Opposed expression of IKK': Loss in keratinizing carcinomas and gain in non-keratinizing carcinomas

Oncotarget

Volumn 6, Issue 28, 2015, Pages 25499-25505

  Xiao, Desheng ^a   Jia, Jiantao ^b   Shi, Ying ^b,c,d   Fu, Chunyan ^a   Chen, Ling ^b,c,d   Jiang, Yiqun ^b,c,d   Zhou, Li ^a   Liu, Shuang ^a   Tao, Yongguang ^b,c,d  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d National Health and Family Planning Commission   (China)

Author keywords

IKKa; Keratinizing cancer; Non keratinizing cancer

Indexed keywords

I KAPPA B KINASE; CHUK PROTEIN, HUMAN; KERATIN; TUMOR MARKER;

ARTICLE; CANCER CLASSIFICATION; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; KERATINIZATION; KERATINIZING NASOPHARYNGEAL CARCINOMA; KERATINIZING SQUAMOUS CELL CARCINOMA; NASOPHARYNX CARCINOMA; NON KERATINIZING NASOPHARYNGEAL CARCINOMA; PROTEIN EXPRESSION; SQUAMOUS CELL LUNG CARCINOMA; TUMOR DIFFERENTIATION; COMPARATIVE STUDY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; LUNG TUMOR; META ANALYSIS; MORTALITY; NASOPHARYNX TUMOR; PATHOLOGY; PHENOTYPE; PROGNOSIS; SQUAMOUS CELL CARCINOMA; TIME FACTOR;

BIOMARKERS, TUMOR; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; KAPLAN-MEIER ESTIMATE; KERATINS; LUNG NEOPLASMS; NASOPHARYNGEAL NEOPLASMS; PHENOTYPE; PROGNOSIS; TIME FACTORS;

EID: 84944472828     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4548     Document Type: Article

References (37)

1. Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008; 132:344-362.
2. Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nature reviews Molecular cell biology. 2007; 8:49-62.
3. Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nature reviews Immunology. 2005; 5:749-759.
4. Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001; 293:1495-1499.
5. Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annual review of immunology. 2009; 27:693-733.
6. Cao Y, Luo JL, Karin M. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2- transformed mammary tumor-initiating cells. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104:15852-15857.
7. Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. Nuclear cytokineactivated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007; 446:690-694.
8. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011; 470:548-553.
9. Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. A NIKIKKalpha module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer cell. 2013; 23:647-659.
10. Goktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, et al. IKKalpha promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells. Cell reports. 2014; 7:1914-1925.
11. Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer cell. 2008; 14:212-225.
12. Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, et al. The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer cell. 2013; 23:527-540.
13. Lieberman PM. Virology. Epstein-Barr virus turns 50. Science. 2014; 343:1323-1325.
14. Mesri EA, Feitelson MA, Munger K. Human viral oncogenesis: a cancer hallmarks analysis. Cell host & microbe. 2014; 15:266-282.
15. Deng L, Li Y, Ai P, Xie Y, Zhu H, Chen N. Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma. Mol Carcinog. 2015; 54:156-65.
16. Valentine R, Dawson CW, Hu C, Shah KM, Owen TJ, Date KL, Maia SP, Shao J, Arrand JR, Young LS, O'Neil JD. Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation. Molecular cancer. 2010; 9:1.
17. Xie Y, Li Y, Peng X, Henderson F Jr., Deng L, Chen N. Ikappa B kinase alpha involvement in the development of nasopharyngeal carcinoma through a NF-kappaBindependent and ERK-dependent pathway. Oral oncology. 2013; 49:1113-1120.
18. Yan M, Zhang Y, He B, Xiang J, Wang ZF, Zheng FM, Xu J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, Wang J, et al. IKKalpha restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nature communications. 2014; 5:3661.
19. Fisseler-Eckhoff A. [Malignant lung tumors- histomorphological classification, immunohistological techniques and prognostic factors] Kongressband / Deutsche Gesellschaft fur Chirurgie Deutsche Gesellschaft fur Chirurgie Kongress!. 2001; 118:590-595.
20. Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature. 2003; 423:659-663.
21. Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature. 2003; 423:655-659.
22. Huang WC, Ju TK, Hung MC, Chen CC. Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Molecular cell. 2007; 26:75-87.
23. Chariot A. The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends in cell biology. 2009; 19:404-413.
24. Hinz M, Scheidereit C. The IkappaB kinase complex in NF-kappaB regulation and beyond. EMBO reports. 2014; 15:46-61.
25. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013; 503:218-223.
26. Visvader JE. Cells of origin in cancer. Nature. 2011; 469:314-322.
27. Han X, Li F, Fang Z, Gao Y, Li F, Fang R, Yao S, Sun Y, Li L, Zhang W, Ma H, Xiao Q, Ge G, Fang J, Wang H, Zhang L, et al. Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nature communications. 2014; 5:3261.
28. Eckhart L, Lippens S, Tschachler E, Declercq W. Cell death by cornification. Biochim Biophys Acta. 2013; 1833:3471-3480.
29. Bragulla HH, Homberger DG. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. Journal of anatomy. 2009; 214:516-559.
30. Liu B, Willette-Brown J, Liu S, Chen X, Fischer SM, Hu Y. IKKalpha represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin. Cell death and differentiation. 2011; 18:1854-1864.
31. Alameda JP, Moreno-Maldonado R, Fernandez-Acenero MJ, Navarro M, Page A, Jorcano JL, Bravo A, Ramirez A, Casanova ML. Increased IKKalpha expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors. PLoS One. 2011; 6:e21984.
32. Jiang R, Xia Y, Li J, Deng L, Zhao L, Shi J, Wang X, Sun B. High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. Int J Cancer. 2010; 126:1263-1274.
33. Merkhofer EC, Cogswell P, Baldwin AS. Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. Oncogene. 2010; 29:1238-1248.
34. Mahato R, Qin B, Cheng K. Blocking IKKalpha expression inhibits prostate cancer invasiveness. Pharmaceutical research. 2011; 28:1357-1369.
35. Fernandez-Majada V, Aguilera C, Villanueva A, Vilardell F, Robert-Moreno A, Aytes A, Real FX, Capella G, Mayo MW, Espinosa L, Bigas A. Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer. Proc Natl Acad Sci U S A. 2007; 104:276-281.
36. Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nature reviews Molecular cell biology. 2005; 6:328-340.
37. Hayez A, Malaisse J, Roegiers E, Reynier M, Renard C, Haftek M, Geenen V, Serre G, Simon M, de Rouvroit CL, Michiels C, Poumay Y. High TMEM45A expression is correlated to epidermal keratinization. Experimental dermatology. 2014; 23:339-344.