Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma

New England Journal of Medicine

Volumn 340, Issue 15, 1999, Pages 1154-1161

  Keys, Henry M ^a   Bundy, Brian N ^b   Stehman, Frederick B ^c   Muderspach, Laila I ^d   Chafe, Weldon E ^g   Suggs III, Charles L ^g   Walker, Joan L ^e   Gersell, Deborah ^g   Mackey, Denise ^f  

^a ALBANY MEDICAL COLLEGE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e Section of Gynecologic Oncology   (United States)

^f GOG Administrative Office   (United States)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL; HYDROXYUREA;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYSTERECTOMY; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; NEUROTOXICITY; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SKIN DEFECT; TREATMENT OUTCOME; TREATMENT PLANNING; UROGENITAL TRACT DISEASE; UTERINE CERVIX CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BRACHYTHERAPY; CARCINOMA; CISPLATIN; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; FEMALE; HUMANS; HYSTERECTOMY; MIDDLE AGED; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS; UTERINE CERVICAL NEOPLASMS;

EID: 0033561259     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199904153401503     Document Type: Article

References (33)

1. Cervix uteri. In: Beahrs OH, Henson DE, Hutter RVP, Kennedy BJ, eds. Manual for staging of cancer. 4th ed. Philadelphia: J.B. Lippincott, 1992:155-60.
2. Delgado G, Bundy BN, Fowler WC Jr, et al. A prospective surgical study of stage I squamous carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 1989;35:314-20.
3. Homesley HD, Raben M, Blake DD, et al. Relationship of lesion size to survival in patients with stage IB squamous cell carcinoma of the cervix uteri treated by radiation therapy. Surg Gynecol Obstet 1989;150:529-31.
4. Perez CA, Grigsby PW, Nene SM, et al. Effect of tumor size on the prognosis of carcinoma of the uterine cervix treated with irradiation alone. Cancer 1992;69:2796-806.
5. Durrance FY, Fletcher GH, Rutledge FN. Analysis of central recurrent disease in stages I and II squamous cell carcinomas of the cervix on intact uterus. AJR Am J Roentgenol 1969;106:831-8.
6. Rutledge FN, Wharton JT, Fletcher GH. Clinical studies with adjunctive surgery and irradiation therapy in the treatment of carcinoma of the cervix. Cancer 1976;38:596-602.
7. Gallion HH, van Nagell JRJr, Donaldson ES, et al. Combined radiation therapy and extra-fascial hysterectomy in the treatment of stage IB barrel-shaped cervical cancer. Cancer 1985;56:262-5.
8. Perez CA, Breaux S, Askin F, Camel HM, Powers WE. Irradiation alone or in combination with surgery in stage IB and IIA carcinoma of the uterine cervix: a nonrandomized comparison. Cancer 1979;43:1062-72.
9. Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F. Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 1990;38:352-7.
10. Monyak DJ, Twiggs LB, Potish RA, et al. Tolerance and preliminary results of simultaneous therapy with radiation and cisplatin for advanced cervical cancer. In: Conference on the interaction of radiation therapy and chemotherapy. NCI monographs. No. 6. Washington, D.C.: Government Printing Office, 1988:369-73. (NIH publication no. 88-2939.)
11. Runowicz CD, Wadler S, Rodriguez-Rodriguez L, et al. Concomitant cisplatin and radiotherapy in locally advanced cervical carcinoma. Gynecol Oncol 1989;34:395-401.
12. Malfetano JH, Keys H. Aggressive multimodality treatment for cervical cancer with paraaortic lymph node metastases. Gynecol Oncol 1991;42: 44-7.
13. Malfetano JH, Keys H, Kredentser D, Cunningham M, Kotlove D, Weiss L. Weekly cisplatin and radical radiation therapy for advanced, recurrent, and poor prognosis cervical carcinoma. Cancer 1993;71:3703-6.
14. Malfetano JH, Keys H, Cunningham MJ, Gibbons S, Ambros R. Extended field radiation and cisplatin for stage IIB and IIIB cervical carcinoma. Gynecol Oncol 1997;67:203-7.
15. Malviya VK., Deppe G, Kim Y, Gove N. Concurrent radiation therapy, cis-platinum, and mitomycin C in patients with poor prognosis cancer of the cervix: a pilot study. Am J Clin Oncol 1989;12:434-7.
16. Chang HC, Lai CH, Chen MS, Chao AS, Chen LH, Soong YK. Preliminary results of concurrent radiotherapy and chemotherapy with cis-platinum, vincristine, and bleomycin in bulky, advanced cervical carcinoma: a pilot study. Gynecol Oncol 1992;44:182-8.
17. Lin J, Ho ES, Jan JS, Yang CH, Liu PS. High complete response rate of concomitant chemoradiotherapy for locally advanced squamous cell carcinoma of the uterine cervix. Gynecol Oncol 1996;61:101-8.
18. Blessing JA. Design, analysis and interpretation of chemotherapy trials in gynecologic cancer. In: Deppe G, ed. Chemotherapy of gynecologic cancer. 2nd ed. New York: Alan R. Liss, 1990:63-97.
19. Schoenfeld DA. Sample-size formula for the proportional-hazards regression model. Biometrics 1983;39:499-503.
20. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
21. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-70.
22. Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972;34: 187-220.
23. Snedecor GW, Cochran WG. Statistical methods. 6th ed. Ames: Iowa State University Press, 1967.
24. O'Quinn AG, Fletcher GH, Wharton JT. Guidelines for conservative hysterectomy after irradiation. Gynecol Oncol 1980;9:68-79.
25. Thorns WW Jr, Eifel PJ, Smith TL, et al. Bulky endoccrvical carcinoma: a 23-year experience. Int J Radiat Oncol Biol Phys 1992;23:491-9.
26. Stehman FB, Bundy BN, DiSaia PJ, Keys HM, Larson JE, Fowler WC. Carcinoma of the cervix treated with irradiation therapy. I. A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer 1991;67:2776-85.
27. Heaton D, Yordan E, Reddy S, et al. Treatment of 29 patients with bulky squamous cell carcinoma of the cervix with simultaneous cisplatin, 5-fluorouracil, and split-course hyperfractionated radiation therapy. Gynecol Oncol 1990;38:323-7.
28. Carde P, Laval F. Effect of cis-dichlorodiammine platinum II and X rays on mammalian cell survival. Int J Radiat Oncol Biol Phys 1981;7:929-33.
29. Wallner KE, Li GC. Effect of cisplatin resistance on cellular radiation response. Int J Radiat Oncol Biol Phys 1987;13:587-91.
30. Bonomi P, Blessing JA, Stehman FB, DiSaia PJ, Walton L, Major FJ. Randomized trial of three cisplatin dose schedules in squamous-cell carcinoma of the cervix: a Gynecologic Oncology Group study. J Clin Oncol 1985;3:1079-85.
31. Malkasian GD Jr, Decker DG, Jorgensen EO. Chemotherapy of carcinoma of the cervix. Gynccol Oncol 1977;5:109-20.
32. Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 1999;340:1144-53.
33. Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 1999;340:1137-43.