara, T.1
  • 50
    • 0022870943 scopus 로고
    • Evaluation of 2, 3, 5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
    • Bederson, J. B. et al. Evaluation of 2, 3, 5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17, 1304-1308 (1986
    • (1986) Stroke , vol.17 , pp. 1304-1308
    • Bederson, J.B.1
  • 51
    • 0035399884 scopus 로고    scopus 로고
    • Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant
    • Mackensen, G. B. et al. Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. J. Neurosci. 21, 4582-4592 (2001
    • (2001) J. Neurosci. , vol.21 , pp. 4582-4592
    • Mackensen, G.B.1


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