V̇O2 kinetics reveal a central limitation at the onset of subthreshold exercise in heart transplant recipients

Journal of Applied Physiology

Volumn 88, Issue 4, 2000, Pages 1228-1238

  Mettauer, Bertrand ^a   Zhao, Quan Ming ^a   Epailly, Eric ^a   Charloux, Anne ^a   Lampert, Eliane ^a   Heitz Naegelen, Bernadette ^a   Piquard, François ^a   Di Prampero, Pietro E ^b   Lonsdorfer, Jean ^a  

^a Hopital Central Strasbourg   (France)

^b UNIVERSITY OF UDINE   (Italy)

Author keywords

Heart rate; Heart transplantation; Oxygen consumption; Pulmonary gas exchange

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; EXPIRED AIR; GAS ANALYSIS; HEART RATE; HEART TRANSPLANTATION; HUMAN; LUNG GAS EXCHANGE; LUNG VENTILATION; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; BREATHING; EXERCISE TEST; PHYSIOLOGY; REFERENCE VALUE;

ADULT; EXERCISE; EXERCISE TEST; EXERTION; HEART RATE; HEART TRANSPLANTATION; HUMANS; MALE; OXYGEN CONSUMPTION; REFERENCE VALUES; RESPIRATION;

EID: 0034167418     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.4.1228     Document Type: Article

References (40)

1. 2 uptakes by circulatory dynamics during exercise. J Appl Physiol 68: 979-989, 1990.
2. Beaver WL, Lamarra N, and Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol 51: 1662-1675, 1981.
3. Beaver WL, Wasserman K, and Whipp BJ. On-line computer analysis and breath-by-breath graphical display of exercise function tests. J Appl Physiol 34: 128-132, 1973.
4. Bernardi L, Bianchini B, Spadacini G, Leuzzi S, Valle F, Marchesi E, Passino C, Calciati A, Vigano M, Rinaldi M, Martinelli L, Finardi G, and Sleight P. Demonstrable cardiac reinnervation after human heart transplantation by carotid baroreflex modulation of RR interval. Circulation 92: 2895-2903, 1995.
5. Bussières LM, Pflugfelder PW, Menkis AH, Novick RJ, McKenzie N, Taylor AW, and Kostuk WJ. Basis for aerobic impairment in patients after heart transplantation. J Heart Lung Transplant 14: 1073-1080, 1995.
6. Casaburi R, Daly J, Hansen JE, and Effros RM. Abrupt changes in mixed venous blood gas composition after the onset of exercise. J Appl Physiol 67: 1106-1112, 1989.
7. Casaburi R, Spitzer S, and Wasserman K. Effects of altering heart rate on oxygen uptake at exercise onset. Chest 95: 6-12, 1989.
8. Cerretelli P, Marconi C, Meyer M, Ferretti G, and Grassi B. Gas exchange and metabolic transients in heart transplant recipients. Respir Physiol 74: 355-371, 1988.
9. Cerretelli P, Marconi C, Meyer M, Ferretti G, and Grassi B. Gas exchange kinetics in heart transplant recipients. Chest 101: 199S-205S, 1992.
10. 2 transport and utilization mechanisms at the onset of exercise. J Appl Physiol 73: 2382-2388, 1992.
11. 2 deficit at the onset of stepping and cycling. J Appl Physiol 66: 2023-2031, 1989.
12. Gaesser GA and Poole DC. The slow component of oxygen uptake kinetics in humans. Exerc Sports Sci Rev 24: 35-71, 1996.
13. Gilbert EM, Eiswirth CC, Mealey PC, Larrabee P, Herrick CM, and Bristow MR. β-Adrenergic supersensitivity of the transplanted human heart is presynaptic in origin. Circulation 79: 344-349, 1989.
14. Grassi B, Ferretti G, Xi L, Rieu M, Meyer M, Marconi C, and Cerretelli P. Ventilatory response to exercise after heart and lung denervation in humans. Respir Physiol 92: 289-304, 1993.
15. Grassi B, Marconi C, Meyer M, Rieu M, and Cerretelli P. Gas exchange and cardiovascular kinetics with different exercise protocols in heart transplant recipients. J Appl Physiol 82: 1952-1962, 1997.
16. 2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80: 988-998, 1996.
17. Jones PW, French W, Weissman ML, and Wasserman K. Ventilatory response to cardiac output changes in patients with pacemakers. J Appl Physiol 51: 1103-1107, 1981.
18. Kao AC, Van Trigt P III, Shaeffer-McCall GS, Shaw JP, Kuzil BB, Page RP, and Higginbotham MB. Central and peripheral limitations to upright exercise in untrained cardiac transplant recipients. Circulation 89: 2605-2615, 1994.
19. Kavanagh T, Yacoub MH, Mertens DJ, Kennedy J, Campbell RB, and Sawyer P. Cardiorespiratory response to exercise training after orthotopic cardiac transplantation. Circulation 77: 162-171, 1988.
20. Koike A, Wasserman K, McKenzie DK, Zanconato S, and Weiler-Ravell D. Evidence that diffusion limitation determines oxygen uptake kinetics during exercise in humans. J Clin Invest 86: 1698-1706, 1990.
21. Krogh A and Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J Physiol (Lond) 47: 112-136, 1913.
22. Lamarra N, Whipp BJ, Ward SA, and Wasserman K. Breath by breath "noise" and parameter estimation of gas exchange kinetics. J Appl Physiol 62: 2003-2012, 1987.
23. Lampert E, Mettauer B, Hoppeler H, Charloux A, Charpentier A, and Lonsdorfer J. Structure of skeletal muscle in heart transplant recipients. J Am Coll Cardiol 28: 980-984, 1996.
24. Mandak JS, Aaronson KD, and Mancini DM. Serial assessment of exercise capacity after heart transplantation. J Heart Lung Transplant 14: 468-478, 1995.
25. McCreary CR, Chilibeck PD, Marsh GD, Paterson DH, Cunningham DA, and Thompson RT. Kinetics of pulmonary oxygen uptake and muscle phosphates during moderate-intensity calf exercise. J Appl Physiol 81: 1331-1338, 1996.
26. 2 Transport and Tissue Oxygenation, edited by Reinhart K and Eyrich K. Berlin: Springer Verlag, 1989, p. 476-499.
27. Paterson DH, Cunningham DA, Pickering JG, Babcock MA, and Boughner DR. Oxygen uptake kinetics in cardiac transplant recipients. J Appl Physiol 77: 1935-1940, 1994.
28. Paulus WJ, Bronzwaer JGF, Felice H, Kishan N, and Wellens F. Deficient acceleration of left ventricular relaxation during exercise after heart transplantation. Circulation 86: 1175-1185, 1992.
29. Perini R, Orizio C, Gamba A, and Veicsteinas A. Kinetics of heart rate and catecholamines during exercise in humans, the effects of heart denervation. Eur J Appl Physiol 66: 500-506, 1993.
30. Sietsema KE. Oxygen uptake kinetics in response to exercise in patients with pulmonary vascular disease. Am Rev Respir Dis 145: 1052-1057, 1992.
31. Sietsema KE, Cooper DM, Perloff JK, Rosove MH, Child JS, Canobbio MM, Whipp BJ, and Wasserman K. Dynamics of oxygen uptake during exercise in adults with cyanotic congenital heart disease. Circulation 73: 1137-1144, 1986.
32. 2 uptake and heart rate as affected by exercise work rate. J Appl Physiol 67: 2535-2541, 1989.
33. Simonini A, Long CS, Dudley GA, Yue P, McElhinny J, and Massie BM. Heart failure in rats causes changes in skeletal muscle morphology and gene expression that are not explained by reduced activity. Circ Res 79: 128-136, 1996.
34. Valantine HA, Appleton CP, Hatle LK, Hunt SA, Billingham ME, Shumway NE, Stinson EB, and Popp RL. A hemodynamic and doppler echocardiographic study of ventricular function in long term cardiac allograft recipients. Circulation 79: 66-75, 1989.
35. Van de Meer BJ, Woltjer HH, Sousman AM, Schreuder WO, Bulder ER, Huybregts MA, and de Vries PM. Impedance cardiography. Importance of the equation and electrode configuration. Int Care Med 22: 1120-1124, 1996.
36. Whipp BJ and Ward SA. Physiological determinants of pulmonary gas exchange kinetics during exercise. Med Sci Sports Exerc 22: 62-71, 1990.
37. Whipp BJ, Ward SA, Lamarra N, Davies JA, and Wasserman K. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 52: 1506-1513, 1982.
38. Wilson RF, Laxson DD, Christensen BV, McGinn AL, and Kubo SH. Regional differences in sympathetic reinnervation after human orthotopic cardiac transplantation. Circulation 88: 165-171, 1993.
39. Xu F and Rhodes EC. Oxygen uptake kinetics during exercise. Sports Med 27: 313-327, 1999.
40. Yoshida T, Yamamoto K, and Udo M. Relationship between cardiac output and oxygen uptake at the onset of exercise. Eur J Appl Physiol 66: 155-160, 1993.