RNA interference of influenza a virus replication by microRNA-adapted lentiviral loop short hairpin RNA

Journal of General Virology

Volumn 96, Issue 10, 2015, Pages 2971-2981

  Xu, Fang ^a   Liu, Guanqun ^a   Liu, Qiang ^a   Zhou, Yan ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; LENTIVIRUS VECTOR; MICRORNA; MIRNA 30; NONSTRUCTURAL PROTEIN 1; POLYMERASE BASIC PROTEIN 1; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VIRUS PROTEIN; BIOLOGICAL PRODUCT; CORE PROTEIN; INFLUENZA VIRUS POLYMERASE BASIC PROTEIN 1; NP PROTEIN, INFLUENZA A VIRUS; RNA BINDING PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DRUG DESIGN; DRUG EFFICACY; DRUG STABILITY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; EXPRESSION VECTOR; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLUENZA A; INFLUENZA A VIRUS; KIDNEY CELL; MDCK CELL LINE; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; RNA ANALYSIS; RNA INTERFERENCE; RNA SEQUENCE; RNA STRUCTURE; THERMOSTABILITY; TRANSIENT EXPRESSION; VIRAL GENE DELIVERY SYSTEM; VIROGENESIS; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENETIC TRANSDUCTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LENTIVIRINAE; METABOLISM;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL PRODUCTS; CELL LINE; DRUG DELIVERY SYSTEMS; HUMANS; INFLUENZA A VIRUS; LENTIVIRUS; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; TRANSDUCTION, GENETIC; VIRAL CORE PROTEINS; VIRAL PROTEINS;

EID: 84944747163     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/jgv.0.000247     Document Type: Article

References (39)

1. Boudreau, R., L., Martins, I, & Davidson, B, L, (2009), Artificial, microRNAs as siRNA shuttles: improved safety as compared to, shRNAs in vitro and in vivo, Mol Ther 17, 169–175
2. Bouvier, N, M, & Palese, P, (2008), The biology of influenza viruses, Vaccine 26 (Suppl, 4), D49–D53
3. Bridge, A, J,, Pebernard, S,, Ducraux, A,, Nicoulaz, A,-L, & Iggo, R, (2003), Induction of an interferon response by RNAi vectors in, mammalian cells, Nat Genet 34, 263–264
4. Castanotto, D,, Sakurai, K,, Lingeman, R,, Li, H,, Shively, L,, Aagaard, L,, Soifer, H,, Gatignol, A,, Riggs, A, & Rossi, J, J, (2007), Combinatorial delivery of small interfering RNAs reduces RNAi, efficacy by selective incorporation into RISC, Nucleic Acids Res 35,, 5154–5164
5. Chang, K,, Elledge, S, J, & Hannon, G, J, (2006), Lessons from nature:, microRNA-based shRNA libraries, Nat Methods 3, 707–714
6. Chang, K,, Marran, K,, Valentine, A, & Hannon, G, J, (2013), Creating, an miR30-based shRNA vector, Cold Spring Harb Protoc 2013
7. Chi, S, W,, Hannon, G, J, & Darnell, R, B, (2012), An alternative, mode of microRNA target recognition, Nat Struct Mol Biol 19,, 321–327
8. Chung, K,-H,, Hart, C, C,, Al-Bassam, S,, Avery, A,, Taylor, J,, Patel, P, D,, Vojtek, A, B, & Turner, D, L, (2006), Polycistronic RNA, polymerase II expression vectors for RNA interference based on, BIC/miR-155, Nucleic Acids Res 34, e53
9. Cullen, B, R, (2004), Transcription and processing of human, microRNA precursors, Mol Cell 16, 861–865
10. DeKelver, R, C,, Choi, V, M,, Moehle, E, A,, Paschon, D, E,, Hockemeyer, D,, Meijsing, S, H,, Sancak, Y,, Cui, X,, Steine, E, J, &, other authors (2010), Functional genomics, proteomics, and, regulatory DNA analysis in isogenic settings using zinc finger, nuclease-driven transgenesis into a safe harbor locus in the human, genome, Genome Res 20, 1133–1142
11. Dykxhoorn, D, M, & Lieberman, J, (2006), Silencing viral infection, PLoS Med 3, e242
12. Fellmann, C,, Hoffmann, T,, Sridhar, V,, Hopfgartner, B,, Muhar, M,, Roth, M,, Lai, D, Y,, Barbosa, I, A, M,, Kwon, J, S, & other authors, (2013), An optimized microRNA backbone for effective single-copy, RNAi, Cell Reports 5, 1704–1713
13. Ge, Q,, McManus, M, T,, Nguyen, T,, Shen, C,-H,, Sharp, P, A,, Eisen, H, N, & Chen, J, (2003), RNA interference of influenza virus, production by directly targeting mRNA for degradation and, indirectly inhibiting all viral RNA transcription, Proc Natl Acad Sci, U S A 100, 2718–2723
14. Ge, Q,, Filip, L,, Bai, A,, Nguyen, T,, Eisen, H, N, & Chen, J, (2004), Inhibition of influenza virus production in virus-infected mice by, RNA interference, Proc Natl Acad Sci U S A 101, 8676–8681
15. Gitlin, L,, Stone, J, K, & Andino, R, (2005), Poliovirus escape from, RNA interference: short interfering RNA: target recognition and, implications for therapeutic approaches, J Virol 79, 1027–1035
16. Grimm, D, & Kay, M, A, (2007), Combinatorial RNAi: a winning, strategy for the race against evolving targets? Mol Ther 15, 878–888
17. Grimm, D,, Streetz, K, L,, Jopling, C, L,, Storm, T, A,, Pandey, K,, Davis, C, R,, Marion, P,, Salazar, F, & Kay, M, A, (2006), Fatality in, mice due to oversaturation of cellular microRNA/short hairpin RNA, pathways, Nature 441, 537–541
18. Grimson, A,, Farh, K, K,-H,, Johnston, W, K,, Garrett-Engele, P,, Lim, L, P, & Bartel, D, P, (2007), MicroRNA targeting specificity, in mammals: determinants beyond seed pairing, Mol Cell 27,, 91–105
19. Haasnoot, J, & Berkhout, B, (2006), RNA interference: its use as, antiviral therapy, In RNA Towards Medicine (Handbook of, Experimental Pharmacology), vol, 173, pp, 117–150, Berlin: Springer
20. Haasnoot, P, C,, Cupac, D, & Berkhout, B, (2003), Inhibition of virus, replication by RNA interference, J Biomed Sci 10, 607–616
21. Hannon, G, J, (2002), RNA interference, Nature 418, 244–251
22. Jackson, A, L,, Bartz, S, R,, Schelter, J,, Kobayashi, S, V,, Burchard, J,, Mao, M,, Li, B,, Cavet, G, & Linsley, P, S, (2003), Expression profiling, reveals off-target gene regulation by RNAi, Nat Biotechnol 21,, 635–637
23. Khan, I, F,, Hirata, R, K, & Russell, D, W, (2011), AAV-mediated gene, targeting methods for human cells, Nat Protoc 6, 482–501
24. Kim, V, N, (2005), MicroRNA biogenesis: coordinated cropping and, dicing, Nat Rev Mol Cell Biol 6, 376–385
25. Lee, Y,, Jeon, K,, Lee, J, T,, Kim, S, & Kim, V, N, (2002), MicroRNA, maturation: stepwise processing and subcellular localization, EMBO, J 21, 4663–4670
26. Li, Y,, Anderson, D, H,, Liu, Q, & Zhou, Y, (2008), Mechanism of, influenza A virus NS1 protein interaction with the p85b, but not, the p85a, subunit of phosphatidylinositol 3-kinase (PI3K) and upregulation, of PI3K activity, J Biol Chem 283, 23397–23409
27. Lin, L,, Liu, Q,, Berube, N,, Detmer, S, & Zhou, Y, (2012a), 59-, Triphosphate-short interfering RNA: potent inhibition of influenza, A virus infection by gene silencing and RIG-I activation, J Virol 86,, 10359–10369
28. Lin, L,, Li, Y,, Pyo, H,-M,, Lu, X,, Raman, S, N, T,, Liu, Q,, Brown, E, G, &, Zhou, Y, (2012b), Identification of RNA helicase A as a cellular factor, that interacts with influenza A virus NS1 protein and its role in the, virus life cycle, J Virol 86, 1942–1954
29. Liu, Y, P,, Haasnoot, J,, ter Brake, O,, Berkhout, B, & Konstantinova, P, (2008), Inhibition of HIV-1 by multiple siRNAs expressed from a, single microRNA polycistron, Nucleic Acids Res 36, 2811–2824
30. Liu, Y, P, & Berkhout, B, (2013), Design of lentivirally expressed, siRNAs, Methods Mol Biol 942, 233–257
31. Martin, H, C,, Wani, S,, Steptoe, A, L,, Krishnan, K,, Nones, K,, Nourbakhsh, E,, Vlassov, A,, Grimmond, S, M, & Cloonan, N, (2014), Imperfect centered miRNA binding sites are common and, can mediate repression of target mRNAs, Genome Biol 15, R51
32. McBride, J, L,, Boudreau, R, L,, Harper, S, Q,, Staber, P, D,, Monteys, A, M,, Martins, I,, Gilmore, B, L,, Burstein, H,, Peluso, R, W, & other, authors (2008), Artificial miRNAs mitigate shRNA-mediated, toxicity in the brain: implications for the therapeutic development, of RNAi, Proc Natl Acad Sci U S A 105, 5868–5873
33. Saladino, R,, Barontini, M,, Crucianelli, M,, Nencioni, L,, Sgarbanti, R, & Palamara, A, T, (2010), Current advances in anti-influenza therapy, Curr Med Chem 17, 2101–2140
34. Shin, Y,-K,, Liu, Q,, Tikoo, S, K,, Babiuk, L, A, & Zhou, Y, (2007a), Influenza A virus NS1 protein activates the phosphatidylinositol 3-, kinase (PI3K)/Akt pathway by direct interaction with the p85, subunit of PI3K, J Gen Virol 88, 13–18
35. Shin, Y,-K,, Liu, Q,, Tikoo, S, K,, Babiuk, L, A, & Zhou, Y, (2007b), Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza, A virus propagation, J Gen Virol 88, 942–950
36. Tiscornia, G,, Singer, O,, Ikawa, M, & Verma, I, M, (2003), A general, method for gene knockdown in mice by using lentiviral vectors, expressing small interfering RNA, Proc Natl Acad Sci U S A 100,, 1844–1848
37. Tompkins, S, M,, Lo, C,-Y,, Tumpey, T, M, & Epstein, S, L, (2004), Protection against lethal influenza virus challenge by RNA, interference in vivo, Proc Natl Acad Sci U S A 101, 8682–8686
38. Tumpey, T, M, & Belser, J, A, (2009), Resurrected pandemic influenza, viruses, Annu Rev Microbiol 63, 79–98
39. Wilson, J, A, & Richardson, C, D, (2005), Hepatitis C virus replicons, escape RNA interference induced by a short interfering RNA, directed against the NS5b coding region, J Virol 79, 7050–7058