Trapping channel block of NMDA-activated responses by amantadine and memantine

Journal of Neurophysiology

Volumn 77, Issue 1, 1997, Pages 309-323

  Blanpied, Thomas A ^a   Boeckman, Faye A ^a   Aizenman, Elias ^a   Johnson, Jon W ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; AMANTADINE; ANTIPARKINSON AGENT; DIZOCILPINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; PHENCYCLIDINE;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL MEMBRANE TRANSPORT; CHANNEL GATING; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; MEMBRANE CHANNEL; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

EID: 0031020529     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.77.1.309     Document Type: Article

References (52)

1. ADAMS, P. R. Drug blockade of open end-plate channels. J. Physiol. Lond. 260: 531-551, 1976.
2. ANTONOV, S. M., JOHNSON, J. W., LUKOMSKAYA, N. Y., POTAPYEVA, N. N., GMIRO, V. E., AND MAGAZANIK, L. G. Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants. Mol. Pharmacol. 47: 558-567, 1995.
3. ANTONOV, S. M. AND JOHNSON, J. W. Voltage-dependent interaction of open channel blocking molecules with gating of NMDA receptors in rat cortical neurons. J. Physiol. Lond. 493: 425-445, 1996.
4. BENVENISTE, M., CLEMENTS, J., VYKLICKY, L. J., AND MAYER, M. L. A kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocarnpal neurones. J. Physiol. Lond. 428: 333-357, 1990.
5. BENVENISTE, M. AND MAYER, M. L. Kinetic analysis of antagonist action at N-methyl-D-aspartate receptors. Two binding sites each for glutamate and glycine. Biophys. J. 59: 560-573, 1991.
6. BENVENISTE, M. AND MAYER, M. L. Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9-aminoacridine. J. Physiol. Lond. 483: 367-384, 1995.
7. BLANPIED, T. A. AND JOHNSON, J. W. NMDA channel open probability does not affect ketamine blocking affinity. Soc. Neurosci. Abstr. 19: 466, 1993.
8. BLANPIED, T. A. AND JOHNSON, J. W. Trapping open channel block and noncompetitive inhibition of NMDA-activated responses by amantadine and memantine. Soc. Neurosci. Abstr. 20: 212, 1994.
9. BOECKMAN, F. A. AND AIZENMAN, E. Stable transfection of the NR1 subunit in Chinese hamster ovary cells fails to produce a functional N-methyl-D-asparate receptor. Neurosci. Lett. 173: 189-192, 1994.
10. BOECKMAN, F. A. AND AIZENMAN, E. Acquisition of excitotoxicity in Chinese hamster ovary (CHO) cells transfected with NMDA receptor subunits: use of a luciferase reporter assay. Soc. Neurosci. Abstr. 21: 86, 1995.
11. BORMANN, J. Memantine is a potent blocker of N-methyl-D-aspartate channels, Eur. J. Pharmacol. 166: 591-592, 1989.
12. BRENNER, M., HAASS, A., JACOBI, P., AND SCHIMRIGK, K. Amantadine sulphate in treating Parkinson's disease: clinical effects, psychometric tests and serum concentrations. J. Neurol. 236: 153-156, 1989.
13. CHALFIE, M., TU, Y., EUSKIRCHEN, G., WARD, W. W., AND PRASHBR, D. C. Green fluorescent protein as a marker for gene expression. Science Wash. DC 263: 802-805, 1994.
14. CHEN, H.-S. V., PELLEGRINI, J. W., AGGARWAL, S. K., LEI. S. Z., WARACH, S., JENSEN, F. E., AND LIPTON, S. A. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci. 12: 4427- 4436, 1992.
15. CIK, M., CHAZOT, P. L., AND STEPHENSON, F. A. Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: a biochemical characterization. Biochem. J. 296: 877-883, 1993.
16. CLEMENTS, J. D. AND WESTBROOK, G. L. Kinetics of AP5 dissociation from NMDA receptors: evidence for two identical cooperative binding sites. J. Neurophysiol. 71: 2566-2569, 1994.
17. DITZLER, K. Efficacy and tolerability of memantine in patients with dementia syndrome. Drug Res. 41: 773-780, 1991.
18. DUFF, K. C., CUDMORE, A. J., AND BRADSHAW, J. P. The location of amantadine hydrochloride and free base within phospholipid multilayers - neutron and x-ray-diffraction study. Biochim. Biophys. Acta 1145: 149-156, 1993.
19. FISCHER, P.-A., JACOBI, P., SCHNEIDER, E., AND SCHÖNBERGER, B. Die Wirkung intravenöser Gaben von Memantin bei Parkinson-Kranken. Drug Res. 27: 1487-1489, 1977.
20. FRANKIEWICZ, T., POTIER, B., BASHIR, Z. I., COLLINGRIDGE, G. L., AND PARSONS, C. G. Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices. Br. J. Pharmacol. 117: 689-697, 1996.
21. GIBB, A. J. AND COLQUHOUN, D. Activation of NMDA receptors by L-glutamate in cells dissociated from adult rat hippocampus. J. Physiol. Lond. 456: 143-179, 1992.
22. HOLLMANN, M. AND HEINEMANN, S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17: 31-108, 1994.
23. HUETTNER, J. E. AND BEAN, B. P. Block of N-methyl-D-aspartate-activated current by the anticon-vulsant MK-801: selective binding to open channels. Proc. Natl. Acad. Sci. USA 85: 1307-1311, 1988.
24. JAHR, C. E. High probability opening of NMDA receptor channels by L-glutamate. Science Wash. DC 255: 470-472, 1992.
25. JAHR, C. E. AND STEVENS, C. F. Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. J. Neurosci. 10: 3178-3182, 1990.
26. JAVITT, D. C. AND ZUKIN, S. R. Recent advances in the phencyclidine model of schizophrenia. Am. J. Psychiatry 148: 1301-1308, 1991.
27. KORNHUBER, J., BORMANN, J., HÜBERS, M., RUSCHE, K., AND RIEDERER, P. Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study. Eur. J. Pharmacol. 206: 297-300, 1991.
28. KORNHUBER, J. AND QUACK, G. Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man. Neurosci. Lett. 195: 137-139, 1995.
29. KORNHUBER, J., QUACK, G., DANYSZ, W., JELLINGER, K., DANIELCZYK, W., GSELL, W., AND RIEDERER, P. Therapeutic brain concentration of the NMDA receptor antagonist amantadine. Neuropharmacology 34: 713-721, 1995.
30. KORNHUBER, J., WELLER, M., AND RIEDERER, P. Glutamate receptor antagonists for neuroleptic malignant syndrome and akinetic hyperthermic Parkinsonian crisis. J. Neural Transm. Parkinson's Dis. Dementia Sect. 6: 63-72, 1993.
31. KOSHELEV, S. AND KHODOROV, B. Tetraethylammonium and tetrabutylammonium as tools to study NMDA channels of neuronal membrane. Biol. Membr. 9: 1064-1068, 1992.
32. KRYSTAL, J. H., KARPER, L. P., SEIBYL, J. P., FREEMAN, G. K., DELANEY, R., BREMNER, J. D., HENINGER, G. R., BOWERS, M. J., AND CHARNEY, D. S. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 51: 199-214, 1994.
33. LEGENDRE, P., ROSENMUND, C., AND WESTBROOK, G. L. Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium. J. Neurosci. 13: 674-684, 1993.
34. 2+ and phencyclidine in use-dependent block of NMDA channels. Neurosci. Lett. 123: 187-191, 1991.
35. LESTER, R. A. AND JAHR, C. E. NMDA channel behavior depends on agonist affinity. J. Neurosci. 12: 635-643, 1992.
36. LINGLE, C. Blockade of cholinergic channels by chlorisondamine on a crustacean muscle. J. Physiol. Lond. 339: 395-417, 1983.
37. LUBY, E. D., COHEN, B. D., ROSENBAUM, F., GOTTLEIB, J., AND KELLEY, R. Study of a new schizophrenomimetic drug. Arch. Neurol. Psychiatry 81: 363-369, 1959.
38. MACDONALD, J. F., BARTLETT, M. C., MODY, I., PAHAPILL, P., REYNOLDS, J. N., SALTER, M. W., SCHNEIDERMAN, J. H., AND PENNEFEATHER, P. S. Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones. J. Physiol. Lond. 432: 483-508, 1991.
39. MACDONALD, J. F., MILJKOVIC, Z., AND PENNEFEATHER, P. Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine. J. Neurophysiol. 58: 251-266, 1987.
40. MAYER, M. L. AND WESTBROOK, G. L. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J. Physiol. Lond. 394: 501-527, 1987.
41. MONYER, H., SPRENGEL, R., SCHOEPFER, R., HERB, A., HIGUCHI, M., LOMELI, H., BURNASHEV, N., SAKMANN, B., AND SEEBURG, P. H. Heteromeric MDMA receptors: molecular and functional distinction of subtypes. Science Wash. DC 256: 1217-1221, 1992.
42. NEHER, E. AND STEINBACH, J. H. Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J. Physiol. Lond. 277: 153-176, 1978.
43. PARSONS, C. G., PANCHENKO, V. A., PINCHENKO, V. O., TSYNDRENKO, A. Y., AND KRISHTAL, O. A. Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. Eur. J. Neurosci. 8: 446-454, 1996.
44. ROGAWSKI, M. A. Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends Pharmacol. Sci. 14: 325-331, 1993.
45. ROSENMUND, C., FELTZ, A., AND WESTBROOK, G. L. Synaptic NMDA receptors have low open probability. J. Neurosci. 15: 2788-2795, 1995.
46. SCHWAB, R. S., ENGLAND, A. C. J., POSKANZER, D. C., AND YOUNG, R. R. Amantadine in the treatment of Parkinson's disease. J. Am. Med. Assoc. 208: 1168-1170, 1969.
47. SEIF EL NASR, M., PERUCKE, B., ROSBERG, C., MENNEL, H.-D., AND KRIEGLSTEIN, J. Neuroprotective effect of memantine demonstrated in vivo and in vitro. Eur. J. Pharmacol. 185: 19-24, 1990.
48. WATANABE, M., SAKIMURA, K., AND MISHINA, M. Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J. Comp. Neurol. 338: 377-390, 1992.
49. WELLER, M., FINIELSMARLIER, F., AND PAUL, S. M. NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons-neuroprotective properties of amantadine and memantine. Brain Res. 613: 143-148, 1993.
50. WELLER, M. AND KORNHUBER, J. Pathophysiology and therapy of malignant neuroleptic syndrome. Nervenarzt 63: 645-655, 1991.
51. WOODHULL, A. M. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61: 687-708, 1973.
52. ZHONG, J., RUSSELL, S. L., PRITCHETT, D. B., MOLINOFF, P. B., AND WILLIAMS, K. Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Mol. Pharmacol. 45: 846-853, 1994.