Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix

Journal of Clinical Oncology

Volumn 18, Issue 8, 2000, Pages 1606-1613

  Peters III, William A ^a   Liu, P Y ^a   Barrett II, Rolland J ^a   Stock, Richard J ^a   Monk, Bradley J ^a   Berek, Jonathan S ^a   Souhami, Luis ^a   Grigsby, Perry ^a   Gordon Jr , William ^a   Alberts, David S ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TREATMENT INDICATION; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA;

EID: 0033993937     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2000.18.8.1606     Document Type: Article

References (39)

1. Morley GW, Seski JC: Radical pelvic surgery versus radiation therapy for stage 1 carcinoma of the cervix (exclusive of microinvasion). Am J Obstet Gynecol 126:785-794, 1976
2. Hopkins MP, Morley GW: Radical hysterectomy versus radiation therapy for stage IB squamous cell carcinoma of the cervix. Cancer 68:272-277, 1991
3. Landoni F, Maneo A, Colombo A, et al: Randomised study of radical surgery versus radiotherapy for stages IB-IIA cervical cancer. Lancet 350:535-540, 1997
4. Shingleton HM, Jones WB, Russell A, et al: Hysterectomy in invasive cervical cancer: A national patterns of care study of the American College of Surgeons. J Am Coll Surg 183:393-400, 1996
5. Russell AH, Shingleton HM, Jones WB, et al: Trends in the use of radiation and chemotherapy in the initial management of patients with carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 40:605-613, 1998
6. Inoue T, Okumura M: Prognostic significance of parametrial extension in patients with cervical carcinoma stages IB, IIA and IIB: A study of 628 cases treated by radical hysterectomy and lymphadenectomy with and without postoperative radiation. Cancer 54:1714-1719, 1984
7. Alvarez RD, Soong SJ, Kinney WK, et al: Identification of prognostic factors and risk groups in patients found to have nodal metastasis at time of radical hysterectomy for early-stage squamous carcinoma of the cervix. Gynecol Oncol 35:130-135, 1989
8. Fuller AF Jr, Elliott N, Kosloff C, et al: Determinants of increased risk for recurrence in patients undergoing radical hysterectomy for stage IA and IIB carcinoma of the cervix. Gynecol Oncol 33:34-39, 1989
9. Delgado G, Bundy B, Zaino R, et al: Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study. Gynecol Oncol 38:352-357, 1990
10. Sevin BU, Lu Y, Bloch BA, et al: Surgically defined prognostic parameters in patients with early cervical carcinoma: A multivariate survival tree analysis. Cancer 78:1438-1446, 1996
11. Zreik TG, Chambers JT, Chambers SK: Parametrial involvement, regardless of nodal status: A poor prognostic factor for cervical cancer. Obstet Gynecol 87:741-746, 1996
12. Lin HH, Cheng WF, Chan KW, et al: Risk factors for recurrence in patients with stage IB, IIA and IIB cervical carcinoma after radical hysterectomy and postoperative pelvic irradiation. Obstet Gynecol 88:274-279, 1996
13. Kamura T, Tsukamoto N, Tsuruchi N, et al: Multivariate analysis of the histopathologic prognostic factors of cervical cancer in patients undergoing radical hysterectomy. Cancer 69:181-186. 1992
14. Estape RE, Angioli R, Madrigal M, et al: Close vaginal margins as a prognostic factor after radical hysterectomy. Gynecol Oncol 68:229-232, 1998
15. Morrow CP, Shingleton HM, Averette HE, et al: Is pelvic radiation beneficial in the postoperative management of stage IB squamous cell carcinoma of the cervix with pelvic node metastasis treated by radical hysterectomy and pelvic lymphadenectomy? A report from the Presidential Panel at the 1979 Annual Meeting of the Society of Gynecologic Oncologists. Gynecol Oncol 10:105-110, 1980
16. Kinney WK, Alvarez RD, Reid GC, et al: Value of adjuvant whole-pelvis irradiation after Wertheim hysterectomy for early-stage squamous carcinoma of the cervix with pelvic nodal metastasis: A matched-control study. Gynecol Oncol 34:258-262, 1989
17. Rotmensch J, Senekjian EK, Javaheri G, et al: Evaluation of bolus cis-platinum and continuous 5-fluorouracil infusion for metastatic and recurrent squamous cell carcinoma of the cervix. Gynecol Oncol 29:76-81, 1988
18. Bonomi P, Blessing J, Ball H, et al: A phase II evaluation of cisplatin and 5-fluorouracil in patients with advanced squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study. Gynecol Oncol 34:357-359, 1989
19. Weiss GR, Green S, Hannigan EV, et al: A phase II trial of cisplatin and 5-fluorouracil with allopurinol for recurrent or metastatic carcinoma of the uterine cervix: A Southwest Oncology Group trial. Gynecol Oncol 37:354-358, 1990
20. Vokes EE, Weichselbaum RR: Concomitant chemoradiotherapy: Rationale and clinical experience in patients with solid tumors. J Clin Oncol 8:911-934, 1990
21. Roberts WS, Kavanagh JJ, Greenberg H, et al: Concomitant radiation therapy and chemotherapy in the treatment of advanced squamous carcinoma of the lower female genital tract. Gynecol Oncol 34:183-186, 1989
22. Rose PG, Bundy BN, Watkins EB, et al: Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340:1144-1153, 1999
23. Keys HM, Bundy BN, Stehman FB, et al: Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340:1154-1161, 1999
24. Morris M, Eifel PJ, Lu J, et al: Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 340:1137-1143, 1999
25. Whitney CW, Sause W, Bundy BN, et al: Randomized Comparison of fluorouracil plus cisplatin versus hydroxyurea on an adjuvant to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: A Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 17:1339-1348, 1999
26. Piver MS, Rutledge F, Smith JP: Five classes of extended hysterectomy for women with cervical cancer. Obstet Gynecol 44:263-272, 1974
27. Green S, Weiss GR: Southwest Oncology Group standard response criteria, end point definitions and toxicity criteria, Invest New Drugs 10:239-253, 1992
28. Crowley J, Green S, Liu PY, et al: Data monitoring committees and early stopping guidelines: The Southwest Oncology Group experience. Stat Med 13:1391-1399, 1994
29. Anderson JR, Cain KC, Gelber RD: Analysis of survival by tumor response. J Clin Oncol 1:710-719, 1983
30. Sedlis A, Bundy BN, Rotman M, et al: A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group study. Gynecol Oncol 73:177-183, 1999
31. Smith MR, Peters WA III, Goodman G, et al. Advanced cervical carcinoma: New strategies, in Russell KP, Maharry JM (edx): Transactions of the Pacific Coast Obstetrical and Gynecological Society. St Louis, MO, CV Mosby Co, 1985, p 98
32. Werthheim MS, Hakes TB, Daghestani AN, et al: A pilot study of adjuvant therapy in patients with cervical cancer at high risk for recurrence after radical hysterectomy and pelvic lymphadenectomy. J Clin Oncol 3:912-916, 1985
33. Ashraf M, Boyd MD: Adjunctive postoperative cisplatin in carcinoma of the cervix stage IB and IIA with positive lymph nodes. Gynecol Oncol 26:406-407, 1987 (abstr 2)
34. Lai CH, Lin TS, Soong YK, et al: Adjuvant chemotherapy after radical hysterectomy for cervical carcinoma. Gynecol Oncol 35:193-198, 1989
35. Killackey MA, Boardman L, Carroll DS: Adjuvant chemotherapy and radiation in patients with poor prognostic stage IB/IIA cervical cancer. Gynecol Oncol 49:377-379, 1993
36. Iwasaka T, Kamura T, Yokoyama M, et al: Adjuvant chemotherapy alter radical hysterectomy for cervical carcinoma: A comparison with effects of adjuvant radiotherapy. Obstet Gynecol 91:977-981, 1998
37. Curtin JP, Hoskins WJ, Venkatraman ES, et al: Adjuvant chemotherapy versus chemotherapy plus pelvic irradiation for high-risk cervical cancer patients after radical hysterectomy and pelvic lymphadenectomy (RH-PLND): A randomized phase III trial. Gynecol Oncol 61:3-10, 1996
38. Tattersall MH, Ramirez C, Coppleson M: A randomised trial of adjuvant chemotherapy after radical hysterectomy in stage Ib-IIa cervical cancer patients with pelvic lymph node metastases. Gynecol Oncol 46:176-181, 1992
39. Hopkins MP, Morley GW: A comparison of adenocarcinoma and squamous cell carcinoma of the cervix. Obstet Gynecol 77:912-917, 1991