Prolonged oxygen kinetics during constant workload submaximal exercise is associated with disease severity in adult subjects with cystic fibrosis

Respiratory Care

Volumn 60, Issue 8, 2015, Pages 1164-1171

  Armeniakou, Eleni ^a   Perpati, Georgia ^a   Dimopoulos, Stavros ^b   Roditis, Petros ^b   Avdikou, Maria ^a   Barouchos, Nikolaos ^a   Dionisopoulou, Vasiliki ^a   Nanas, Serafim ^b  

^a Athens Chest Hospital   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cystic fibrosis; Submaximal exercise; Time constant (tau)

Indexed keywords

ADULT; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE SEVERITY; FEMALE; HUMAN; INSPIRATORY CAPACITY; LUNG FUNCTION TEST; MALE; OXYGEN CONSUMPTION; PULSE OXIMETER; SPIROMETRY; THORAX RADIOGRAPHY; WORKLOAD; YOUNG ADULT; BREATH ANALYSIS; BREATHING; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; NORMAL HUMAN; PATHOPHYSIOLOGY; PEAK EXPIRATORY FLOW; PHYSIOLOGY; PROCEDURES; RESISTANCE TRAINING; SEVERITY OF ILLNESS INDEX; STATISTICS AND NUMERICAL DATA;

ADULT; BREATH TESTS; CYSTIC FIBROSIS; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; OXYGEN CONSUMPTION; PEAK EXPIRATORY FLOW RATE; RESISTANCE TRAINING; RESPIRATION; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84944721796     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.03258     Document Type: Article

References (36)

1. Rohlfs EM, Zhou Z, Heim RA, Nagan N, Rosenblum LS, Flynn K, et al. Cystic fibrosis carrier testing in an ethnically diverse US population. Clin Chem 2011;57(6):841-848.
2. Cant N, Pollock N, Ford RC. CFTR structure and cystic fibrosis. Int J Biochem Cell Biol 2014;52:15-25.
3. Hewer SC, Tyrrell J. Cystic fibrosis and the transition to adult health services. Arch Dis Child 2008;93(10):817-821.
4. Sawicki GS, Dill EJ, Asher D, Sellers DE, Robinson WM. Advance care planning in adults with cystic fibrosis. J Palliat Med 2008;11(8): 1135-1141.
5. Simmonds NJ, Macneill SJ, Cullinan P, Hodson ME. Cystic fibrosis and survival to 40 years: a case-control study. Eur Respir J 2010; 36(6):1277-1283.
6. MacKenzie T, Gifford AH, Sabadosa KA, Quinton HB, Knapp EA, Goss CH, et al. Longevity of patients with cystic fibrosis in 2000 to 2010 and beyond: survival analysis of the cystic fibrosis foundation patient registry. Ann Int Med 2014;161(4):233-241.
7. Courtney JM, Bradley J, McCaughan J, O’Connor TM, Shortt C, Bredin CP, et al. Predictors of mortality in adults with cystic fibrosis. Pediatr Pulmonol 2007;42(6):525-532.
8. Urquhart DS. Exercise testing in cystic fibrosis: why (and how)? J R Soc Med 104 Suppl 1:S6-14, 2011.
9. Shwachman H, Kulczycki LL. Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteenyear period. J Dis Child 1958;96(1):6-15.
10. Pouliou E, Nanas S, Papamichalopoulos A, Kyprianou T, Perpati G, Mavrou I, Roussos. Prolonged oxygen kinetics during early recovery from maximal exercise in adult patients with cystic fibrosis. Chest 2001;119(4):1073-1078.
11. Pastre J, Prevotat A, Tardif C, Langlois C, Duhamel A, Wallaert B. Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease. BMC Pulm Med 2014;14:74.
12. Almajed A, Lands LC. The evolution of exercise capacity and its limiting factors in cystic fibrosis. Paediatr Respir Rev 2012;13(4): 195-199.
13. Hebestreit H, Hebestreit A, Trusen A, Hughson RL. Oxygen uptake kinetics are slowed in cystic fibrosis. Med Sci Sports Exerc 2005; 37(1):10-17.
14. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005;26(2):319-338.
15. Papazachou O, Anastasiou-Nana M, Sakellariou D, Tassiou A, Dimopoulos S, Venetsanakos J, et al. Pulmonary function at peak exercise in patients with chronic heart failure. Int J Cardiol 2007; 118(1):28-35.
16. Perpati G, Nanas S, Pouliou E, Dionyssopoulou V, Stefanatou E, Armeniakou E, et al. Resting respiratory variables and exercise capacity in adult patients with cystic fibrosis. Respir Med 2010;104(10): 1444-1449.
17. Hansen JE, Sue DY, Wasserman K. Predicted values for clinical exercise testing. Am J Respir Dis 129(2 Pt 2):S49-55, 1984.
18. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986;60(6): 2020-2027.
19. Nanas S, Nanas J, Kassiotis C, Alexopoulos G, Samakovli A, Kanakakis J, et al. Respiratory muscles performance is related to oxygen kinetics during maximal exercise and early recovery in patients with congestive heart failure. Circulation 1999;100(5): 503-508.
20. Roditis P, Dimopoulos S, Sakellariou D, Sarafoglou S, Kaldara E, Venetsanakos J, et al. The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure. Eur J Cardiovasc Prev Rehab 2007;14(2):304-311.
21. Vasileiadis I, Roditis P, Dimopoulos S, Ladis V, Pangalis G, Aessopos A, et al. Impaired oxygen kinetics in beta-thalassaemia major patients. Acta Physiol 2009;196(3):357-363.
22. Lamarra N, Whipp BJ, Ward SA, Wasserman K. Effect of interbreath fluctuations on characterizing exercise gas exchange kinetics. J Appl Physiol 1987;62(5):2003-2012.
23. Whipp BJ, Rossiter HB, Ward SA. Exertional oxygen uptake kinetics: a stamen of stamina? Biochem Soc Trans 2002;30(2): 237-247.
24. Whipp BJ, Ward SA, Lamarra N, Davis JA, Wasserman K. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 1982;52(6):1506-1513.
25. Somfay A, Pórszász J, Lee SM, Casaburi R. Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patients. Chest 2002;121(2):393-400.
26. Chiappa GR, Borghi-Silva A, Ferreira LF, Carrascosa C, Oliveira CC, Maia J, et al. Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics. J Appl Physiol 2008; 104(5):1341-1350.
27. Mettauer B, Zhao QM, Epailly E, Charloux A, Lampert E, Heitz- Naegelen B, et al. VO(2) kinetics reveal a central limitation at the onset of subthreshold exercise in heart transplant recipients. J Appl Physiol 2000;88(4):1228-1238.
28. Fukuoka Y, Grassi B, Conti M, Guiducci D, Sutti M, Marconi C, et al. Early effects of exercise training on on- and off-kinetics in 50-year-old subjects. Pflugers Arch Eur J Physiol 2002:443(5-6):690-697.
29. Grassi B. Skeletal muscle VO2 on-kinetics: set by O2 delivery or by O2 utilization? New insights into an old issue. Med Sci Sports Exercise 2000;32(1):108-116.
30. Manika K, Pitsiou GG, Boutou AK, Tsaoussis V, Chavouzis N, Antoniou M, et al. The impact of pulmonary arterial pressure on exercise capacity in mild-to-moderate cystic fibrosis: a case control study. Pulm Med 2012;252345, 2012.
31. Shapiro BL. Evidence for a mitochondrial lesion in cystic fibrosis. Life Sci 1989;44(19):1327-1334.
32. Valdivieso AG, Santa-Coloma TA. CFTR activity and mitochondrial function. Redox Biol 2013;1(1):190-202.
33. Shapiro BL, Feigal RJ, Lam LF. Mitrochondrial NADH dehydrogenase in cystic fibrosis. Proc Natl Acad Sci USA 1979;76(6):2979-2983.
34. de Meer K, Jeneson JA, Gulmans VA, van der Laag J, Berger R. Efficiency of oxidative work performance of skeletal muscle in patients with cystic fibrosis. Thorax 1995;50(9):980-983.
35. O’Rawe A, Dodge JA, Redmond AO, McIntosh J, Brock DJ. Gene/ energy interaction in cystic fibrosis. Lancet 1990;335(8688):552-553.
36. Xu F, Rhodes EC. Oxygen uptake kinetics during exercise. Sports Med 1999;27(5):313-327.evel2