Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer

Cochrane Database of Systematic Reviews

Volumn 2015, Issue 4, 2015, Pages

  Kokka, Fani ^a   Bryant, Andrew ^b   Brockbank, Elly ^c   Powell, Melanie ^c   Oram, David ^c  

^a Queen Elizabeth the Queen Mother Hospital   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ADVANCED CANCER; ADVERSE OUTCOME; ALLERGY; ALOPECIA; ANEMIA; ANOREXIA; BLADDER DYSFUNCTION; BLEEDING; BLOOD TOXICITY; BRACHYTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CHEMORADIOTHERAPY; CLINICAL EFFECTIVENESS; DIARRHEA; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG SAFETY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYSTERECTOMY; INTERVENTION STUDY; LEUKOPENIA; LIVER TOXICITY; LUNG DISEASE; LUNG INJURY; LYMPHEDEMA; MONOTHERAPY; MUCOSA INFLAMMATION; NAUSEA; NEUROLOGIC DISEASE; NEUTROPENIA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROCTITIS; PROGRESSION FREE SURVIVAL; PSYCHOSEXUAL DISORDER; QUALITY OF LIFE; RADIATION DERMATITIS; RECURRENCE FREE SURVIVAL; REVIEW; SKIN DISEASE; STOMATITIS; SURVIVAL ANALYSIS; SURVIVAL TIME; SYSTEMATIC REVIEW; THROMBOCYTOPENIA; UROGENITAL TRACT DISEASE; UTERINE CERVIX CANCER; VOMITING; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; META ANALYSIS; MORTALITY; PATHOLOGY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); UTERINE CERVICAL NEOPLASMS;

CHEMORADIOTHERAPY; CHEMOTHERAPY, ADJUVANT; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; HYSTERECTOMY; NEOADJUVANT THERAPY; RADIOTHERAPY, ADJUVANT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; UTERINE CERVICAL NEOPLASMS;

EID: 84944472707     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD010260.pub2     Document Type: Review

References (69)

1. Benedetti-Panici P, Greggi S, Colombo A, Amoroso M, Smaniotto D, Giannarelli D, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. Journal of Clinical Oncology 2002;20(1):179-88.
2. Cetina L, González-Enciso A, Cantú D, Coronel J, Pérez-Montiel D, Hinojosa J, et al. Brachytherapy versus radical hysterectomy after external beam chemoradiation with gemcitabine plus cisplatin: a randomized, phase III. study in IB2-IIB cervical cancer patients. Annals of Oncology 2013;24:2043-7. [DOI: 10.1093/annonc/mdt142]
3. Chang T-C, Lai C-H, Hong J-H, Hsueh S, Huang K-G, Chou H-H, et al. Randomized trial of neoadjuvant cisplatin, vincristine, bleomycin, and radical hysterectomy versus radiation therapy for bulky stage IB and IIA cervical cancer. Journal of Clinical Oncology 2000;18(8):1840-7.
4. Keys HM, Bundy BN, Stehman FB, Okagaki T, Gallup DG, Burnett AF, et al. Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: a randomized trial of the Gynecologic Oncology Group. Gynecologic Oncology 2003;89(3):343-53.
5. Morice P, Rouanet P, Rey A, Romestaing P, Houvenaeghel G, Boulanger JC, et al. Results of the GYNECO 02 study, an FNCLCC phase III. trial comparing hysterectomy with no hysterectomy in patients with a (clinical and radiological) complete response after chemoradiation therapy for stage IB2 or II. cervical cancer. The Oncologist 2012;17(1):64-71.
6. Perez CA, Camel HM, Kao MS, Hederman MA. Randomized study of preoperative radiation and surgery or irradiation alone in the treatment of stage IB and IIA carcinoma of the uterine cervix: final report. Gynecologic Oncology 1987;27(2):129-40.
7. Noriyuki Y, Hiroshi S, Kazuko F, Kimihiro N, Tsuyomu I. A randomized trial of neoadjuvant chemotherapy followed by radical surgery versus radiotherapy alone in stage III.b carcinoma of the uterine cervix. Journal Of Gynecologic Surgery 2010;26(2):105-13.
8. Katsumata N, Yoshikawa H, Kobayashi H, Saito T, Kuzuya K, Nakanishi T, et al. Phase III. randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102). British Journal of Cancer 2013;108(10):1957-63.
9. Keys HM, Bundy BN, Stehman FB, Muderspach LI, Chafe WE, Suggs CL, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. The New England Journal of Medicine 1999;340(15):1154-61.
10. Sardi JE, Giaroli A, Sananes C, Ferreira M, Soderini A, Bermudez A, et al. Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix: the final results. Gynecologic Oncology 1997;67(1):61-9.
11. Sun H, Xin J, Lu Z, Wang N, Liu N, Guo Q. Potential molecular mechanisms for improved prognosis and outcome with neoadjuvant chemotherapy prior to laparoscopical radical hysterectomy for patients with cervical cancer. Cellular Physiology and Biochemistry 2013;32(5):1528-40.
12. Sundfor K, Trope CG, Kjorstad KE. Radical radiotherapy versus brachytherapy plus surgery in carcinoma of the cervix 2A and 2B. Long-term results from a randomized study 1968-1980. Acta Oncologica 1996;35 Suppl 8:99-107.
13. Landoni F, Colombo A, Greggi S, Kenter GG. NCT00039338-Chemotherapy followed by surgery versus radiotherapy plus chemotherapy in patients with stage IB or II. cervical cancer. ClinicalTrials.gov 2002.
14. Alvarez RD, Soong SJ, Kinney WK, Reid GC, Schray MF, Podratz KC, et al. Identification of prognostic factors and risk groups in patients found to have nodal metastasis at the time of radical hysterectomy for early-stage squamous carcinoma of the cervix. Gynecologic Oncology 1989;36:130-5.
15. Azria E, Morice P, Haie-Meder C, Thoury A, Pautier P, Lhomme C, et al. Results of hysterectomy in patients with bulky residual disease at the end of chemoradiotherapy for stage IB2/II. cervical carcinoma. Annals of Surgical Oncology 2005;12:332-7.
16. Benedet JL, Odicino F, Maisonneuve P, Beller U, Creasman WT, Heintz AP, et al. Carcinoma of the cervix uteri. International Journal of Gynaecology and Obstetrics 2003;83 Suppl 1:41-78.
17. Benedetti Panici P, Bellati F, Manci N, Pernice M, Plotti F, Di Donato V, et al. Neoadjuvant chemotherapy followed by radical surgery in patients affected by FIGO stage IVA cervical cancer. Annals of Surgical Oncology 2007;14(9):2643-8.
18. Bijen CB, Vermeulen KM, Mourits MJ, de Bock GH. Costs and effects of abdominal versus laparoscopic hysterectomy: systematic review of controlled trials. PLoS One 2009;4(10):e7340.
19. Burghardt E, Pickel H. Local spread and lymph node involvement in cervical cancer. Obstetrics and Gynecology 1978;52:138-45.
20. Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC). Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis. Cochrane Database of Systematic Reviews 2010, Issue 1. [DOI: 10.1002/14651858.CD008285]
21. Chung CK, Nahhas WA, Stryker JA, Curry SL, Abt AB, Mortel R. Analysis of factors contributing to treatment failures in stage IB and IIA carcinoma of the cervix. American Journal of Obstetrics and Gynecology 1980;138:550-6.
22. Classe JM, Rauch P, Rodier JF, Morice P, Stoeckle E, Lasry S, et al. Surgery after concurrent chemoradiotherapy and brachytherapy for the treatment of advanced cervical cancer: morbidity and outcome: results of a multicenter study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer). Gynecologic Oncology 2006;102:523-9.
23. Colombo PE, Bertrand MM, Gutowski M, Mourregot A, Fabbro M, Saint-Aubert B, et al. Total laparoscopic radical hysterectomy for locally advanced cervical carcinoma (stages IIB, IIA and bulky stages IB) after concurrent chemoradiation therapy: surgical morbidity and oncological results. Gynecologic Oncology 2009;114(3):404-9.
24. Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey Smith G, Altman DG editor(s). Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd Edition. London: BMJ Publication Group, 2001.
25. Delgado E, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F. Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study. Gynecologic Oncology 1990;38:352-7.
26. DerSimonian R, Laird N. Meta-analysis in clinical trials. Controlled Clinical Trials 1986;7(3):177-88.
27. Eifel PJ. Radiotherapy versus radical surgery for gynecologic neoplasms: carcinomas of the cervix and vulva. Frontiers of Radiation Therapy and Oncology 1993;27:130-42.
28. Coleman MP, Gatta G, Verdecchia A, Esteve J, Sant M, Storm H, et al. EUROCARE-3 summary: cancer survival in Europe at the end of the 20th century. Annals of Oncology 2003;14 Suppl 5:v128-49.
29. Ferrandina G, Ercoli A, Fagotti A, Fanfani F, Gallotta V, Margariti AP, et al. Completion surgery after concomitant chemoradiation in locally advanced cervical cancer: a comprehensive analysis of pattern of postoperative complications. Annals of Surgical Oncology 2014 May;21(5):1692-9.
30. Gadducci A, Sartori E, Maggino T, Zola P, Cosio S, Zizioli V, et al. Pathological response on surgical samples is an independent prognostic variable for patients with Stage Ib2-IIb cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy: an Italian multicenter retrospective study (CTF Study). Gynecologic Oncology 2013;131(3):640-4. [DOI: 10.1016/j.ygyno.2013.09.029]
31. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. Cancer incidence and mortality worldwide. IARC CancerBase No. 11 [Internet].Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 11/3/2015. Lyon, France.
32. GRADE Working Group. Grading quality of evidence and strength of recommendations. BMJ 2004;328:1490-4.
33. Green JA, Kirwan JM, Tierney JF, Symonds P, Fresco L, Collingwood M, et al. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet 2001;358(9284):781-6.
34. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60.
35. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration 2011; Vol. 5.1.0:www.cochrane-handbook.org.
36. Houvenaeghel G, Martino M, Bladou F, Moutardier V, Ternier F, Delpero JR, et al. Value of surgery in the treatment of advanced cervical cancers. Annales de Chirurgie 1998;52:425-33.
37. Houvenaeghel G, Lelievre L, Buttarelli M, Jacquemier J, Carcopino X, Viens P, et al. Contribution of surgery in patients with bulky residual disease after chemoradiation for advanced cervical carcinoma. European Journal of Surgical Oncology 2007;33:498-503.
38. Kesic V. Management of cervical cancer. European Journal of Surgical Oncology 2006;32:832-7.
39. Khuhaprema T, Srivatanakul P, Sriplung H, Wiangnon S, Sumitsawan Y, Attasara P. Cancer in Thailand 2001-2003. Bangkok: National Cancer Institute 2010;V:3-76.
40. Kornovski Y, Gorchev G. Histopathological findings in postoperative specimens in cervical cancer patients with stages Ib2-IVa after neoadjuvant chemotherapy and preoperative plus postoperative radiotherapy. Journal of the Balkan Union of Oncology 2007;12:57-63.
41. Kundargi RS, Guruprasad B, Hanumantappa N, Rathod PS, Devi UK, Bafna UD. The role of surgery in locally advanced carcinoma of cervix after sub-optimal chemoradiation: Indian scenario. South Asian Journal of Cancer 2013;2(3):137-9.
42. Laara E, Day NE, Hakama M. Trends in mortality from cervical cancer in the Nordic countries: association with organised screening programmes. Lancet 1987;1(8544):1247-9.
43. Landoni F, Maneo A, Colombo A, Placa F, Milani R, Perego P, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet 1997;350(9077):535-40.
44. Landoni F, Sartori E, Maggino T, Zola P, Zanagnolo V, Cosio S, et al. Is there a role for postoperative treatment in patients with stage Ib2-IIb cervical cancer treated with neo-adjuvant chemotherapy and radical surgery? An Italian multicenter retrospective study. Gynecologic Oncology 2013;14:pii: S0090-8258(13)01374-7. [DOI: 10.1016/j.ygyno.2013.12.010]
45. Leino R, Grenman S, Rantanen V, Kiilholma P, Salmi T. Operative treatment of advanced cervical cancer after full pelvic irradiation. Annales Chirurgiae et Gynaecologiae 1994;208 Suppl:50-3.
46. Morris M, Eifel PJ, Lu J, Grigsby PW, Levenback C, Stevens RE, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. The New England Journal of Medicine 1999;340(15):1137-43.
47. Mathers C, Boerma T, Fat DM. The Global Burden of Disease. WHO Press 2004.
48. National Cancer Institute. NCI Clinical Announcement. Bethesda, MD, United States Department of Health and Human Services, Public Health Service, National Institutes of Health February 1999.
49. National Cancer Institute. Stage IVB Cervical Cancer Treatment. http://www.cancer.gov/cancertopics/pdq/treatment/cervical/HealthProfessional/page9.
50. NCIN. Cervical Cancer Incidence and Screening Coverage. National Cancer Intelligence Network www.ncin.org.uk/publication/data_briefings/cervical_incidence:and_screening.aspx.
51. Noterman D, Philippson C, Hertens D, Veys I, Schobbens JC, Nogaret JM. Neoadjuvant radiochemotherapy and surgery of locally advanced cervical carcinoma: review of 22 patients treated at the Bordet Institute. Journal de Gynecologie Obstetrique et Biologie de la Reproduction 2006;35:23-7.
52. Ota T, Takeshima N, Tabata T, Hasumi K, Takizawa K. Adjuvant hysterectomy for treatment of residual disease in patients with cervical cancer treated with radiation therapy. British Journal of Cancer 2008 Oct 21;99(8):1216-20.
53. Park JY, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Laparoscopic versus open radical hysterectomy in patients with stage IB2 and IIA2 cervical cancer. Journal of Surgical Oncology 2013;108(1):63-9.
54. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine 1998;17:2815-34.
55. Peters WA 3rd, Liu PY, Barrett RJ 2nd, Stock RJ, Monk BJ, Berek JS, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. Journal of Clinical Oncology 2000;18(8):1606-13.
56. Piver MS, Chung WS. Prognostic significance of cervical lesion size and pelvic node metastases in cervical carcinoma. Obstetrics and Gynecology 1975;46(5):507-10.
57. Potish RA, Twiggs LB, Prem KA, Carson LF, Adcock LL. Surgical intervention following multimodality therapy for advanced cervical cancer. Gynecologic Oncology 1990 1990;38:175-80.
58. Quinn M, Babb P, Jones J, Allen E. Effect of screening on incidence of and mortality from cancer of cervix in England: evaluation based on routinely collected statistics. BMJ 1999;318(7188):904-8.
59. The Nordic Cochrane Centre. Review Manager (RevMan). 5.1. Copenhagen: The Cochrane Collaboration, 2011.
60. Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England Journal of Medicine 1999;340(15):1144-53.
61. Rydzewska L, Tierney J, Vale CL, Symonds PR. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. Cochrane Database of Systematic Reviews 2012, Issue 12. [DOI: 10.1002/14651858.CD007406.pub3]
62. Sardi J, Sananes C, Giaroli A, Maya G, di Paola G. Neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri. Gynecologic Oncology 1990;38(3):486-93.
63. Sardi J, Giaroli A. Sananes C, Rueda N G, Vighi S, Ferreira M, et al. Randomized trial with neoadjuvant chemotherapy in stage III.B squamous carcinoma cervix uteri: an unexpected therapeutic management. International Journal of Gynecological Cancer 1996;6:85-93.
64. Shepherd JH. Cervical cancer. Best Practice & Research. Clinical Obstetrics & Gynaecology 2012;26(3):293-309.
65. Sun L, Sheng X, Jiang J, Li X, Liu N, Liu Y, et al. Surgical morbidity and oncologic results after concurrent chemoradiation therapy for advanced cervical cancer. International Journal of Gynaecology and Obstetrics 2014;125(2):111-5. [DOI: 10.1016/j.ijgo.2013.07.041]
66. Hequet D, Marchand E, Place V, Fourchotte V, De La Rochefordière A, Dridi S, et al. Evaluation and impact of residual disease in locally advanced cervical cancer after concurrent chemoradiation therapy: results of a multicenter study. European Journal of Surgical Oncology 2013;39(12):1428-34. [DOI: 10.1016/j.ejso.2013.10.006]
67. Tsuda H, Tanaka M, Manabe T, Nakata S, Ishiko O, Yamamoto K. Phase I-II. study of neoadjuvant chemoradiotherapy followed by radical surgery in locally advanced cervical cancer. Anticancer Drugs 2001 2001;12:853-8.
68. Wang Y, Cao P, Zhang X, Zeng Q. Combined treatment for locally advanced carcinoma of uterine cervix. Zhonghua Zhong Liu Za Zhi 2002;24:508-10.
69. Whitney CW1, Sause W, Bundy BN, Malfetano JH, Hannigan EV, Fowler WC Jr, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. Journal of Clinical Oncology 1999;17(5):1339-48.