Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells

Oncotarget

Volumn 6, Issue 29, 2015, Pages 27312-27331

  Jimbo, Masaya ^a   Blanco, Fernando F ^a,b   Huang, Yu Hung ^c   Telonis, Aristeidis G ^a   Screnci, Brad A ^a   Cosma, Gabriela L ^a   Alexeev, Vitali ^a   Gonye, Gregory E ^d   Yeo, Charles J ^a   Sawicki, Janet A ^e   Winter, Jordan M ^a   Brody, Jonathan R ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d NANOSTRING TECHNOLOGIES   (United States)

^e LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

ELAVL1; HuR; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Post transcriptional regulation

Indexed keywords

DOXYCYCLINE; HUR PROTEIN; MESSENGER RNA; ELAV LIKE PROTEIN 1; ELAVL1 PROTEIN, HUMAN; ELAVL1 PROTEIN, MOUSE; NANOPARTICLE; RNA;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPAIR; DOWN REGULATION; ELAVL1 GENE; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUR GENE; INHIBITION KINETICS; MIA PACA 2 CELL LINE; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREATIC CANCER CELL LINE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GENE; TUMOR INVASION; UPREGULATION; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; CANCER TRANSPLANTATION; CARCINOMA, PANCREATIC DUCTAL; CELL ADHESION; CELL MOTION; CELL SURVIVAL; CHEMISTRY; CYTOPLASM; DNA MICROARRAY; METABOLISM; PANCREATIC NEOPLASMS; PRINCIPAL COMPONENT ANALYSIS; RNA PROCESSING; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CYTOPLASM; DOXYCYCLINE; ELAV-LIKE PROTEIN 1; FEMALE; GENE SILENCING; HUMANS; MICE; NANOPARTICLES; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; RNA; RNA PROCESSING, POST-TRANSCRIPTIONAL; SIGNAL TRANSDUCTION;

EID: 84944462903     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4743     Document Type: Article

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