메뉴 건너뛰기




Volumn 54, Issue 2, 2015, Pages 156-165

Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma

Author keywords

IkappaB kinase alpha; Nasopharyngeal carcinoma; Prognostic marker; Tumor malignant behaviors; Tumor suppressor

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN 1; I KAPPA B KINASE ALPHA; I KAPPA B KINASE;

EID: 84920573691     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22087     Document Type: Article
Times cited : (9)

References (23)
  • 1
    • 55949089769 scopus 로고    scopus 로고
    • The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway
    • Marinari B, Moretti F, Botti E, et al. The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci USA 2008; 105:17091-17096.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17091-17096
    • Marinari, B.1    Moretti, F.2    Botti, E.3
  • 2
    • 34548844747 scopus 로고    scopus 로고
    • Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression
    • Maeda G, Chiba T, Kawashiri S, Satoh T, Imai K. Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression. Clin Cancer Res 2007; 13:5041-5047.
    • (2007) Clin Cancer Res , vol.13 , pp. 5041-5047
    • Maeda, G.1    Chiba, T.2    Kawashiri, S.3    Satoh, T.4    Imai, K.5
  • 3
    • 0038511129 scopus 로고    scopus 로고
    • Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
    • Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 2003; 423:655-659.
    • (2003) Nature , vol.423 , pp. 655-659
    • Yamamoto, Y.1    Verma, U.N.2    Prajapati, S.3    Kwak, Y.T.4    Gaynor, R.B.5
  • 4
    • 0033537757 scopus 로고    scopus 로고
    • Limb and skin abnormalities in mice lacking IKKalpha
    • Takeda K, Takeuchi O, Tsujimura T, et al. Limb and skin abnormalities in mice lacking IKKalpha. Science 1999; 284:313-316.
    • (1999) Science , vol.284 , pp. 313-316
    • Takeda, K.1    Takeuchi, O.2    Tsujimura, T.3
  • 5
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
    • Hu Y, Baud V, Delhase M, et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999; 284:316-320.
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1    Baud, V.2    Delhase, M.3
  • 6
    • 47749125369 scopus 로고    scopus 로고
    • IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas
    • Moreno-Maldonado R, Ramirez A, Navarro M, et al. IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. Cell Cycle 2008; 7:2021-2029.
    • (2008) Cell Cycle , vol.7 , pp. 2021-2029
    • Moreno-Maldonado, R.1    Ramirez, A.2    Navarro, M.3
  • 7
    • 33751217161 scopus 로고    scopus 로고
    • A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    • Liu B, Park E, Zhu F, et al. A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci USA 2006; 103:17202-17207.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17202-17207
    • Liu, B.1    Park, E.2    Zhu, F.3
  • 8
    • 34447333358 scopus 로고    scopus 로고
    • IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing
    • Zhu F, Xia X, Liu B, Shen J, Hu Y, Person M. IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. Mol Cell 2007; 27:214-227.
    • (2007) Mol Cell , vol.27 , pp. 214-227
    • Zhu, F.1    Xia, X.2    Liu, B.3    Shen, J.4    Hu, Y.5    Person, M.6
  • 9
    • 35148897233 scopus 로고    scopus 로고
    • Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas
    • Park E, Zhu F, Liu B, et al. Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. Cancer Res 2007; 67:9158-9168.
    • (2007) Cancer Res , vol.67 , pp. 9158-9168
    • Park, E.1    Zhu, F.2    Liu, B.3
  • 10
    • 84876355029 scopus 로고    scopus 로고
    • The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas
    • Xiao Z, Jiang Q, Willette-Brown J, et al. The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 2013; 23:527-540.
    • (2013) Cancer Cell , vol.23 , pp. 527-540
    • Xiao, Z.1    Jiang, Q.2    Willette-Brown, J.3
  • 11
    • 79957556359 scopus 로고    scopus 로고
    • How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients
    • Lai SZ, Li WF, Chen L, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys 2011; 80:661-668.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 661-668
    • Lai, S.Z.1    Li, W.F.2    Chen, L.3
  • 12
    • 0036463895 scopus 로고    scopus 로고
    • Molecular mechanisms of tumorgenesis and metastasis in nasopharyngeal carcinoma cell sublines
    • Song LB, Yan J, Jian SW, et al. Molecular mechanisms of tumorgenesis and metastasis in nasopharyngeal carcinoma cell sublines. Ai Zheng 2002; 21:158-162.
    • (2002) Ai Zheng , vol.21 , pp. 158-162
    • Song, L.B.1    Yan, J.2    Jian, S.W.3
  • 13
    • 10644225068 scopus 로고    scopus 로고
    • Identification and characterization of the IKKalpha promoter: Positive and negative regulation by ETS-1 and p53, respectively
    • Gu L, Zhu N, Findley HW, Woods WG, Zhou M. Identification and characterization of the IKKalpha promoter: Positive and negative regulation by ETS-1 and p53, respectively. J Biol Chem 2004; 279:52141-52149.
    • (2004) J Biol Chem , vol.279 , pp. 52141-52149
    • Gu, L.1    Zhu, N.2    Findley, H.W.3    Woods, W.G.4    Zhou, M.5
  • 14
    • 84875250817 scopus 로고    scopus 로고
    • Mouse genetic models reveal surprising functions of IkB kinase alpha in skin development and skin carcinogenesis
    • Xia X, Park E, Fischer S, Hu Y. Mouse genetic models reveal surprising functions of IkB kinase alpha in skin development and skin carcinogenesis. Cancers 2013; 5:170-183.
    • (2013) Cancers , vol.5 , pp. 170-183
    • Xia, X.1    Park, E.2    Fischer, S.3    Hu, Y.4
  • 15
    • 4644345181 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy
    • Chua DT, Nicholls JM, Sham JS. Au GK. Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys 2004; 59:11-20.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 11-20
    • Chua, D.T.1    Nicholls, J.M.2    Sham, J.S.3    Au, G.K.4
  • 16
    • 0034992521 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
    • Prenzel N, Fischer OM, Streit S, Hart S, Ullrich A. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer 2001; 8:11-31.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 11-31
    • Prenzel, N.1    Fischer, O.M.2    Streit, S.3    Hart, S.4    Ullrich, A.5
  • 17
    • 84859104051 scopus 로고    scopus 로고
    • IKK-beta mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death
    • Tezil T, Bodur C, Kutuk O, Basaga H. IKK-beta mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death. Cell Signal 2012; 24:1361-1368.
    • (2012) Cell Signal , vol.24 , pp. 1361-1368
    • Tezil, T.1    Bodur, C.2    Kutuk, O.3    Basaga, H.4
  • 18
    • 34047248402 scopus 로고    scopus 로고
    • Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB
    • Huang WC, Ju TK, Hung MC, Chen CC. Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell 2007; 26:75-87.
    • (2007) Mol Cell , vol.26 , pp. 75-87
    • Huang, W.C.1    Ju, T.K.2    Hung, M.C.3    Chen, C.C.4
  • 19
    • 40849083857 scopus 로고    scopus 로고
    • IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
    • Bakkar N, Wang J, Ladner KJ, et al. IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol 2008; 180:787-802.
    • (2008) J Cell Biol , vol.180 , pp. 787-802
    • Bakkar, N.1    Wang, J.2    Ladner, K.J.3
  • 20
    • 80051986818 scopus 로고    scopus 로고
    • The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1
    • Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW. The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol 2011; 12:834-843.
    • (2011) Nat Immunol , vol.12 , pp. 834-843
    • Shembade, N.1    Pujari, R.2    Harhaj, N.S.3    Abbott, D.W.4    Harhaj, E.W.5
  • 21
    • 57749121470 scopus 로고    scopus 로고
    • IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis
    • DeBusk LM, Massion PP, Lin PC. IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis. Cancer Res 2008; 68:10223-10228.
    • (2008) Cancer Res , vol.68 , pp. 10223-10228
    • DeBusk, L.M.1    Massion, P.P.2    Lin, P.C.3
  • 22
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441:431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 23
    • 76749150968 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation
    • Valentine R, Dawson CW, Hu C, et al. Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation. Mol Cancer 2010; 9:1.
    • (2010) Mol Cancer , vol.9 , pp. 1
    • Valentine, R.1    Dawson, C.W.2    Hu, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.