Mass spectrometry evaluation of the hepcidin-25 assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients

European Journal of Haematology

Volumn 95, Issue 5, 2015, Pages 467-471

  Karlsson, Torbjörn ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Anaemia of inflammation; Hepcidin 25; Iron deficiency

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; HEPCIDIN; HEPCIDIN 25; IRON; UNCLASSIFIED DRUG; HEPCIDIN 25, HUMAN;

AGED; ANEMIA; ANEMIA OF INFLAMMATION; ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; GASTROINTESTINAL HEMORRHAGE; GERIATRIC PATIENT; HEPCIDIN 25 ASSAY; HUMAN; INFECTION; INFLAMMATION; IRON DEFICIENCY ANEMIA; MALE; NEOPLASM; PRIORITY JOURNAL; PROTEIN DETERMINATION; SENSITIVITY AND SPECIFICITY; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; VASCULITIS; ANEMIA, IRON-DEFICIENCY; BLOOD; CLINICAL TRIAL; MASS SPECTROMETRY; METABOLISM; PREDICTIVE VALUE; PROCEDURES; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; C-REACTIVE PROTEIN; DIAGNOSIS, DIFFERENTIAL; FEMALE; HEPCIDINS; HUMANS; INFLAMMATION; MALE; MASS SPECTROMETRY; PREDICTIVE VALUE OF TESTS;

EID: 84944513543     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12518     Document Type: Article

References (30)

1. Merchant A, Roy C. Not so benign haematology: anaemia of the elderly. Br J Haematol 2012;156:173-85.
2. Woorwood M. Laboratory determination of iron status. In: Brock J, Halliday J, Pippard M, Powell M, eds. Iron Metabolism in Health and Disease. London: W B Saunders; 1994:449-76.
3. Nemeth E, Valore E, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation is a type II acute phase protein. Blood 2003;101:2461-3.
4. Roy C, Andrews N. Anemia of inflammation: the hepcidin link. Curr Opin Hematol 2005;12:107-11.
5. Baer A, Dessypris E, Krantz S. The pathogenesis of anemia in rheumatoid arthritis: a clinical and laboratory analysis. Semin Arthritis Rheum 1990;19:209-23.
6. D'Angelo G. Role of hepcidin in the pathophysiology and diagnosis of anaemia. Blood Res 2013;48:10-5.
7. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Novel urine hepcidin assay by mass spectrometry. Blood 2005;106:3268-70.
8. Kemna E, Tjalsma H, Podust V, Swinkels D. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 2007;53:620-8.
9. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human hepcidin. Blood 2008;112:4292-7.
10. Ward D, Roberts K, Stonelake P, Goon P, Zampronio C, Martin A, Johnson P, Iqbal T, Tselepis T. SELDI-TOF-MS determination of hepcidin in clinical samples using stable isotope labelled hepcidin as an internal standard. Proteome Sci 2008;6:28.
11. Brugnara C, Zurakowski D, DiCanzio J, Boyd T, Platt O. Reticulocyte hemoglobin content to diagnose iron deficiency in children. JAMA 1999;281:2225-30.
12. Punnonen K, Irjala K, Rajamäki A. Iron-deficiency anemia is associated with high concentrations of transferrin receptor in serum. Clin Chem 1994;40:774-6.
13. Punnonen K, Irjala K, Rajamäki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 1997;89:1052-7.
14. Burns E, Goldberg H, Lawrence C, Wenz B. Clinical utility of serum tests for iron deficiency in hospitalized patients. Am J Pathol 1990;93:240-5.
15. Intragumtornchai T, Rojnukkarin P, Swasdikul D, Israsena S. The role of serum ferritin in the diagnosis of iron deficiency anaemia in patients with liver cirrhosis. J Intern Med 1998;243:233-41.
16. Mast A, Blinder M, Gronowski A, Chumley C, Scott M. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 1998;44:45-51.
17. Genc S, Erten N, Bessik S, Saka B, Tascioglu C, Sivas A. Soluble transferrin receptor and soluble transferrin receptor-ferritin index for evaluation of the iron status in elderly patients. Tohuko J Exp Med 2004;20:135-42.
18. Karlsson T. Comparative evaluation of the reticulocyte hemoglobin content assay when screening for iron deficiency in elderly anemic patients. Anemia 2011;2011: article ID 925907.
19. Kroot J, Laarakkers C, Geurts-Moespot A, et al. Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders. Clin Chem 2010;56:1570-9.
20. Van Santen S, Dongen-Lases E, de Vegt F, Laarakkers C, van Riel P, van Ede A, Swinkels D. Hepcidin and hemoglobin content parameters in the diagnosis of iron deficiency in rheumatoid arthritis patients with anemia. Arthritis Rheum 2011;63:3672-80.
21. Butterfield A, Luan P, Witcher D, Manetta J, Murphy A, Wroblewski V, Konrad R. A dual-monoclonal sandwich ELISA specific for hepcidin-25. Clin Chem 2010;56:1725-32.
22. Toima S, Saleh A, Madkour M, Hamman O, Baioumi E. Role of hepcidin in anemia of chronic hepatitis c patients. J Am Sci 2010;6:145-54.
23. Shu T, Jing C, Lv Z, Xie Y, Xu J, Wu J. Hepcidin in tumor-related iron deficiency anemia and tumor-related anemia of chronic disease: pathogenic mechanisms and diagnosis. Eur J Haematol 2014. doi:10.1111/ejh.12402; Online first 31 July.
24. Geerts I, Vermeersch P, Joosten E. Evaluation of the first commercial hepcidin ELISA for the differential diagnosis of anemia of chronic disease and iron deficiency anemia in hospitalized geriatric patients. ISRN Hematol 2012;2012:article ID 567491.
25. Grivennikov S, Greten F, Karin M. Immunity, inflammation and cancer. Cell 2010;140:883-99.
26. Silverstein D. Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease. Pediatr Nephrol 2009;24:1445-52.
27. Anker S, von Haehling S. Inflammatory mediators in chronic heart failure: an overview. Heart 2004;90:464-70.
28. Thomas C, Kobold U, Balan S, Roedigger R, Thomas L. Serum hepcidin-25 may replace the ferritin index index in the Thomas plot in assessing iron status in anemic patients. Int J Lab Hematol 2011;33:187-93.
29. Lasocki S, Baron G, Driss F, Westerman M, Puy H, Boutron I, Beaumont C, Montravers P. Diagnostic accuracy of serum hepcidin for iron deficiency in critically ill patients with anemia. Intensive Care Med 2010;36:1044-8.
30. Ganter U, Arcone R, Toniatti C, Morrone G, Ciliberto G. Dual control of c-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J 1989;8:3773-9.