The evolution of exercise capacity and its limiting factors in Cystic Fibrosis

Paediatric Respiratory Reviews

Volumn 13, Issue 4, 2012, Pages 195-199

  Almajed, Athari ^a   Lands, Larry C ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

Cardiac function; CF outcome; CF prognosis; Deadspace; Habitual physical activity; Nutrition; Pulmonary function; Skeletal muscle

Indexed keywords

CYSTIC FIBROSIS; EXERCISE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HABITUATION; HUMAN; LONGEVITY; LUNG CLEARANCE; LUNG DEAD SPACE; LUNG FUNCTION; LUNG VENTILATION; LUNG VOLUME; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUALITY OF LIFE; RESPIRATORY FUNCTION; REVIEW; SPIROMETRY;

AGE FACTORS; CYSTIC FIBROSIS; EXERCISE TOLERANCE; HUMANS;

EID: 84867626368     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2012.01.001     Document Type: Review

References (48)

1. Nixon P.A., Orenstein D.M., Kelsey S.F., Doershuk C.F. The prognostic value of exercise testing in patients with cystic fibrosis. N Engl J Med 1992 Dec 17, 327:1785-1788.
2. Pianosi P., LeBlanc J., Almudevar A. Relationship between FEV1 and peak oxygen uptake in children with cystic fibrosis. Pediatr Pulmonol 2005 Oct, 40:324-329.
3. de Jong W., Kaptein A.A., van der Schans C.P., Mannes G.P., van Aalderen W.M., Grevink R.G., Koëter G.H. Quality of life in patients with cystic fibrosis. Pediatr Pulmonol 1997 Feb, 23:95-100.
4. Cystic Fibrosis Foundation Patient Registry: Annual Data Report 2010. http://www.cff.org/UploadedFiles/LivingWithCF/CareCenterNetwork/PatientRegistry/Patient-Registry-Report-2010.pdf.
5. Canadian CF Patient Data Registry 2009 Report. http://www.cysticfibrosis.ca/assets/files/pdf/CPDR_ReportE.pdf.
6. Lands L.C., Heigenhauser G.J., Jones N.L. Analysis of factors limiting maximal exercise performance in cystic fibrosis. Clin Sci (Lond) 1992 Oct, 83:391-397.
7. Cropp G.J., Pullano T.P., Cerny F.J., Nathanson I.T. Exercise tolerance and cardiorespiratory adjustments at peak work capacity in cystic fibrosis. Am Rev Respir Dis 1982 Aug, 126:211-216.
8. Clinical Exercise Testing 4th ed. NL Jones. WB Saunders Company Philadelphia, 1997 pages 10-152.
9. Alison J.A., Regnis J.A., Donnelly P.M., Adams R.D., Sullivan C.E., Bye P.T. End-expiratory lung volume during arm and leg exercise in normal subjects and patients with cystic fibrosis. Am J Respir Crit Care Med 1998 Nov, 158(5 Pt 1):1450-1458.
10. Godfrey S., Mearns M. Pulmonary function and response to exercise in cystic fibrosis. Arch Dis Child 1971 Apr, 46:144-151.
11. Kraemer R., Blum A., Schibler A., et al. Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis. Am J Respir Crit Care Med 2005, 171:371e8.
12. Owens C.M., Aurora P., Stanojevic S., Bush A., Wade A., Oliver C., Calder A., Price J., Carr S.B., Shankar A., Stocks J. London Cystic Fibrosis Collaboration. Lung Clearance Index and HRCT are complementary markers of lung abnormalities in young children with CF. Thorax 2011 Jun, 66:481-488.
13. Robinson P.D., Cooper P., Van Asperen P., et al. Using index of ventilation to assess response to treatment for acute pulmonary exacerbation in children with cystic fibrosis. Pediatr Pulmonol 2009, 44. 733e42.18.
14. Scrase E., Oliver C., Kozlowska W., et al. Change in lung clearance index (LCI) following intravenous antibiotic intervention in children with CF [abstract]. Eur Respir J 2008, 32. 514se15s.
15. Amin R., Subbarao P., Lou W., Jabar A., Balkovec S., Jensen R., Kerrigan S., Gustafsson P., Ratjen F. The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis. Eur Respir J 2011 Apr, 37:806-812.
16. Amin R., Subbarao P., Jabar A., et al. Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function. Thorax 2010, 65:379e83.
17. McKone E.F., Barry S.C., Fitzgerald M.X., Gallagher C.G. Role of arterial hypoxemia and pulmonary mechanics in exercise limitation in adults with cystic fibrosis. J Appl Physiol 2005 Sep, 99:1012-1018.
18. Leroy S., Perez T., Neviere R., Aguilaniu B., Wallaert B. Determinants of dyspnea and alveolar hypoventilation during exercise in cystic fibrosis: impact of inspiratory muscle endurance. J Cyst Fibros 2011 May, 10:159-165. 10.1016/j.jcf.2010.12.0.
19. Bellemare F., Jeanneret A. Sex differences in thoracic adaptation to pulmonary hyperinflation in cystic fibrosis. Eur Respir J 2007, 29:98-107.
20. Orenstein D.M., Nixon P.A. Exercise performance and breathing patterns in cystic fibrosis: male-female differences and influence of resting pulmonary function. Pediatr Pulmonol 1991, 10:101-105.
21. Lands L.C., Heigenhauser G.J., Jones N.L. Cardiac output determination during progressive exercise in cystic fibrosis. Chest 1992 Oct, 102:1118-1123.
22. Pianosi P., Pelech A. Stroke volume during exercise in cystic fibrosis. Am J Respir Crit Care Med 1996 Mar, 153:1105-1109.
23. Koelling T.M., Dec G.W., Ginns L.C., Semigran M.J. Left ventricular diastolic function in patients with advanced cystic fibrosis. Chest 2003 May, 123:1488-1494.
24. Labombarda F., Pellissier A., Ellafi M., Creveuil C., Ribault V., Laurans M., Guillot M., Bergot E., Grollier G., Milliez P., Zalcman G., Saloux E. Myocardial strain assessment in cystic fibrosis. J Am Soc Echocardiogr 2011 Sep, 24(9):1037-1045.
25. Pinet C., Scillia P., Cassart M., Lamotte M., Knoop C., Mélot C., Estenne M. Preferential reduction of quadriceps over respiratory muscle strength and bulk after lung transplantation for cystic fibrosis. Thorax 2004 Sep, 59:783-789.
26. Laviolette L., Lands L.C., Dauletbaev N., Saey D., Milot J., Provencher S., LeBlanc P., Maltais F. Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot study. J Med Food 2010 Jun, 13:589-598.
27. Troosters T., Langer D., Vrijsen B., Segers J., Wouters K., Janssens W., Gosselink R., Decramer M., Dupont L. Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis. Eur Respir J 2009 Jan, 33:99-106.
28. Selvadurai H.C., Allen J., Sachinwalla T., Macauley J., Blimkie C.J., Van Asperen P.P. Muscle function and resting energy expenditure in female athletes with cystic fibrosis. Am J Respir Crit Care Med 2003 Dec 15, 168:1476-1480.
29. Wells G.D., Wilkes D.L., Schneiderman J.E., Rayner T., Elmi M., Selvadurai H., Dell S.D., Noseworthy M.D., Ratjen F., Tein I., Coates A.L. Skeletal muscle metabolism in cystic fibrosis and primary ciliary dyskinesia. Pediatr Res 2011 Jan, 69:40-45.
30. Tirakitsoontorn P., Nussbaum E., Moser C., Hill M., Cooper D.M. Fitness, acute exercise, and anabolic and catabolic mediators in cystic fibrosis. Am J Respir Crit Care Med 2001 Oct 15, 164(8 Pt 1):1432-1437.
31. Lamhonwah A.M., Bear C.E., Huan L.J., Kim Chiaw P., Ackerley C.A., Tein I. Cystic fibrosis transmembrane conductance regulator in human muscle: Dysfunction causes abnormal metabolic recovery in exercise. Ann Neurol 2010 Jun, 67:802-808.
32. Leifke E., Friemert M., Heilmann M., Puvogel N., Smaczny C., von zur Muhlen A., Brabant G. Sex steroids and body composition in men with cystic fibrosis. Eur J Endocrinol 2003 May, 148:551-557.
33. Barry P.J., Waterhouse D.F., Reilly C.M., McKenna T.J., McKone E.F., Gallagher C.G. Androgens, exercise capacity, and muscle function in cystic fibrosis. Chest 2008 Dec, 134:1258-1264.
34. Barry S.C., Gallagher C.G. Corticosteroids and skeletal muscle function in cystic fibrosis. J Appl Physiol 2003 Oct, 95:1379-1384.
35. Hebestreit H., Kieser S., Rüdiger S., Schenk T., Junge S., Hebestreit A., Ballmann M., Posselt H.G., Kriemler S. Physical activity is independently related to aerobic capacity in cystic fibrosis. Eur Respir J 2006 Oct, 28:734-739.
36. Hebestreit A., Kersting U., Basler B., Jeschke R., Hebestreit H. Exercise inhibits epithelial sodium channels in patients with cystic fi brosis. Am J Respir Crit Care Med 2001, 164(3):443-446.
37. Klijn P.H., van der Net J., Kimpen J.L., Helders P.J., van der Ent C.K. Longitudinal determinants of peak aerobic performance in children with cystic fibrosis. Chest 2003, 124:2215-2219.
38. Selvadurai H.C., Blimkie C.J., Meyers N., Mellis C.M., Cooper P.J., Van Asperen P.P. Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis. Pediatr Pulmonol 2002, 33:194-200.
39. Klijn P.H., Oudshoorn A., van der Ent C.K., van der Net J., Kimpen J.L., Helders P.J. Effects of anaerobic training in children with cystic fibrosis: a randomized controlled study. Chest 2004, 125:1299-1305.
40. Button B., Picher M., Boucher R.C. Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia. J Physiol 2007, 580(pt 2):577-592.
41. Nixon P.A., Orenstein D.M., Kelsey S.F. Habitual physical activity in children and adolescents with cystic fibrosis. Med Sci Sports Exerc 2001 Jan, 33(1):30-35.
42. Alarie N. Assessment of habitual physical activity should be part of the regular assessment of CF patients. Ped Pulmonol Suppl 2011, 34:134-135.
43. Wells G.D., Wilkes D.L., Schneiderman-Walker J., Elmi M., Tullis E., Lands L.C., Ratjen F., Coates A.L. Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosis. Pediatr Pulmonol 2008 Apr, 43:345-353.
44. Malina R.M., Katzmarzyk P.T. Physical activity and fitness in an international growth standard for preadolescent and adolescent children. Food Nutr Bull 2006 Dec, 27(4 Suppl Growth Standard):S295-S313.
45. Klijn P.H., Oudshoorn A., van der Ent C.K., van der Net J., Kimpen J.L., Helders P.J. Effects of anaerobic training in children with cystic fibrosis: a randomized controlled study. Chest 2004 Apr, 125:1299-1305.
46. Moorcroft A.J., Dodd M.E., Webb A.K. Exercise testing and prognosis in adult cystic fibrosis. Thorax 1997 Mar, 52:291-293.
47. Lands L.C., Milner R., Cantin A.M., Manson D., Corey M. High-dose ibuprofen in cystic fibrosis: Canadian safety and effectiveness trial. J Pediatr 2007 Sep, 151:249-254.
48. Saiman L., Anstead M., Mayer-Hamblett N., Lands L.C., Kloster M., Hocevar-Trnka J., Goss C.H., Rose L.M., Burns J.L., Marshall B.C., Ratjen F. Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 2010 May 5, 303:1707-1715. AZ0004 Azithromycin Study Group.