Small-Molecule Regulators of MicroRNAs in Biomedicine

Drug Development Research

Volumn 76, Issue 7, 2015, Pages 375-381

  Xia, Tingting ^a   Li, Jinbo ^a   Cheng, Hao ^a   Zhang, Chenyu ^a   Zhang, Yan ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

microRNA; probe; regulation; small molecule; therapeutic

Indexed keywords

ARGONAUTE 2 PROTEIN; DICER; MICRORNA; MICRORNA 122; MICRORNA 21; MICRORNA 34A; SMALL MOLECULE TRANSPORT AGENT; MOLECULAR LIBRARY;

BIOMEDICINE; CANCER RESEARCH; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR PROBE; NONHUMAN; REVIEW; DRUG DEVELOPMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MOLECULAR LIBRARY; PHARMACOLOGY; PROCEDURES;

DRUG DISCOVERY; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; SMALL MOLECULE LIBRARIES;

EID: 84944685830     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.21271     Document Type: Review

References (43)

1. Bartel DP., 2009. MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
2. Bose D, Jayaraj G, Suryawanshi H, Agarwala P, Pore SK, Banerjee R, Maiti S., 2012. The tuberculosis drug streptomycin as a potential cancer therapeutic: inhibition of miR-21 function by directly targeting its precursor. Angew Chem Int Ed 51: 1019-1023.
3. Bouchie A., 2013. First microRNA mimic enters clinic. Nat Biotechnol 31: 577.
4. Callis TE, Chen JF, Wang DZ., 2007. MicroRNAs in skeletal and cardiac muscle development. DNA Cell Biol 26: 219-225.
5. Chan JA, Krichevsky AM, Kosik KS., 2005. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029-6033.
6. Chandrasekhar S, Pushpavalli SN, Chatla S, Mukhopadhyay D, Ganganna B, Vijeender K, Srihari P, Reddy CR, Janaki Ramaiah M, Bhadra U., 2012. aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle. Bioorg Med Chem Lett 22: 645-648.
7. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ., 2006. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet 38: 228-233.
8. Chen X, Huang C, Zhang W, Wu Y, Chen X, Zhang CY, Zhang Y., 2012. A universal activator of microRNAs identified from photoreaction products. Chem Commun 48: 6432-6434.
9. Connelly CM, Thomas M, Deiters A., 2012. High-throughput luciferase reporter assay for small-molecule inhibitors of microRNA function. J Biomol Screen 17: 822-828.
10. Davies BP, Arenz C., 2008. A fluorescence probe for assaying micro RNA maturation. Bioorg Med Chem 16: 49-55.
11. Deiters A., 2010. Small molecule modifiers of the microRNA and RNA interference pathway. AAPS J 12: 51-60.
12. Frey AG, Nandal A, Park JH, Smith PM, Yabe T, Ryu MS, Ghosh MC, Lee J, Rouault TA, Park MH, et al., 2014. Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. Proc Natl Acad Sci USA 111: 8031-8036.
13. Gumireddy K, Young DD, Xiong X, Hogenesch JB, Huang Q, Deiters A., 2008. Small-molecule inhibitors of microRNA miR-21 function. Angew Chem Int Ed 47: 7482-7484.
14. Jopling C., 2012. Liver-specific microRNA-122: biogenesis and function. RNA Biol 9: 137-142.
15. Karagonlar ZF, Korhan P., Atabey N., 2015. Targeting c-Met in Cancer by MicroRNAs: potential therapeutic applications in hepatocellular carcinoma. Drug Dev Res.
16. Khong A, Forestieri R, Williams DE, Patrick BO, Olmstead A, Svinti V, Schaeffer E, Jean F, Roberge M, Andersen RJ, et al.,. 2012. A daphnane diterpenoid isolated from Wikstroemia polyantha induces an inflammatory response and modulates miRNA activity. PLoS One 7: e39621.
17. Klemm CM, Berthelmann A, Neubacher S, Arenz C., 2009. Short and efficient synthesis of alkyne-modified amino glycoside building blocks. Eur J Organ Chem 17: 2788-2794.
18. Kornfeld JW, Bruning JC., 2012. MyomiRs-133a/b turn off the heat. Nat Cell Biol 14: 1248-1249.
19. Lewis BP, Burge CB, Bartel DP., 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15-20.
20. Li J, Tan S, Kooger R, Zhang C, Zhang Y., 2014. MicroRNAs as novel biological targets for detection and regulation. Chem Soc Rev 43: 506-517.
21. Li J, Zhang W, Zhou M, Kooger R, Zhang Y., 2013. Small molecules modulating biogenesis or processing of microRNAs with therapeutic potentials. Curr Med Chem 20: 3604-3612.
22. Li Y, Lin L, Li Z, Ye X, Xiong K, Aryal B, Xu Z, Paroo Z, Liu Q, He C, et al., 2012. Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2. Cell Metab 15: 895-904.
23. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al., 2005. MicroRNA expression profiles classify human cancers. Nature 435: 834-838.
24. Madsen C, Hooper I, Lundberg L, Shafagati N, Johnson A, Senina S, de la Fuente C, Hoover LI, Fredricksen BL, Dinman J, et al., 2014. Small molecule inhibitors of Ago2 decrease Venezuelan equine encephalitis virus replication. Antiviral Res 112: 26-37.
25. Maiti M, Nauwelaerts K, Herdewijn P., 2012. Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing. Bioorg Med Chem Lett 22: 1709-1711.
26. Masciarelli S, Quaranta R, Iosue I, Colotti G, Padula F, Varchi G, Fazi F, Del Rio A., 2014. A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4. ACS Chem Biol 9: 1674-1679.
27. Melo S, Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, et al., 2011. Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci USA 108: 4394-4399.
28. Murata A, Fukuzumi T, Umemoto S, Nakatani K., 2013. Xanthone derivatives as potential inhibitors of miRNA processing by human Dicer: targeting secondary structures of pre-miRNA by small molecules. Bioorg Med Chem Lett 23: 252-255.
29. Rao PK, Kumar RM, Farkhondeh M, Baskerville S, Lodish HF., 2006. Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci USA 103: 8721-8726.
30. Shan G, Li Y, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, et al., 2008. A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol 26: 933-940.
31. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, et al., 2012. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148: 213-227.
32. Tan GS, Chiu CH, Garchow BG, Metzler D, Diamond SL, Kiriakidou M., 2012. Small molecule inhibition of RISC loading. ACS Chem Biol 7: 403-410.
33. Tan S, Wu Y, Zhang CY, Li J., 2013a. Potential microRNA targets for cancer chemotherapy. Curr Med Chem 20: 3574-3581.
34. Tan SB, Huang C, Chen X, Wu Y, Zhou M, Zhang C, Zhang Y., 2013b. Small molecular inhibitors of miR-1 identified from photocycloadducts of acetylenes with 2-methoxy-1,4-naphthalenequinone. Bioorg Med Chem 21: 6124-61231.
35. Tan SB, Li J, Chen X, Zhang W, Zhang D, Zhang C, Li D, Zhang Y., 2014. Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway. Chem Biol 21: 1265-1270.
36. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H., 2007. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 104: 15472-15477.
37. Velagapudi SP, Gallo SM, Disney MD., 2014. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat Chem Biol 10: 291-297.
38. Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, et al.,. 2013. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol 9: 84-89.
39. Watashi K, Yeung ML, Starost MF, Hosmane RS, Jeang KT., 2010. Identification of small molecules that suppress microRNA function and reverse tumorigenesis. J Biol Chem 285: 24707-24716.
40. Welch C, Chen Y, Stallings RL., 2007. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26: 5017-5022.
41. Xiao Z, Li CH, Chan SL, Xu F, Feng L, Wang Y, Jiang JD, Sung JJ, Cheng CH, Chen Y., 2014. A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma. Cancer Res 74: 6236-6247.
42. Yamakuchi M, Ferlito M, Lowenstein CJ., 2008. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA 105: 13421-13426.
43. Young DD, Connelly CM, Grohmann C, Deiters A., 2010. Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma. J Am Chem Soc 132: 7976-7981.